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Article

Reference Values for Cardiorespiratory Fitness in Healthy Koreans

by
Won Young Jang
1,†,
Woohyeun Kim
1,†,
Dong Oh Kang
1,
Yoonjee Park
1,
Jieun Lee
1,
Jah Yeon Choi
1,
Seung-Young Roh
1,
Jin Oh Na
1,
Cheol Ung Choi
1,
Seung-Woon Rha
1,
Chang Gyu Park
1,
Hong Seog Seo
1,
Soo Hyun Park
2,
Saejong Park
2,* and
Eung Ju Kim
1,*
1
Cardiovascular Center, Korea University Guro Hospital, Seoul 08308, Korea
2
Korea Institute of Sport Science, Seoul 01794, Korea
*
Authors to whom correspondence should be addressed.
†
W.Y.J. and W.K. contributed equally to this work.
J. Clin. Med. 2019, 8(12), 2191; https://doi.org/10.3390/jcm8122191
Submission received: 29 October 2019 / Revised: 30 November 2019 / Accepted: 9 December 2019 / Published: 12 December 2019
(This article belongs to the Special Issue Cardiovascular Rehabilitation)
Browse Figures
Versions Notes

Abstract

:
We investigated reference values for cardiorespiratory fitness (CRF) for healthy Koreans and Koreans with coronary heart disease (CHD) and used them to identify inter-ethnic differences in CRF, differences over time in CRF, and differences in CRF between the healthy population and patients with CHD. The study population for healthy Koreans was derived from the database of KISS FitS (Korea Institute of Sports Science Fitness Standards) between 2014 and 2015. The study population for Koreans with CHD was derived from the database of the Korea University Guro Hospital Cardiac Rehabilitation Registry between June 2015 and December 2018. In healthy Koreans, there was a significant difference between sex and age groups for VO2 max. The VO2 max of healthy Koreans differed from that of Westerners in age-related reference values. Our results were not significantly different from those of the Korean population in the past, except for a small decline in the young population. There seemed to be a clear inter-ethnic difference in CRF. We could also identify signs of small change in CRF in younger age groups. Therefore, CRF should be assessed according to ethnic or national standards, and it will be necessary to establish a reference for each nation or ethnicity with periodic updates.

1. Introduction

Cardiorespiratory fitness (CRF) is defined as the circulatory and respiratory ability to supply oxygen properly to skeletal muscles during physical activity. Many studies have shown that better CRF can lower the risk of cardiovascular disease (CVD) and all-cause mortality [1,2,3,4]. Recently, it has been argued that CRF should be regarded as one of the clinical vital signs, and it is expected that assessing CRF in clinical practice can improve patient management [5].
CRF can be measured directly by a conventional exercise test with gas analysis and can be estimated indirectly by exercise tests with various protocols [5]. Furthermore, non-exercise-based models that can predict CRF using clinical variables and can be easily assessed in clinical settings without an exercise test have been also reported [6,7,8,9]. Similar to these CRF measurements or estimates for individual subjects, it is important to establish a reference value that can be used to determine whether a subject is fit or unfit compared to a healthy population.
Since simple nomograms were introduced based on a U.S. cohort in the 1980s for men and the 1990s for women [10,11], there have been many efforts to update the reference for normal CRF. Recently, age-related mean reference values for American and Norwegian populations have been reported [12,13,14]. However, there has been no updated reference data for Asian populations. As CRF is influenced by genetic factors such as race [15,16,17], it is unreasonable to apply the reference values of Westerners to Asians. In addition, compared with the past, nutritional status has improved, but the obese population has increased significantly as the rate of sedentary life styles has increased. It could be also unreasonable to apply the past reference values to current subjects.
In this study, we investigated the CRF reference values for an Asian population using a Korean cohort from the 2010s and compared them with past Korean CRF results, as well as the reported CRF results for Westerners. We also compared the CRF of patients with coronary heart disease (CHD) with this reference value to determine the difference in CRF between patients with CHD and the healthy population.

