Silicate-Based Electro-Conductive Inks for Printing Soft Electronics and Tissue Engineering
Abstract
:1. Introduction
2. Results and Discussion
2.1. Hydrogel Preparation
2.2. Chemical and Physical Characterization
2.2.1. Zeta Potential
2.2.2. Fourier Transform Infrared Spectroscopy
2.2.3. X-ray Diffraction
2.2.4. Scanning Electron Microscopy
2.2.5. Mechanical Properties of the Bio-Ink
2.3. Printing and Electrical Conductivity Measurements of the Bio-Ink
2.4. Design and Fabrication of the Flexible Conductor on Alginate Substrate
3. Conclusions
4. Materials and Methods
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
- Sasaki, M.; Karikkineth, B.C.; Nagamine, K.; Kaji, H.; Torimitsu, K.; Nishizawa, M. Highly Conductive Stretchable and Biocompatible Electrode-Hydrogel Hybrids for Advanced Tissue Engineering. Adv. Healthc. Mater. 2014, 3, 1919–1927. [Google Scholar] [CrossRef] [PubMed]
- Murphy, S.V.; Atala, A. 3D bioprinting of tissues and organs. Nat. Biotechnol. 2014, 32, 773–785. [Google Scholar] [CrossRef]
- Zhang, Y.S.; Yue, K.; Aleman, J.; Mollazadeh-Moghaddam, K.; Bakht, S.M.; Yang, J.; Jia, W.; Dell’Erba, V.; Assawes, P.; Shin, S.R.; et al. 3D Bioprinting for Tissue and Organ Fabrication. Ann. Biomed. Eng. 2017, 45, 148–163. [Google Scholar] [CrossRef] [Green Version]
- Zhang, B.; Gao, L.; Ma, L.; Luo, Y.; Yang, H.; Cui, Z. 3D Bioprinting: A Novel Avenue for Manufacturing Tissues and Organs. Engineering 2019, 5, 777–794. [Google Scholar] [CrossRef]
- Indermun, S.; Choonara, Y.E.; Kumar, P.; Du Toit, L.C.; Modi, G.; Luttge, R.; Pillay, V. An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery. Int. J. Pharm. 2014, 462, 52–65. [Google Scholar] [CrossRef]
- Tsai, T.-S.; Pillay, V.; Choonara, Y.E.; Du Toit, L.C.; Modi, G.; Naidoo, D.; Kumar, P. A Polyvinyl Alcohol-Polyaniline Based Electro-Conductive Hydrogel for Controlled Stimuli-Actuable Release of Indomethacin. Polymers 2011, 3, 150–172. [Google Scholar] [CrossRef] [Green Version]
- Distler, T.; Boccaccini, A.R. 3D printing of electrically conductive hydrogels for tissue engineering and biosensors—A review. Acta Biomater. 2020, 101, 1–13. [Google Scholar] [CrossRef] [PubMed]
- Shin, S.R.; Farzad, R.; Tamayol, A.; Manoharan, V.; Mostafalu, P.; Zhang, Y.S.; Akbari, M.; Jung, S.M.; Kim, D.; Comotto, M.; et al. A Bioactive Carbon Nanotube-Based Ink for Printing 2D and 3D Flexible Electronics. Adv. Mater. 2016, 28, 3280–3289. [Google Scholar] [CrossRef] [PubMed]
- Saberi, A.; Jabbari, F.; Zarrintaj, P.; Saeb, M.R.; Mozafari, M. Electrically Conductive Materials: Opportunities and Challenges in Tissue Engineering. Biomolecules 2019, 9, 448. [Google Scholar] [CrossRef] [Green Version]
- Zhou, J.; Chen, J.; Sun, H.; Qiu, X.; Mou, Y.; Liu, Z.; Zhao, Y.; Li, X.; Han, Y.; Duan, C.; et al. Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function. Sci. Rep. 2014, 4, 3733. [Google Scholar] [CrossRef] [Green Version]
