Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Using the Likelihood Ratio to Compute the Optimal Decision Thresholds and the Decision Error Probabilities for the TNF—NFκB/ATF-2 System
2.1.1. Univariate Decision Analysis
2.1.2. Bivariate Decision Analysis
2.2. Using the Discriminant Function to Compute the Decision Error Probabilities for the TNF—NFκB/ATF-2 System
3. Results and Discussion
3.1. Single Cell Data of the Two-Output TNF—NFκB/ATF-2 System
3.2. Graphical Representation of the Two-Output System Data and the Decision Thresholds
3.3. Decision Error Probabilities of the Two-Output System
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Time | High TNF Level (ng/mL) | Importance Score | |
---|---|---|---|
NFκB | ATF-2 | ||
30 min | 0.082 | 0.18 | 0 |
3.2 | 0.49 | 0.15 | |
50 | 0.57 | 0.2 | |
4 h | 0.082 | 0.05 | 0.01 |
3.2 | 0.3 | 0.1 | |
50 | 0.24 | 0.07 |
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Emadi, A.; Lipniacki, T.; Levchenko, A.; Abdi, A. Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules. Biology 2023, 12, 1461. https://doi.org/10.3390/biology12121461
Emadi A, Lipniacki T, Levchenko A, Abdi A. Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules. Biology. 2023; 12(12):1461. https://doi.org/10.3390/biology12121461
Chicago/Turabian StyleEmadi, Ali, Tomasz Lipniacki, Andre Levchenko, and Ali Abdi. 2023. "Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules" Biology 12, no. 12: 1461. https://doi.org/10.3390/biology12121461