Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults
Abstract
:Simple Summary
Abstract
1. Introduction
2. Danio rerio as a Model Organism
3. Biochemical Effects on Zebrafish
3.1. Antibiotics and Anthelmintics
Drug | Environmental Concentrations | Concentration/ Time Exposure | Samples | Biomarker Analysed | Biochemical Responses | Reference |
---|---|---|---|---|---|---|
Oxytetracycline | ng/L to µg/L [113] | 0, 0.1, 10, 10,000 µg/L for Two Months | Whole Body | Total Protein; Lipid; Total Glutathione; Glutathione S-Transferase; Catalase; Acetylcholinesterase; Lactate Dehydrogenase | (+) Total Protein (−) Lipid Level, Total Glutathione, Glutathione S-Transferase, Catalase | [68] |
Sulfamethoxazole Oxytetracycline | 259,6 ng/L and 350 ng/L Respectively [120] | 260 ng/L 420 ng/L for Six Weeks | Intestine, Liver, Muscle | Superoxide Dismutase; Peroxidase; Reduced Glutathione; Alkaline Phosphatase; Acid Phosphatase | (−) Alkaline Phosphatase, Acid Phosphatase, Antioxidant Enzymes | [69] |
Sulfamethoxazole Oxytetracycline | 100 and 80 mg/kg for Six Weeks | Intestine, Liver, Muscle | Amylase; Lipase; Malondialdehyde; Superoxide Dismutase; Peroxidase; Reduced Glutathione; Alkaline Phosphatase; Acid Phosphatase | (+) Malondialdehyde (−) Peroxidase, Superoxide Dismutase, Reduced Glutathione, Alkaline Phosphatase, Acid Phosphatase | [121] | |
Sulfamethoxazole | 50, 100 and 500 mg/L for 3 and 14 Days | Whole-Body | Glutathione Peroxidase; Glutathione Reductase; Glutathione S-Transferase; Lipid Peroxidation | No Significant Effects | [124] | |
Amoxicillin Oxytetracycline | 6 and 340 ng/L, Respectively [125] | 0,1, 10, 25, 50, 100 mg/L for 96 h | Head, Muscle, Liver, Gills | Catalase; Glutathione S-Transferases; Lactate Dehydrogenase | (−) Catalase, Glutathione S-Transferase, Lactate Dehydrogenase | [66] |
Ivermectin | 25 up to 60 ng/L [129,130] | 10, 20, 40, 60, 80, 100, 200 μg/L for 96 h | Head, Muscle, Liver, Gills | Acetylcholinesterase; Glutathione S-Transferases; Lactate Dehydrogenase | No Change in Acetylcholinesterase, Lactate Dehydrogenase (−) Glutathione S-Transferase | [105] |
Ivermectin | 10, 20, 40, 60, 80, 100 µg/L for 96 h | Head, Trunk | Catalase; Glutathione S-Transferase; Acetylcholinesterase | (−) Catalase Activity, Glutathione S-Transferase No Change in Acetylcholinesterase | [106] |
3.2. Antiepileptics and Antipsychotics
3.3. Antidyslipidemics
Drug | Environmental Concentrations | Concentration/ Time Exposure | Samples | Biomarker Analysed | Biochemical Responses | Reference |
---|---|---|---|---|---|---|
Gemfibrozil Atorvastatin | 1500–2100 ng/L and 15–44 ng/L, Respectively [178] | 16 μg/g 0.53 μg/g for 30 Days | Whole Body | Cholesterol; Triglycerides; Cortisol; Testosterone; Estradiol | (−) Cholesterol (−) Triglycerides (−) Cortisol (−) Testosterone (−) in Estradiol | [177] |
Gemfibrozil | 10 μg/L for 67 Days | Whole Body, Plasma, Gonads | 11-Chetotestosterone | (−) 11-Chetotestosterone | [169] | |
Gemfibrozil | 0.5 and 10 μg/L for 6 Weeks | Plasma | 11-Ketotestosterone; Estradiol | (−) 11-Ketotestosterone | [170] | |
Bezafibrate | Up to 3.1 [186] | 1.7, 33 and 70 mg/g for 48 h, 7 and 21 Days | Plasma | Cholesterol; 11-Chetotestosterone | (−) Cholesterol 11-Chetotestosterone | [185] |
3.4. Analgesic, Antipyretic and Anti-Inflammatory Drugs
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Albano, M.; Panarello, G.; Di Paola, D.; Capparucci, F.; Crupi, R.; Gugliandolo, E.; Spanò, N.; Capillo, G.; Savoca, S. The Influence of Polystyrene Microspheres Abundance on Development and Feeding Behavior of Artemia Salina (Linnaeus, 1758). Appl. Sci. 2021, 11, 3352. [Google Scholar] [CrossRef]
- Stara, A.; Pagano, M.; Albano, M.; Savoca, S.; Di Bella, G.; Albergamo, A.; Koutkova, Z.; Sandova, M.; Velisek, J.; Fabrello, J.; et al. Effects of Long-Term Exposure of Mytilus Galloprovincialis to Thiacloprid: A Multibiomarker Approach. Environ. Pollut. 2021, 289, 117892. [Google Scholar] [CrossRef] [PubMed]
- Vazzana, M.; Mauro, M.; Ceraulo, M.; Dioguardi, M.; Papale, E.; Mazzola, S.; Arizza, V.; Beltrame, F.; Inguglia, L.; Buscaino, G. Underwater High Frequency Noise: Biological Responses in Sea Urchin Arbacia Lixula (Linnaeus, 1758). Comp. Biochem. Physiol. Part A Mol. Integr. Physiol. 2020, 242, 110650. [Google Scholar] [CrossRef]
- Vazzana, M.; Ceraulo, M.; Mauro, M.; Papale, E.; Dioguardi, M.; Mazzola, S.; Arizza, V.; Chiaramonte, M.; Buscaino, G. Effects of Acoustic Stimulation on Biochemical Parameters in the Digestive Gland of Mediterranean Mussel Mytilus galloprovincialis (Lamarck, 1819). J. Acoust. Soc. Am. 2020, 147, 2414–2422. [Google Scholar] [CrossRef] [PubMed]
- Mauro, M.; Pérez-Arjona, I.; Perez, E.J.B.; Ceraulo, M.; Bou-Cabo, M.; Benson, T.; Espinosa, V.; Beltrame, F.; Mazzola, S.; Vazzana, M.; et al. The Effect of Low Frequency Noise on the Behaviour of Juvenile Sparus Aurata. J. Acoust. Soc. Am. 2020, 147, 3795. [Google Scholar] [CrossRef]
- Komijani, M.; Shamabadi, N.S.; Shahin, K.; Eghbalpour, F.; Tahsili, M.R.; Bahram, M. Heavy Metal Pollution Promotes Antibiotic Resistance Potential in the Aquatic Environment. Environ. Pollut. 2021, 274, 116569. [Google Scholar] [CrossRef]
- Li, J.; Chen, Y.; Lu, H.; Zhai, W. Spatial Distribution of Heavy Metal Contamination and Uncertainty-Based Human Health Risk in the Aquatic Environment Using Multivariate Statistical Method. Environ. Sci. Pollut. Res. Int. 2021, 28, 22804–22822. [Google Scholar] [CrossRef]
- Chen, M.-H.; Ma, W.-L. A Review on the Occurrence of Organophosphate Flame Retardants in the Aquatic Environment in China and Implications for Risk Assessment. Sci. Total Environ. 2021, 783, 147064. [Google Scholar] [CrossRef]
- Suman, K.H.; Haque, M.N.; Uddin, M.J.; Begum, M.S.; Sikder, M.H. Toxicity and Biomarkers of Micro-Plastic in Aquatic Environment: A Review. Biomarkers 2021, 26, 13–25. [Google Scholar] [CrossRef]
- Hollerová, A.; Hodkovicová, N.; Blahová, J.; Faldyna, M.; Maršálek, P.; Svobodová, Z. Microplastics as a Potential Risk for Aquatic Environment Organisms—A Review. Acta Vet. Brno 2021, 90, 99–107. [Google Scholar] [CrossRef]
- Wang, F.; Gao, J.; Zhai, W.; Cui, J.; Liu, D.; Zhou, Z.; Wang, P. Effects of Antibiotic Norfloxacin on the Degradation and Enantioselectivity of the Herbicides in Aquatic Environment. Ecotoxicol. Environ. Saf. 2021, 208, 111717. [Google Scholar] [CrossRef]
- Sumudumali, R.G.I.; Jayawardana, J.M.C.K. A Review of Biological Monitoring of Aquatic Ecosystems Approaches: With Special Reference to Macroinvertebrates and Pesticide Pollution. Environ. Manag. 2021, 67, 263–276. [Google Scholar] [CrossRef]
- Shefali; Kumar, R.; Sankhla, M.S.; Kumar, R.; Sonone, S.S. Impact of Pesticide Toxicity in Aquatic Environment. Biointerface Res. Appl. Chem. 2020, 11, 10131–10140. [Google Scholar] [CrossRef]
- Xiang, Y.; Wu, H.; Li, L.; Ren, M.; Qie, H.; Lin, A. A Review of Distribution and Risk of Pharmaceuticals and Personal Care Products in the Aquatic Environment in China. Ecotoxicol. Environ. Saf. 2021, 213, 112044. [Google Scholar] [CrossRef] [PubMed]
- Inguglia, L.; Chiaramonte, M.; Di Stefano, V.; Schillaci, D.; Cammilleri, G.; Pantano, L.; Mauro, M.; Vazzana, M.; Ferrantelli, V.; Nicolosi, R.; et al. Salmo Salar Fish Waste Oil: Fatty Acids Composition and Antibacterial Activity. PeerJ 2020, 8, e9299. [Google Scholar] [CrossRef]
- Punginelli, D.; Schillaci, D.; Mauro, M.; Deidun, A.; Barone, G.; Arizza, V.; Vazzana, M. The Potential of Antimicrobial Peptides Isolated from Freshwater Crayfish Species in New Drug Development: A Review. Dev. Comp. Immunol. 2021, 126, 104258. [Google Scholar] [CrossRef] [PubMed]
- Lazzara, V.; Arizza, V.; Luparello, C.; Mauro, M.; Vazzana, M. Bright Spots in The Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action. Mar. Drugs 2019, 17, 617. [Google Scholar] [CrossRef] [Green Version]
- Mauro, M.; Lazzara, V.; Punginelli, D.; Arizza, V.; Vazzana, M. Antitumoral Compounds from Vertebrate Sister Group: A Review of Mediterranean Ascidians. Dev. Comp. Immunol. 2020, 108, 103669. [Google Scholar] [CrossRef] [PubMed]
- Mauro, M.; Queiroz, V.; Arizza, V.; Campobello, D.; Custódio, M.R.; Chiaramonte, M.; Vazzana, M. Humoral Responses during Wound Healing in Holothuria Tubulosa (Gmelin, 1788). Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2021, 253, 110550. [Google Scholar] [CrossRef]
- Luparello, C.; Ragona, D.; Asaro, D.M.L.; Lazzara, V.; Affranchi, F.; Celi, M.; Arizza, V.; Vazzana, M. Cytotoxic Potential of the Coelomic Fluid Extracted from the Sea Cucumber Holothuria Tubulosa against Triple-Negative MDA-MB231 Breast Cancer Cells. Biology 2019, 8, 76. [Google Scholar] [CrossRef] [Green Version]
- Luparello, C.; Ragona, D.; Asaro, D.M.L.; Lazzara, V.; Affranchi, F.; Arizza, V.; Vazzana, M. Cell-Free Coelomic Fluid Extracts of the Sea Urchin Arbacia Lixula Impair Mitochondrial Potential and Cell Cycle Distribution and Stimulate Reactive Oxygen Species Production and Autophagic Activity in Triple-Negative MDA-MB231 Breast Cancer Cells. JMSE 2020, 8, 261. [Google Scholar] [CrossRef] [Green Version]
- Luparello, C.; Mauro, M.; Lazzara, V.; Vazzana, M. Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates. Molecules 2020, 25, 2471. [Google Scholar] [CrossRef] [PubMed]
- Luparello, C.; Mauro, M.; Arizza, V.; Vazzana, M. Histone Deacetylase Inhibitors from Marine Invertebrates. Biology 2020, 9, 429. [Google Scholar] [CrossRef] [PubMed]
- Häder, D.-P.; Banaszak, A.T.; Villafañe, V.E.; Narvarte, M.A.; González, R.A.; Helbling, E.W. Anthropogenic Pollution of Aquatic Ecosystems: Emerging Problems with Global Implications. Sci. Total Environ. 2020, 713, 136586. [Google Scholar] [CrossRef] [PubMed]
- Lazorchak, J. What Are Contaminants of Emerging Concern (CECs)? Examples of Biological and Chemistry Approaches to Their Detection, Exposure and Effects? Available online: https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=335793&Lab=NERL (accessed on 30 November 2016).