- Chung, D.D.L. Review Exfoliation of Graphite. J. Mater. Sci. 1987, 22, 4190–4198. [Google Scholar] [CrossRef]
- Li, H.; Tan, C.; Li, L. Review of 3D printable hydrogels and constructs. Mater. Des. 2018, 159, 20–38. [Google Scholar] [CrossRef]
- Kyle, S.; Jessop, Z.M.; Al-Sabah, A.; Whitaker, I.S. ‘Printability’ of Candidate Biomaterials for Extrusion Based 3D Printing: State-of-the-Art. Adv. Healthc. Mater. 2017, 6, 1–16. [Google Scholar] [CrossRef]
- Naahidi, S.; Jafari, M.; Logan, M.; Wang, Y.; Yuan, Y.; Bae, H.; Dixon, B.; Chen, P. Biocompatibility of hydrogel-based scaffolds for tissue engineering applications. Biotechnol. Adv. 2017, 35, 530–544. [Google Scholar] [CrossRef]
- Ouyang, L.; Highley, C.B.; Rodell, C.B.; Sun, W.; Burdick, J.A. 3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking. ACS Biomater. Sci. Eng. 2016, 2, 1743–1751. [Google Scholar] [CrossRef]
- López-Marcial, G.R.; Zeng, A.Y.; Osuna, C.; Dennis, J.; García, J.M.; O’Connell, G.D. Agarose-Based Hydrogels as Suitable Bioprinting Materials for Tissue Engineering. ACS Biomater. Sci. Eng. 2018, 4, 3610–3616. [Google Scholar] [CrossRef] [PubMed]
- Axpe, E.; Oyen, M.L. Applications of alginate-based bioinks in 3D bioprinting. Int. J. Mol. Sci. 2016, 17, 1976. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ding, H.; Illsley, N.P.; Chang, R.C. 3D Bioprinted GelMA Based Models for the Study of Trophoblast Cell Invasion. Sci. Rep. 2019, 9, 18854. [Google Scholar] [CrossRef] [Green Version]
- Zheng, Z.; Wu, J.; Liu, M.; Wang, H.; Li, C.; Rodriguez, M.J.; Li, G.; Wang, X.; Kaplan, D.L. 3D Bioprinting of Self-Standing Silk-Based Bioink. Adv. Healthc. Mater. 2018, 7, e1701026. [Google Scholar] [CrossRef]
- Salinas-Fernández, S.; Santos, M.; Alonso, M.; Quintanilla, L.; Rodríguez-Cabello, J.C. Genetically engineered elastin-like recombinamers with sequence-based molecular stabilization as advanced bioinks for 3D bioprinting. Appl. Mater. Today 2020, 18, 100500. [Google Scholar] [CrossRef]
- Ashammakhi, N.; Ahadian, S.; Xu, C.; Montazerian, H.; Ko, H.; Nasiri, R.; Barros, N.; Khademhosseini, A. Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs. Mater. Today Bio 2019, 1, 100008. [Google Scholar] [CrossRef]
- Sun, J.; Tan, H. Alginate-based biomaterials for regenerative medicine applications. Materials 2013, 6, 1285–1309. [Google Scholar] [CrossRef]
- Lee, K.Y.; Mooney, D.J. Alginate: Properties and biomedical applications. Prog. Polym. Sci. 2012, 37, 106–126. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Drury, J.L.; Dennis, R.G.; Mooney, D.J. The tensile properties of alginate hydrogels. Biomaterials 2004, 25, 3187–3199. [Google Scholar] [CrossRef]
- Ghadiri, M.; Chrzanowski, W.; Lee, W.H.; Fathi, A.; Dehghani, F.; Rohanizadeh, R. Physico-chemical, mechanical and cytotoxicity characterizations of Laponite®/alginate nanocomposite. Appl. Clay Sci. 2013, 85, 64–73. [Google Scholar] [CrossRef]