2. Experimental Section

2.1. Study Population

This cross-sectional study consisted of two separate studies. One was a study to investigate the reference value for healthy adults, and the other was a study to measure the CRF in CHD patients. The study to investigate the reference value for healthy adults was conducted with healthy Koreans aged 19 years or older participating in the Korea Institute of Sports Science Fitness Standards (KISS FitS) project. KISS FitS was designed to measure the nationwide physical fitness of healthy Koreans, assess their health status, and suggest appropriate levels of fitness for disease prevention. We analyzed all subjects with available maximal oxygen uptake (VO2 max) who participated in KISS FitS between 2014 and 2015. The exclusion criteria for this project were pregnant women, patients with cardiovascular disease, renal disease, and systemic infections, and those with orthopedic injuries whose physical fitness could not be measured. This study was approved by the Korea Bioethics Committee for Institutional Bioethics (KISS-201504-EFS-002-01) and received voluntary consent from participants.
The study to measure the CRF in patients with CHD was conducted for those who underwent coronary angiography with or without revascularization and participated in cardiac rehabilitation at Korea University Guro Hospital between June 2015 and December 2018. Patients whose CRF could not be measured for the following reasons were excluded: (1) hemodynamic instability; (2) comorbidities such as pulmonary disease and/or orthopedic disease; and (3) non-cooperation due to a neurologic problem. This study was approved by the Institutional Review Board (IRB) of Korea University Guro Hospital. The requirement for written informed consent was waived because of the retrospective design of the study.

2.2. CRF of Healthy Koreans

Participants performed a treadmill exercise test with the Bruce protocol. The exercise test started at a speed of 1.7 mph and a slope of 10%, and the speed (2.5, 3.4, 4.2, 5.0 mph) and slope (12, 14, 16, 18, 20%) were increased every 3 min until the participants became exhausted. The criteria for termination of the exercise are as follows. (1) Rating of perceived exertion (RPE) of 17 or more; (2) the heart rate did not increase even when the intensity of exercise increased; (3) 85% of the heart rate reserve was reached; (4) Request for interruption by participants. VO2 max was estimated by converting the highest workload attained to exercise time [18].

2.3. CRF of Patients with CHD

CRF was measured as VO2 max directly through the gas exchange analyzer (Quark b2, COSMED, Rome, Italy) during the exercise test. The treadmill test was performed according to the modified Bruce protocol.

2.4. Statistical Analysis

Continuous data are presented as mean ± standard deviation (SD), whereas categorical data are presented as frequencies (percentages). The subjects were divided according to their ages at intervals of 10 years. CRF values were recorded and analyzed separately for men and women. The student’s t-test was used to assess the differences between the sexes. Analysis of variance (ANOVA) was used to evaluate the differences in VO2 max according to age groups. No formal statistical techniques were used when comparing cohorts between the West [13,14,19] and Korea, as well as past [10,11,20] and present [13,14,19] cohorts because of the unavailability of the individual participant data from the other cohorts. Considering that the VO2 max using the cycle ergometer was 10–20% lower than the VO2 max using the treadmill [21], VO2 max values of Danish [19] and past Korean cohorts [20] using the cycle ergometer were multiplied by 1.15 when comparing these VO2 max values. The CRF of patients with CHD was compared with the normal reference value using one-way ANOVA. Analyses were conducted using IBM SPSS Statistics 20.0 (Chicago, IL, USA).

3. Results

3.1. CRF of Healthy Koreans

A total of 2646 healthy subjects with available VO2 max data in the KISS FitS project were analyzed. Among them, 42.3% were men, and most metrics for men were higher than those for women except for age and percentage of body fat. The baseline characteristics are shown in Table 1. The mean VO2 max estimated from the treadmill test was presented for each age group by sex in Table 2. As the age increased, the VO2 max tended to decrease significantly. The VO2 max of men was significantly higher than that of women in all age groups, and the difference in VO2 max between the sexes decreased with age.

3.2. Predicted Exercise Capacity

The exercise capacity and age had a linear inverse correlation, and the following predictive equation was derived from a logistic linear regression: VO2 max = 50.54 − 0.26 × (age) for healthy Korean men; VO2 max = 40.0 − (0.22 × age) for healthy Korean women. A nomogram of healthy Korean CRF is shown in Figure 1.