- Santos, L.H.M.L.M.; Araújo, A.N.; Fachini, A.; Pena, A.; Delerue-Matos, C.; Montenegro, M.C.B.S.M. Ecotoxicological Aspects Related to the Presence of Pharmaceuticals in the Aquatic Environment. J. Hazard. Mater. 2010, 175, 45–95. [Google Scholar] [CrossRef] [Green Version]
- Montagner, C.C.; Vidal, C.; Acayaba, R.D. Contaminantes Emergentes Em Matrizes Aquáticas Do Brasil: Cenário Atual e Aspectos Analíticos, Ecotoxicológicos e Regulatórios. Química Nova 2017, 40, 1094–1110. [Google Scholar] [CrossRef]
- Sapkota, A.; Sapkota, A.R.; Kucharski, M.; Burke, J.; McKenzie, S.; Walker, P.; Lawrence, R. Aquaculture Practices and Potential Human Health Risks: Current Knowledge and Future Priorities. Environ. Int. 2008, 34, 1215–1226. [Google Scholar] [CrossRef] [PubMed]
- Rodgers, C.J.; Furones, M.D. Antimicrobial agents in aquaculture: Practice, needs and issues. In The Use of Veterinary Drugs and Vaccines in Mediterranean Aquaculture; Basurco, B., Rogers, C., Eds.; Options Méditerranéennes: Série, A. Séminaires Méditerranéens; CIHEAM: Zaragoza, Spain, 2009; Volume 86, pp. 41–59. [Google Scholar]
- Christen, V.; Hickmann, S.; Rechenberg, B.; Fent, K. Highly Active Human Pharmaceuticals in Aquatic Systems: A Concept for Their Identification Based on Their Mode of Action. Aquat. Toxicol. 2010, 96, 167–181. [Google Scholar] [CrossRef]
- Hummel, D.; Löffler, D.; Fink, G.; Ternes, T.A. Simultaneous Determination of Psychoactive Drugs and Their Metabolites in Aqueous Matrices by Liquid Chromatography Mass Spectrometry. Environ. Sci. Technol. 2006, 40, 7321–7328. [Google Scholar] [CrossRef] [PubMed]
- Wu, M.; Xiang, J.; Que, C.; Chen, F.; Xu, G. Occurrence and Fate of Psychiatric Pharmaceuticals in the Urban Water System of Shanghai, China. Chemosphere 2015, 138, 486–493. [Google Scholar] [CrossRef]
- McCall, A.-K.; Bade, R.; Kinyua, J.; Lai, F.Y.; Thai, P.K.; Covaci, A.; Bijlsma, L.; van Nuijs, A.L.N.; Ort, C. Critical Review on the Stability of Illicit Drugs in Sewers and Wastewater Samples. Water Res. 2016, 88, 933–947. [Google Scholar] [CrossRef] [Green Version]
- Daughton, C.G.; Ternes, T.A. Pharmaceuticals and Personal Care Products in the Environment: Agents of Subtle Change? Environ. Health Perspect. 1999, 107 (Suppl. 6), 907–938. [Google Scholar] [CrossRef]
- Heberer, T. Occurrence, Fate, and Removal of Pharmaceutical Residues in the Aquatic Environment: A Review of Recent Research Data. Toxicol. Lett. 2002, 131, 5–17. [Google Scholar] [CrossRef]
- Kolpin, D.W.; Furlong, E.T.; Meyer, M.T.; Thurman, E.M.; Zaugg, S.D.; Barber, L.B.; Buxton, H.T. Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in US Streams, 1999−2000: A National Reconnaissance. Environ. Sci. Technol. 2002, 36, 1202–1211. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kostich, M.S.; Batt, A.L.; Lazorchak, J.M. Concentrations of Prioritized Pharmaceuticals in Effluents from 50 Large Wastewater Treatment Plants in the US and Implications for Risk Estimation. Environ. Pollut. 2014, 184, 354–359. [Google Scholar] [CrossRef] [PubMed]
- Petrie, B.; Barden, R.; Kasprzyk-Hordern, B. A Review on Emerging Contaminants in Wastewaters and the Environment: Current Knowledge, Understudied Areas and Recommendations for Future Monitoring. Water Res. 2015, 72, 3–27. [Google Scholar] [CrossRef] [PubMed]
- Cunha, D.L.; de Araujo, F.G.; Marques, M. Psychoactive Drugs: Occurrence in Aquatic Environment, Analytical Methods, and Ecotoxicity—A Review. Environ. Sci. Pollut. Res. Int. 2017, 24, 24076–24091. [Google Scholar] [CrossRef]
- Ekpeghere, K.I.; Sim, W.-J.; Lee, H.-J.; Oh, J.-E. Occurrence and Distribution of Carbamazepine, Nicotine, Estrogenic Compounds, and Their Transformation Products in Wastewater from Various Treatment Plants and the Aquatic Environment. Sci. Total Environ. 2018, 640–641, 1015–1023. [Google Scholar] [CrossRef]
- Calamari, D.; Zuccato, E.; Castiglioni, S.; Bagnati, R.; Fanelli, R. Strategic Survey of Therapeutic Drugs in the Rivers Po and Lambro in Northern Italy. Environ. Sci. Technol. 2003, 37, 1241–1248. [Google Scholar] [CrossRef]
- Calisto, V.; Esteves, V.I. Psychiatric Pharmaceuticals in the Environment. Chemosphere 2009, 77, 1257–1274. [Google Scholar] [CrossRef]
- Boxall, A.B.A.; Rudd, M.A.; Brooks, B.W.; Caldwell, D.J.; Choi, K.; Hickmann, S.; Innes, E.; Ostapyk, K.; Staveley, J.P.; Verslycke, T.; et al. Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions? Environ. Health Perspect. 2012, 120, 1221–1229. [Google Scholar] [CrossRef]
- Meierjohann, A.; Brozinski, J.-M.; Kronberg, L. Seasonal Variation of Pharmaceutical Concentrations in a River/Lake System in Eastern Finland. Environ. Sci. Process Impacts 2016, 18, 342–349. [Google Scholar] [CrossRef] [PubMed]
- Calcagno, E.; Durando, P.; Valdés, M.E.; Franchioni, L.; de los Ángeles Bistoni, M. Effects of Carbamazepine on Cortisol Levels and Behavioral Responses to Stress in the Fish Jenynsia Multidentata. Physiol. Behav. 2016, 158, 68–75. [Google Scholar] [CrossRef] [PubMed]
- Valdés, M.E.; Huerta, B.; Wunderlin, D.A.; Bistoni, M.A.; Barceló, D.; Rodriguez-Mozaz, S. Bioaccumulation and Bioconcentration of Carbamazepine and Other Pharmaceuticals in Fish under Field and Controlled Laboratory Experiments. Evidences of Carbamazepine Metabolization by Fish. Sci. Total Environ. 2016, 557–558, 58–67. [Google Scholar] [CrossRef]
- Vera-Chang, M.N.; Moon, T.W.; Trudeau, V.L. Ancestral Fluoxetine Exposure Sensitizes Zebrafish to Venlafaxine-Induced Reductions in Cortisol and Spawning. Endocrinology 2019, 160, 2137–2142. [Google Scholar] [CrossRef] [PubMed]
- Gavrilescu, M.; Demnerová, K.; Aamand, J.; Agathos, S.; Fava, F. Emerging Pollutants in the Environment: Present and Future Challenges in Biomonitoring, Ecological Risks and Bioremediation. New Biotechnol. 2015, 32, 147–156. [Google Scholar] [CrossRef]
- Buser, H.-R.; Poiger, T.; Müller, M.D. Occurrence and Fate of the Pharmaceutical Drug Diclofenac in Surface Waters: Rapid Photodegradation in a Lake. Environ. Sci. Technol. 1998, 32, 3449–3456. [Google Scholar] [CrossRef]
- Rainsford, K.D. Ibuprofen: Pharmacology, Efficacy and Safety. Inflammopharmacology 2009, 17, 275–342. [Google Scholar] [CrossRef]
- Salgado, R.; Pereira, V.J.; Carvalho, G.; Soeiro, R.; Gaffney, V.; Almeida, C.; Vale Cardoso, V.; Ferreira, E.; Benoliel, M.J.; Ternes, T.A.; et al. Photodegradation Kinetics and Transformation Products of Ketoprofen, Diclofenac and Atenolol in Pure Water and Treated Wastewater. J. Hazard. Mater. 2013, 244–245, 516–527. [Google Scholar] [CrossRef]
- Kümmerer, K. Significance of Antibiotics in the Environment. J. Antimicrob. Chemother. 2003, 52, 5–7. [Google Scholar] [CrossRef] [Green Version]
- Rigos, G.; Troisi, G.M. Antibacterial Agents in Mediterranean Finfish Farming: A Synopsis of Drug Pharmacokinetics in Important Euryhaline Fish Species and Possible Environmental Implications. Rev. Fish Biol. Fish. 2005, 15, 53–73. [Google Scholar] [CrossRef]
- Sarmah, A.K.; Meyer, M.T.; Boxall, A.B.A. A Global Perspective on the Use, Sales, Exposure Pathways, Occurrence, Fate and Effects of Veterinary Antibiotics (VAs) in the Environment. Chemosphere 2006, 65, 725–759. [Google Scholar] [CrossRef] [PubMed]
- Pioletti, M.; Schlünzen, F.; Harms, J.; Zarivach, R.; Glühmann, M.; Avila, H.; Bashan, A.; Bartels, H.; Auerbach, T.; Jacobi, C.; et al. Crystal Structures of Complexes of the Small Ribosomal Subunit with Tetracycline, Edeine and IF3. EMBO J. 2001, 20, 1829–1839. [Google Scholar] [CrossRef] [Green Version]
- European Medicines Agency. Sales of Veterinary Antimicrobial Agents in 30 European Countries in 2015: Trends from 2010 to 2015: Seventh ESVAC Report; Publications Office: Luxembourg, 2017. [Google Scholar]
- Ferrari, B.; Paxéus, N.; Lo Giudice, R.; Pollio, A.; Garric, J. Ecotoxicological Impact of Pharmaceuticals Found in Treated Wastewaters: Study of Carbamazepine, Clofibric Acid, and Diclofenac. Ecotoxicol. Environ. Saf. 2003, 55, 359–370. [Google Scholar] [CrossRef]