- Thompson, D.W.; Butterworth, J.T. The nature of laponite and its aqueous dispersions. J. Colloid Interface Sci. 1992, 151, 236–243. [Google Scholar] [CrossRef]
- Tabernero, A.; Cardea, S.; Masa, R.; Baldino, L.; del Valle, E.M.M.; Reverchon, E. Preparation and characterization of cellulose acetate-Laponite® composite membranes produced by supercritical phase inversion. J. Supercrit. Fluids 2020, 155, 104651. [Google Scholar] [CrossRef]
- Dávila, J.L.; d’Ávila, M.A. Rheological evaluation of Laponite/alginate inks for 3D extrusion-based printing. Int. J. Adv. Manuf. Technol. 2019, 101, 675–686. [Google Scholar] [CrossRef]
- Dávila, J.L.; d’Ávila, M.A. Laponite as a rheology modifier of alginate solutions: Physical gelation and aging evolution. Carbohydr. Polym. 2017, 157, 1–8. [Google Scholar] [CrossRef]
- Ahlfeld, T.; Cidonio, G.; Kilian, D.; Duin, S.; Akkineni, A.R.; Dawson, J.I.; Yang, S.; Lode, A.; Oreffo, R.O.C.; Gelinsky, M. Development of a clay based bioink for 3D cell printing for skeletal application. Biofabrication 2017, 9, 034103. [Google Scholar] [CrossRef]
- Habib, M.A.; Khoda, B. Development of clay based novel bio-ink for 3D bio-printing process. Procedia Manuf. 2018, 26, 846–856. [Google Scholar] [CrossRef]
- Tondera, C.; Akbar, T.F.; Thomas, A.K.; Lin, W.; Werner, C.; Busskamp, V.; Zhang, Y.; Minev, I.R. Highly Conductive, Stretchable, and Cell-Adhesive Hydrogel by Nanoclay Doping. Small 2019, 15, 1901406. [Google Scholar] [CrossRef] [PubMed]
- Zhu, K.; Shin, S.R.; van Kempen, T.; Li, Y.C.; Ponraj, V.; Nasajpour, A.; Mandla, S.; Hu, N.; Liu, X.; Leijten, J.; et al. Gold Nanocomposite Bioink for Printing 3D Cardiac Constructs. Adv. Funct. Mater. 2017, 27, 1605352. [Google Scholar] [CrossRef]
- Ahn, B.Y.; Lewis, J.A. Amphiphilic silver particles for conductive inks with controlled wetting behavior. Mater. Chem. Phys. 2014, 148, 686–691. [Google Scholar] [CrossRef]
- Vlăsceanu, G.M.; Iovu, H.; Ioniţă, M. Graphene inks for the 3D printing of cell culture scaffolds and related molecular arrays. Compos. Part B Eng. 2019, 162, 712–723. [Google Scholar] [CrossRef]
- Huang, C.T.; Kumar Shrestha, L.; Ariga, K.; Hsu, S.H. A graphene-polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells. J. Mater. Chem. B 2017, 5, 8854–8864. [Google Scholar] [CrossRef] [PubMed]
- He, Q.; Sudibya, H.G.; Yin, Z.; Wu, S.; Li, H.; Boey, F.; Huang, W.; Chen, P.; Zhang, H. Centimeter-long and large-scale micropatterns of reduced graphene oxide films: Fabrication and sensing applications. ACS Nano 2010, 4, 3201–3208. [Google Scholar] [CrossRef]
- Zhu, Y.; Murali, S.; Cai, W.; Li, X.; Suk, J.W.; Potts, J.R.; Ruoff, R.S. Graphene and graphene oxide: Synthesis, properties, and applications. Adv. Mater. 2010, 22, 3906–3924. [Google Scholar] [CrossRef]
- Stankovich, S.; Dikin, D.A.; Piner, R.D.; Kohlhaas, K.A.; Kleinhammes, A.; Jia, Y.; Wu, Y.; Nguyen, S.B.T.; Ruoff, R.S. Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide. Carbon N. Y. 2007, 45, 1558–1565. [Google Scholar] [CrossRef]