3.3. Comparison of Koreans and Westerners: Inter-Ethnic Differences

In Figure 2 and Table S1, we compared the CRF of the previously reported American, Norwegian, and Danish cohorts to that of the Korean cohort [13,14,19]. Young healthy Korean men and women had a lower CRF compared than other cohorts. The annual decrease of CRF was the smallest in Korea, and therefore the difference in CRF between young and older participants was also the smallest in Korea. In particular, Korean women have lower CRF reduction with age, and those older than 30 years have a higher CRF than American women. As the age increased, the gap also increased. Similarly, the gap between Korean women and Scandinavian women decreased with age.

3.4. Comparison between Past and Present: Difference Over Time

Compared with previous Korean CRF data that were measured directly by a cycle ergometer with gas analysis [20], the VO2 max was different from our result (Table S1). Old Korean CRF values were lower than our result by around 1 metabolic equivalents (METs) in all age groups. However, considering the 10–20% difference between the cycle ergometer and the treadmill test, 21 CRF values were similar (Figure 3A). To confirm the changes in CRF over time, we compared the American cohort from the 1980s with those from the 2010s [10,14]. In the American cohort, there was also no significant difference in CRF over time (Figure 3B,C). Although only a numerical comparison was made without statistical techniques, the current values of CRF were consistently slightly lower in younger age groups than the past values in both the US and Korea (US men in 20s, Current vs past, 47.6 ± SD vs 49.9 ± SD; US women in 20s, Current vs past, 37.6 ± SD vs 40.1 ± SD; Korean men in 20s, Current vs past, 42.3 ± SD vs 45.5 ± SD).

3.5. CRF for Patients with CHD: Comparison with Reference Values of Healthy Koreans

From a total of 775 patients, 496 patients with available CRF data were included in this study. The population of patients with CHD consisted of 395 men (79.6%), with a mean age of 61.4 ± 10.1 years (Table 3). Furthermore, 82.5% of the patients had normal LV systolic function, and the average LV ejection fraction (EF) was 59.4%. Unstable angina was the most common diagnosis (42.1%). STEMI, NSTEMI, and stable angina accounted for 16.1%, 15.7%, and 26.0% of diagnoses, respectively. Baseline characteristics of CHD patients are presented in Table 3. In CHD patients, as in healthy adults, CRF decreased with increasing age, and the CRF of men was higher than that of women. In both men and women over all ages, the CRF of CHD patients was lower than that of the healthy population (Table 4). The difference in CRF between patients with CHD and the healthy population varied from 15–35% for each age group. When the nomogram was applied to patients with CHD, three-quarters of CHD patients (372, 75.0%) had a CRF of less than 85% of the predicted value, one of the indicators of a poor prognosis [11]. In particular, men with CHD aged 30–59 years have a significant reduction in CRF by more than 10 mL/kg/min. In addition, in this age group of men, more patients (152, 81.3%) had CRF less than 85% of the predicted value.

