Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents
2.2. Apparatus
2.3. MEA Fabrication Procedures
2.4. In Vivo Testing of MEAs
2.5. Data Acquisition and Analysis
3. Results
3.1. Neural Spike Firing Variations during DBS
3.2. Dual-Mode Signals Variations during DBS
3.3. MSNs and FSIs Respond Different to DBS
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Xiao, G.; Song, Y.; Zhang, Y.; Xing, Y.; Xu, S.; Wang, M.; Wang, J.; Chen, D.; Chen, J.; Cai, X. Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease. Biosensors 2020, 10, 136. https://doi.org/10.3390/bios10100136
Xiao G, Song Y, Zhang Y, Xing Y, Xu S, Wang M, Wang J, Chen D, Chen J, Cai X. Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease. Biosensors. 2020; 10(10):136. https://doi.org/10.3390/bios10100136
Chicago/Turabian StyleXiao, Guihua, Yilin Song, Yu Zhang, Yu Xing, Shengwei Xu, Mixia Wang, Junbo Wang, Deyong Chen, Jian Chen, and Xinxia Cai. 2020. "Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease" Biosensors 10, no. 10: 136. https://doi.org/10.3390/bios10100136