Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subject Enrollment
2.2. Blood Sample Collection
2.3. Determination of Serum VEGF
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
- Chang, L.S.; Weng, K.P.; Yan, J.H.; Lo, W.S.; Guo, M.M.; Huang, Y.H.; Kuo, H.C. Desquamation in Kawasaki Disease. Children 2021, 8, 317. [Google Scholar] [CrossRef]
- Weng, K.P.; Li, S.C.; Chien, K.J.; Tsai, K.W.; Kuo, H.C.; Hsieh, K.S.; Huang, S.H. Prediction Model for Diagnosis of Kawasaki Disease Using iTRAQ-Based Analysis. Children 2021, 8, 576. [Google Scholar] [CrossRef]
- Weng, K.P.; Hsieh, K.S.; Ho, T.Y.; Huang, S.H.; Lai, C.R.; Chiu, Y.T.; Huang, S.C.; Lin, C.C.; Hwang, Y.T.; Ger, L.P. IL-1B polymorphism in association with initial intravenous immunoglobulin treatment failure in Taiwanese children with Kawasaki disease. Circ. J. 2010, 74, 544–551. [Google Scholar] [CrossRef]
- McCrindle, B.W.; Rowley, A.H.; Newburger, J.W.; Burns, J.C.; Bolger, A.F.; Gewitz, M.; Baker, A.L.; Jackson, M.A.; Takahashi, M.; Shah, P.B.; et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation 2017, 135, e927–e999. [Google Scholar] [CrossRef]
- Weng, K.P.; Ho, T.Y.; Chiao, Y.H.; Cheng, J.T.; Hsieh, K.S.; Huang, S.H.; Ou, S.F.; Liu, K.H.; Hsu, C.J.; Lu, P.J.; et al. Cytokine genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children. Circ. J. 2010, 74, 2726–2733. [Google Scholar] [CrossRef]
- Park-Windhol, C.; D’Amore, P.A. Disorders of vascular permeability. Annu. Rev. Pathol. 2016, 11, 251–281. [Google Scholar] [CrossRef]
- Ohno, T.; Yuge, T.; Kariyazono, H.; Igarashi, H.; Joh-o, K.; Kinugawa, N.; Kusuhara, K.; Hara, T. Serum hepatocyte growth factor combined with vascular endothelial growth factor as a predictive indicator for the occurrence of coronary artery lesions in Kawasaki disease. Eur. J. Pediatr. 2002, 161, 105–111. [Google Scholar] [CrossRef] [PubMed]
- Terai, M.; Honda, T.; Yasukawa, K.; Higashi, K.; Hamada, H.; Kohno, Y. Prognostic impact of vascular leakage in acute Kawasaki disease. Circulation 2003, 108, 325–330. [Google Scholar] [CrossRef]
- Huang, J.; Zhang, S. Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease. Mediat. Inflamm. 2021, 2021, 9914071. [Google Scholar] [CrossRef]
- Maeno, N.; Takei, S.; Masuda, K.; Akaike, H.; Matsuo, K.; Kitajima, I.; Maruyama, I.; Miyata, K. Increased serum levels of vascular endothelial growth factor in Kawasaki disease. Pediatr. Res. 1998, 44, 596–599. [Google Scholar] [CrossRef] [Green Version]
- Ohno, T.; Igarashi, H.; Inoue, K.; Akazawa, K.; Joho, K.; Hara, T. Serum vascular endothelial growth factor: A new predictive indicator for the occurrence of coronary artery lesions in Kawasaki disease. Eur. J. Pediatr. 2000, 159, 424–429. [Google Scholar] [CrossRef] [PubMed]
- Takeshita, S.; Kawamura, Y.; Takabayashi, H.; Yoshida, N.; Nonoyama, S. Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease. Clin. Exp. Immunol. 2005, 139, 575–579. [Google Scholar] [CrossRef] [PubMed]
- Lin, I.C.; Sheen, J.M.; Tain, Y.L.; Chou, M.H.; Huang, L.T.; Yang, K.D. Vascular endothelial growth factor-a in lactobacillus casei cell wall extract-induced coronary arteritis of a murine model. Circ. J. 2014, 78, 752–762. [Google Scholar] [CrossRef] [PubMed]