- Cuklev, F.; Fick, J.; Cvijovic, M.; Kristiansson, E.; Förlin, L.; Larsson, D.G.J. Does Ketoprofen or Diclofenac Pose the Lowest Risk to Fish? J. Hazard. Mater. 2012, 229–230, 100–106. [Google Scholar] [CrossRef]
- Zhang, Q.; Cheng, J.; Xin, Q. Effects of Tetracycline on Developmental Toxicity and Molecular Responses in Zebrafish (Danio Rerio) Embryos. Ecotoxicology 2015, 24, 707–719. [Google Scholar] [CrossRef]
- Palacios-Rosas, E.; Castro-Pastrana, L.I. Pharmaceuticals Reaching the Environment: Concepts, Evidence, and Concerns. In Ecopharmacovigilance; Gómez-Oliván, L.M., Ed.; The Handbook of Environmental Chemistry; Springer International Publishing: Cham, Switzerland, 2017; Volume 66, pp. 21–41. ISBN 978-3-319-73475-0. [Google Scholar]
- Grill, G.; Li, J.; Khan, U.; Zhong, Y.; Lehner, B.; Nicell, J.; Ariwi, J. Estimating the Eco-Toxicological Risk of Estrogens in China’s Rivers Using a High-Resolution Contaminant Fate Model. Water Res. 2018, 145, 707–720. [Google Scholar] [CrossRef] [PubMed]
- McRae, N.K.; Glover, C.N.; Burket, S.R.; Brooks, B.W.; Gaw, S. Acute Exposure to an Environmentally Relevant Concentration of Diclofenac Elicits Oxidative Stress in the Culturally Important Galaxiid Fish Galaxias Maculatus. Environ. Toxicol. Chem. 2018, 37, 224–235. [Google Scholar] [CrossRef]
- Rodrigues, S.; Antunes, S.C.; Correia, A.T.; Nunes, B. Rainbow Trout (Oncorhynchus Mykiss) pro-Oxidant and Genotoxic Responses Following Acute and Chronic Exposure to the Antibiotic Oxytetracycline. Ecotoxicology 2017, 26, 104–117. [Google Scholar] [CrossRef]
- Pês, T.S.; Saccol, E.M.H.; Londero, É.P.; Bressan, C.A.; Ourique, G.M.; Rizzetti, T.M.; Prestes, O.D.; Zanella, R.; Baldisserotto, B.; Pavanato, M.A. Protective Effect of Quercetin against Oxidative Stress Induced by Oxytetracycline in Muscle of Silver Catfish. Aquaculture 2018, 484, 120–125. [Google Scholar] [CrossRef]
- Nakano, T.; Hayashi, S.; Nagamine, N. Effect of Excessive Doses of Oxytetracycline on Stress-Related Biomarker Expression in Coho Salmon. Environ. Sci. Pollut. Res. 2018, 25, 7121–7128. [Google Scholar] [CrossRef] [PubMed]
- Oliveira, R.; McDonough, S.; Ladewig, J.C.L.; Soares, A.M.V.M.; Nogueira, A.J.A.; Domingues, I. Effects of Oxytetracycline and Amoxicillin on Development and Biomarkers Activities of Zebrafish (Danio Rerio). Environ. Toxicol. Pharmacol. 2013, 36, 903–912. [Google Scholar] [CrossRef]
- Nicosia, A.; Celi, M.; Vazzana, M.; Damiano, M.A.; Parrinello, N.; D’Agostino, F.; Avellone, G.; Indelicato, S.; Mazzola, S.; Cuttitta, A. Profiling the Physiological and Molecular Response to Sulfonamidic Drug in Procambarus Clarkii. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol. 2014, 166, 14–23. [Google Scholar] [CrossRef]
- Almeida, A.R.; Tacão, M.; Machado, A.L.; Golovko, O.; Zlabek, V.; Domingues, I.; Henriques, I. Long-Term Effects of Oxytetracycline Exposure in Zebrafish: A Multi-Level Perspective. Chemosphere 2019, 222, 333–344. [Google Scholar] [CrossRef]
- Zhou, L.; Limbu, S.M.; Shen, M.; Zhai, W.; Qiao, F.; He, A.; Du, Z.-Y.; Zhang, M. Environmental Concentrations of Antibiotics Impair Zebrafish Gut Health. Environ. Pollut. 2018, 235, 245–254. [Google Scholar] [CrossRef] [PubMed]
- Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions. Available online: https://ec.europa.eu/info/publications/communication-commission-european-parliament-council-european-economic-and-social-committee-and-committee-regions_it (accessed on 15 October 2021).
- Juncker Commission Presents Third Annual Work Programme: Delivering a Europe that Protects, Empowers and Defends. Available online: http://europa.eu/rapid/press-release_IP-16-3500_en.htm (accessed on 15 October 2021).
- A Sustainable Europe by 2030. Available online: https://ec.europa.eu/commission/publications/reflection-paper-towards-sustainable-europe-2030_en (accessed on 15 October 2021).
- Water Reuse Milestone in Europe: Regulation (EU) 2020/741 on Minimum Requirements for Water Reuse. 2021. Available online: https://www.water-reuse-europe.org/water-reuse-milestone-in-europe-regulation-eu-2020-741-on-minimum-requirements-for-water-reuse/#page-content (accessed on 15 October 2021).
- De Oliveira Souza, H.; dos Santos Costa, R.; Quadra, G.R.; dos Santos Fernandez, M.A. Pharmaceutical Pollution and Sustainable Development Goals: Going the Right Way? Sustain. Chem. Pharm. 2021, 21, 100428. [Google Scholar] [CrossRef]
- Barbazuk, W.B.; Korf, I.; Kadavi, C.; Heyen, J.; Tate, S.; Wun, E.; Bedell, J.A.; McPherson, J.D.; Johnson, S.L. The Syntenic Relationship of the Zebrafish and Human Genomes. Genome Res. 2000, 10, 1351–1358. [Google Scholar] [CrossRef] [Green Version]
- Zon, L.I.; Peterson, R.T. In Vivo Drug Discovery in the Zebrafish. Nat. Rev. Drug Discov. 2005, 4, 35–44. [Google Scholar] [CrossRef] [PubMed]
- Howe, K.; Clark, M.D.; Torroja, C.F.; Torrance, J.; Berthelot, C.; Muffato, M.; Collins, J.E.; Humphray, S.; McLaren, K.; Matthews, L.; et al. The Zebrafish Reference Genome Sequence and Its Relationship to the Human Genome. Nature 2013, 496, 498–503. [Google Scholar] [CrossRef] [Green Version]
- Bailone, R.L.; Fukushima, H.C.S.; Ventura Fernandes, B.H.; De Aguiar, L.K.; Corrêa, T.; Janke, H.; Grejo Setti, P.; Roça, R.D.O.; Borra, R.C. Zebrafish as an Alternative Animal Model in Human and Animal Vaccination Research. Lab. Anim. Res. 2020, 36, 13. [Google Scholar] [CrossRef]
- Choi, T.-Y.; Choi, T.-I.; Lee, Y.-R.; Choe, S.-K.; Kim, C.-H. Zebrafish as an Animal Model for Biomedical Research. Exp. Mol. Med. 2021, 53, 310–317. [Google Scholar] [CrossRef]
- Postlethwait, J.H.; Yan, Y.L.; Gates, M.A.; Horne, S.; Amores, A.; Brownlie, A.; Donovan, A.; Egan, E.S.; Force, A.; Gong, Z.; et al. Vertebrate Genome Evolution and the Zebrafish Gene Map. Nat. Genet. 1998, 18, 345–349. [Google Scholar] [CrossRef] [PubMed]
- Goldsmith, P. Zebrafish as a pharmacological tool: The how, why and when. Curr. Opin. Pharmacol. 2004, 4, 504–512. [Google Scholar] [CrossRef] [PubMed]
- Siebel, A.M.; Rico, E.O.; Capiotti, K.N.; Piato, A.L.; Cusinato, C.T.; Franco, T.M.A.; Bogo, M.R.; Bonan, C.D. In vitro effects of antiepileptic drugs on acetylcholinesterase and ectonucleotidase activities in zebrafish (Danio rerio) brain. Toxicol. Vitro. 2010, 24, 1279–1284. [Google Scholar] [CrossRef]
- Volgin, A.D.; Yakovlev, O.A.; Demin, K.A.; Alekseeva, P.A.; Kalueff, A.V. Acute behavioral effects of deliriant hallucinogens atropine and scopolamine in adult zebrafish. Behav. Brain Res. 2019, 359, 274–280. [Google Scholar] [CrossRef] [PubMed]
- Reis, C.G.; Mocelin, R.; Benvenutti, R.; Marcon, M.; Sachett, A.; Herrmann, A.P.; Elisabetsky, E.; Piato, A. Effects of N-acetylcysteine amide on anxiety and stress behavior in zebrafish. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2020, 393, 591–601. [Google Scholar] [CrossRef]
- Mayden, R.L.; Tang, K.L.; Conway, K.W.; Freyhof, J.; Chamberlain, S.; Haskins, M.; Schneider, L.; Sudkamp, M.; Wood, R.M.; Agnew, M.; et al. Phylogenetic Relationships of Danio within the Order Cypriniformes: A Framework for Comparative and Evolutionary Studies of a Model Species. J. Exp. Zool. B Mol. Dev. Evol. 2007, 308, 642–654. [Google Scholar] [CrossRef]
- Oliveira, R.; Domingues, I.; Koppe Grisolia, C.; Soares, A.M.V.M. Effects of Triclosan on Zebrafish Early-Life Stages and Adults. Environ. Sci. Pollut. Res. Int. 2009, 16, 679–688. [Google Scholar] [CrossRef]
- Blahová, J.; Plhalová, L.; Hostovský, M.; Divišová, L.; Dobšíková, R.; Mikulíková, I.; Stěpánová, S.; Svobodová, Z. Oxidative Stress Responses in Zebrafish Danio Rerio after Subchronic Exposure to Atrazine. Food Chem. Toxicol. 2013, 61, 82–85. [Google Scholar] [CrossRef]
- Bambino, K.; Chu, J. Zebrafish in Toxicology and Environmental Health. Curr. Top. Dev. Biol. 2017, 124, 331–367. [Google Scholar] [CrossRef] [Green Version]
