Three-Dimensional Bioprinting in Soft Tissue Engineering for Plastic and Reconstructive Surgery
Abstract
:1. Introduction
2. Skeletal Muscle Tissue Engineering
2.1. Cellular Aspects of Skeletal Muscle TE
2.2. Three-Dimensional (Bio) Printing and Skeletal Muscle TE
3. Adipose Tissue Engineering
Paper | Cell Type | Bioink | Experiment Type | Key Findings | Limitations |
---|---|---|---|---|---|
Pati et al. (2015) [63] | hADSC | PCL + hdECM | In vitro | Successful cultivation of the cells and differentiation | Mechanical properties do not match adipose tissue |
In vivo murine VML model | dECM showed proangiogenic effect, printed scaffold superior over non-printed | Small size of construct | |||
Ahn et al. (2022) [65] | hADSC | hdECM + Alginate | In vitro | In-bath hybrid printing technique superior to 3D printing; culturing of functional adipose tissue | Low dimensions of the tissue, no in vivo application |
Lee et al. (2021) [64] | - | PCL + mixture of collagen type I and hdECM hydrogels | In vivo murine model | hdECM hydrogel promotes neovascularization and tissue formation | Small size of construct |
Van Damme et al. (2020) [66] | - | GelMa + PLA (sacrificial) | In silico | Comparison of indirect vs. direct printing technique -> similar results regarding mechanical properties | No biological testing |
Negrini et al. (2019) [67] | hMSC * | Alginate microbeads (sacrificial) MBA crosslinked gelatin hydrogel | In vitro | Microporous gelatin hydrogels, suitable as scaffolds for AT (porosity, mechanical properties, enzymatic degradability, and hMSC proliferation and differentiation) | In vivo application pending |
Ex vivo | Perfusable vascular channel in the scaffold | ||||
Negrini et al. (2020) [70] | hADSC | MBA crosslinked gelatin hydrogel | In vitro | Physical and mechanical properties for use as AT scaffolds Support cell proliferation and differentiation | In vivo application pending |
Säljö et al. (2022) [62] | Stroma vascular fraction | Alginate and nanocellulose | In vivo murine model | Printability of mechanically purified lipoaspirate and in vivo long-term survival | Control group missing, formation of fibrotic tissue rather than mature adipose tissue |
4. Vascularization
Paper | Cell Type | Bioink | Experiment Type | Key Findings | Limitations |
---|---|---|---|---|---|
Sousa et al. (2021) [76] | HUVEC | Alginate (sacrificial) and photocrosslinkable glycidyl methacrylated xanthan gum (XG-GMA) | In vitro | Layer-by-layer-coated 3D-printed perfusable microchannels embedded in XG-GMA hydrogels | No in vivo investigation, upscaling needed |
Shao et al. (2020) [77] | HUVEC, MC3T3-E1 (mouse osteoblast cell line) | GelMa, gelatin (sacrificial) | In vitro | Synchronous 3D bioprinting of cell-laden constructs with nutrient networks, construct size up to 3 × 3 × 3 cm3 | Cultivation with osteoblast with no investigation for differentiation, no in vivo application |
Machour et al. (2022) [71] | Human adipose microvascular endothelial cells + dental pulp stem cells | Recombinant human collagen methacrylate (rhCollMA) hydrogel, PLLA + PLGA | In vivo rat model | Hierarchical vessel network composed of microscale and mesoscale vasculatures, anastomosis with rat femoral artery | Proof of principle of the anastomosis, studies on successful in vivo tissue engineering pending, small size of the construct |
Szklanny et al. (2021) [79] | Human adipose microvascular endothelial cells + dental pulp stem cells iPS-derived cardiomyocytes | Recombinant human collagen methacrylate (rhCollMA) hydrogel, PLLA + PLGA | In vitro | Supply of nutrients to differentiated and functional cardiomyocytes via the vascular network | |
In vivo rat model | Anastomosis with rat femoral artery | ||||
Kolesky et al. (2016) [78] | HUVEC, hMSC * | Pluronic F-127 and thrombin (sacrificial); gelatin and fibrinogen | In vitro | Creation of thick human tissues (>1 cm) replete with an engineered extracellular matrix, embedded vasculature, and multiple cell types | No in vivo investigation, upscaling needed |
Kreimendahl et al. (2021) [75] | HUVECs + HDFs | Fibrin + hyaluronic acid | In vitro | Use of FRESH printing technique: enables printing of low-viscose natural polymers with high shape stability, formation of a vascular network | No in vivo investigation, upscaling needed |
