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Microorganisms
Volume 10
Issue 9
10.3390/microorganisms10091801
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Article
Peer-Review Record

Trends in Occurrence and Phenotypic Resistance of Coagulase-Negative Staphylococci (CoNS) Found in Human Blood in the Northern Netherlands between 2013 and 2019

Microorganisms 2022, 10(9), 1801; https://doi.org/10.3390/microorganisms10091801
by Matthijs S. Berends 1,2,*, Christian F. Luz 2, Alewijn Ott 1, Gunnar I. Andriesse 1, Karsten Becker 3,4, Corinna Glasner 2,† and Alex W. Friedrich 2,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Microorganisms 2022, 10(9), 1801; https://doi.org/10.3390/microorganisms10091801
Submission received: 17 August 2022 / Revised: 1 September 2022 / Accepted: 3 September 2022 / Published: 7 September 2022
(This article belongs to the Special Issue Characterisation and Molecular Analysis of Staphylococcal Species: Their Impact on Colonization and Infection)

Round 1

Reviewer 1 Report

This study entitled "" was carried out to determine a multi-year, full-region approach to comprehensively assess both occurrence and ABR patterns of CoNS species based on MALDI-TOF, however the following points should be addressed:

-Did authors calculate sample size prior sampling from patients.

-One limitation for this study that different Vitek cartridge were used for testing antimicrobial susceptibility. It is recommended to use the same cartridge for for testing isolates from different districts, labs to the same panel of antimicrobials.

-More details about how AMR package, R software, used to exclude and select isolates for their antimicrobial resistance patterns, should be given.

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Authors provide extensive retrospective study on antibiotic resistance of  CoNS isolated from blood cultures in 15 hospitals within the Northern Netherlands. It highlights the differentiation of this particular group of staphylococci and the resistance to species level. Although the study has some limitations as part of the routine work in the hospitals, it has laboratory and clinical  significance.

Suggestions:

- In the current title the origin of blood is not specified; for readers is important to understand at glans if the study would refer to human or animal blood cultures; please specify

- Keywords: coagulase-negative staphylococci (CoNS); antimicrobial resistance; Staphylococcus haemolyticus; Staphylococcus epidermidis; blood, humans, epidemiology; trends

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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