- Alzualde, A.; Behl, M.; Sipes, N.S.; Hsieh, J.-H.; Alday, A.; Tice, R.R.; Paules, R.S.; Muriana, A.; Quevedo, C. Toxicity Profiling of Flame Retardants in Zebrafish Embryos Using a Battery of Assays for Developmental Toxicity, Neurotoxicity, Cardiotoxicity and Hepatotoxicity toward Human Relevance. Neurotoxicol. Teratol. 2018, 70, 40–50. [Google Scholar] [CrossRef] [PubMed]
- Zhou, R.; Lu, G.; Yan, Z.; Bao, X.; Zhang, P.; Jiang, R. Bioaccumulation and Biochemical Effects of Ethylhexyl Methoxy Cinnamate and Its Main Transformation Products in Zebrafish. Aquat. Toxicol. 2019, 214, 105241. [Google Scholar] [CrossRef]
- Zhou, R.; Lu, G.; Yan, Z.; Jiang, R.; Shen, J.; Bao, X. Parental Transfer of Ethylhexyl Methoxy Cinnamate and Induced Biochemical Responses in Zebrafish. Aquat. Toxicol. 2019, 206, 24–32. [Google Scholar] [CrossRef]
- Wang, G.; Xiong, D.; Wu, M.; Wang, L.; Yang, J. Induction of Time- and Dose-Dependent Oxidative Stress of Triazophos to Brain and Liver in Zebrafish (Danio Rerio). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2020, 228, 108640. [Google Scholar] [CrossRef] [PubMed]
- Huang, X.; Li, Y.; Wang, T.; Liu, H.; Shi, J.; Zhang, X. Evaluation of the Oxidative Stress Status in Zebrafish (Danio Rerio) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA). Int. J. Environ. Res. Public Health 2020, 17, 651. [Google Scholar] [CrossRef] [Green Version]
- Gerlai, R.; Lee, V.; Blaser, R. Effects of Acute and Chronic Ethanol Exposure on the Behavior of Adult Zebrafish (Danio Rerio). Pharmacol. Biochem. Behav. 2006, 85, 752–761. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hill, A.J.; Teraoka, H.; Heideman, W.; Peterson, R.E. Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity. Toxicol. Sci. 2005, 86, 6–19. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Selderslaghs, I.W.T.; Van Rompay, A.R.; De Coen, W.; Witters, H.E. Development of a Screening Assay to Identify Teratogenic and Embryotoxic Chemicals Using the Zebrafish Embryo. Reprod. Toxicol. 2009, 28, 308–320. [Google Scholar] [CrossRef]
- Cassar, S.; Adatto, I.; Freeman, J.L.; Gamse, J.T.; Iturria, I.; Lawrence, C.; Muriana, A.; Peterson, R.T.; Van Cruchten, S.; Zon, L.I. Use of Zebrafish in Drug Discovery Toxicology. Chem. Res. Toxicol. 2020, 33, 95–118. [Google Scholar] [CrossRef] [Green Version]
- Hallare, A.V.; Köhler, H.-R.; Triebskorn, R. Developmental Toxicity and Stress Protein Responses in Zebrafish Embryos after Exposure to Diclofenac and Its Solvent, DMSO. Chemosphere 2004, 56, 659–666. [Google Scholar] [CrossRef]
- Van den Brandhof, E.-J.; Montforts, M. Fish Embryo Toxicity of Carbamazepine, Diclofenac and Metoprolol. Ecotoxicol. Environ. Saf. 2010, 73, 1862–1866. [Google Scholar] [CrossRef] [PubMed]
- Mitchell, K.M.; Moon, T.W. Behavioral and Biochemical Adjustments of the Zebrafish Danio Rerio Exposed to the β-Blocker Propranolol. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2016, 199, 105–114. [Google Scholar] [CrossRef] [PubMed]
- Wang, H.; Che, B.; Duan, A.; Mao, J.; Dahlgren, R.A.; Zhang, M.; Zhang, H.; Zeng, A.; Wang, X. Toxicity Evaluation of β-Diketone Antibiotics on the Development of Embryo-Larval Zebrafish (Danio Rerio). Environ. Toxicol. 2014, 29, 1134–1146. [Google Scholar] [CrossRef] [PubMed]
- Praskova, E.; Voslarova, E.; Siroka, Z.; Macova, S.; Plhalova, L.; Bedanova, I.; Marsalek, P.; Pistekova, V.; Svobodova, Z. Comparison of Acute Toxicity of Ketoprofen to Juvenile and Embryonic Stages of Danio Rerio. Neuro Endocrinol. Lett. 2011, 32 (Suppl. 1), 117–120. [Google Scholar] [PubMed]
- Bachour, R.-L.; Golovko, O.; Kellner, M.; Pohl, J. Behavioral Effects of Citalopram, Tramadol, and Binary Mixture in Zebrafish (Danio Rerio) Larvae. Chemosphere 2020, 238, 124587. [Google Scholar] [CrossRef]
- Giari, L.; Dezfuli, B.S.; Astolfi, L.; Martini, A. Ultrastructural Effects of Cisplatin on the Inner Ear and Lateral Line System of Zebrafish (Danio Rerio) Larvae. J. Appl. Toxicol. 2012, 32, 293–299. [Google Scholar] [CrossRef]
- Oliveira, R.; Grisolia, C.K.; Monteiro, M.S.; Soares, A.M.V.M.; Domingues, I. Multilevel Assessment of Ivermectin Effects Using Different Zebrafish Life Stages. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016, 187, 50–61. [Google Scholar] [CrossRef]
- Domingues, I.; Oliveira, R.; Soares, A.M.V.M.; Amorim, M.J.B. Effects of Ivermectin on Danio Rerio: A Multiple Endpoint Approach: Behaviour, Weight and Subcellular Markers. Ecotoxicology 2016, 25, 491–499. [Google Scholar] [CrossRef]
- Dai, Y.-J.; Jia, Y.-F.; Chen, N.; Bian, W.-P.; Li, Q.-K.; Ma, Y.-B.; Chen, Y.-L.; Pei, D.-S. Zebrafish as a Model System to Study Toxicology. Environ. Toxicol. Chem. 2014, 33, 11–17. [Google Scholar] [CrossRef] [PubMed]
- Saravanan, M.; Ramesh, M.; Petkam, R. Alteration in Certain Enzymological Parameters of an Indian Major Carp, Cirrhinus Mrigala Exposed to Short- and Long-Term Exposure of Clofibric Acid and Diclofenac. Fish Physiol. Biochem. 2013, 39, 1431–1440. [Google Scholar] [CrossRef]
- Ramesh, M.; Anitha, S.; Poopal, R.K.; Shobana, C. Evaluation of Acute and Sublethal Effects of Chloroquine (C18H26CIN3) on Certain Enzymological and Histopathological Biomarker Responses of a Freshwater Fish Cyprinus Carpio. Toxicol. Rep. 2018, 5, 18–27. [Google Scholar] [CrossRef] [PubMed]
- Goossens, H.; Ferech, M.; Vander Stichele, R.; Elseviers, M.; ESAC Project Group. Outpatient Antibiotic Use in Europe and Association with Resistance: A Cross-National Database Study. Lancet 2005, 365, 579–587. [Google Scholar] [CrossRef]
- Aarestrup, F. Sustainable Farming: Get Pigs off Antibiotics. Nature 2012, 486, 465–466. [Google Scholar] [CrossRef]
- Andreozzi, R.; Caprio, V.; Ciniglia, C.; de Champdoré, M.; Lo Giudice, R.; Marotta, R.; Zuccato, E. Antibiotics in the Environment: Occurrence in Italian STPs, Fate, and Preliminary Assessment on Algal Toxicity of Amoxicillin. Environ. Sci. Technol. 2004, 38, 6832–6838. [Google Scholar] [CrossRef] [PubMed]
- Carvalho, I.T.; Santos, L. Antibiotics in the Aquatic Environments: A Review of the European Scenario. Environ. Int. 2016, 94, 736–757. [Google Scholar] [CrossRef]
- Magdeldin, S.; Blaser, R.E.; Yamamoto, T.; Yates, J.R. Behavioral and Proteomic Analysis of Stress Response in Zebrafish (Danio Rerio). J. Proteome Res. 2015, 14, 943–952. [Google Scholar] [CrossRef] [Green Version]
- Smolders, R.; De Boeck, G.; Blust, R. Changes in Cellular Energy Budget as a Measure of Whole Effluent Toxicity in Zebrafish (Danio Rerio). Environ. Toxicol. Chem. 2003, 22, 890–899. [Google Scholar] [CrossRef]
- Lemaire, P.; Matthews, A.; Förlin, L.; Livingstone, D.R. Stimulation of Oxyradical Production of Hepatic Microsomes of Flounder (Platichthys Flesus) and Perch (Perca Fluviatilis) by Model and Pollutant Xenobiotics. Arch. Environ. Contam. Toxicol. 1994, 26, 191–200. [Google Scholar] [CrossRef]
- Van der Oost, R.; Beyer, J.; Vermeulen, N.P.E. Fish Bioaccumulation and Biomarkers in Environmental Risk Assessment: A Review. Environ. Toxicol. Pharmacol. 2003, 13, 57–149. [Google Scholar] [CrossRef]
- Canales-Aguirre, A.; Padilla-Camberos, E.; Gómez-Pinedo, U.; Salado-Ponce, H.; Feria-Velasco, A.; De Celis, R. Genotoxic Effect of Chronic Exposure to DDT on Lymphocytes, Oral Mucosa and Breast Cells of Female Rats. Int. J. Environ. Res. Public Health 2011, 8, 540–553. [Google Scholar] [CrossRef] [Green Version]
- Massarsky, A.; Kozal, J.S.; Di Giulio, R.T. Glutathione and Zebrafish: Old Assays to Address a Current Issue. Chemosphere 2017, 168, 707–715. [Google Scholar] [CrossRef] [Green Version]
- Chen, K.; Zhou, J. Occurrence and Behavior of Antibiotics in Water and Sediments from the Huangpu River, Shanghai, China. Chemosphere 2014, 95, 604–612. [Google Scholar] [CrossRef] [PubMed]
- Zhou, L.; Limbu, S.M.; Qiao, F.; Du, Z.-Y.; Zhang, M. Influence of Long-Term Feeding Antibiotics on the Gut Health of Zebrafish. Zebrafish 2018, 15, 340–348. [Google Scholar] [CrossRef]
