Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients
Abstract
:1. MSC and the Tumor Microenvironment
1.1. Harnessing Macrophages and T Cells in the Tumor Microenvironment for Cancer Elimination
1.2. Immunomodulatory Properties of MSCs
1.3. Immunomodulatory Effects of MSCs on TME
Studies | Findings | Effect on TME |
---|---|---|
Müller et al. (2021) [24] |
| Pro-tumorigenic |
Boutilier AJ et al. (2021) [21] Prockop DJ et al. (2012) [22] |
| Pro-tumorigenic |
Galland et al. (2020) [33] |
| Mixed |
Rivera-Cruz CM et al. (2017) [23] |
| Mixed |
Harrell et al. (2021) [25] |
| Anti-tumorigenic |
Stamatopoulos et al. (2019) [36] |
| Anti-Tumorigenic |
Kim et al. (2009) [34] |
| Anti-Tumorigenic |
2. The Application of MSCs after OS Tumor Excision to Promote Bone Regeneration
2.1. MSCs Bone Regeneration Properties
2.2. MSC-Based Strategies for Bone Regeneration In Vivo
2.3. Combinatory Reparative and Anti-Cancer MSCs Effects after OS Tumor Excision
2.4. Safety Profile of MSCs in the Context of Osteosarcoma Treatment
3. Summary
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Cell Type | Role in TME |
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M1 Macrophages |
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M2 Macrophages |
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T Cells |
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BM-MSCs | ASCs | ||
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Studies | Outcomes | Studies | Outcomes |
Jo et al. (2023) [106] |
| Smakaj et al. (2022) [89] Vériter et al. (2015) [107] Dufrane et al. (2015) [108] |
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Baron, M.; Drohat, P.; Crawford, B.; Hornicek, F.J.; Best, T.M.; Kouroupis, D. Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients. Bioengineering 2023, 10, 1187. https://doi.org/10.3390/bioengineering10101187
Baron M, Drohat P, Crawford B, Hornicek FJ, Best TM, Kouroupis D. Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients. Bioengineering. 2023; 10(10):1187. https://doi.org/10.3390/bioengineering10101187
Chicago/Turabian StyleBaron, Max, Philip Drohat, Brooke Crawford, Francis J. Hornicek, Thomas M. Best, and Dimitrios Kouroupis. 2023. "Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients" Bioengineering 10, no. 10: 1187. https://doi.org/10.3390/bioengineering10101187