- Lin, M.T.; Chang, C.H.; Hsieh, W.C.; Chang, C.E.; Chang, Y.M.; Chen, Y.C.; Hsu, J.Y.; Huang, Y.L.; Ma, J.Y.; Sun, L.C.; et al. Coronary Diameters in Taiwanese Children Younger than 6 Years Old: Z-Score Regression Equations Derived from Body Surface Area. Acta Cardiol. Sin. 2014, 30, 266–273. [Google Scholar] [PubMed]
- Terai, M.; Yasukawa, K.; Narumoto, S.; Tateno, S.; Oana, S.; Kohno, Y. Vascular endothelial growth factor in acute Kawasaki disease. Am. J. Cardiol. 1999, 83, 337–339. [Google Scholar] [CrossRef]
- Yasukawa, K.; Terai, M.; Shulman, S.T.; Toyozaki, T.; Yajima, S.; Kohno, Y.; Rowley, A.H. Systemic production of vascular endothelial growth factor and fms-like tyrosine kinase-1 receptor in acute Kawasaki disease. Circulation 2002, 105, 766–769. [Google Scholar] [CrossRef]
- Zhou, Y.; Wang, S.; Zhao, J.; Fang, P. Correlations of complication with coronary arterial lesion with VEGF, PLT, D-dimer and inflammatory factor in child patients with Kawasaki disease. Eur. Rev. Med. Pharmacol. Sci. 2018, 22, 5121–5126. [Google Scholar]
- Fukunishi, M.; Kikkawa, M.; Hamana, K.; Onodera, T.; Matsuzaki, K.; Matsumoto, Y.; Hara, J. Prediction of non-responsiveness to intravenous highdose gamma-globulin therapy in patients with Kawasaki disease at onset. J. Pediatr. 2000, 137, 172–176. [Google Scholar] [CrossRef]
- Kobayashi, T.; Inoue, Y.; Takeuchi, K.; Okada, Y.; Tamura, K.; Tomomasa, T.; Kobayashi, T.; Morikawa, A. Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease. Circulation 2006, 113, 2606–2612. [Google Scholar] [CrossRef]
- Sano, T.; Kurotobi, S.; Matsuzaki, K.; Yamamoto, T.; Maki, I.; Miki, K.; Kogaki, S.; Hara, J. Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Eur. J. Pediatr. 2007, 166, 131–137. [Google Scholar] [CrossRef]
- Egami, K.; Muta, H.; Ishii, M.; Suda, K.; Sugahara, Y.; Iemura, M.; Matsuishi, T. Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease. J. Pediatr. 2006, 149, 237–240. [Google Scholar] [CrossRef] [PubMed]
- Ueno, K.; Nomura, Y.; Hashiguchi, T.; Masuda, K.; Morita, Y.; Hazeki, D.; Eguchi, T.; Maruyama, I.; Kawano, Y. Platelet vascular endothelial growth factor is a useful predictor for prognosis in Kawasaki syndrome. Br. J. Haematol. 2010, 148, 285–292. [Google Scholar] [CrossRef] [PubMed]
- Suzuki, A.; Miyagawa-Tomita, S.; Komatsu, K.; Nishikawa, T.; Sakomura, Y.; Horie, T.; Nakazawa, M. Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease: Immunohistochemical study. Circulation 2000, 101, 2935–2941. [Google Scholar] [CrossRef] [PubMed]
- Suzuki, A.; Miyagawa-Tomita, S.; Komatsu, K.; Nakazawa, M.; Fukaya, T.; Baba, K.; Yutani, C. Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Pediatr. Int. 2004, 46, 590–596. [Google Scholar] [CrossRef]
- Breunis, W.B.; Davila, S.; Shimizu, C.; Oharaseki, T.; Takahashi, K.; van Houdt, M.; Khor, C.C.; Wright, V.J.; Levin, M.; Burns, J.C.; et al. International Kawasaki Disease Genetics Consortium. Disruption of vascular homeostasis in patients with Kawasaki disease: Involvement of vascular endothelial growth factor and angiopoietins. Arthritis. Rheum. 2012, 64, 306–315. [Google Scholar] [CrossRef]