- Najafabadi, A.H.; Tamayol, A.; Annabi, N.; Ochoa, M.; Mostafalu, P.; Akbari, M.; Nikkhah, M.; Rahimi, R.; Dokmeci, M.R.; Sonkusale, S.; et al. Biodegradable nanofibrous polymeric substrates for generating elastic and flexible electronics. Adv. Mater. 2014, 26, 5823–5830. [Google Scholar] [CrossRef]
- Hu, Y.; Zhao, T.; Zhu, P.; Zhu, Y.; Shuai, X.; Liang, X.; Sun, R.; Lu, D.D.; Wong, C.P. Low cost and highly conductive elastic composites for flexible and printable electronics. J. Mater. Chem. C 2016, 4, 5839–5848. [Google Scholar] [CrossRef]
- Kim, J.H.; Hwang, J.Y.; Hwang, H.R.; Kim, H.S.; Lee, J.H.; Seo, J.W.; Shin, U.S.; Lee, S.H. Simple and cost-effective method of highly conductive and elastic carbon nanotube/polydimethylsiloxane composite for wearable electronics. Sci. Rep. 2018, 8, 1375. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Rastin, H.; Zhang, B.; Bi, J.; Hassan, K.; Tung, T.T.; Losic, D. 3D printing of cell-laden electroconductive bioinks for tissue engineering applications. J. Mater. Chem. B 2020, 8, 5862–5876. [Google Scholar] [CrossRef] [PubMed]
- Ruiz-Hitzky, E.; Sobral, M.M.C.; Gómez-Avilés, A.; Nunes, C.; Ruiz-García, C.; Ferreira, P.; Aranda, P. Clay-Graphene Nanoplatelets Functional Conducting Composites. Adv. Funct. Mater. 2016, 26, 7394–7405. [Google Scholar] [CrossRef]
- Alhassan, S.M.; Qutubuddin, S.; Schiraldi, D.A. Graphene arrested in laponite-water colloidal glass. Langmuir 2012, 28, 4009–4015. [Google Scholar] [CrossRef]
- Vashist, A.; Kaushik, A.; Vashist, A.; Sagar, V.; Ghosal, A.; Gupta, Y.K.; Ahmad, S.; Nair, M. Advances in Carbon Nanotubes-Hydrogel Hybrids in Nanomedicine for Therapeutics. Adv. Healthc. Mater. 2018, 7, 1701213. [Google Scholar] [CrossRef]
- Xu, X.; Wang, J.; Wang, Y.; Zhao, L.; Li, Y.; Liu, C. Formation of graphene oxide-hybridized nanogels for combinative anticancer therapy. Nanomed. Nanotechnol. Biol. Med. 2018, 14, 2387–2395. [Google Scholar] [CrossRef]
- Chouhan, D.K.; Patro, T.U.; Harikrishnan, G.; Kumar, S.; Gupta, S.; Kumar, G.S.; Cohen, H.; Wagner, H.D. Graphene oxide-Laponite hybrid from highly stable aqueous dispersion. Appl. Clay Sci. 2016, 132–133, 105–113. [Google Scholar] [CrossRef]
- Li, J.; Cui, J.C.; Yang, Z.Z.; Qiu, H.X.; Tang, Z.H.; Yang, J.H. Stabilizing graphene layers by intercalating laponite between them. Xinxing Tan Cailiao/New Carbon Mater. 2018, 33, 19–25. [Google Scholar] [CrossRef]
- Jin, Y.; Liu, C.; Chai, W.; Compaan, A.; Huang, Y. Self-Supporting Nanoclay as Internal Scaffold Material for Direct Printing of Soft Hydrogel Composite Structures in Air. ACS Appl. Mater. Interfaces 2017, 9, 17456–17465. [Google Scholar] [CrossRef]
- Nethravathi, C.; Rajamathi, J.T.; Ravishankar, N.; Shivakumara, C.; Rajamathi, M. Graphite oxide-intercalated anionic clay and its decomposition to graphene-inorganic material nanocomposites. Langmuir 2008, 24, 8240–8244. [Google Scholar] [CrossRef]
