Retinal OCT Findings in Patients after COVID Infection
Abstract
:1. Introduction
2. Materials and Methods
3. Statistical Analysis
4. Results
Study Group Results
5. Correlations
6. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
- Zheng, Y.-Y.; Ma, Y.-T.; Zhang, J.-Y.; Xie, X. COVID-19 and the cardiovascular system. Nat. Rev. Cardiol. 2020, 17, 259–260. [Google Scholar] [CrossRef] [Green Version]
- Soiza, R.L.; Donaldson, A.I.C.; Myint, P.K. Vaccine against arteriosclerosis: An update. Ther. Adv. Vaccines 2018, 9, 259–261. [Google Scholar]
- Gupta, A.; Madhavan, M.V.; Sehgal, K.; Nair, N.; Mahajan, S.; Sehrawat, T.S.; Bikdeli, B.; Ahluwalia, N.; Ausiello, J.C.; Wan, E.Y.; et al. Extrapulmonary manifestations of COVID-19. Nat. Med. 2020, 26, 1017–1032. [Google Scholar] [CrossRef] [PubMed]
- Abrishami, M.; Emamverdian, Z.; Shoeibi, N.; Omidtabrizi, A.; Daneshvar, R.; Rezvani, T.S.; Saeedian, N.; Eslami, S.; Mazloumi, M.; Sadda, S.; et al. Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: A case-control study. Can. J. Ophthalmol. 2021, 56, 24–30. [Google Scholar] [CrossRef]
- Douglas, K.A.A.; Douglas, V.P.; Moschos, M.M. Ocular manifestations of COVID-19 (SARS-CoV-2): A critical review of current literature. In Vivo 2020, 34, 1619–1628. [Google Scholar] [CrossRef] [PubMed]
- Wyle˛gała, A.; Bolek, B.; Wyle˛gała, E. Trends in optical coherence tomography angiography use in university clinic and private practice setting between 2014–2018. Expert Rev. Med. Devices 2020, 10, 1106–1113. [Google Scholar]
- Wylęgała, A.; Teper, S.; Dobrowolski, D.; Wyle˛gała, E. Optical Coherence Angiography. Medicine 2016, 95, e4907. [Google Scholar] [CrossRef]
- Hazar, L.; Karahan, M.; Vural, E.; Ava, S.; Erdem, S.; Dursun, M.E.; Keklikçi, U. Macular vessel density in patients recovered from COVID-19 disease. Photodiagnosis Photodyn. Ther. 2021, 27, 102267. [Google Scholar]
- Invernizzi, A.; Torre, A.; Parrulli, S.; Zicarelli, F.; Schiuma, M.; Colombo, V.; Giacomelli, A.; Cigada, M.; Milazzo, L.; Ridolfo, A.; et al. Retinal findings in patients with COVID-19: Results from the SERPICO-19 study. EClinicalMedicine 2020, 27, 100550. [Google Scholar] [CrossRef]
- Burgos-Blasco, B.; Güemes-Villahoz, N.; Vidal-Villegas, B.; Martinez-De-La-Casa, J.M.; Donate-Lopez, J.; Martín-Sánchez, F.J.; González-Armengol, J.J.; Porta-Etessam, J.; Martin, J.L.R.; Garcia-Feijoo, J. Optic nerve and macular optical coherence tomography in recovered COVID-19 patients. Eur. J. Ophthalmol. 2021. [Google Scholar] [CrossRef]
- Abrishami, M.; Tohidinezhad, F.; Daneshvar, R.; Omidtabrizi, A.; Amini, M.; Sedaghat, A.; Amini, S.; Reihani, H.; Allahyari, A.; Seddigh-Shamsi, M.; et al. Ocular Manifestations of Hospitalized Patients with COVID-19 in Northeast of Iran. Ocul. Immunol. Inflamm. 2020, 28, 739–744. [Google Scholar] [CrossRef] [PubMed]
- Bostanci Ceran, B.; Ozates, S. Ocular manifestations of coronavirus disease 2019. Graefe’s Arch. Clin. Exp. Ophthalmol. 2020, 258, 1959–1963. [Google Scholar] [CrossRef] [PubMed]
