Glycation-Associated Diabetic Nephropathy and the Role of Long Noncoding RNAs
Abstract
:1. Introduction
1.1. Structural Properties of LncRNAs
1.2. Functional Properties of LncRNAs
1.2.1. Role in Transcription Regulation
1.2.2. Role in Post-Transcriptional Regulation
1.2.3. Role in Epigenetic Regulation
2. Techniques for Identification of LncRNAs
2.1. Immunoprecipitation for LncRNAs Isolation
2.2. Microarray for Known LncRNAs Identification
2.3. RNA Sequencing for Novel LncRNAs Identification
3. Working Models of LncRNAs
4. Diabetic Nephropathy at a Glance
5. Glycation and AGEs at a Glance
5.1. Complex Network of AGEs Formation
5.2. AGEs and Their Receptors on Cells
5.2.1. RAGEs
5.2.2. AGER (1, 2 and 3)
5.3. Role of AGEs in DN Development and Progression
6. Understanding the Role of LncRNAs in AGEs-Related DN
6.1. LncRNA-Mediated RAGE Gene Expression and Signaling
6.2. LncRNAs That Regulate AGER Gene Expression and Signaling
7. Future Perspectives: LncRNAs as Biomarkers, Therapeutic Agents, and Therapeutic Targets
7.1. LncRNAs as Biomarkers
7.2. LncRNAs as Therapeutic Agents
7.3. LncRNAs as Therapeutic Targets
7.3.1. RNA Gene Transcription Deregulation
7.3.2. Post-Transcriptional Deregulation
7.3.3. Functional Disruption
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
LncRNAs | long noncoding RNAs |
ncRNAs | noncoding RNAs |
AGEs | advanced glycation end products |
RAGE | receptor for AGEs |
AGER | AGEs receptor |
DN | diabetic nephropathy |
ROS | reactive oxygen species |
lncRNA HOTAIR | lncRNAs HOX transcript antisense RNA |
HG | high glucose |
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Diabetic Complications | lncRNA Involved | Mode of Action | References |
---|---|---|---|
Diabetic neuropathy | lncRNA NEAT1 | Regulate disease progression by targeting two miRNAs, miR-183-5p and miR-433-3p. | [9] |
lncRNA TP73-AS1 | Sponges decreases miR-142 and upregulates HMGB1 expression as well as promotes cell proliferation. Its silencing decreases neuropathic pain. | [10] | |
Diabetic retinopathy | lncRNA HOTTIP | Induces p38/MAPK signaling and promotes retinal cell inflammatory response and diabetic retinopathy progression. | [11] |
lncRNA BANCR | Regulates cell apoptosis | [12] | |
lncRNA MEG3 | Regulates VEGF and TGF-β1 expressions | [13] | |
Inflammatory diabetes complications | lncRNA DRAIR | Regulates macrophages/monocyte pro/anti-inflammatory phenotypes in T2DM. Down-regulated by diabetogenic factors | [14] |
Diabetic wound healing | lncRNA URIDS | Impairs collagen production and crosslinking by interacting with Plod1 and delays wound healing | [15] |
lncRNA MALAT1 | Increases wound healing and upregulate fibroblast activation in diabetic mice by activating the HIF-1α signaling pathway. | [16] | |
Diabetic cardiomyopathy | lncRNA HOTAIR | Downregulates DCM effects by activating SIRT1 expressions and sponging miR-34a. | [17] |
lncRNA Kcnq1ot1 | Promotes pyroptosis by regulating expressions of miR-214-3p and caspase-1 | [18] | |
lncRNA H19 | Regulates high glucose-induced apoptosis by targeting VDAC1. It also improves left ventricular function when overexpressed. | [19] | |
lncRNA Crende | Negatively regulates cardiac fibroblast differentiation. Also, its expression is induced by Smad3 in cardiac fibroblasts. It inhibits myofibroblastic gene transcription. | [20] | |
lncRNA TUG1 | Its knockdown lessened DCM-induced hypertrophy and diastolic function. Also, its silencing upregulates the expression of some miRNAs | [21] | |
Diabetic nephropathy | lncRNA Blnc1 | Attenuates renal fibrosis and inflammation and affects oxidative stress by NF-κB and NRF2/HO-1 pathways | [22] |
lncRNA TCF7 | It acts as a sponge against miR-200c and triggers endoplasmic reticulum stress in patients with DN. | [23] | |
lncRNA Gas5 | Alleviates cell proliferation and fibrosis sponging miR-221 and upregulates SIRT1 | [24] |
LncRNA Involved | Diabetic Complication | Mode of Action | References |
---|---|---|---|
lncRNA Arid2-IR | Diabetic retinopathy | Regulates oxidative stress, inflammatory responses, and endothelial cell dysfunction via interacting with Smad3 | [96] |
lncRNA MIAT | Diabetic retinopathy | AGE-induced HRPCs MIAT and CASP1 expressions increase, followed by the release of IL-1β, IL-18, and suppression of cell viability. | [98] |
lncRNA MEG3 | Diabetic vascular diseases | Upregulates in AGE-induced cells and suppresses cell viability and proliferation by modulating the MEG3/miR-193/p21 pathway | [97] |
lncRNA URIDS | Diabetic Wound Healing | Upregulates upon AGE induction. Regulates collagen production and deposition by targeting Plod1. It delays the wound healing process. | [15] |
lncRNA E330013P06 | Inflammatory diabetes complications | Increases inflammatory response upon AGE induction; by triggering pro-inflammatory gene. It also enhances foam cell formation. | [99] |
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Durge, A.; Sharma, I.; Tupe, R.S. Glycation-Associated Diabetic Nephropathy and the Role of Long Noncoding RNAs. Biomedicines 2022, 10, 2623. https://doi.org/10.3390/biomedicines10102623
Durge A, Sharma I, Tupe RS. Glycation-Associated Diabetic Nephropathy and the Role of Long Noncoding RNAs. Biomedicines. 2022; 10(10):2623. https://doi.org/10.3390/biomedicines10102623
Chicago/Turabian StyleDurge, Ankita, Isha Sharma, and Rashmi Santosh Tupe. 2022. "Glycation-Associated Diabetic Nephropathy and the Role of Long Noncoding RNAs" Biomedicines 10, no. 10: 2623. https://doi.org/10.3390/biomedicines10102623