Free Radical-Mediated Grafting of Natural Polysaccharides Such as Chitosan, Starch, Inulin, and Pectin with Some Polyphenols: Synthesis, Structural Characterization, Bioactivities, and Applications—A Review
Abstract
:1. Introduction
2. Free Radical-Mediated Grafting Method
3. Structural Characterization
3.1. Thin-Layer Chromatography
3.2. Ultraviolet-Visible Spectroscopy
3.3. Fourier Transform Infrared Spectroscopy
3.4. Nuclear Magnetic Resonance Analysis
3.5. Crystallinity Analysis
3.6. Scanning Electron Microscope
4. Gallic Acid–Polysaccharide Conjugate
4.1. Gallic Acid
4.2. Biological Activity
4.2.1. Antioxidant Activity
4.2.2. Antibacterial Activity
5. Ferulic Acid–Polysaccharide Conjugate
5.1. Ferulic Acid
5.2. Biological Activity
Antioxidant Activity
5.3. Applications
5.3.1. Drug Delivery System
5.3.2. Emulsions for Nutraceutical Delivery Systems
6. Catechin–Polysaccharide Conjugate
6.1. Catechin
6.2. Biological Activity
6.2.1. Antioxidant Activity
6.2.2. Antibacterial Activity
6.2.3. Antidiabetic Activity
6.2.4. Neuroprotection Activity
7. Other Polyphenol-Polysaccharide Conjugates
Polyphenols | Polysaccharides | Characterization Methods | Biological Activities | Applications | References |
---|---|---|---|---|---|
FA | Curdlan | UV-vis, FT-IR, XRD, DSC, 1H NMR, 13C NMR, | DPPH scavenging activity; antioxidant capacity | Antioxidant additive | [47] |
FA | Pectin | UV-vis, FT-IR, XRD, DSC, 1H NMR, 13C NMR, SEM, SEC–MALLS | DPPH scavenging activity; antioxidant capacity | Antioxidant additive | [48] |
Catechin | Tremella fuciformis polysaccharide | FT-IR, 1H NMR, TGA, XRD, SEM | DPPH scavenging activity; reducing power | Antioxidant additive | [49] |
GA, CA, FA | Carboxymethyl CS | UV-vis, FT-IR, 1H NMR, XRD | Superoxide, hydroxyl radical, H2O2, and DPPH scavenging activity; lipid peroxidation inhibition effect, reducing power | Antioxidant additive | [50] |
CA, FA | CS | UV-vis, FT-IR, 1H NMR, 13C NMR, XRD, TGA | Superoxide, hydroxyl radical, and H2O2 scavenging activity; lipid peroxidation inhibition effect; | Antioxidant additive | [63] |
GA | O–carboxymethyl CS | TLC, UV-vis, FT-IR, 1H NMR, XRD, SEM | DPPH radicals scavenging activity; reducing power; protective effect against H2O2-induced oxidative damage in RAW264.7 cells | Antioxidant additive | [56] |
Quercetin | Starch | FT-IR, Fluorescence analyses, DSC | DPPH scavenging activity; total antioxidant activity; scavenging properties on peroxynitrite anion; α–amylase inhibitory activity | Drug delivery; drugs in the treatment of Alzheimer’s disease and diabetes | [166] |
Catechin | CS | 1H NMR, FE-SEM, TGA, XRD | Reducing power; hydroxyl and DPPH activity; in vitro anti-diabetic activity | Antioxidant additive; anti-diabetic agent | [76] |
Banana condensed tannins | Inulin | UV-vis, FT-IR, XRD, TGA, 1H NMR, FE-SEM | Free radical scavenging activity; reducing power; the in vitro hypoglycemic activity | Antioxidant additive; anti-diabetic agent | [61] |
GA, Catechin | CS | Total antioxidant activity; hydroxyl radical scavenging activity | Food preservatives | [51] | |
Catechin | CS | 1H NMR | DPPH scavenging activity; protection ability against hydrogen peroxide-induced hepatic damage; inhibition activity against intracellular ROS formation and cell membrane lipid peroxidation | Antioxidant additive; antimicrobial | [128] |
Catechin | Dextran | GPC, UV-vis, 1H–NMR, FT-IR | DPPH, ABTS, and hydroxyl scavenging activity; peroxyl radicals; the inhibition of lipid peroxidation; anticancer activity; | Drugs for pancreatic ductal adenocarcinoma | [129] |
Catechin | Arabinoxylan | UV-vis, FT-IR, NMR, TGA, DTG | reducing starch digestibility and affecting gut fermentation | A novel dietary fiber | [67] |
Vanilla acid, coumarin acid | CS | TLC, UV-vis, FT-IR | DPPH scavenging activity; total antioxidant activity; spectrum antibacterial activity against an array of bacteria; | Food preservative | [57] |