4. Discussion

There have been many studies that have presented mean reference values of CRF for each nation [22]. In a systemic review [22], Paap and Takken pointed out that the methodological quality of most studies was unsatisfactory when evaluated using the quality list based on the ATS/ACCP guidelines [23]. They noted that most of these studies had small sample sizes and used the cycle ergometer instead of the treadmill test. Only four studies [12,24,25,26] met the high quality criteria, and only two [12,24] of them used the treadmill test. Among these two studies, there were only 204 subjects in the study by Itoh et al. [24] and only one study had a relatively large sample size of 759 subjects who performed treadmill tests [12]. Recently, well-designed studies that measured CRF directly using the treadmill test have been published for relatively large populations, especially for Westerners [12,13,14]. Although there have been attempts to present age-related mean reference values for Asian populations [24,27,28,29], these studies also had small sample sizes and/or used cycle ergometers instead of the treadmill test.
As far as we know, this is the first study to investigate the reference values of CRF using the treadmill test for Asians with a large sample size and high quality. Although the study was confined to Koreans, it was meaningful because it was aimed at a relatively large population group as compared with the previous studies of Asian populations [24,27,28,29]. Another advantage of this study was that the percentage of predicted exercise capacity of Koreans by sex and age can be easily ascertained through the nomogram. Similar to other studies conducted in different countries [10,11,13,14,19], the following was also found in Korean CRF: (1) as age increases, CRF decreases, (2) CRF was higher in men than in women of all ages, and (3) the decrease in CRF according to age was greater for men than for women, and the difference in CRF between men and women decreased with age.
In this study, we also objectively showed the difference of CRF between an Eastern and Western population. The age-specific reference of CRFs were reported differently in each study [10,11,13,14,19], with Scandinavian people having the highest CRF over all ages (Figure 2, Table S1 in the supplement). The Danish study is a cycle-based study, which was difficult to compare directly, but considering that CRF measurements using cycles were 10–20% lower than those measured using the treadmill [21], the age-specific reference of CRF in Norway and that in Denmark were similar. On the other hand, there were differences between Korean, Americans, and Scandinavians. In Korean populations, CRF reduction by age was characteristically smaller than other Westerners. As a result, the CRF of Americans was higher than that of Koreans in the younger age group, but the CRF of Koreans was higher than that of Americans in the age groups of 30–40 years and older. In particular, Korean women had the least decrease in CRF according to age, and older women were closer to Scandinavian CRF.
In addition, this study provided clues to indirectly compare the past and present CRF. We compared the results of this study with those of a past Korean study [20] (Figure 3A and Table S1). A simple numerical comparison suggests that the CRF of Koreans has improved over the years for all ages; however, this finding requires further interpretation (Table S1). The past study with Koreans was conducted using a cycle ergometer with only 82 men [20]. Subsequently, there might be limitations in the comparison with current data. Moreover, as mentioned above, considering that VO2 max is approximately 10–20% lower when using a cycle ergometer compared to a treadmill test [21], our results can be judged to be similar when compared with the past (Figure 3a). Intriguingly, the age-related mean reference values of Americans in the 1980s and 2010s also did not change much [10,14] (Figure 3B,C). Despite medical progress and lifestyle changes, this finding that CRF has remained almost unchanged for 30 years might indicate that CRF is affected more by genetic factors.
There were minor but interesting changes, which might be a coincidence, but in both the U.S. and Korea, the current CRF was consistently slightly lower in the younger age groups compared to the past (Figure 3). Intriguingly, in a study of 18-year-old men in Norway, Dyrstad et al. reported that CRF in young men had decreased over the 20 years [30]. Because it was accompanied by an increase in body weight and BMI over the same period, they argued that a decrease in CRF in younger men might have been due to a decrease in daily physical activity. Considering the increasing trend of obesity worldwide, including Korea [31,32,33,34], the observed decrease in CRF in younger age groups in the U.S. and Korea is convincing. Because the decrease of CRF in younger age groups may indicate a decrease of CRF in the whole population of the future, a periodic assessment of CRF is needed along with lifestyle modifications.
Another advantage of this study was that the CRF of patients with CHD was compared with that of a healthy population. Considering previous studies where CRF had a strong inverse correlation with incident CHD [35] and a measured CRF of less than 85% of the predicted value suggested a poor prognosis in the general population [11], patients with CHD may have a lower CRF than the healthy population. In our study, the decrease in CRF of patients with CHD was objectively confirmed, with most patients having CRF <85% of the predicted values.
This study has some limitations. Unlike previous studies in which CRF was directly measured using gas analysis during the treadmill test [12,13,14,20], CRF was indirectly estimated from the treadmill test in this study for a healthy Korean reference. Although the measured and estimated CRF were moderately correlated, there was a clear difference between the two values [36]. Because this was a retrospective cross-sectional study based on a cohort that has already been investigated, one limitation of our study was that CRF was estimated indirectly. However, at least for Koreans, the estimated CRF of the healthy population by the treadmill test with the Bruce protocol was relatively accurate, with an error rate of less than 1.5%, compared to the measured CRF [37]. Thus, although we used the estimated CRF instead of the directly measured CRF in this study, it was not unreasonable to compare the estimated CRF of our study with the directly measured CRF of other studies.
When comparing the CRF between Korean and Westerners, or comparing the past and current CRF, we simply compared the results observed in each study without statistical techniques. Therefore, it cannot be interpreted that the inter-ethnic difference of CRF has a statistical meaning, but it should be satisfied only to confirm tendency.
Because it has not been yet proven in Korea as to whether CRF values using the treadmill test and cycle ergometer differ by 10–20%, comparing the past and current CRF of Koreans can be criticized as being logically outrageous. In this regard, it may be also necessary to investigate the CRF reference values using a cycle ergometer as well as treadmill tests for Koreans.