- An, X.; Lv, H.; Tian, J.; He, X.; Ling, N. Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease. Exp. Ther. Med. 2016, 11, 1318–1322. [Google Scholar] [CrossRef]
- Miura, M.; Kohno, K.; Ohki, H.; Yoshiba, S.; Sugaya, A.; Satoh, M. Effects of methylprednisolone pulse on cytokine levels in Kawasaki disease patients unresponsive to intravenous immunoglobulin. Eur. J. Pediatr. 2008, 167, 1119–1123. [Google Scholar] [CrossRef]
- Hirono, K.; Kemmotsu, Y.; Wittkowski, H.; Foell, D.; Saito, K.; Ibuki, K.; Watanabe, K.; Watanabe, S.; Uese, K.; Kanegane, H.; et al. Infliximab reduces the cytokine-mediated inflammation but does not suppress cellular infiltration of the vessel wall in refractory Kawasaki disease. Pediatr. Res. 2009, 65, 696–701. [Google Scholar] [CrossRef]
- Su, Y.; Feng, S.; Luo, L.; Liu, R.; Yi, Q. Association between IL-35 and coronary arterial lesions in children with Kawasaki disease. Clin. Exp. Med. 2019, 19, 87–92. [Google Scholar] [CrossRef]
- Page, A.V.; Liles, W.C. Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence 2013, 4, 507–516. [Google Scholar] [CrossRef]
- Norooznezhad, A.H.; Mansouri, K. Endothelial cell dysfunction, coagulation, and angiogenesis in coronavirus disease 2019 (COVID-19). Microvasc. Res. 2021, 137, 104188. [Google Scholar] [CrossRef] [PubMed]
Factors\Category | KD Patients (n = 42) | Febrile Controls (n = 30) | p Value |
---|---|---|---|
n (%) | n (%) | ||
Sex | |||
Male | 22 (52.4) | 13 (43.3) | 0.537 |
Female | 20 (47.6) | 17 (56.7) | |
Age (months) | 18.9 ± 12.2 | 19.1 ± 13.7 | 0.835 |
Acute CALs | |||
Yes | 20 (47.6) | ||
No | 22 (52.4) | ||
IVIG resistance | |||
Yes | 0 (0%) | ||
No | 42 (100%) |
Variables | Pre-IVIG Acute Phase (n = 42) | Post-IVIG Acute Phase (n = 42) | ||
---|---|---|---|---|
Correlation Coefficient | p Value | Correlation Coefficient | p Value | |
WBC | 0.024 | 0.881 | 0.008 | 0.960 |
PMN | 0.188 | 0.234 | 0.201 | 0.203 |
Lymphocyte | −0.063 | 0.692 | −0.200 | 0.204 |
Monocyte | 0.030 | 0.849 | −0.026 | 0.869 |
Eosinophil | −0.008 | 0.960 | 0.201 | 0.201 |
Albumin | −0.320 | 0.039 | −0.041 | 0.804 |
Hemoglobin | −0.050 | 0.754 | 0.092 | 0.561 |
Platelet | 0.356 | 0.021 | 0.325 | 0.036 |
AST | 0.028 | 0.861 | −0.095 | 0.549 |
ALT | −0.063 | 0.691 | −0.069 | 0.663 |
CRP | 0.311 | 0.045 | 0.443 | 0.003 |
TG | −0.073 | 0.647 | 0.280 | 0.072 |
TC | −0.055 | 0.730 | 0.005 | 0.976 |
HDL | −0.207 | 0.189 | −0.110 | 0.490 |
TC/HDL ratio | 0.142 | 0.368 | 0.086 | 0.588 |
LDL | −0.031 | 0.844 | 0.019 | 0.906 |
D-dimer | 0.036 | 0.823 | 0.139 | 0.381 |
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Chen, C.-Y.; Huang, S.-H.; Chien, K.-J.; Lai, T.-J.; Chang, W.-H.; Hsieh, K.-S.; Weng, K.-P. Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease. Children 2022, 9, 1343. https://doi.org/10.3390/children9091343
Chen C-Y, Huang S-H, Chien K-J, Lai T-J, Chang W-H, Hsieh K-S, Weng K-P. Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease. Children. 2022; 9(9):1343. https://doi.org/10.3390/children9091343
Chicago/Turabian StyleChen, Chun-Yu, Shih-Hui Huang, Kuang-Jen Chien, Tsung-Jen Lai, Wei-Hsiang Chang, Kai-Sheng Hsieh, and Ken-Pen Weng. 2022. "Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease" Children 9, no. 9: 1343. https://doi.org/10.3390/children9091343