Anthocyanin | CS | FT-IR, 1H NMR, XRD, TGA, DSC | DPPH, ABTS, hydroxyl radical scavenging activity; reducing power; antibacterial activity | Antioxidant additive; antimicrobial | [156] |
Catechin | CS | UV-vis, FT-IR, 1H NMR | DPPH scavenging activity; excellent emulsifying activity and superior emulsifying stability | Natural food antioxidant and emulsifier | [131] |
Catechin | Inulin | UV-vis, FT-IR, 1H NMR, SEM, DSC, TGA, XRD, Helix-coil transition assay | In vitro anti-diabetic activity | Anti-diabetic agent | [77] |
FA | Carboxylic curdlan | UV-vis, FT-IR, SEC–MALLS, SEM, TGA | Antioxidant activity | Emulsions for β–carotene delivery | [62] |
GA | CS | 1H NMR, FT-IR, UV-vis, SEM | Osteogenic effects in murine bone marrow-derived mesenchymal stem cells (mBMMSCs) | Drugs for osteogenic effects | [78] |
GA | CS | TGA | DPPH radical scavenging ability | Antioxidant active packaging film | [91] |
GA | CS | UV-vis, FT-IR, 1H NMR, 13C NMR | Hypoglycemic activity | Anti-diabetic agent | [58] |
FA | CS | FT-IR, UV-vis, DSC, XRD, SEM | A functional wall material for microencapsulation of BSA | Drug delivery | [104] |
Chlorogenic acid | CS | UV-vis, FT-IR, 1H NMR | ABTS and DPPH scavenging activity; ferric and cupric reducing antioxidant power | Preservative agent and edible coating material in peach fruit | [90] |
CA, Chlorogenic acid | CS | UV-vis, FT-IR, XRD, 1H NMR, 13C NMR | Antioxidant activity; antimicrobial activity | A post-harvest fresh-keeping agent for fruits and vegetables | [161] |
GA | CS gallate | UV-vis, GPC, 1HNMR | Antioxidant activity; In vitro antimicrobial activity | Food packaging materials | [92] |
Protocatechuic acid | CS | FT-IR, 1H NMR, XRD, UV-vis | Antioxidant activity; cytotoxic and neuroprotective assessment on PC12 cells | Antioxidative drug release; tissue engineering scaffolds materials | [75] |
Epigallocatechin gallate | CS gallate | UV-vis, FT-IR, XPS, DSC, TGA | ABTS and DPPH scavenging activity; antibacterial activity | Antioxidant additive; antibacterial agent | [130] |
GA | Chitin–glucan | 1H NMR, FT-IR, XRD, SEM | ABTS and DPPH scavenging activity; antibacterial activity | Antioxidant additive; antibacterial agent | [93] |
CA | CS | TLC, UV-vis, FT-IR | [54] | ||
GA | CS | TLC, 1H NMR | DPPH and hydrogen peroxide scavenging capacity; Reducing power; good cytocompatibility against RAW264.7 mouse macrophages | Drugs in the treatment of diseases related to oxidative damage | [59] |
8. Conclusions and Future Perspectives
Funding
Data Availability Statement
Conflicts of Interest
References
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Zhang, W.; Sun, J.; Li, Q.; Liu, C.; Niu, F.; Yue, R.; Zhang, Y.; Zhu, H.; Ma, C.; Deng, S. Free Radical-Mediated Grafting of Natural Polysaccharides Such as Chitosan, Starch, Inulin, and Pectin with Some Polyphenols: Synthesis, Structural Characterization, Bioactivities, and Applications—A Review. Foods 2023, 12, 3688. https://doi.org/10.3390/foods12193688
Zhang W, Sun J, Li Q, Liu C, Niu F, Yue R, Zhang Y, Zhu H, Ma C, Deng S. Free Radical-Mediated Grafting of Natural Polysaccharides Such as Chitosan, Starch, Inulin, and Pectin with Some Polyphenols: Synthesis, Structural Characterization, Bioactivities, and Applications—A Review. Foods. 2023; 12(19):3688. https://doi.org/10.3390/foods12193688
Chicago/Turabian StyleZhang, Wenting, Jian Sun, Qiang Li, Chanmin Liu, Fuxiang Niu, Ruixue Yue, Yi Zhang, Hong Zhu, Chen Ma, and Shaoying Deng. 2023. "Free Radical-Mediated Grafting of Natural Polysaccharides Such as Chitosan, Starch, Inulin, and Pectin with Some Polyphenols: Synthesis, Structural Characterization, Bioactivities, and Applications—A Review" Foods 12, no. 19: 3688. https://doi.org/10.3390/foods12193688