- Au, P.I.; Hassan, S.; Liu, J.; Leong, Y.K. Behaviour of laponite gels: Rheology, ageing, pH effect and phase state in the presence of dispersant. Chem. Eng. Res. Des. 2015, 101, 65–73. [Google Scholar] [CrossRef]
- Cummins, H.Z. Liquid, glass, gel: The phases of colloidal Laponite. J. Non. Cryst. Solids 2007, 353, 3891–3905. [Google Scholar] [CrossRef]
- Jin, Y.; Chai, W.; Huang, Y. Printability study of hydrogel solution extrusion in nanoclay yield-stress bath during printing-then-gelation biofabrication. Mater. Sci. Eng. C 2017, 80, 313–325. [Google Scholar] [CrossRef]
- Liu, B.; Li, J.; Lei, X.; Miao, S.; Zhang, S.; Cheng, P.; Song, Y.; Wu, H.; Gao, Y.; Bi, L.; et al. Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model. RSC Adv. 2020, 10, 25652–25661. [Google Scholar] [CrossRef]
- Zhang, J.; Eyisoylu, H.; Qin, X.-H.; Rubert, M.; Müller, R. 3D Bioprinting of Graphene Oxide-Incorporated Cell-laden Bone Mimicking Scaffolds for Promoting Scaffold Fidelity, Osteogenic Differentiation and Mineralization. bioRxiv 2020. [Google Scholar] [CrossRef]
- Pawar, N.; Bohidar, H.B. Spinodal decomposition and phase separation kinetics in nanoclay-biopolymer solutions. J. Polym. Sci. Part B Polym. Phys. 2010, 48, 555–565. [Google Scholar] [CrossRef]
- Ye, S.; Yang, Z.; Xu, J.; Shang, Z.; Xie, J. Clay–graphene oxide liquid crystals and their aerogels: Synthesis, characterization and properties. R. Soc. Open Sci. 2019, 6, 181439. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Liu, L.; Li, C.; Bao, C.; Jia, Q.; Xiao, P.; Liu, X.; Zhang, Q. Preparation and characterization of chitosan/graphene oxide composites for the adsorption of Au(III) and Pd(II). Talanta 2012, 93, 350–357. [Google Scholar] [CrossRef] [PubMed]
- Xu, J.; Wang, K.; Zu, S.Z.; Han, B.H.; Wei, Z. Hierarchical nanocomposites of polyaniline nanowire arrays on graphene oxide sheets with synergistic effect for energy storage. ACS Nano 2010, 4, 5019–5026. [Google Scholar] [CrossRef] [PubMed]
- Pan, Y.; Wu, T.; Bao, H.; Li, L. Green fabrication of chitosan films reinforced with parallel aligned graphene oxide. Carbohydr. Polym. 2011, 83, 1908–1915. [Google Scholar] [CrossRef]
- Li, P.; Dai, Y.N.; Zhang, J.P.; Wang, A.Q.; Wei, Q. Chitosan-alginate nanoparticles as a novel drug delivery system for nifedipine. Int. J. Biomed. Sci. 2008, 4, 221–228. [Google Scholar] [PubMed]
- Mahmoodi, N.M. Magnetic ferrite nanoparticle-alginate composite: Synthesis, characterization and binary system dye removal. J. Taiwan Inst. Chem. Eng. 2013, 44, 322–330. [Google Scholar] [CrossRef]
- Bippus, L.; Jaber, M.; Lebeau, B. Laponite and hybrid surfactant/laponite particles processed as spheres by spray-drying. New J. Chem. 2009, 33, 1116–1126. [Google Scholar] [CrossRef]
- Brahimi, B.; Labbe, P.; Reverdy, G. Study of the Adsorption of Cationic Surfactants on Aqueous Laponite Clay Suspensions and Laponite Clay Modified Electrodes. Langmuir 1992, 8, 1908–1918. [Google Scholar] [CrossRef]
