The Effectiveness of Different Eradication Schemes for Pediatric Helicobacter pylori Infection—A Single-Center Comparative Study from Romania
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Variables | Number of Patients | % |
---|---|---|---|
Sex | Female | 103 | 69.12 |
Male | 46 | 30.87 | |
Age | 6–9 years | 26 | 17.46 |
10–14 years | 53 | 35.57 | |
15–17 years | 70 | 46.97 | |
Indications for upper digestive endoscopy and H. pylori testing | Epigastric pain | 84 | 56.37 |
Recurrent abdominal pain | 24 | 16.10 | |
Epigastric pain and other symptoms | 23 | 15.43 | |
Recurrent abdominal pain and other symptoms | 6 | 4.04 | |
Dyspepsia | 2 | 1.34 | |
Other symptoms | 10 | 6.72 | |
Prescribed treatment | PPI + AMO + MTZ 14 days | 62 | 41.62 |
PPI + AMO + CLR 14 days | 49 | 32.88 | |
PPI + AMO 5 days followed by PPI + CLR+MTZ 5 days | 38 | 25.50 |
Drug | Range for Bodyweight | Doses |
---|---|---|
PPI | 15–24 kg | 20 mg + 20 mg |
25–34 kg | 30 mg + 30 mg | |
>35 kg | 40 mg + 40 mg | |
Amoxicillin | 15–24 kg | 500 mg + 500 mg |
25–34 kg | 750 mg + 500 mg | |
>35 kg | 1000 mg + 1000 mg | |
Metronidazole | 15–24 kg | 250 mg + 250 mg |
25–34 kg | 500 mg + 250 mg | |
>35 kg | 500 mg + 500 mg | |
Clarithromycin | 15–24 kg | 250 mg + 250 mg |
25–34 kg | 500 mg + 250 mg | |
>35 kg | 500 mg + 500 mg |
Treatment Regimen | Fecal Antigen (−) | Fecal Antigen (+) | p | ||
---|---|---|---|---|---|
n | % | n | % | ||
PPI + AMO + MTZ 14 days | 50 | 49.5 | 12 | 25.0 | 0.001 |
PPI + AMO + CLR 14 days | 27 | 26.7 | 22 | 45.8 | |
PPI + AMO 5 days followed by PPI + CLR + MTZ 5 days | 24 | 23.8 | 14 | 29.2 |
Treatment Regimen | Side Effects | p | |||
---|---|---|---|---|---|
Yes | No | ||||
n | % | n | % | ||
PPI + AMO + MTZ 14 days | 12 | 22.6 | 50 | 52.1 | 0.001 |
PPI + AMO + CLR 14 days | 21 | 39.6 | 28 | 29.2 | |
PPI + AMO 5 days followed by PPI + CLR + MTZ 5 days | 20 | 37.7 | 18 | 18.8 |
Side Effects | Interruption of Treatment | ||||
---|---|---|---|---|---|
Yes | No | p | |||
n | % | n | % | ||
Yes | 22 | 41.5 | 6 | 6.3 | 0.432 |
No | 31 | 58.5 | 90 | 93.8 |
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Rosu, O.-M.; Gimiga, N.; Stefanescu, G.; Ioniuc, I.; Tataranu, E.; Balan, G.G.; Ion, L.-M.; Plesca, D.A.; Schiopu, C.G.; Diaconescu, S. The Effectiveness of Different Eradication Schemes for Pediatric Helicobacter pylori Infection—A Single-Center Comparative Study from Romania. Children 2022, 9, 1391. https://doi.org/10.3390/children9091391
Rosu O-M, Gimiga N, Stefanescu G, Ioniuc I, Tataranu E, Balan GG, Ion L-M, Plesca DA, Schiopu CG, Diaconescu S. The Effectiveness of Different Eradication Schemes for Pediatric Helicobacter pylori Infection—A Single-Center Comparative Study from Romania. Children. 2022; 9(9):1391. https://doi.org/10.3390/children9091391
Chicago/Turabian StyleRosu, Oana-Maria, Nicoleta Gimiga, Gabriela Stefanescu, Ileana Ioniuc, Elena Tataranu, Gheorghe G. Balan, Laura-Mihaela Ion, Doina Anca Plesca, Cristina Gabriela Schiopu, and Smaranda Diaconescu. 2022. "The Effectiveness of Different Eradication Schemes for Pediatric Helicobacter pylori Infection—A Single-Center Comparative Study from Romania" Children 9, no. 9: 1391. https://doi.org/10.3390/children9091391