- Celi, M.; Filiciotto, F.; Maricchiolo, G.; Genovese, L.; Quinci, E.M.; Maccarrone, V.; Mazzola, S.; Vazzana, M.; Buscaino, G. Vessel Noise Pollution as a Human Threat to Fish: Assessment of the Stress Response in Gilthead Sea Bream (Sparus Aurata, Linnaeus 1758). Fish Physiol. Biochem. 2016, 42, 631–641. [Google Scholar] [CrossRef]
- Parisi, M.G.; Mauro, M.; Sarà, G.; Cammarata, M. Temperature Increases, Hypoxia, and Changes in Food Availability Affect Immunological Biomarkers in the Marine Mussel Mytilus Galloprovincialis. J. Comp. Physiol. B 2017, 187, 1117–1126. [Google Scholar] [CrossRef] [PubMed]
- Tokanová, N.; Dobšíková, R.; Doubková, V.; Blahová, J.; Svobodová, Z.; Maršálek, P. The Effect of Sulfamethoxazole on Oxidative Stress Indices in Zebrafish (Danio Rerio). Drug Chem. Toxicol. 2021, 44, 58–63. [Google Scholar] [CrossRef]
- Park, S.; Choi, K. Hazard Assessment of Commonly Used Agricultural Antibiotics on Aquatic Ecosystems. Ecotoxicology 2008, 17, 526–538. [Google Scholar] [CrossRef]
- Längin, A.; Alexy, R.; König, A.; Kümmerer, K. Deactivation and Transformation Products in Biodegradability Testing of Beta-Lactams Amoxicillin and Piperacillin. Chemosphere 2009, 75, 347–354. [Google Scholar] [CrossRef]
- Rajter, J.C.; Sherman, M.S.; Fatteh, N.; Vogel, F.; Sacks, J.; Rajter, J.-J. Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019. Chest 2021, 159, 85–92. [Google Scholar] [CrossRef] [PubMed]
- Chaccour, C.; Hammann, F.; Ramón-García, S.; Rabinovich, N.R. Ivermectin and COVID-19: Keeping Rigor in Times of Urgency. Am. J. Trop. Med. Hyg. 2020, 102, 1156–1157. [Google Scholar] [CrossRef]
- Montforts, M.H.M.M.; van Rijswick, H.F.M.W.; de Haes, H.A.U. Legal Constraints in EU Product Labelling to Mitigate the Environmental Risk of Veterinary Medicines at Use. Regul. Toxicol. Pharmacol. 2004, 40, 327–335. [Google Scholar] [CrossRef] [PubMed]
- Sanderson, H.; Laird, B.; Pope, L.; Brain, R.; Wilson, C.; Johnson, D.; Bryning, G.; Peregrine, A.S.; Boxall, A.; Solomon, K. Assessment of the Environmental Fate and Effects of Ivermectin in Aquatic Mesocosms. Aquat. Toxicol. 2007, 85, 229–240. [Google Scholar] [CrossRef] [PubMed]
- Jentoft, S.; Aastveit, A.H.; Torjesen, P.A.; Andersen, O. Effects of Stress on Growth, Cortisol and Glucose Levels in Non-Domesticated Eurasian Perch (Perca Fluviatilis) and Domesticated Rainbow Trout (Oncorhynchus Mykiss). Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2005, 141, 353–358. [Google Scholar] [CrossRef] [PubMed]
- Vazzana, M.; Vizzini, A.; Sanfratello, M.A.; Celi, M.; Salerno, G.; Parrinello, N. Differential Expression of Two Glucocorticoid Receptors in Seabass (Teleost Fish) Head Kidney after Exogeneous Cortisol Inoculation. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2010, 157, 49–54. [Google Scholar] [CrossRef] [Green Version]
- Barcellos, L.J.G.; Ritter, F.; Kreutz, L.C.; Quevedo, R.M.; da Silva, L.B.; Bedin, A.C.; Finco, J.; Cericato, L. Whole-Body Cortisol Increases after Direct and Visual Contact with a Predator in Zebrafish, Danio Rerio. Aquaculture 2007, 272, 774–778. [Google Scholar] [CrossRef]
- De Abreu, M.S.; Koakoski, G.; Ferreira, D.; Oliveira, T.A.; da Rosa, J.G.S.; Gusso, D.; Giacomini, A.C.V.; Piato, A.L.; Barcellos, L.J.G. Diazepam and Fluoxetine Decrease the Stress Response in Zebrafish. PLoS ONE 2014, 9, e103232. [Google Scholar] [CrossRef] [PubMed]
- Togunde, O.P.; Oakes, K.D.; Servos, M.R.; Pawliszyn, J. Determination of Pharmaceutical Residues in Fish Bile by Solid-Phase Microextraction Couple with Liquid Chromatography-Tandem Mass Spectrometry (LC/MS/MS). Environ. Sci. Technol. 2012, 46, 5302–5309. [Google Scholar] [CrossRef]
- Abreu, M.S.; Giacomini, A.C.V.; Koakoski, G.; Oliveira, T.A.; Gusso, D.; Baldisserotto, B.; Barcellos, L.J.G. Effects of Waterborne Fluoxetine on Stress Response and Osmoregulation in Zebrafish. Environ. Toxicol. Pharmacol. 2015, 40, 704–707. [Google Scholar] [CrossRef]
- Dang, Z.; Balm, P.H.; Flik, G.; Wendelaar Bonga, S.E.; Lock, R.A. Cortisol Increases Na(+)/K(+)-ATPase Density in Plasma Membranes of Gill Chloride Cells in the Freshwater Tilapia Oreochromis Mossambicus. J. Exp. Biol. 2000, 203, 2349–2355. [Google Scholar] [CrossRef]
- Giacomini, A.C.V.V.; Abreu, M.S.; Zanandrea, R.; Saibt, N.; Friedrich, M.T.; Koakoski, G.; Gusso, D.; Piato, A.L.; Barcellos, L.J.G. Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner. Sci. Rep. 2016, 6, 28986. [Google Scholar] [CrossRef] [Green Version]
- Egan, R.J.; Bergner, C.L.; Hart, P.C.; Cachat, J.M.; Canavello, P.R.; Elegante, M.F.; Elkhayat, S.I.; Bartels, B.K.; Tien, A.K.; Tien, D.H.; et al. Understanding Behavioral and Physiological Phenotypes of Stress and Anxiety in Zebrafish. Behav. Brain Res. 2009, 205, 38–44. [Google Scholar] [CrossRef] [Green Version]
- Vossen, L.E.; Cerveny, D.; Österkrans, M.; Thörnqvist, P.-O.; Jutfelt, F.; Fick, J.; Brodin, T.; Winberg, S. Chronic Exposure to Oxazepam Pollution Produces Tolerance to Anxiolytic Effects in Zebrafish (Danio Rerio). Environ. Sci. Technol. 2020, 54, 1760–1769. [Google Scholar] [CrossRef]
- Vossen, L.E.; Červený, D.; Sen Sarma, O.; Thörnqvist, P.-O.; Jutfelt, F.; Fick, J.; Brodin, T.; Winberg, S. Low Concentrations of the Benzodiazepine Drug Oxazepam Induce Anxiolytic Effects in Wild-Caught but Not in Laboratory Zebrafish. Sci. Total Environ. 2020, 703, 134701. [Google Scholar] [CrossRef]
- Klaminder, J.; Brodin, T.; Sundelin, A.; Anderson, N.J.; Fahlman, J.; Jonsson, M.; Fick, J. Long-Term Persistence of an Anxiolytic Drug (Oxazepam) in a Large Freshwater Lake. Environ. Sci. Technol. 2015, 49, 10406–10412. [Google Scholar] [CrossRef] [PubMed]
- Brodin, T.; Fick, J.; Jonsson, M.; Klaminder, J. Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations. Science 2013, 339, 814–815. [Google Scholar] [CrossRef] [PubMed]
- Millan, M.J. The Neurobiology and Control of Anxious States. Prog. Neurobiol. 2003, 70, 83–244. [Google Scholar] [CrossRef]
- Soares, M.C.; Gerlai, R.; Maximino, C. The Integration of Sociality, Monoamines and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences. J. Fish Biol. 2018, 93, 170–191. [Google Scholar] [CrossRef]
- Backström, T.; Winberg, S. Serotonin Coordinates Responses to Social Stress-What We Can Learn from Fish. Front. Neurosci. 2017, 11, 595. [Google Scholar] [CrossRef] [PubMed]
- Graeff, F.G.; Guimarães, F.S.; De Andrade, T.G.; Deakin, J.F. Role of 5-HT in Stress, Anxiety, and Depression. Pharmacol. Biochem. Behav. 1996, 54, 129–141. [Google Scholar] [CrossRef]
- De Alcantara Barcellos, H.H.; Kalichak, F.; da Rosa, J.G.S.; Oliveira, T.A.; Koakoski, G.; Idalencio, R.; de Abreu, M.S.; Giacomini, A.C.V.; Fagundes, M.; Variani, C.; et al. Waterborne Aripiprazole Blunts the Stress Response in Zebrafish. Sci. Rep. 2016, 6, 37612. [Google Scholar] [CrossRef] [Green Version]
- Subedi, B.; Kannan, K. Occurrence and Fate of Select Psychoactive Pharmaceuticals and Antihypertensives in Two Wastewater Treatment Plants in New York State, USA. Sci. Total Environ. 2015, 514, 273–280. [Google Scholar] [CrossRef]
- Snyder, S.A. Occurrence, Treatment, and Toxicological Relevance of EDCs and Pharmaceuticals in Water. Ozone Sci. Eng. 2008, 30, 65–69. [Google Scholar] [CrossRef]
- Idalencio, R.; Kalichak, F.; Rosa, J.G.S.; de Oliveira, T.A.; Koakoski, G.; Gusso, D.; de Abreu, M.S.; Giacomini, A.C.V.; De Alcantara Barcellos, H.H.; Piato, A.L.; et al. Waterborne Risperidone Decreases Stress Response in Zebrafish. PLoS ONE 2015, 10, e0140800. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Griffin, C.E.; Kaye, A.M.; Bueno, F.R.; Kaye, A.D. Benzodiazepine Pharmacology and Central Nervous System-Mediated Effects. Ochsner J. 2013, 13, 214–223. [Google Scholar]
- Hoffmann-La Roche Limited Rivotril 2021. Available online: https://www.rochecanada.com/PMs/Rivotril/Rivotril_PM_CIE.pdf (accessed on 15 October 2021).
