Biofunctionization and  Applications of Magnetic Particles

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Magnetic Nanospecies".

Deadline for manuscript submissions: closed (20 July 2022) | Viewed by 8314

Special Issue Editors

Dr. Minglian Wang
E-Mail Website
Guest Editor
Faculty of Environment and Life Science, Beijing University of Technology, Beijing, China
Interests: biofunctionalization of magnetic materials; application of magnetic beads in cell sorting, virus enrichment, gene transfection, tumor hyperthermia, etc
Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing, China
Interests: electromagnetic functional materials; nitride ceramics; nano-magnetic materials; materials solution for electromagnetic compatibility
Department of Engineering Mechanics, Dalian University of Technology, Dalian, China
Interests: hydrogels for drug release and tissue engineering; magnetic induction of hyperthermia; cell mechanics
Special Issues, Collections and Topics in MDPI journals
Colleague of Dentistry, The University of Hong Kong, Hong Kong SAR, China
Interests: bio-composites of magnetic nanoparticles with soft-matter, polymers, nucleic acids, and peptides for theranostics; metal-alloy nanocomposites with complex core-shell structures; Iron-oxide/Metal nanostructures with organic interfaces; magnetic quantum dots with semi-conducting properties and structural complexities; nano-magnets, coordination complexes, and nano-zeolites with spin-transitions; bio-analysis based nano-approaches on molecular electronics; nano-MOFs and COFs based molecular hetero-junctions on magnetic materials for therapeutic and bio-sensing applications

Special Issue Information

Dear Colleagues,

Magnetic nanomaterials(MNMs) have been widely used not only in electrical industry but especially potential in the biomedical field, including hyperthermia, magnetic resonance imaging, drug carriers, gene delivery,biological detection, cell sorting, fishing any biological macromolecules or microorganisms after loading specific probes, etc. So, the preparation of different types of nanomaterials and their functional modification have been an attractive subject. In addition to a few MNMs are based on cobalt (Co) and nickel (Ni), iron (Fe) is the most common ferromagnetic transition elements in MNMs be it pure iron, iron based alloy, iron oxides, or coordination complexes of iron. Fe is also an element playing multiple roles in biochemical activities reflecting its biosafety to human body. Still, there is room for improvements in preparation technology of MNMs, development of new types of magnetic nanospecies with different geometries and functionalities, and broad application areas. We expect all your research and reviews from areas of magnetism, biology, chemistry, materials science, especially interdisciplinary research combining the different fields. Other related studies not mentioned above are also welcome.

Dr. Minglian Wang
Prof. Dr. Qun Wang
Prof. Dr. Wei Zhang
Dr. Mirza Muhammad Faran Ashraf Baig
Guest Editors

Manuscript Submission Information

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Keywords

  • magnetic nanomaterials
  • surface modification
  • biofunctionalization
  • preparation

Published Papers (3 papers)

