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Sci. Pharm.
Volume 75
Issue 4
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Sci. Pharm., Volume 75, Issue 4 (December 2007) – 4 articles , Pages 147-193

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414 KiB  
Article
Antioxidant Active Principles Isolated from Psidium guajava Grown in Thailand
by Suganya Tachakittirungrod, Fumio Ikegami and Siriporn Okonogi
Sci. Pharm. 2007, 75(4), 179-193; https://doi.org/10.3797/scipharm.2007.75.179 - 31 Dec 2007
Cited by 46 | Viewed by 3190
Abstract
Antioxidant active compounds were isolated from methanol crude extracts of the leaves of Guava (Psidium guajava L.) grown in Thailand. The isolated compounds were screened for their in vitro antioxidant activity by a DPPH free radical scavenging assay. Results indicate that three [...] Read more.
Antioxidant active compounds were isolated from methanol crude extracts of the leaves of Guava (Psidium guajava L.) grown in Thailand. The isolated compounds were screened for their in vitro antioxidant activity by a DPPH free radical scavenging assay. Results indicate that three isolated compounds contribute importantly to the antioxidant activity of guava leaves, providing a scientific basis for the use of this plant in traditional medicine. Their structures were determined on the basis of spectroscopic and chemical methods. The most active compound was found to be quercetin along with two flavonoid compounds, quercetin-3-O-glucopyranoside and morin. The isolated quercetin, quercetin-3-O-glucopyranoside and morin showed significant scavenging activity with IC50 of 1.20±0.02, 3.58±0.05 and 5.41±0.20 µg/ml, respectively. Full article
201 KiB  
Article
Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC
by Jan Šubert, Oldřich Fars and Marie Marečková
Sci. Pharm. 2007, 75(4), 171-178; https://doi.org/10.3797/scipharm.2007.75.171 - 31 Dec 2007
Cited by 9 | Viewed by 3541
Abstract
HPLC was used to determine the content of methylparaben (MP), propylparaben (PP) and 4-hydroxybenzoic acid (4-HYB) as their decomposition product in the water solution Aqua Conservans (AQCO) in accordance with the Czech Pharmacopoeia and the Slovak Pharmaceutical Codex (0.067 % MP and 0.033 [...] Read more.
HPLC was used to determine the content of methylparaben (MP), propylparaben (PP) and 4-hydroxybenzoic acid (4-HYB) as their decomposition product in the water solution Aqua Conservans (AQCO) in accordance with the Czech Pharmacopoeia and the Slovak Pharmaceutical Codex (0.067 % MP and 0.033 % PP). Based on the results of the analyses of 10 samples of AQCO from 8 pharmacies, 4-42 months after their preparation, an expiration period of 3 years was proposed for AQCO. Full article
198 KiB  
Article
A New Sesquiterpene Derivative from the Fruit Peel of Citrus Limon (Linn.) Burm. f.
by Shahnaz Sultana, M. Ali, S. H. Ansari and Priyanka Bagri
Sci. Pharm. 2007, 75(4), 165-170; https://doi.org/10.3797/scipharm.2007.75.165 - 31 Dec 2007
Cited by 19 | Viewed by 1540
Abstract
A new sesquiterpene derivative of phloroglucinol glycoside isolated from the fruit peels of Citrus limon (Linn.) Burm.f. has been characterized as phloroglucinolyl-D-glucuronosyl-6″-longifolan-1″-ol-2″-one on the basis of spectral analyses. Full article
838 KiB  
Article
Factors Influencing Drug Dissolution Characteristic from Hydrophilic Polymer Matrix Tablet
by Kiattisak Saeio, Yanee Pongpaibul, Helmut Viernstein and Siriporn Okonogi
Sci. Pharm. 2007, 75(4), 147-164; https://doi.org/10.3797/scipharm.2007.75.147 - 31 Dec 2007
Cited by 27 | Viewed by 2261
Abstract
The aim of this work was to investigate the factors influencing the dissolution characteristics of drug substances from hydrophilic polymer matrix tablets. Various kinds of cellulose derivative polymers were used in for matrix formation. Their swelling propertiesy waswere measured. The effects on drug [...] Read more.
The aim of this work was to investigate the factors influencing the dissolution characteristics of drug substances from hydrophilic polymer matrix tablets. Various kinds of cellulose derivative polymers were used in for matrix formation. Their swelling propertiesy waswere measured. The effects on drug release was firstly carried were studiedout in comparison with lactose. Results showedindicate that drug release characteristics from polymer matrix tablets followed a Higuchi square root time kinetics. It was found that the polymers could retard the release of drugs in both simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), but at different levels. The dissolution constants of drugs exhibitedwere higher when the pH of the dissolution medium was increased. Results also demonstratedindicate a the linear correlation between the proportions of matrix-forming structures in the tablets and the extent of dissolution retardation. It was found that not only the swelling property of the polymer but also its hydrophobicity and the hardness of the tablet played an important role onin the retardation of drug release. Results also revealedindicate that PVP K30 could supports cellulose polymers so as to improve the release behavior in order keep a better control to maintain a constant drug release in each time interval.in order to better keep drug release constant in each time interval. Full article
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