- Patro, T.U.; Wagner, H.D. Influence of graphene oxide incorporation and chemical cross-linking on structure and mechanical properties of layer-by-layer assembled poly(Vinyl alcohol)-Laponite free-standing films. J. Polym. Sci. Part B Polym. Phys. 2016, 54, 2377–2387. [Google Scholar] [CrossRef]
- Fatnassi, M.; Solterbeck, C.H.; Es-Souni, M. Clay nanomaterial thin film electrodes for electrochemical energy storage applications. RSC Adv. 2014, 4, 46976–46979. [Google Scholar] [CrossRef] [Green Version]
- Ionita, M.; Pandele, M.A.; Iovu, H. Sodium alginate/graphene oxide composite films with enhanced thermal and mechanical properties. Carbohydr. Polym. 2013, 94, 339–344. [Google Scholar] [CrossRef]
- Chouhan, D.K.; Kumar, A.; Rath, S.K.; Kumar, S.; Alegaonkar, P.S.; Harikrishnan, G.; Umasankar Patro, T. Laponite-graphene oxide hybrid particulate filler enhances mechanical properties of cross-linked epoxy. J. Polym. Res. 2018, 25, 60. [Google Scholar] [CrossRef]
- Lapasin, R.; Abrami, M.; Grassi, M.; Šebenik, U. Rheology of Laponite-scleroglucan hydrogels. Carbohydr. Polym. 2017, 168, 290–300. [Google Scholar] [CrossRef]
- Shin, S.R.; Zihlmann, C.; Akbari, M.; Assawes, P.; Cheung, L.; Zhang, K.; Manoharan, V.; Zhang, Y.S.; Yüksekkaya, M.; Wan, K.; et al. Reduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering. Small 2016, 12, 3677–3689. [Google Scholar] [CrossRef] [Green Version]
- Yu, F.; Zhang, F.; Luan, T.; Zhang, Z.; Zhang, H. Rheological studies of hyaluronan solutions based on the scaling law and constitutive models. Polymer 2014, 55, 295–301. [Google Scholar] [CrossRef]
- Samimi Gharaie, S.; Dabiri, S.; Akbari, M.; Samimi Gharaie, S.; Dabiri, S.M.H.; Akbari, M. Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems. Polymers 2018, 10, 1317. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Avery, R.K.; Albadawi, H.; Akbari, M.; Zhang, Y.S.; Duggan, M.J.; Sahani, D.V.; Olsen, B.D.; Khademhosseini, A.; Oklu, R. An injectable shear-thinning biomaterial for endovascular embolization. Sci. Transl. Med. 2016, 8, 365ra156. [Google Scholar] [CrossRef]
- Aalaie, J. Rheological Behavior of Polyacrylamide/Laponite Nanoparticle Suspensions in Electrolyte Media. J. Macromol. Sci. Part B 2012, 51, 1139–1147. [Google Scholar] [CrossRef]
- Gaharwar, A.K.; Avery, R.K.; Assmann, A.; Paul, A.; McKinley, G.H.; Khademhosseini, A.; Olsen, B.D. Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage. ACS Nano 2014, 8, 9833–9842. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cui, X.; Li, J.; Hartanto, Y.; Durham, M.; Tang, J.; Zhang, H.; Hooper, G.; Lim, K.; Woodfield, T. Advances in Extrusion 3D Bioprinting: A Focus on Multicomponent Hydrogel-Based Bioinks. Adv. Healthc. Mater. 2020, 9, 1901648. [Google Scholar] [CrossRef]
- Blaeser, A.; Duarte Campos, D.F.; Puster, U.; Richtering, W.; Stevens, M.M.; Fischer, H. Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity. Adv. Healthc. Mater. 2016, 5, 326–333. [Google Scholar] [CrossRef]