- Li, Z.-H.; Zlabek, V.; Velisek, J.; Grabic, R.; Machova, J.; Randak, T. Responses of Antioxidant Status and Na+-K+-ATPase Activity in Gill of Rainbow Trout, Oncorhynchus Mykiss, Chronically Treated with Carbamazepine. Chemosphere 2009, 77, 1476–1481. [Google Scholar] [CrossRef]
- Li, Z.-H.; Zlabek, V.; Velisek, J.; Grabic, R.; Machova, J.; Randak, T. Modulation of Antioxidant Defence System in Brain of Rainbow Trout (Oncorhynchus Mykiss) after Chronic Carbamazepine Treatment. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2010, 151, 137–141. [Google Scholar] [CrossRef] [PubMed]
- Gomes, T.B.; Fernandes Sales Junior, S.; Saint’Pierre, T.D.; Correia, F.V.; Hauser-Davis, R.A.; Saggioro, E.M. Sublethal Psychotropic Pharmaceutical Effects on the Model Organism Danio Rerio: Oxidative Stress and Metal Dishomeostasis. Ecotoxicol. Environ. Saf. 2019, 171, 781–789. [Google Scholar] [CrossRef]
- Hauser-Davis, R.A.; Silva, J.A.N.; Rocha, R.C.; Saint’Pierre, T.; Ziolli, R.L.; Arruda, M.A.Z. Acute Selenium Selenite Exposure Effects on Oxidative Stress Biomarkers and Essential Metals and Trace-Elements in the Model Organism Zebrafish (Danio Rerio). J. Trace Elem. Med. Biol. 2016, 33, 68–72. [Google Scholar] [CrossRef]
- Douglas, K.T. Mechanism of Action of Glutathione-Dependent Enzymes. Adv. Enzymol. Relat. Areas Mol. Biol. 1987, 59, 103–167. [Google Scholar] [CrossRef]
- Espinosa-Diez, C.; Miguel, V.; Mennerich, D.; Kietzmann, T.; Sánchez-Pérez, P.; Cadenas, S.; Lamas, S. Antioxidant Responses and Cellular Adjustments to Oxidative Stress. Redox Biol. 2015, 6, 183–197. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Mytilineou, C.; Kramer, B.C.; Yabut, J.A. Glutathione Depletion and Oxidative Stress. Parkinsonism Relat. Disord. 2002, 8, 385–387. [Google Scholar] [CrossRef]
- Lennicke, C.; Rahn, J.; Lichtenfels, R.; Wessjohann, L.A.; Seliger, B. Hydrogen Peroxide—Production, Fate and Role in Redox Signaling of Tumor Cells. Cell Commun. Signal. 2015, 13, 39. [Google Scholar] [CrossRef] [Green Version]
- Eftekhari, A.; Ahmadian, E.; Azarmi, Y.; Parvizpur, A.; Hamishehkar, H.; Eghbal, M.A. In Vitro/Vivo Studies towards Mechanisms of Risperidone-Induced Oxidative Stress and the Protective Role of Coenzyme Q10 and N-Acetylcysteine. Toxicol. Mech. Methods 2016, 26, 520–528. [Google Scholar] [CrossRef] [PubMed]
- Lepping, P.; Delieu, J.; Mellor, R.; Williams, J.H.H.; Hudson, P.R.; Hunter-Lavin, C. Antipsychotic Medication and Oxidative Cell Stress: A Systematic Review. J. Clin. Psychiatry 2011, 72, 273–285. [Google Scholar] [CrossRef]
- Da Silva Santos, N.; Oliveira, R.; Lisboa, C.A.; Mona E Pinto, J.; Sousa-Moura, D.; Camargo, N.S.; Perillo, V.; Oliveira, M.; Grisolia, C.K.; Domingues, I. Chronic Effects of Carbamazepine on Zebrafish: Behavioral, Reproductive and Biochemical Endpoints. Ecotoxicol. Environ. Saf. 2018, 164, 297–304. [Google Scholar] [CrossRef] [PubMed]
- Zhang, X.J.; Yang, L.; Zhao, Q.; Caen, J.P.; He, H.Y.; Jin, Q.H.; Guo, L.H.; Alemany, M.; Zhang, L.Y.; Shi, Y.F. Induction of Acetylcholinesterase Expression during Apoptosis in Various Cell Types. Cell Death Differ. 2002, 9, 790–800. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Zhang, B.; Yang, L.; Yu, L.; Lin, B.; Hou, Y.; Wu, J.; Huang, Q.; Han, Y.; Guo, L.; Ouyang, Q.; et al. Acetylcholinesterase Is Associated with Apoptosis in β Cells and Contributes to Insulin-Dependent Diabetes Mellitus Pathogenesis. Acta Biochim. Biophys. Sin. 2012, 44, 207–216. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ferreira, G.K.; Carvalho-Silva, M.; Gonçalves, C.L.; Vieira, J.S.; Scaini, G.; Ghedim, F.V.; Deroza, P.F.; Zugno, A.I.; Pereira, T.C.B.; Oliveira, G.M.T.; et al. L-Tyrosine Administration Increases Acetylcholinesterase Activity in Rats. Neurochem. Int. 2012, 61, 1370–1374. [Google Scholar] [CrossRef] [Green Version]
- Jia, D.; Li, X.; Du, S.; Xu, N.; Zhang, W.; Yang, R.; Zhang, Y.; He, Y.; Zhang, Y. Single and Combined Effects of Carbamazepine and Copper on Nervous and Antioxidant Systems of Zebrafish (Danio Rerio). Environ. Toxicol. 2020, 35, 1091–1099. [Google Scholar] [CrossRef]
- Fraz, S.; Lee, A.H.; Wilson, J.Y. Gemfibrozil and Carbamazepine Decrease Steroid Production in Zebrafish Testes (Danio Rerio). Aquat. Toxicol. 2018, 198, 1–9. [Google Scholar] [CrossRef]
- Galus, M.; Kirischian, N.; Higgins, S.; Purdy, J.; Chow, J.; Rangaranjan, S.; Li, H.; Metcalfe, C.; Wilson, J.Y. Chronic, Low Concentration Exposure to Pharmaceuticals Impacts Multiple Organ Systems in Zebrafish. Aquat. Toxicol. 2013, 132–133, 200–211. [Google Scholar] [CrossRef]
- Choy, P.C.; Mymin, D.; Zhu, Q.; Dakshinamurti, K.; O, K. Atherosclerosis Risk Factors: The Possible Role of Homocysteine. Mol. Cell. Biochem. 2000, 207, 143–148. [Google Scholar] [CrossRef]
- Boden, W.E.; O’rourke, R.A.; Teo, K.K.; Hartigan, P.M.; Maron, D.J.; Kostuk, W.; Knudtson, M.; Dada, M.; Casperson, P.; Harris, C.L.; et al. The Evolving Pattern of Symptomatic Coronary Artery Disease in the United States and Canada: Baseline Characteristics of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) Trial. Am. J. Cardiol. 2007, 99, 208–212. [Google Scholar] [CrossRef]
- Saunders, R.L.; Farrell, A.P.; Knox, D.E. Progression of Coronary Arterial Lesions in Atlantic Salmon (Salmo Salar) as a Function of Growth Rate. Can. J. Fish. Aquat. Sci. 1992, 49, 878–884. [Google Scholar] [CrossRef]
- Larsson, A.; Fänge, R. Cholesterol and Free Fatty Acids (FFA) in the Blood of Marine Fish. Comp. Biochem. Physiol. B 1977, 57, 191–196. [Google Scholar] [CrossRef]
- Mimeault, C.; Woodhouse, A.J.; Miao, X.-S.; Metcalfe, C.D.; Moon, T.W.; Trudeau, V.L. The Human Lipid Regulator, Gemfibrozil Bioconcentrates and Reduces Testosterone in the Goldfish, Carassius Auratus. Aquat. Toxicol. 2005, 73, 44–54. [Google Scholar] [CrossRef] [PubMed]
- Ellesat, K.S.; Holth, T.F.; Wojewodzic, M.W.; Hylland, K. Atorvastatin Up-Regulate Toxicologically Relevant Genes in Rainbow Trout Gills. Ecotoxicology 2012, 21, 1841–1856. [Google Scholar] [CrossRef]
- Al-Habsi, A.A.; Massarsky, A.; Moon, T.W. Exposure to Gemfibrozil and Atorvastatin Affects Cholesterol Metabolism and Steroid Production in Zebrafish (Danio Rerio). Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2016, 199, 87–96. [Google Scholar] [CrossRef] [PubMed]
- Metcalfe, C.D.; Koenig, B.G.; Bennie, D.T.; Servos, M.; Ternes, T.A.; Hirsch, R. Occurrence of Neutral and Acidic Drugs in the Effluents of Canadian Sewage Treatment Plants. Environ. Toxicol. Chem. 2003, 22, 2872. [Google Scholar] [CrossRef]
- Westerfield, M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish Danio (“Brachydanio Rerio”); University of Oregon: Eugene, OR, USA, 2007. [Google Scholar]
- Bose, H.S.; Lingappa, V.R.; Miller, W.L. Rapid Regulation of Steroidogenesis by Mitochondrial Protein Import. Nature 2002, 417, 87–91. [Google Scholar] [CrossRef]
- Stein, E.A. Drug and Alternative Therapies for Hyperlipidemia. Atherosclerosis 1994, 108, S105–S116. [Google Scholar] [CrossRef]
- Rudney, H.; Sexton, R.C. Regulation of Cholesterol Biosynthesis. Annu. Rev. Nutr. 1986, 6, 245–272. [Google Scholar] [CrossRef]
- Fruchart, J.-C.; Duriez, P. Mode of Action of Fibrates in the Regulation of Triglyceride and HDL-Cholesterol Metabolism. Drugs Today 2006, 42, 39–64. [Google Scholar] [CrossRef]
- Kasprzyk-Hordern, B.; Dinsdale, R.M.; Guwy, A.J. The Occurrence of Pharmaceuticals, Personal Care Products, Endocrine Disruptors and Illicit Drugs in Surface Water in South Wales, UK. Water Res. 2008, 42, 3498–3518. [Google Scholar] [CrossRef] [PubMed]
- Velasco-Santamaría, Y.M.; Korsgaard, B.; Madsen, S.S.; Bjerregaard, P. Bezafibrate, a Lipid-Lowering Pharmaceutical, as a Potential Endocrine Disruptor in Male Zebrafish (Danio Rerio). Aquat. Toxicol. 2011, 105, 107–118. [Google Scholar] [CrossRef] [PubMed]