- Ma, N.; Li, P.; Wang, X.; Yu, Y.; Tan, X.; Chen, P.; Li, S.; Jiang, F. Ocular Manifestations and Clinical Characteristics of Children With Laboratory-Confirmed COVID-19 in Wuhan, China. JAMA Ophthalmol. 2020, 138, 1079. [Google Scholar] [CrossRef]
- Meduri, A.; Oliverio, G.W.; Mancuso, G.; Giuffrida, A.; Guarneri, C.; Rullo, E.V.; Nunnari, G.; Aragona, P. Ocular surface manifestation of COVID-19 and tear film analysis. Sci. Rep. 2020, 10, 1–7. [Google Scholar] [CrossRef]
- Ortiz-Seller, A.; Costa, L.M.; Hernández-Pons, A.; Pascual, E.V.; Alemany, A.S.; Albert-Fort, M. Ophthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19). Ocul. Immunol. Inflamm. 2020, 28, 1285–1289. [Google Scholar] [CrossRef]
- Montesel, A.; Bucolo, C.; Mouvet, V.; Moret, E.; Eandi, C.M. Case Report: Central Retinal Artery Occlusion in a COVID-19 Patient. Front. Pharmacol. 2020, 11, 588384. [Google Scholar] [CrossRef]
- Benito-Pascual, B.; Gegúndez, J.A.; Díaz-Valle, D.; Arriola-Villalobos, P.; Carreño, E.; Culebras, E.; Rodríguez-Avial, I.; Benitez-Del-Castillo, J.M. Panuveitis and Optic Neuritis as a Possible Initial Presentation of the Novel Coronavirus Disease 2019 (COVID-19). Ocul. Immunol. Inflamm. 2020, 28, 922–925. [Google Scholar] [CrossRef]
- Pereira, L.A.; Soares, L.C.M.; Nascimento, P.A.; Cirillo, L.R.N.; Sakuma, H.T.; da Veiga, G.L.; Fonseca, F.L.A.; Lima, V.L.; Abucham-Neto, J.Z. Retinal findings in hospitalised patients with severe COVID-19. Br. J. Ophthalmol. 2020. [Google Scholar] [CrossRef]
- Marinho, P.M.; Marcos, A.A.A.; Romano, A.C.; Nascimento, H.; Belfort, R. Retinal findings in patients with COVID-19. Lancet 2020, 395, 1610. [Google Scholar] [CrossRef]
- Vavvas, D.G.; Sarraf, D.; Sadda, S.R.; Eliott, D.; Ehlers, J.P.; Waheed, N.K.; Morizane, Y.; Sakamoto, T.; Tsilimbaris, M.; Miller, J.B. Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication. Eye [Internet] 2020, 34, 2153–2154. [Google Scholar] [CrossRef] [PubMed]
- Providência, J.; Fonseca, C.; Henriques, F.; Proença, R. Serpiginous choroiditis presenting after SARS-CoV-2 infection: A new immunological trigger? Eur. J. Ophthalmol. 2020. [Google Scholar] [CrossRef] [PubMed]
- Sawalha, K.; Adeodokun, S.; Kamoga, G.-R. COVID-19-Induced Acute Bilateral Optic Neuritis. J. Investig. Med. High Impact Case Rep. 2020, 8. [Google Scholar] [CrossRef]
- Invernizzi, A.; Pellegrini, M.; Messenio, D.; Cereda, M.; Olivieri, P.; Brambilla, A.M.; Staurenghi, G. Impending Central Retinal Vein Occlusion in a Patient with Coronavirus Disease 2019 (COVID-19). Ocul. Immunol. Inflamm. 2020, 28, 1290–1292. [Google Scholar] [CrossRef]
- Landecho, M.F.; Yuste, J.R.; Gándara, E.; Sunsundegui, P.; Quiroga, J.; Alcaide, A.B.; García-Layana, A. COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? J. Intern. Med. 2021, 289, 116–120. [Google Scholar] [CrossRef]
