Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Biosynthetic Gene Cluster Structure and Phylogeny
3.2. Overexpression of the In-Cluster Transcription Factor Gene Results in Impaired Growth and Overproduction of New Compounds
3.3. Functional Characterization of the NRPS NRRL3_00036
3.4. Antimicrobial Assays
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Evdokias, G.; Semper, C.; Mora-Ochomogo, M.; Di Falco, M.; Nguyen, T.T.M.; Savchenko, A.; Tsang, A.; Benoit-Gelber, I. Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics. J. Fungi 2021, 7, 374. https://doi.org/10.3390/jof7050374
Evdokias G, Semper C, Mora-Ochomogo M, Di Falco M, Nguyen TTM, Savchenko A, Tsang A, Benoit-Gelber I. Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics. Journal of Fungi. 2021; 7(5):374. https://doi.org/10.3390/jof7050374
Chicago/Turabian StyleEvdokias, Gregory, Cameron Semper, Montserrat Mora-Ochomogo, Marcos Di Falco, Thi Truc Minh Nguyen, Alexei Savchenko, Adrian Tsang, and Isabelle Benoit-Gelber. 2021. "Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics" Journal of Fungi 7, no. 5: 374. https://doi.org/10.3390/jof7050374