5. Conclusions

In our study, the CRF of healthy Koreans differed from that of Westerners in age-related reference values. There seemed to be a clear inter-ethnic difference in CRF. Therefore, CRF should be assessed according to ethnic or national standards, and it will be necessary to establish a reference for each nation or ethnicity. While it looked like there was no significant change in CRF over time in the same ethnic group, we could also identify signs of small change in CRF in younger age groups. It will be necessary to periodically update these references. We also found that the CRF of patients with CHD was significantly lower than that of the healthy population. Further studies are needed to determine the effect of decreased CRF in patients with CHD.

Supplementary Materials

The following are available online at https://www.mdpi.com/2077-0383/8/12/2191/s1, Table S1: Comparison with previous studies to evaluate a reference cardiorespiratory fitness of healthy population.

Author Contributions

Conceptualization, W.Y.J. and E.J.K.; Data curation, W.Y.J., W.K. and S.H.P.; Formal analysis, W.Y.J., W.K. and S.H.P.; Funding acquisition, S.P. and E.J.K.; Project administration, D.O.K., Y.P., J.L., J.Y.C., S.-Y.R., J.O.N., C.U.C., S.-W.R., C.G.P. and H.S.S.; Resources, S.H.P.; Supervision, S.P. and E.J.K.; Validation, W.K. and S.H.P.; Visualization, W.Y.J. and W.K.; Writing—original draft, W.Y.J. and W.K.; Writing—review & editing, W.Y.J., W.K., D.O.K., Y.P., J.L., J.Y.C., S.-Y.R., J.O.N., C.U.C., S.-W.R., C.G.P., H.S.S., S.H.P., S.P. and E.J.K.

Funding

This study was conducted with support of the Korea Sports Promotion Foundation (2014–2015) and supported by a grant of the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health& Welfare, Republic of Korea (grant number: HI16C0483) and supported by a Korea University Grant (Grant No: K1710671).

Acknowledgments

We would like to thank Editage (www.editage.co.kr) for English language editing.

Conflicts of Interest

The authors declare no conflict of interest.