- Weston, A.; Caminada, D.; Galicia, H.; Fent, K. Effects of Lipid-Lowering Pharmaceuticals Bezafibrate and Clofibric Acid on Lipid Metabolism in Fathead Minnow (Pimephales Promelas). Environ. Toxicol. Chem. 2009, 28, 2648–2655. [Google Scholar] [CrossRef]
- Kümmerer, K. The Presence of Pharmaceuticals in the Environment Due to Human Use—Present Knowledge and Future Challenges. J. Environ. Manag. 2009, 90, 2354–2366. [Google Scholar] [CrossRef]
- Kümmerer, K. Pharmaceuticals in the Environment. Annu. Rev. Environ. Resour. 2010, 35, 57–75. [Google Scholar] [CrossRef] [Green Version]
- Verlicchi, P.; Al Aukidy, M.; Zambello, E. Occurrence of Pharmaceutical Compounds in Urban Wastewater: Removal, Mass Load and Environmental Risk after a Secondary Treatment—A Review. Sci. Total Environ. 2012, 429, 123–155. [Google Scholar] [CrossRef]
- Balbi, T.; Montagna, M.; Fabbri, R.; Carbone, C.; Franzellitti, S.; Fabbri, E.; Canesi, L. Diclofenac Affects Early Embryo Development in the Marine Bivalve Mytilus Galloprovincialis. Sci. Total Environ. 2018, 642, 601–609. [Google Scholar] [CrossRef]
- Praskova, E.; Plhalova, L.; Chromcova, L.; Stepanova, S.; Bedanova, I.; Blahova, J.; Hostovsky, M.; Skoric, M.; Maršálek, P.; Voslarova, E.; et al. Effects of Subchronic Exposure of Diclofenac on Growth, Histopathological Changes, and Oxidative Stress in Zebrafish (Danio Rerio). Sci. World J. 2014, 2014, 645737. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Valavanidis, A.; Vlahogianni, T.; Dassenakis, M.; Scoullos, M. Molecular Biomarkers of Oxidative Stress in Aquatic Organisms in Relation to Toxic Environmental Pollutants. Ecotoxicol. Environ. Saf. 2006, 64, 178–189. [Google Scholar] [CrossRef] [PubMed]
- Monserrat, J.M.; Geracitano, L.A.; Bianchini, A. Current and Future Perspectives Using Biomarkers to Assess Pollution in Aquatic Ecosystems. Comments Toxicol. 2003, 9, 255–269. [Google Scholar] [CrossRef]
- De Carvalho Penha, L.C.C.; Rola, R.C.; Martinez, C.B.D.R.; de Martins, C.M.G. Effects of Anti-Inflammatory Diclofenac Assessed by Toxicity Tests and Biomarkers in Adults and Larvae of Danio Rerio. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2021, 242, 108955. [Google Scholar] [CrossRef]
- Rangasamy, B.; Hemalatha, D.; Shobana, C.; Nataraj, B.; Ramesh, M. Developmental Toxicity and Biological Responses of Zebrafish (Danio Rerio) Exposed to Anti-Inflammatory Drug Ketoprofen. Chemosphere 2018, 213, 423–433. [Google Scholar] [CrossRef]
- Spongberg, A.L.; Witter, J.D.; Acuña, J.; Vargas, J.; Murillo, M.; Umaña, G.; Gómez, E.; Perez, G. Reconnaissance of Selected PPCP Compounds in Costa Rican Surface Waters. Water Res. 2011, 45, 6709–6717. [Google Scholar] [CrossRef] [PubMed]
- Marsik, P.; Rezek, J.; Židková, M.; Kramulová, B.; Tauchen, J.; Vaněk, T. Non-Steroidal Anti-Inflammatory Drugs in the Watercourses of Elbe Basin in Czech Republic. Chemosphere 2017, 171, 97–105. [Google Scholar] [CrossRef]
- Verlicchi, P.; Al Aukidy, M.; Galletti, A.; Petrovic, M.; Barceló, D. Hospital Effluent: Investigation of the Concentrations and Distribution of Pharmaceuticals and Environmental Risk Assessment. Sci. Total Environ. 2012, 430, 109–118. [Google Scholar] [CrossRef]
- Nunes, B.; Miranda, A.F.; Ozório, R.O.A.; Gonçalves, F.; Gonçalves, J.F.M.; Correia, A.T. Modulation of Neuronal Activity and Hepatic Metabolism by Ploidy and L -Carnitine Supplement in Rainbow Trout (Oncorhynchus Mykiss). Aquac. Nutr. 2014, 20, 242–252. [Google Scholar] [CrossRef]
- Wang, L.; Peng, Y.; Nie, X.; Pan, B.; Ku, P.; Bao, S. Gene Response of CYP360A, CYP314, and GST and Whole-Organism Changes in Daphnia Magna Exposed to Ibuprofen. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016, 179, 49–56. [Google Scholar] [CrossRef]
- Oppenländer, T. Photochemical Purification of Water and Air; Wiley-VCH: Weinheim, Germany; Cambridge, UK, 2003; ISBN 978-3-527-61088-4. [Google Scholar]
- Canonica, S.; Meunier, L.; von Gunten, U. Phototransformation of Selected Pharmaceuticals during UV Treatment of Drinking Water. Water Res. 2008, 42, 121–128. [Google Scholar] [CrossRef]
- Rosario-Ortiz, F.L.; Wert, E.C.; Snyder, S.A. Evaluation of UV/H2O2 Treatment for the Oxidation of Pharmaceuticals in Wastewater. Water Res. 2010, 44, 1440–1448. [Google Scholar] [CrossRef]
- Salgado, R.; Marques, R.; Noronha, J.P.; Carvalho, G.; Oehmen, A.; Reis, M.A.M. Assessing the Removal of Pharmaceuticals and Personal Care Products in a Full-Scale Activated Sludge Plant. Environ. Sci. Pollut. Res. Int. 2012, 19, 1818–1827. [Google Scholar] [CrossRef]
- Coelho, A.D.; Sans, C.; Agüera, A.; Gómez, M.J.; Esplugas, S.; Dezotti, M. Effects of Ozone Pre-Treatment on Diclofenac: Intermediates, Biodegradability and Toxicity Assessment. Sci. Total Environ. 2009, 407, 3572–3578. [Google Scholar] [CrossRef]
- Diniz, M.S.; Salgado, R.; Pereira, V.J.; Carvalho, G.; Oehmen, A.; Reis, M.A.M.; Noronha, J.P. Ecotoxicity of Ketoprofen, Diclofenac, Atenolol and Their Photolysis Byproducts in Zebrafish (Danio Rerio). Sci. Total Environ. 2015, 505, 282–289. [Google Scholar] [CrossRef]
- Bendz, D.; Paxéus, N.A.; Ginn, T.R.; Loge, F.J. Occurrence and Fate of Pharmaceutically Active Compounds in the Environment, a Case Study: Höje River in Sweden. J. Hazard. Mater. 2005, 122, 195–204. [Google Scholar] [CrossRef] [PubMed]
- Han, S.; Choi, K.; Kim, J.; Ji, K.; Kim, S.; Ahn, B.; Yun, J.; Choi, K.; Khim, J.S.; Zhang, X.; et al. Endocrine Disruption and Consequences of Chronic Exposure to Ibuprofen in Japanese Medaka (Oryzias Latipes) and Freshwater Cladocerans Daphnia Magna and Moina Macrocopa. Aquat. Toxicol. 2010, 98, 256–264. [Google Scholar] [CrossRef] [PubMed]
- Saravanan, M.; Devi, K.U.; Malarvizhi, A.; Ramesh, M. Effects of Ibuprofen on Hematological, Biochemical and Enzymological Parameters of Blood in an Indian Major Carp, Cirrhinus Mrigala. Environ. Toxicol. Pharmacol. 2012, 34, 14–22. [Google Scholar] [CrossRef]
- Kozisek, F.; Pomykacova, I.; Jeligova, H.; Cadek, V.; Svobodova, V. Survey of Human Pharmaceuticals in Drinking Water in the Czech Republic. J. Water Health 2013, 11, 84–97. [Google Scholar] [CrossRef] [PubMed]
- Ginebreda, A.; Muñoz, I.; de Alda, M.L.; Brix, R.; López-Doval, J.; Barceló, D. Environmental Risk Assessment of Pharmaceuticals in Rivers: Relationships between Hazard Indexes and Aquatic Macroinvertebrate Diversity Indexes in the Llobregat River (NE Spain). Environ. Int. 2010, 36, 153–162. [Google Scholar] [CrossRef]
- Ji, K.; Liu, X.; Lee, S.; Kang, S.; Kho, Y.; Giesy, J.P.; Choi, K. Effects of Non-Steroidal Anti-Inflammatory Drugs on Hormones and Genes of the Hypothalamic-Pituitary-Gonad Axis, and Reproduction of Zebrafish. J. Hazard. Mater. 2013, 254–255, 242–251. [Google Scholar] [CrossRef]
- Ternes, T.A. Occurrence of Drugs in German Sewage Treatment Plants and Rivers. Water Res. 1998, 32, 3245–3260. [Google Scholar] [CrossRef]
- Morthorst, J.E.; Lister, A.; Bjerregaard, P.; Van Der Kraak, G. Ibuprofen Reduces Zebrafish PGE(2) Levels but Steroid Hormone Levels and Reproductive Parameters Are Not Affected. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2013, 157, 251–257. [Google Scholar] [CrossRef] [Green Version]
- Parolini, M.; Binelli, A.; Provini, A. Chronic Effects Induced by Ibuprofen on the Freshwater Bivalve Dreissena Polymorpha. Ecotoxicol. Environ. Saf. 2011, 74, 1586–1594. [Google Scholar] [CrossRef] [PubMed]
- Buser, H.-R.; Poiger, T.; Müller, M.D. Occurrence and Environmental Behavior of the Chiral Pharmaceutical Drug Ibuprofen in Surface Waters and in Wastewater. Environ. Sci. Technol. 1999, 33, 2529–2535. [Google Scholar] [CrossRef]
- Johannsen, M. Separation of Enantiomers of Ibuprofen on Chiral Stationary Phases by Packed Column Supercritical Fluid Chromatography. J. Chromatogr. A 2001, 937, 135–138. [Google Scholar] [CrossRef]
- Zhang, W.; Song, Y.; Chai, T.; Liao, G.; Zhang, L.; Jia, Q.; Qian, Y.; Qiu, J. Lipidomics Perturbations in the Brain of Adult Zebrafish (Danio Rerio) after Exposure to Chiral Ibuprofen. Sci. Total Environ. 2020, 713, 136565. [Google Scholar] [CrossRef]
