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Peer-Review Record

Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure

J. Pers. Med. 2023, 13(5), 860; https://doi.org/10.3390/jpm13050860
by Alessandra Stella Caporale 1,2,*, Marco Nezzo 3, Maria Giovanna Di Trani 4, Alessandra Maiuro 5,6, Roberto Miano 7, Pierluigi Bove 7, Alessandro Mauriello 8, Guglielmo Manenti 9 and Silvia Capuani 5,6,*
Reviewer 1: Anonymous
Reviewer 2:
J. Pers. Med. 2023, 13(5), 860; https://doi.org/10.3390/jpm13050860
Submission received: 10 April 2023 / Revised: 18 May 2023 / Accepted: 18 May 2023 / Published: 20 May 2023
(This article belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Round 1

Reviewer 1 Report

We consider this an interesting paper on prostate cancer detection on MRI diffusion-weighted images.

Since the subject is a prostate biopsy specimen, it is difficult to evaluate prostate cancer in areas that cannot be identified by MRI. I look forward to further findings.

The text is too long in general, could it be shortened a little?

Author Response

R1.1 We consider this an interesting paper on prostate cancer detection on MRI diffusion-weighted images. Since the subject is a prostate biopsy specimen, it is difficult to evaluate prostate cancer in areas that cannot be identified by MRI. I look forward to further findings.

R1.2 The text is too long in general, could it be shortened a little?

Response to R1.1. We thank the Reviewer for the positive comments on the manuscript. We agree with the Reviewer that it is most interesting and useful to investigate the direct correspondence between the biopsy specimens and high-resolution prostate MRI, which will be the object of future studies.

Response to R1.2. Following the Reviewer’s suggestion, we have tried condensing the writing in some portions of the manuscript, to improve its readability.

Reviewer 2 Report

The article is suitable for JPM and will be of interest to readers. The number of patients evaluated is small but it is an innovative topic in an exam that is increasingly widespread and can help improve the diagnosis of prostate cancer.

The text is well written and the tables and figures are illustrative.

Author Response

R2. The article is suitable for JPM and will be of interest to readers. The number of patients evaluated is small but it is an innovative topic in an exam that is increasingly widespread and can help improve the diagnosis of prostate cancer. The text is well written and the tables and figures are illustrative.

Response to R2. We thank the Reviewer for the positive comments on our manuscript.  

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