Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Population
2.2. MRI Acquisition
2.3. Analysis: Manual Inspection and FreeSurfer Analysis
2.4. Statistical Analysis
3. Results
3.1. Study Population
3.2. Volumetric Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Age Group | 7–12 Months | 13 Months to 18 Years | |
---|---|---|---|
Number of subjects | GJB2 | 4 | 11 |
Controls | 9 | 70 | |
Number of males | GJB2 | 2 | 6 |
Controls | 5 | 39 | |
Number of females | GJB2 | 2 | 5 |
Controls | 4 | 31 | |
Average age (range) (months) | GJB2 | 8 (7–9) | 73 (14–177) |
Controls | 9 (7–12) | 74 (15–187) | |
p-value | 0.12 | 0.47 | |
Brain volume (L) | GJB2 | 0.64 | 1.1 |
Controls | 0.69 | 1 | |
p-value | 0.29 | 0.25 |
Age Group | 7–12 Months | 13 Months to 18 Years | |
---|---|---|---|
Heschl’s gyrus (%) | GJB2 | 0.09(0.02) | 0.09(0.02) |
Controls | 0.075(0.02) | 0.1(0.02) | |
p-value | 0.09 | 0.02 | |
Anterior Heschl’s gyrus (%) | GJB2 | N/A | 0.08(0.02) |
Controls | N/A | 0.1(0.02) | |
p-value | N/A | 0.0055 | |
Planum temporale (%) | GJB2 | N/A | 0.14(0.05) |
Controls | N/A | 0.15(0.05) | |
p-value | N/A | 0.2 | |
MGN (%) | GJB2 | N/A | 0.008(0.002) |
Controls | N/A | 0.009(0.002) | |
p-value | N/A | 0.11 | |
Nucleus accumbens (%) | GJB2 | 0.03(0.01) | 0.05(0.01) |
Controls | 0.03(0.01) | 0.05(0.01) | |
p-value | 0.2 | 0.2 |
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Wagner, M.W.; Cushing, S.L.; Tshuma, M.; Gordon, K.A.; Ertl-Wagner, B.B.; Vidarsson, L. Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness. Children 2022, 9, 800. https://doi.org/10.3390/children9060800
Wagner MW, Cushing SL, Tshuma M, Gordon KA, Ertl-Wagner BB, Vidarsson L. Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness. Children. 2022; 9(6):800. https://doi.org/10.3390/children9060800
Chicago/Turabian StyleWagner, Matthias W., Sharon L. Cushing, Makabongwe Tshuma, Karen A. Gordon, Birgit B. Ertl-Wagner, and Logi Vidarsson. 2022. "Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness" Children 9, no. 6: 800. https://doi.org/10.3390/children9060800