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Jcm 08 02191 g001 550
Figure 1. Nomogram of the percentage of predicted exercise capacity for age in healthy Korean participants. When a line connecting the subject’s age (on the left scale) and the metabolic equivalents (METS) value (on the right scale) is drawn, that line intersects the percentage line. The intersection point is the percentage of predicted exercise capacity for age. The red line is the women’s percentage line and the blue line is the male’s one.
Figure 1. Nomogram of the percentage of predicted exercise capacity for age in healthy Korean participants. When a line connecting the subject’s age (on the left scale) and the metabolic equivalents (METS) value (on the right scale) is drawn, that line intersects the percentage line. The intersection point is the percentage of predicted exercise capacity for age. The red line is the women’s percentage line and the blue line is the male’s one.
Jcm 08 02191 g001
Jcm 08 02191 g002 550
Figure 2. Comparison of cardiorespiratory fitness (CRF) of men (A) and women (B) between recent Korea, US, Norway, and Denmark. VO2max, maximal oxygen uptake (mL/kg/min). * CRF of Danish cohort was measured by cycle ergometer with the maximal power output (MPO) protocol. Due to the difference in VO2max from exercise test methods, for simple comparison, the VO2max measured by the cycle ergometer was multiplied by 1.15 times. The original VO2max values of the Danish cohort can be found in Table S1.
Figure 2. Comparison of cardiorespiratory fitness (CRF) of men (A) and women (B) between recent Korea, US, Norway, and Denmark. VO2max, maximal oxygen uptake (mL/kg/min). * CRF of Danish cohort was measured by cycle ergometer with the maximal power output (MPO) protocol. Due to the difference in VO2max from exercise test methods, for simple comparison, the VO2max measured by the cycle ergometer was multiplied by 1.15 times. The original VO2max values of the Danish cohort can be found in Table S1.
Jcm 08 02191 g002
Jcm 08 02191 g003a 550Jcm 08 02191 g003b 550
Figure 3. Comparison of cardiorespiratory fitness (CRF) between past and recent cohort. (A) Past and recent Korean men; (B) Past and recent US Men; (C) Past and recent US women. VO2max, maximal oxygen uptake (mL/kg/min). * CRF of past Korean participants was measured directly by cycle ergometer with gas analysis. Due to the difference in VO2max from the exercise test methods, the VO2max measured by cycle ergometer was multiplied by 1.15 for a more simple comparison. The original VO2max values of past Korean participants can be found in Table S1.
Figure 3. Comparison of cardiorespiratory fitness (CRF) between past and recent cohort. (A) Past and recent Korean men; (B) Past and recent US Men; (C) Past and recent US women. VO2max, maximal oxygen uptake (mL/kg/min). * CRF of past Korean participants was measured directly by cycle ergometer with gas analysis. Due to the difference in VO2max from the exercise test methods, the VO2max measured by cycle ergometer was multiplied by 1.15 for a more simple comparison. The original VO2max values of past Korean participants can be found in Table S1.
Jcm 08 02191 g003aJcm 08 02191 g003b
Table
Table 1. Baseline characteristics of the healthy Korean participants.
Table 1. Baseline characteristics of the healthy Korean participants.
MenWomenp-Value
Sample size, number1119 (42.3)1527 (57.7)
Age, years46.4 (16.1)52.8 (14.9)<0.001
Height, cm170.8 (6.6)157.0 (6.0)<0.001
Weight, kg72.2 (10.9)58.2 (8.3)<0.001
BMI, kg/m224.7 (3.0)23.6 (3.1)<0.001
WC, cm86.6 (7.7)83.0 (8.5)<0.001
Resting SBP, mmHg126.0 (12.1)119.1 (14.5)<0.001
Resting DBP, mmHg79.4 (10.8)74.1 (9.0)<0.001
Percent body fat, %22.8 (6.0)32.2 (6.4)<0.001
Lean mass, kg31.1 (4.4)21.0 (2.7)<0.001
Smoking, number233(20.8)9(0.6)<0.001
Hypertension, number220(19.7)325(21.3)0.340
Dyslipidemia, number135(12.1)241(15.8)0.009
Family history *, number55(4.9)78(5.1)0.853
Data are presented as mean (standard deviation), or as numbers followed by percentages. * Family history of cardiovascular disease. BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure.
Table
Table 2. Cardiorespiratory fitness of the healthy Korean participants.