- Zhou, Y.; Wan, C.; Yang, Y.; Yang, H.; Wang, S.; Dai, Z.; Ji, K.; Jiang, H.; Chen, X.; Long, Y. Highly Stretchable, Elastic, and Ionic Conductive Hydrogel for Artificial Soft Electronics. Adv. Funct. Mater. 2019, 29, 1806220. [Google Scholar] [CrossRef]
- Motealleh, A.; Kehr, N.S. Nanocomposite Hydrogels and Their Applications in Tissue Engineering. Adv. Healthc. Mater. 2017, 6, 1600938. [Google Scholar] [CrossRef]
- Huang, W.; Li, J.; Zhao, S.; Han, F.; Zhang, G.; Sun, R.; Wong, C.P. Highly electrically conductive and stretchable copper nanowires-based composite for flexible and printable electronics. Compos. Sci. Technol. 2017, 146, 169–176. [Google Scholar] [CrossRef]
- Ding, X.; Liu, H.; Fan, Y. Graphene-Based Materials in Regenerative Medicine. Adv. Healthc. Mater. 2015, 4, 1451–1468. [Google Scholar] [CrossRef] [PubMed]
- Tyunina, E.Y.; Afanasiev, V.N.; Chekunova, M.D. Electroconductivity of tetraethylammonium tetrafluoroborate in propylene carbonate at various temperatures. J. Chem. Eng. Data 2011, 56, 3222–3226. [Google Scholar] [CrossRef]
- Mao, H.; Yang, L.; Zhu, H.; Wu, L.; Ji, P.; Yang, J.; Gu, Z. Recent advances and challenges in materials for 3D bioprinting. Prog. Nat. Sci. Mater. Int. 2020, 30, 618–634. [Google Scholar] [CrossRef]
- Szekalska, M.; Pucibowska, A.; Szymanska, E.; Ciosek, P.; Winnicka, K. Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. Int. J. Polym. Sci. 2016, 2016, 7697031. [Google Scholar] [CrossRef] [Green Version]
- Bao, Z.; Xian, C.; Yuan, Q.; Liu, G.; Wu, J. Natural Polymer-Based Hydrogels with Enhanced Mechanical Performances: Preparation, Structure, and Property. Adv. Healthc. Mater. 2019, 8, 1900670. [Google Scholar] [CrossRef] [PubMed]
- Jeong, J.W.; Yeo, W.H.; Akhtar, A.; Norton, J.J.S.; Kwack, Y.J.; Li, S.; Jung, S.Y.; Su, Y.; Lee, W.; Xia, J.; et al. Materials and Optimized Designs for HumanMachine Interfaces Via Epidermal Electronics. Adv. Mater. 2013, 25, 6839–6846. [Google Scholar] [CrossRef] [PubMed]
Sample Code | Laponite (wt)% | Graphene Oxide (wt)% |
---|---|---|
S1 | 3 | 0 |
S2 | 3 | 3 |
S3 | 3 | 5 |
S4 | 6 | 0 |
S5 | 6 | 3 |
S6 | 6 | 5 |
S7 | 9 | 0 |
S8 | 9 | 3 |
S9 | 9 | 5 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Samimi Gharaie, S.; Seyfoori, A.; Khun Jush, B.; Zhou, X.; Pagan, E.; Godau, B.; Akbari, M. Silicate-Based Electro-Conductive Inks for Printing Soft Electronics and Tissue Engineering. Gels 2021, 7, 240. https://doi.org/10.3390/gels7040240
Samimi Gharaie S, Seyfoori A, Khun Jush B, Zhou X, Pagan E, Godau B, Akbari M. Silicate-Based Electro-Conductive Inks for Printing Soft Electronics and Tissue Engineering. Gels. 2021; 7(4):240. https://doi.org/10.3390/gels7040240
Chicago/Turabian StyleSamimi Gharaie, Sadaf, Amir Seyfoori, Bardia Khun Jush, Xiong Zhou, Erik Pagan, Brent Godau, and Mohsen Akbari. 2021. "Silicate-Based Electro-Conductive Inks for Printing Soft Electronics and Tissue Engineering" Gels 7, no. 4: 240. https://doi.org/10.3390/gels7040240