- Savastano, A.; Crincoli, E.; Savastano, M.C.; Younis, S.; Gambini, G.; De Vico, U.; Cozzupoli, G.M.; Culiersi, C.; Rizzo, S. Gemelli Against COVID-19 Post-Acute Care Study Group Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients. J. Clin. Med. 2020, 9, 2895. [Google Scholar] [CrossRef]
- Hassan, M.; Sadiq, M.A.; Halim, M.S.; Afridi, R.; Soliman, M.K.; Sarwar, S.; Agarwal, A.; Do, D.V.; Nguyen, Q.D.; Sepah, Y.J. Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography. Int. J. Retin. Vitr. 2017, 3, 27. [Google Scholar] [CrossRef] [Green Version]
- Diniz-Filho, A.; Abe, R.; Zangwill, L.M.; Gracitelli, C.P.; Weinreb, R.N.; Girkin, C.A.; Liebmann, J.M.; Medeiros, F.A. Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography. Ophthalmology 2016, 123, 2058–2065. [Google Scholar] [CrossRef] [Green Version]
Number of Eyes | ||
---|---|---|
COVID | 78 | |
Control | 49 | |
Oxygen supplementation | ||
Yes | 26 | |
No | 52 | |
Hospitalization | ||
Yes | 26 | |
No | 52 | |
Gender | ||
Male | Female | |
COVID | 27 | 51 |
Control | 23 | 26 |
Mean | Std. Err | −95 | 95 | p Value | |
---|---|---|---|---|---|
RNFL | |||||
COVID | 107.24 | 1.6217 | 104.02 | 110.46 | |
Control | 100.49 | 2.1056 | 96.30 | 104.67 | 0.104 |
CMT | |||||
COVID | 253.69 | 3.8282 | 246.09 | 261.30 | |
Control | 267.51 | 4.9704 | 257.64 | 277.39 | 0.249 |
Angio-oct-SPD central | |||||
COVID | 20.291 | 0.3910 | 19.514 | 21.067 | |
Control | 19.755 | 0.5076 | 18.747 | 20.763 | 0.799 |
SPD-superior | |||||
COVID | 48.497 | 0.3407 | 47.821 | 49.174 | |
Control | 49.438 | 0.4423 | 48.560 | 50.316 | 0.767 |
SPD-inferior | |||||
COVID | 47.767 | 0.4684 | 46.836 | 48.697 | |
Control | 48.309 | 0.6081 | 47.101 | 49.517 | 0.526 |
SPD-nasal | |||||
COVID | 45.800 | 0.3073 | 45.189 | 46.410 | |
Control | 45.679 | 0.3990 | 44.886 | 46.471 | 0.403 |
SPD-temporal | |||||
COVID | 46.64 | 0.48 | 45.69 | 47.59 | |
Control | 46.54 | 0.47 | 45.60 | 47.48 | 0.582 |
FAZ | |||||
COVID | 354.64 | 15.038 | 324.78 | 384.51 | |
Control | 322.71 | 19.525 | 283.93 | 361.49 | 0.063 |
Age | |||||
COVID | 50.577 | 1.4776 | 47.630 | 53.524 | |
Control | 48.898 | 1.9009 | 45.076 | 52.720 | 0.640 |
Weeks from COVID | |||||
COVID Control | 6.360000 | 0.540817 | 5.282399 | 7.437601 | |
BCVA | |||||
COVID | 0.92 | 0.02 | 0.88 | 0.96 | |
Control | 0.99 | 0.02 | 0.95 | 1.04 | 0.220 |
BCVA logMAR | |||||
COVID | 0.07 | 0.02 | 0.02 | 0.11 | |
Control | 0.00 | 0.02 | −0.04 | 0.04 | 0.290 |
IOP | |||||
COVID | 14.61 | 0.32 | 13.97 | 15.26 | |
Control | 14.91 | 0.32 | 14.27 | 15.55 | 0.330 |
Variable | Age | sd Inferior | Gender | Weeks from COVID | Oxygen | Hos. | BCVA logMAR | IOP | Alterations | RNFL | CMT | Angio-oct-SPD Central | SPD-Superior | SPD-Inferior | SPD-Nasal | SPD-Temporal | FAZ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | - | 0.41 | 0.26 | 0.38 | 0.20 | 0.15 | 0.33 | −0.23 | 0.14 | 0.13 | −0.10 | −0.20 | −0.09 | 0.06 | −0.18 | 0.01 | 0.14 |
