Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Experiments
2.2. Auditory Function Analysis
2.3. Cells and Virus
2.4. Viral Titration
2.5. Histological Analysis
2.6. Statistical Analysis
3. Results
3.1. Pathogenicity of ML29 in STAT1-/- Mice
3.2. Pathogenicity of ML29 in CD4/CD8 T Cell Double Depleted STAT1-/- Mice
3.3. Pathogenicity of ML29 in Individual CD4 or CD8 T Cell Depleted STAT1-/- Mice
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Reyna, R.A.; Maruyama, J.; Mantlo, E.K.; Manning, J.T.; Taniguchi, S.; Makishima, T.; Lukashevich, I.S.; Paessler, S. Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice. Biomedicines 2022, 10, 2433. https://doi.org/10.3390/biomedicines10102433
Reyna RA, Maruyama J, Mantlo EK, Manning JT, Taniguchi S, Makishima T, Lukashevich IS, Paessler S. Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice. Biomedicines. 2022; 10(10):2433. https://doi.org/10.3390/biomedicines10102433
Chicago/Turabian StyleReyna, Rachel A., Junki Maruyama, Emily K. Mantlo, John T. Manning, Satoshi Taniguchi, Tomoko Makishima, Igor S. Lukashevich, and Slobodan Paessler. 2022. "Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice" Biomedicines 10, no. 10: 2433. https://doi.org/10.3390/biomedicines10102433