Profiling of Urinary Glucuronidated Bile Acids across Age Groups
Abstract
:1. Introduction
2. Methods
3. Results
3.1. Age-Dependent Changes in Urinary Excretion Forms of Bile Acids
3.2. Changes in Urinary Glucuronidated Bile Acids across Age Groups
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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0–2 m | 3–11 m | 1–3 y | ||||
(n = 10, male: 7) | (n = 22, male: 9) | (n = 12, male: 6) | ||||
Mean ± SD *4 | % | Mean ± SD | % | Mean ± SD | % | |
3-Glucuronidated | ||||||
24-Nonamidated | 0.04 ± 0.11 | 0.38 | 0.01 ± 0.01 | 0.23 | 0.01 ± 0.01 | 1.09 |
24-Glycine | 0.01 ± 0.02 | 0.08 | 0.09 ± 0.12 | 3.02 | 0.11 ± 0.21 | 8.59 |
24-Taurine | 0.00 ± 0.01 | 0.02 | 0.03 ± 0.04 | 0.90 | 0.01 ± 0.01 | 0.64 |
3-Sulfated | ||||||
24-Nonamidated | 0.04 ± 0.06 | 0.35 | 0.02 ± 0.02 | 0.75 | 0.01 ± 0.03 | 1.09 |
24-Glycine | 0.65 ± 0.36 | 5.97 | 0.79 ± 0.34 | 25.96 | 0.51 ± 0.53 | 39.06 |
24-Taurine | 0.47 ± 0.46 | 4.36 | 0.24 ± 0.17 | 7.79 | 0.08 ± 0.07 | 5.95 |
3-Unconjugated | ||||||
24-Nonamidated | 012 ± 0.16 | 1.14 | 0.12 ± 0.22 | 3.93 | 0.03 ± 0.03 | 2.03 |
24-Glycine | 0.78 ± 1.09 | 7.18 | 0.27 ± 0.15 | 8.73 | 0.21 ± 0.39 | 15.76 |
24-Taurine | 0.39 ± 0.57 | 3.58 | 0.13 ± 0.16 | 4.16 | 0.01 ± 0.02 | 1.08 |
Polyhydroxylated *2 | 6.74 ± 0.01 | 61.85 | 0.53 ± 0.42 | 17.23 | 0.07 ± 0.11 | 5.33 |
Others *3 | 1.64 ± 0.94 | 15.09 | 0.83 ± 0.44 | 27.30 | 0.25 ± 0.17 | 19.40 |
Total | 10.89 ± 14.23 | 100 | 3.05 ± 1.28 | 100 | 1.31 ± 1.59 | 100 |
4–9 y | 10–15 y | Adult | ||||
(n = 13, male: 7) | (n = 7, male: 4) | (n = 5, male: 2) | ||||
Mean ± SD | % | Mean ± SD | % | Mean ± SD | % | |
3-Glucuronidated | ||||||
24-Nonamidated | 0.02 ± 0.02 | 2.55 | 0.03 ± 0.05 | 5.97 | 0.02 ± 0.01 | 2.81 |
24-Glycine | 0.04 ± 0.01 | 4.85 | 0.03 ± 0.03 | 5.62 | 0.04 ± 0.05 | 6.48 |
24-Taurine | 0.00 ± 0.00 | 0.36 | 0.00 ± 0.01 | 0.71 | 0.00 ± 0.00 | 0.14 |
3-Sulfated | ||||||
24-Nonamidated | 0.34 ± 0.34 | 1.13 | 0.02 ± 0.02 | 2.93 | 0.01 ± 0.01 | 1.49 |
24-Glycine | 0.05 ± 0.06 | 46.41 | 0.26 ± 0.36 | 46.54 | 0.39 ± 0.44 | 62.05 |
24-Taurine | 0.02 ± 0.02 | 6.95 | 0.05 ± 0.08 | 8.99 | 0.03 ± 0.02 | 4.23 |
3-Unconjugated | ||||||
24-Nonamidated | 0.05 ± 0.03 | 2.99 | 0.02 ± 0.03 | 4.11 | 0.02 ± 0.01 | 2.60 |
24-Glycine | 0.01 ± 0.00 | 7.40 | 0.02 ± 0.02 | 3.89 | 0.01 ± 0.02 | 1.99 |
24-Taurine | 0.01 ± 0.00 | 0.82 | 0.00 ± 0.00 | 0.51 | 0.00 ± 0.00 | 0.00 |
Polyhydroxylated *2 | 0.02 ± 0.03 | 3.16 | 0.01 ± 0.01 | 1.30 | 0.00 ± 0.00 | 0.34 |
Others *3 | 0.17 ± 0.09 | 23.38 | 0.11 ± 0.05 | 19.42 | 0.11 ± 0.04 | 17.87 |
Total | 0.74 ± 0.61 | 100 | 0.56 ± 0.68 | 100 | 0.63 ± 0.60 | 100 |
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Muto, Y.; Suzuki, M.; Kakiyama, G.; Sasaki, T.; Murai, T.; Takei, H.; Nittono, H. Profiling of Urinary Glucuronidated Bile Acids across Age Groups. Metabolites 2022, 12, 1230. https://doi.org/10.3390/metabo12121230
Muto Y, Suzuki M, Kakiyama G, Sasaki T, Murai T, Takei H, Nittono H. Profiling of Urinary Glucuronidated Bile Acids across Age Groups. Metabolites. 2022; 12(12):1230. https://doi.org/10.3390/metabo12121230
Chicago/Turabian StyleMuto, Yamato, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Hajime Takei, and Hiroshi Nittono. 2022. "Profiling of Urinary Glucuronidated Bile Acids across Age Groups" Metabolites 12, no. 12: 1230. https://doi.org/10.3390/metabo12121230