sd inferior | 0.41 | - | 0.33 | 0.09 | 0.11 | −0.04 | 0.19 | −0.23 | 0.34 | −0.23 | −0.04 | 0.11 | −0.20 | −0.07 | 0.05 | −0.50 | −0.62 |
Gender | 0.26 | 0.33 | - | 0.06 | 0.24 | 0.18 | 0.12 | −0.08 | 0.22 | −0.16 | −0.57 | −0.20 | 0.29 | 0.14 | 0.39 | 0.21 | −0.20 |
Weeks from covid | 0.38 | 0.09 | 0.06 | - | −0.24 | 0.00 | −0.27 | −0.32 | 0.12 | −0.06 | −0.23 | 0.05 | −0.12 | −0.17 | 0.23 | 0.06 | −0.17 |
Oxygen | 0.20 | 0.11 | 0.24 | −0.24 | - | 0.73 | 0.51 | −0.03 | −0.03 | 0.07 | −0.22 | −0.12 | 0.09 | −0.22 | −0.27 | −0.19 | −0.03 |
Hos. | 0.15 | −0.04 | 0.18 | 0.00 | 0.73 | - | 0.08 | 0.08 | 0.11 | 0.00 | −0.10 | −0.31 | −0.19 | −0.27 | −0.41 | −0.14 | 0.13 |
BCVA logMAR | 0.33 | 0.19 | 0.12 | −0.27 | 0.51 | 0.08 | - | 0.03 | −0.15 | 0.19 | 0.00 | 0.32 | 0.11 | −0.04 | −0.06 | 0.06 | −0.14 |
IOP | −0.23 | −0.23 | −0.08 | −0.32 | −0.03 | 0.08 | 0.03 | - | 0.19 | −0.48 | 0.13 | 0.06 | −0.01 | 0.08 | −0.04 | 0.32 | 0.44 |
alterations | 0.14 | 0.34 | 0.22 | 0.12 | −0.03 | 0.11 | −0.15 | 0.19 | - | −0.28 | −0.27 | −0.08 | −0.19 | 0.08 | −0.07 | −0.07 | −0.18 |
RNFL | 0.13 | −0.23 | −0.16 | −0.06 | 0.07 | 0.00 | 0.19 | −0.48 | −0.28 | - | 0.36 | 0.07 | −0.15 | −0.01 | −0.09 | 0.18 | 0.12 |
CMT | −0.10 | −0.04 | −0.57 | −0.23 | −0.22 | −0.10 | 0.00 | 0.13 | −0.27 | 0.36 | - | 0.06 | −0.51 | −0.13 | −0.14 | −0.04 | 0.25 |
angio-oct-SPD central | −0.20 | 0.11 | −0.20 | 0.05 | −0.12 | −0.31 | 0.32 | 0.06 | −0.08 | 0.07 | 0.06 | - | 0.10 | 0.10 | 0.29 | 0.05 | −0.39 |
SPD-superior | −0.09 | −0.20 | 0.29 | −0.12 | 0.09 | −0.19 | 0.11 | −0.01 | −0.19 | −0.15 | −0.51 | 0.10 | - | 0.69 | 0.38 | 0.49 | −0.10 |
SPD-inferior | 0.06 | −0.07 | 0.14 | −0.17 | −0.22 | −0.27 | −0.04 | 0.08 | 0.08 | −0.01 | −0.13 | 0.10 | 0.69 | - | 0.31 | 0.50 | 0.03 |
SPD-nasal | −0.18 | 0.05 | 0.39 | 0.23 | −0.27 | −0.41 | −0.06 | −0.04 | −0.07 | −0.09 | −0.14 | 0.29 | 0.38 | 0.31 | - | 0.42 | −0.34 |
SPD-temporal | 0.01 | −0.50 | 0.21 | 0.06 | −0.19 | −0.14 | 0.06 | 0.32 | −0.07 | 0.18 | −0.04 | 0.05 | 0.49 | 0.50 | 0.42 | - | 0.39 |
FAZ | 0.14 | −0.62 | −0.20 | −0.17 | −0.03 | 0.13 | −0.14 | 0.44 | −0.18 | 0.12 | 0.25 | −0.39 | −0.10 | 0.03 | −0.34 | 0.39 | - |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Szkodny, D.; Wylęgała, E.; Sujka-Franczak, P.; Chlasta-Twardzik, E.; Fiolka, R.; Tomczyk, T.; Wylęgała, A. Retinal OCT Findings in Patients after COVID Infection. J. Clin. Med. 2021, 10, 3233. https://doi.org/10.3390/jcm10153233
Szkodny D, Wylęgała E, Sujka-Franczak P, Chlasta-Twardzik E, Fiolka R, Tomczyk T, Wylęgała A. Retinal OCT Findings in Patients after COVID Infection. Journal of Clinical Medicine. 2021; 10(15):3233. https://doi.org/10.3390/jcm10153233
Chicago/Turabian StyleSzkodny, Dominika, Edward Wylęgała, Paulina Sujka-Franczak, Edyta Chlasta-Twardzik, Rafał Fiolka, Tomasz Tomczyk, and Adam Wylęgała. 2021. "Retinal OCT Findings in Patients after COVID Infection" Journal of Clinical Medicine 10, no. 15: 3233. https://doi.org/10.3390/jcm10153233