Li et al. (2020) [80] | C3A | Alginate + silk fibroin | In vitro | Development of mechanically improved bioink. Scaffold with hierarchical microchannel network | No in vivo investigation, in vitro testing with cell line |
Erdem et al. (2020) [74] | 3T3 fibroblasts or rat cardiomyocytes | GelMa + CPO | In vitro | Development of a printable, O2 delivering biomaterial, cell viability under hypoxia was similar to normoxic conditions when CPO was added | No in vivo investigation, small size of the construct |
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Paper | Cell Type | Bioink | Experiment Type | Key Findings | Limitations |
---|---|---|---|---|---|
Russell et al. (2020) [51] | C2C12 | GelMa | In vitro | Successful differentiation, mechanical properties similar to skeletal muscle | Use of mouse cell line |
- | In vivo murine VML model | Proof of principle for the handheld printing device | No muscle regeneration in vivo | ||
Kiratitanaporn (2022) [47] | C2C12 | Poly(glycerol sebacate) acrylate + skmdECM coating | In vitro | Superiority of the scaffold coated with dECM | Secondary seeding of the scaffolds with limited infiltration |
- | In vivo rat VML model | Coating with dECM increased cellular infiltration, decreased fibrosis | Good cellular infiltration in the dECM-coated scaffold with limited muscle regeneration | ||
Gokyer et al. (2021) [45] | C2C12 | Thermoplastic polyurethane | In vitro | Development of a biocompatible and biodegradable, elastomeric, segmented TPU | Small size of the construct, vascularization not investigated |
hADSC | In vivo rat VML model | Comparison of cell-laden construct vs. acellular: more regeneration of muscle tissue in cellular construct in contrast to the acellular scaffold or the control group | |||
Choi et al. (2016) [48] | C2C12 | skmdECM (porcine) + PCL | In vitro | Successful differentiation and parallel alignment | Use of mouse cell line, no in vivo evaluation |
Choi et al. (2019) [55] | hSKM + HUVECs | skmdECM (porcine) + vdECM (Aorta descendens, porcine) | In vivo rat VML model | Coaxial nozzle enables the fabrication of a compartmentalized structure; improved de novo muscle fiber formation, vascularization, and innervation, 85% of functional recovery in VML injuries (compared to non-printed constructs) | Small size of construct, upscaling necessary for clinical application |
Fornetti et al. (2023) [56] | Mabs or hSKM | PolyEthylene Glycol (PEG) fibrinogen | In vitro | Newly developed printing system for the use of PEG Fibrinogen | Printing system not explained. Presented results with mainly fibrotic tissue in vivo |
In vivo murine VML model | |||||
Hwangbo et al. (2023) [57] | C2C12 or hADSC | GelMa | In vitro | Symbiotic co-cultivation with cyanobacteria (converting CO2 to O2) to reduce hypoxia, improvement of alignment of the cells through on-time electric stimulation while printing; combination of both led to increased myogenic differentiation in vitro + muscle regeneration in in vivo VML model using hADSC | Bacterial conversion through photosynthesis, light penetration through skin needed; implantation of bacteria in human muscle defects with high regulatory requirements |
In vivo murine VML model | |||||
Fan et al. (2022) [28] | C2C12 | Fibrinogen + gelatin | In vitro | Improved differentiation of thinner muscle bundles (0.6 mm vs. 2 + 5 mm) | Use of mouse cell line, innovation missing |
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Bülow, A.; Schäfer, B.; Beier, J.P. Three-Dimensional Bioprinting in Soft Tissue Engineering for Plastic and Reconstructive Surgery. Bioengineering 2023, 10, 1232. https://doi.org/10.3390/bioengineering10101232
Bülow A, Schäfer B, Beier JP. Three-Dimensional Bioprinting in Soft Tissue Engineering for Plastic and Reconstructive Surgery. Bioengineering. 2023; 10(10):1232. https://doi.org/10.3390/bioengineering10101232
Chicago/Turabian StyleBülow, Astrid, Benedikt Schäfer, and Justus P. Beier. 2023. "Three-Dimensional Bioprinting in Soft Tissue Engineering for Plastic and Reconstructive Surgery" Bioengineering 10, no. 10: 1232. https://doi.org/10.3390/bioengineering10101232