Table 2. Cardiorespiratory fitness of the healthy Korean participants.
MenVO2max
(mL/kg/min)		 WomenVO2max
(mL/kg/min)
AgeMean ± SDNp-Value for Trend *AgeMean ± (SD)Np-Value for Trend *
19–2942.3 ± 6.3209 19–2934.3 ± 4.3110
30–3942.0 ± 5.0170 30-3932.2 ± 4.5211
40–4941.4 ± 5.6238 40–4930.8 ± 4.6284
50–5938.0 ± 5.7274<0.0150–5928.3 ± 4.6367<0.01
60–6932.4 ± 6.2134 60–6926.0 ± 5.7336
70–7927.2 ± 5.683 70–7923.9 ± 4.4195
>8024.1 ± 4.011 >8021.0 ± 3.724
Total38.6 ± 7.41119 total28.5 ± 5.81527
Data are presented as mean ± standard deviation. Analysis of variance was used to evaluate the differences in VO2max according to age. * p-value for the trend refers to testing for the trend of VO2max by decades of age by ANOVA. SD, standard deviation; VO2max, maximal oxygen uptake; N, number.
Table
Table 3. Baseline characteristics of the Korean patients with coronary heart disease.
Table 3. Baseline characteristics of the Korean patients with coronary heart disease.
MenWomenp-Value
Sample size, number395 (79.6)101 (20.4)
Age, year60.4 ± 10.165.7 ± 8.6<0.001
Height, cm172.4 ± 75.7153.4 ± 6.1<0.001
Weight, kg71.9 ± 12.360.4 ± 9.7<0.001
BMI, kg/m225.2 ± 3.925.4 ± 3.20.675
Waist-to-hip ratio0.9 ± 0.10.9 ± 0.10.687
Basal metabolic rate1527.4 ± 177.31207.1 ± 126.5<0.001
Systolic Blood Pressure122.9 ± 14.9123.4 ± 16.30.769
Diastolic Blood Pressure73.9 ± 11.471.9 ± 11.70.119
LVEF59.0 ± 8.260.0 ± 7.80.036
>50%321 (81.3)88 (87.1)0.167
≤50%28 (7.1)6 (5.9)0.684
≤45%22 (5.6)3(3.0)0.287
≤35%10 (2.5)2(2.0)0.748
Underlying disease
Hypertension274 (69.4)78 (77.2)0.120
Diabetes mellitus155 (39.2)34 (33.7)0.303
Hyperlipidemia208 (52.7)59 (58.4)0.300
Chronic renal insufficiency28 (7.1)9 (8.9)0.534
Diagnosis
STEMI71 (18.0)9 (8.9)0.027
NSTEMI65 (16.5)13 (12.9)0.377
Unstable angina157 (39.7)52 (51.5)0.033
Stable angina102 (25.8)27 (26.7)0.852
Data are presented as mean (standard deviation), or as numbers followed by percentages. LVEF, left ventricular ejection fraction; STEMI, ST-elevation myocardial infarction; NSTEMI, non-ST-elevation myocardial infarction; VO2max, maximal oxygen uptake; METs, metabolic equivalents.
Table
Table 4. Comparison of cardiorespiratory fitness between healthy population and patients with coronary heart disease.
Table 4. Comparison of cardiorespiratory fitness between healthy population and patients with coronary heart disease.
MenWomen
HealthyCHD HealthyCHD
AgeVO2max
(mL/kg/min)
Mean ± SD		NVO2max
(mL/kg/min)
Mean ± SD		Np-valueVO2max
(mL/kg/min)
Mean ± SD		NVO2max
(mL/kg/min)
Mean ± SD		Np-value
19–2942.3 ± 6.3209 34.3 ± 4.3110
30–3942.0 ± 5.017028.6 ± 5.07<0.00132.2 ± 4.5211 0.014
40–4941.4 ± 5.623828.3 ± 5.552<0.00130.8 ± 4.628424.2 ± 3.03<0.001
50–5938.0 ± 5.727425.9 ± 5.2128<0.00128.3 ± 4.636723.1 ± 4.119<0.001
60–6932.4 ± 6.213425.5 ± 5.2125<0.00126.0 ± 5.733622.3 ± 3.846<0.001
70–7927.2 ± 5.68321.9± 5.473<0.00123.9 ± 4.419518.0± 3.929<0.001
>8024.1 ± 4.01120.0 ± 5.5100.06821.0 ± 3.72413.5 ± 3.240.001
Data are presented as mean ± standard deviation. Independent-sample t-test was used to compare CRF in healthy population and CRF in CHD patients. CHD, coronary heart disease; SD, standard deviation; VO2max, maximal oxygen uptake; N, number.

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MDPI and ACS Style

Jang, W.Y.; Kim, W.; Kang, D.O.; Park, Y.; Lee, J.; Choi, J.Y.; Roh, S.-Y.; Na, J.O.; Choi, C.U.; Rha, S.-W.; et al. Reference Values for Cardiorespiratory Fitness in Healthy Koreans. J. Clin. Med. 2019, 8, 2191. https://doi.org/10.3390/jcm8122191

AMA Style

Jang WY, Kim W, Kang DO, Park Y, Lee J, Choi JY, Roh S-Y, Na JO, Choi CU, Rha S-W, et al. Reference Values for Cardiorespiratory Fitness in Healthy Koreans. Journal of Clinical Medicine. 2019; 8(12):2191. https://doi.org/10.3390/jcm8122191

Chicago/Turabian Style

Jang, Won Young, Woohyeun Kim, Dong Oh Kang, Yoonjee Park, Jieun Lee, Jah Yeon Choi, Seung-Young Roh, Jin Oh Na, Cheol Ung Choi, Seung-Woon Rha, and et al. 2019. "Reference Values for Cardiorespiratory Fitness in Healthy Koreans" Journal of Clinical Medicine 8, no. 12: 2191. https://doi.org/10.3390/jcm8122191

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