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Research

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15 pages, 4598 KiB  
Article
Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia
Magnetochemistry 2022, 8(6), 63; https://doi.org/10.3390/magnetochemistry8060063 - 08 Jun 2022
Cited by 3 | Viewed by 1568
Abstract
The magnetic nanoparticles (MNPs) with decreasing heating efficiency (characterized by specific loss power, SLP) with temperature increase, especially around the Curie temperature (TC), are expected to realize the self-regulated temperature hyperthermia of the tumor. However, the actual decrease of [...] Read more.
The magnetic nanoparticles (MNPs) with decreasing heating efficiency (characterized by specific loss power, SLP) with temperature increase, especially around the Curie temperature (TC), are expected to realize the self-regulated temperature hyperthermia of the tumor. However, the actual decrease of the SLP is gradual, resulting in the deviation of self-regulated temperatures from the measured TC. So far, no method is available for evaluating the heating performances of those MNPs. Here, by simulating the temperature-dependent SLP, the heating performances of MNPs are evaluated from three clinically concerning aspects: the capacity for effective heating, the temperature uniformity in the tumor, and the temperature stability under environmental changes such as MNP loss or tumor progression. The developed methods were applied to ZnCoCrFeO, Fe3O4, and γ-Fe2O3 MNPs. It was found that the uniform temperature distribution relies on lowering the heating power in the inner regions of the tumor, and the stable control of temperature depends on the dynamic adaptation of the heating power to the tumor temperature change. The proposed method may be used to predict the heating ability of MNPs and help the selection of MNPs for hyperthermia. Full article
(This article belongs to the Special Issue Biofunctionization and  Applications of Magnetic Particles)
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14 pages, 2623 KiB  
Article
Graphene-Coated Iron Nitride Streptavidin Magnetic Beads: Preparation and Application in SARS-CoV-2 Enrichment
Magnetochemistry 2022, 8(4), 41; https://doi.org/10.3390/magnetochemistry8040041 - 07 Apr 2022
Viewed by 2899
Abstract
In this study, we prepared a streptavidin magnetic bead based on graphene-coated iron nitride magnetic beads (G@FeN-MB) and tried to use it for the enrichment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The outer shell of our magnetic bead was wrapped with multiple [...] Read more.
In this study, we prepared a streptavidin magnetic bead based on graphene-coated iron nitride magnetic beads (G@FeN-MB) and tried to use it for the enrichment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The outer shell of our magnetic bead was wrapped with multiple graphene sheets, and there is no report on the application of graphene to the magnetic-bead-coating material. First, the graphene shell of G@FeN-MB was oxidized by a modified Hummer method so as to generate the carboxyl groups required for the coupling of streptavidin (SA) on the surface of the magnetic beads. X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM) were used to characterize the oxidized G@FeN-MB (GO@FeN-MB). Streptavidin was then linked to the surface of the GO@FeN-MB by coupling the amino of the streptavidin with the carboxyl on the magnetic beads by carbodiimide method; thus, the streptavidin magnetic beads (SAMBs) were successfully prepared. To prove the practicality of the SAMBs, biotinylated SARS-CoV-2 S1 antibody was linked with it to respectively capture SARS-CoV-2 Spike-protein-coupled polystyrene beads (S-PS) and pseudovirus with S-protein expressed. Microplate reader and fluorescence microscope results show that the SAMBs can effectively enrich viruses. In conclusion, the preparation of SAMBs with G@FeN-MB is feasible and has potential for application in the field of virus enrichment. Full article
(This article belongs to the Special Issue Biofunctionization and  Applications of Magnetic Particles)
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Review

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18 pages, 1078 KiB  
Review
Recent Advances of Magnetic Gold Hybrids and Nanocomposites, and Their Potential Biological Applications
Magnetochemistry 2022, 8(4), 38; https://doi.org/10.3390/magnetochemistry8040038 - 01 Apr 2022
Cited by 12 | Viewed by 2982
Abstract
Magnetic gold nanoparticles (mGNP) have become a great interest of research for nanomaterial scientists because of their significant magnetic and plasmonic properties applicable in biomedical applications. Various synthetic approaches and surface modification techniques have been used for mGNP including the most common being [...] Read more.
Magnetic gold nanoparticles (mGNP) have become a great interest of research for nanomaterial scientists because of their significant magnetic and plasmonic properties applicable in biomedical applications. Various synthetic approaches and surface modification techniques have been used for mGNP including the most common being the coprecipitation, thermal decomposition, and microemulsion methods in addition to the Brust Schiffrin technique, which involves the reduction of metal precursors in a two-phase system (water and toluene) in the presence of alkanethiol. The hybrid magnetic–plasmonic nanoparticles based on iron core and gold shell are being considered as potential theranostic agents. In this critical review, in addition to future works, we have summarized recent developments for synthesis and surface modification of mGNP with their applications in modern biomedical science such as drug and gene delivery, bioimaging, biosensing, and neuro-regeneration, neuro-degenerative and arthritic disorders. This review includes techniques and biological applications of mGNP majorly based on research from the previous six years. Full article
(This article belongs to the Special Issue Biofunctionization and  Applications of Magnetic Particles)
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