Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry
, Matilde Zamboni 4,†, Giovanni Sotgiu 5, Laura Saderi 5, Massimo Federici 6, Giuseppe M. Sangiorgi 7, Mariangela V. Puci 5, Allegra R. Martelli 8, Teresa Messina 9, Paolo Frigatti 10, Maria Pia Borrelli 10, Carlo Ruotolo 11, Ilaria Ficarelli 11, Paolo Rubino 12, Francesco Pezzo 12, Luciano Carbonari 13, Andrea Angelini 13, Edoardo Galeazzi 14, Luca Calia Di Pinto 14, Franco M. Fiore 15, Antonio Bozzani 17, Diego Moniaci 20, Nicola Troisi 21, Umberto M. Bracale 23, Mauro Di Bartolo 27, Giovanni Colacchio 30, Maurizio Taurino 33,34, Pasqualino Sirignano 1,34, Valerio S. Tolva 41, Luca Mezzetto 45, Fabio M. Oddi 7 and Alberto M. Settembrini 37add
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Round 1
Reviewer 1 Report
Interesting retrospective study on short and medium term results of CLTI treatment.
This multicentric and retrospective observational study gives interesting and new informations about outcome of CLTI.
The cases number is very high due to the high number of Vascular Surgery Departments, therefore the results are to be considered significant.
Author Response
We thank the reviewer very much for the work done in revising our manuscript, and for his/her appreciation of our study.
Reviewer 2 Report
This retrospective observational study is well designed, methods are clearly stated, statiystical analysis is adequate and the results are well reported. I have only minor comments/suggestions.
1. Have you considered correction for multiple hypothesis testing? If feasible, given the large number of tests in this study, I would suggest including a Bonferroni adjustment. If not feasible, it should be stated in the limitations.
2. Line 205/206: please provide exact thresholds applied for hyperlipemia
3. Line 425: I suggest replacing gangrene with tissue loss
Author Response
We thank you so much for your help in improving our manuscript # jpm-2116946“Sex-related differences and factors associated with peri-procedural and 1-year mortality in chronic limb-threatening ischemia patients from the CLIMATE Italian registry”.
Following our reply to the your comments.
- “Have you considered correction for multiple hypothesis testing? If feasible, given the large number of tests in this study, I would suggest including a Bonferroni adjustment. If not feasible, it should be stated in the limitations”.
AA: we thank the reviewer #2 for this suggestion: we did not use any Bonferroni corrections because we did not perform any multiple comparisons (i.e. post-hoc test) in our study.
- “Line 205/206: please provide exact thresholds applied for hyperlipemia”.
AA: we thank the reviewer #2 for this note: the cut-off value for hyperlipemia has been added.
- “Line 425: I suggest replacing gangrene with tissue loss"
AA: we thank the reviewer #2 for this suggestion: “gangrene” has been replaced with “tissue loss”, which is definitively more appropriate.