- Song, Y.; Chai, T.; Yin, Z.; Zhang, X.; Zhang, W.; Qian, Y.; Qiu, J. Stereoselective Effects of Ibuprofen in Adult Zebrafish (Danio Rerio) Using UPLC-TOF/MS-Based Metabolomics. Environ. Pollut. 2018, 241, 730–739. [Google Scholar] [CrossRef]
- Ammann, A.A.; Macikova, P.; Groh, K.J.; Schirmer, K.; Suter, M.J.F. LC-MS/MS Determination of Potential Endocrine Disruptors of Cortico Signalling in Rivers and Wastewaters. Anal. Bioanal. Chem. 2014, 406, 7653–7665. [Google Scholar] [CrossRef] [PubMed]
- Chang, H.; Hu, J.; Shao, B. Occurrence of Natural and Synthetic Glucocorticoids in Sewage Treatment Plants and Receiving River Waters. Environ. Sci. Technol. 2007, 41, 3462–3468. [Google Scholar] [CrossRef] [PubMed]
- Zhao, Y.; Zhang, K.; Fent, K. Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio Rerio) at Low Concentrations. Environ. Sci. Technol. 2016, 50, 10245–10254. [Google Scholar] [CrossRef] [PubMed]
- Vizzini, A.; Vazzana, M.; Cammarata, M.; Parrinello, N. Peritoneal Cavity Phagocytes from the Teleost Sea Bass Express a Glucocorticoid Receptor (Cloned and Sequenced) Involved in Genomic Modulation of the In Vitro Chemiluminescence Response to Zymosan. Gen. Comp. Endocrinol. 2007, 150, 114–123. [Google Scholar] [CrossRef]
- Vazzana, M.; Cammarata, M.; Cooper, E.L.; Parrinello, N. Confinement Stress in Sea Bass (Dicentrarchus Labrax) Depresses Peritoneal Leukocyte Cytotoxicity. Aquaculture 2002, 210, 231–243. [Google Scholar] [CrossRef]
- Celi, M.; Vazzana, M.; Sanfratello, M.A.; Parrinello, N. Elevated Cortisol Modulates Hsp70 and Hsp90 Gene Expression and Protein in Sea Bass Head Kidney and Isolated Leukocytes. Gen. Comp. Endocrinol. 2012, 175, 424–431. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Wu, J.; Jin, Z.; Zheng, H.; Yan, L.-J. Sources and Implications of NADH/NAD(+) Redox Imbalance in Diabetes and Its Complications. Diabetes Metab. Syndr. Obes. 2016, 9, 145–153. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Basheer, A.A. Chemical Chiral Pollution: Impact on the Society and Science and Need of the Regulations in the 21st Century. Chirality 2018, 30, 402–406. [Google Scholar] [CrossRef] [PubMed]
Drug | Environmental Concentrations | Concentration/Time Exposure | Samples | Biomarker Analysed | Biochemical Responses | Reference |
---|---|---|---|---|---|---|
Diazepam Fluoxetine | 0.04–0.88 µg/L [41,42] and 0.012 to 1 µg/L, respectively [36,42,135] | Diazepam: 88 μg/L, 16 μg/L and 160 μg/L; Fluoxetine: 1 μg/L, 25 μg/L and 50 μg/L for 0, 15, 60, 240 min | Whole Body | Cortisol | (−) Cortisol | [134] |
Fluoxetine | 1 μg/L for 15 min | Whole Body | Cortisol Ionic Fluxes | (−) Cortisol Alteration Effect on Ionic Fluxes | [136] | |
Diazepam Fluoxetine | 50 μg/L, 16 μg/L for 15 Days | Whole Body | Cortisol | (−) Cortisol | [138] | |
Fluoxetine | 100 μg/L for 2 Weeks | Whole Body | Cortisol | (−) Cortisol | [139] | |
Oxazepam | ng/L to μg/L [142,143] | 7 μg/L for 7 and 28 Days | Whole Body | Cortisol; Serotonin | No Effects on Cortisol level (−) Serotonin turnover | [140] |
Oxazepam | 0.57 μg/L for 9 Days | Whole Body | Cortisol | No Effects on Cortisol Level | [141] | |
Aripiprazole | 5.56 ng/L [149] | 0.0556, 0.556, 5.556, 55.6 and 556 ng/L for 15 min | Whole Body | Cortisol | (+) Cortisol | [148] |
Risperidone | 0.00034 μg/L [42,150] | 0.00034 μg/L, 85 μg/L, 170 μg/L, 340 μg/L and 680 μg/L for 15 min | Whole Body | Cortisol | (+) Cortisol | [151] |
Carbamazepine Clonazepam | 0.002 to 11.5 μg/ L [40]; 145 ng/L [39] | 75 µg/L for 96 h | Brain, Liver, Kidney | Reduced Glutathione; Metallothionein; Catalase; Glutathione S-Transferase; | (−) Glutathione in Liver (+) Glutathione in Brain (−) Metallothionein in Brain and Liver (+) Metallothionein in Kidneys (+) Glutathione S-Transferase in Brain (+) Glutathione S-Transferase in Liver (−) Catalase | [156] |
Carbamazepine | 0, 10 or 10,000 μg/L for 63 Days | Muscle, Head, Gills, Liver, Intestine | Acetylcholinesterase; Catalase; Glutathione S-Transferase; Lactate Dehydrogenase | (+) Acetylcholinesterase (−) Catalase (+) Glutathione S-Transferase (+) Lactate Dehydrogenase in Liver (−) Lactate Dehydrogenase in Brain and Muscle | [164] | |
Carbamazepine | 1, 10 and 100 μg/L for 45 Days | Whole Body | Superoxide Dismutase; Acetylcholinesterase; Catalase; Glutathione S-Transferase | (−) Acetylcholinesterase, Glutathione S-Transferase, Superoxide Dismutase (+) Catalase, Glutathione S-Transferase | [168] | |
Carbamazepine | 10 μg/L for 67 Days | Whole Body, Plasma, Gonads | 11-Chetotestosterone | (−) 11-Chetotestosterone | [169] | |
Carbamazepine | 0.5 and 10 μg/L for 6 Weeks | Plasma | 11-Ketotestosterone; Estradiol | (−) 11-Ketotestosterone | [170] |
Drug | Environmental Concentrations | Concentration/ Time Exposure | Samples | Biomarker Analysed | Biochemical Responses | Reference |
---|---|---|---|---|---|---|
Diclofenac | 0.02 mg/L [191] | 0.02, 5, 15, 30, and 60 mg/L for 28 Days | Whole Body | Glutathione S-Transferase; Reduced Glutathione; Lipid Peroxidation | (−) Lipid Peroxidation | [191] |
Diclofenac | 3 mg/L and 2 μg/L of for 96 h | Gills, Liver | Glutathione S-Transferase; Percentage Of ABC Proteins Activity; Lipoperoxidation; Ethoxyresorufin O-Deethylase Activity | (+) Glutathione S-Transferase Activity, Percentage Of ABC Proteins Activity, Lipoperoxidation | [194] | |
Ketoprofen | Up to 1.0 μg/L [58] | 1, 10 and 100 µg/L for 42 Days | Liver | Glutamic Oxaloacetic Transaminases; Glutamic Pyruvic Transaminases; Lactate Dehydrogenase; Superoxide Dismutase; Catalase; Glutathione Peroxidase; Glutathione S-Transferase; Reduced Glutathione; Lipid Peroxidation | (+)Glutamic Oxaloacetic, Transaminases, Glutamic Pyruvic Transaminases, Lactate Dehydrogenase; (−) Other Parameters | [195] |
Ketoprofen Diclofenac and Their Photodegradation Products | 1 mg/L for Ketoprofen, 7.5 and 60 min; for Diclofenac 1.5 and 5 min | Whole Body | Glutathione S-Transferase; Superoxide Dismutase; Catalase; Lipid Peroxidation | (+) Glutathione S-Transferase, Catalase, Lipid Peroxidation; (−) Catalase, Glutathione S-Transferase, Superoxide Dismutase, Lipid Peroxidation | [206] | |
Acetylsalicylic Acid, Diclofenac, Ibuprofen, Mefenamic Acid and Naproxen | <0.02, 0.15, 0.07, and 0.07 μg/L in Germany Rivers [213] 0.269 μg/L, 0.793 μg/L, 3.528 μg/L, 1.390 μg/L, and 0.326 μg/L in Korea Rivers | 10, 100 or 1000 μg/L for 14 Days | Plasma | 17β-Estradiol; Testosterone | (+) 17β-Estradiol, Testosterone in Females; (−) Testosterone in Male | [212] |
Ibuprofen | 21, 201 or 506 μg/L for 7 Days | Whole Body and Ovaries | Prostaglandin; 11-Ketotestosterone; 17β-Estradiol | (−) Prostaglandin E2 (PGE2); No Change 11-Ketotestosterone, 17β-Estradiol | [214] | |
Ibuprofen | 5 μg/L [218] | 5 μg/L for 28 Days | Brain | Lipidomic Analysis | Changes Lipid Levels | [218] |
Fludrocortisone Acetate | Low ng/L Range in Surface and Ground Waters; Up to Hundreds of ng/L in Influent/Effluent of WWTPs [220,221] | 0.006 to 42 μg/L for 21 Days | Plasma | Glucose; Leukocytes Count | (−) Glucose, Leukocytes | [222] |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Mauro, M.; Lazzara, V.; Arizza, V.; Luparello, C.; Ferrantelli, V.; Cammilleri, G.; Inguglia, L.; Vazzana, M. Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults. Biology 2021, 10, 1064. https://doi.org/10.3390/biology10101064
Mauro M, Lazzara V, Arizza V, Luparello C, Ferrantelli V, Cammilleri G, Inguglia L, Vazzana M. Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults. Biology. 2021; 10(10):1064. https://doi.org/10.3390/biology10101064
Chicago/Turabian StyleMauro, Manuela, Valentina Lazzara, Vincenzo Arizza, Claudio Luparello, Vincenzo Ferrantelli, Gaetano Cammilleri, Luigi Inguglia, and Mirella Vazzana. 2021. "Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults" Biology 10, no. 10: 1064. https://doi.org/10.3390/biology10101064