A Body Shape Index (ABSI) as a Variant of Conicity Index Not Affected by the Obesity Paradox: A Cross-Sectional Study Using Arterial Stiffness Parameter
Abstract
:1. Introduction
2. Results
2.1. Clinical and Biochemical Characteristics of Male and Female Participants
2.2. Correlation of Each Adiposity Index with Age or CAVI by Obesity Grade
2.3. Discriminatory Power of Each Adiposity Index for High CAVI (≥9.0)
2.4. Waist Circumference Distribution Calculated from the Cutoff of Each Abdominal Obesity Index
2.5. Waist Circumference Calculator Chart Corresponding to Cutoff of ABSI
2.6. Correlation between Body Adiposity Indices
3. Discussion
4. Materials and Methods
4.1. Subjects and Design
4.2. Data Collection and Methods of Measurement
4.3. Measurement of CAVI as an Arterial Stiffness Parameter
4.4. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | All Subjects | Males | Females | p Value * |
---|---|---|---|---|
Number of subjects | 62,514 | 26,037 | 36,477 | - |
Age (years) | 42 (34–54) | 40 (33–51) | 45 (36–55) | <0.001 |
Height (m) | 1.62 (1.56–1.69) | 1.71 (1.67–1.75) | 1.57 (1.54–1.61) | <0.001 |
Body weight (kg) | 57.2 (50.1–66.6) | 66.9 (60.7–74.1) | 51.6 (47.2–57.0) | <0.001 |
BMI (kg/m2) | 21.7 (19.8–24.0) | 23.0 (21.2–25.2) | 20.8 (19.1–22.9) | <0.001 |
WC (m) | 0.78 (0.72–0.85) | 0.82 (0.76–0.89) | 0.75 (0.70–0.82) | <0.001 |
ABSI | 0.0785 (0.0757–0.0815) | 0.0778 (0.0754–0.0803) | 0.0791 (0.0760–0.0825) | <0.001 |
Conicity index | 1.21 (1.16–1.26) | 1.207 (1.16–1.25) | 1.210 (1.15–1.26) | 0.012 |
WHtR | 0.480 (0.444–0.521) | 0.484 (0.449–0.520) | 0.477 (0.441–0.521) | <0.001 |
WC/BMI ratio | 0.0358 (0.0342–0.0375) | 0.0357 (0.0342–0.0372) | 0.0360 (0.0342–0.0378) | <0.001 |
CAVI | 7.3 (6.8–8.0) | 7.3 (6.8–8.0) | 7.3 (6.8–8.0) | <0.001 |
SBP (mmHg) | 120 (111–130) | 124 (116–132) | 118 (108–128) | <0.001 |
DBP (mmHg) | 70 (64–78) | 74 (67–81) | 68 (62–76) | <0.001 |
FPG (mg/dL) | 84 (79–90) | 86 (81–91) | 82 (78–88) | <0.001 |
TG (mg/dL) | 76 (54–113) | 96 (67–146) | 66 (49–93) | <0.001 |
HDL-C (mg/dL) | 67 (56–80) | 58 (49–69) | 74 (63–86) | <0.001 |
No. of Subjects | BMI | WC | ABSI | Conicity Index | WHtR | WC/BMI Ratio | ||
---|---|---|---|---|---|---|---|---|
With Age | ||||||||
Total | 62,514 | Rs | 0.111 | 0.203 | 0.389 | 0.387 | 0.346 | 0.128 |
95% CI | 0.103–0.119 | 0.195–0.211 | 0.382–0.396 | 0.380–0.394 | 0.339–0.353 | 0.120–0.136 | ||
BMI < 20 kg/m2 | 17,570 | Rs | 0.044 | 0.197 | 0.322 | 0.326 | 0.355 | 0.186 |
95% CI | 0.029–0.059 | 0.182–0.211 | 0.308–0.336 | 0.312–0.339 | 0.342–0.369 | 0.171–0.200 | ||
20 ≤ BMI < 25 kg/m2 | 33,695 | Rs | 0.082 | 0.241 | 0.426 | 0.430 | 0.463 | 0.215 |
95% CI | 0.071–0.092 | 0.230–0.251 | 0.417–0.435 | 0.421–0.439 | 0.454–0.471 | 0.204–0.225 | ||
25 ≤ BMI < 30 kg/m2 | 9532 | Rs | −0.065 | 0.116 | 0.386 | 0.369 | 0.382 | 0.192 |
95% CI | −0.085–−0.044 | 0.095–0.136 | 0.369–0.404 | 0.351–0.387 | 0.365–0.400 | 0.172–0.211 | ||
30 kg/m2 ≤ BMI | 1717 | Rs | −0.139 | 0.002 | 0.296 | 0.266 | 0.278 | 0.132 |
95% CI | −0.187–−0.090 | −0.048–0.051 | 0.250–0.340 | 0.220–0.311 | 0.232–0.323 | 0.084–0.181 | ||
With CAVI | ||||||||
Total | 62,514 | Rs | 0.034 | 0.149 | 0.332 | 0.305 | 0.217 | 0.197 |
95% CI | 0.026–0.042 | 0.141–0.156 | 0.325–0.340 | 0.298–0.312 | 0.209–0.225 | 0.189–0.205 | ||
BMI < 20 kg/m2 | 17,570 | Rs | 0.001 | 0.193 | 0.291 | 0.287 | 0.263 | 0.221 |
95% CI | −0.014–0.016 | 0.179–0.208 | 0.277–0.305 | 0.273–0.301 | 0.249–0.278 | 0.207–0.236 | ||
20 ≤ BMI < 25 kg/m2 | 33,695 | Rs | 0.058 | 0.250 | 0.364 | 0.365 | 0.342 | 0.250 |
95% CI | 0.047–0.069 | 0.239–0.260 | 0.354–0.373 | 0.356–0.375 | 0.332–0.352 | 0.240–0.261 | ||
25 ≤ BMI < 30 kg/m2 | 9532 | Rs | -0.106 | 0.114 | 0.309 | 0.286 | 0.229 | 0.229 |
95% CI | −0.127–−0.086 | 0.094–0.135 | 0.290–0.328 | 0.267–0.305 | 0.210–0.249 | 0.209–0.248 | ||
30 kg/m2 ≤ BMI | 1717 | Rs | −0.183 | 0.037 | 0.260 | 0.221 | 0.138 | 0.223 |
95% CI | −0.230–−0.134 | −0.012–0.086 | 0.213–0.305 | 0.173–0.267 | 0.089–0.186 | 0.175–0.269 |
Index | Cutoff | C-Statistic | 95% CI | p Value |
---|---|---|---|---|
BMI (kg/m2) | 21.6 | 0.521 | 0.513–0.530 | <0.001 |
WC (m) | 0.799 | 0.597 | 0.589–0.605 | <0.001 |
ABSI | 0.0801 | 0.714 | 0.706–0.721 | <0.001 |
Conicity index | 1.23 | 0.700 | 0.692–0.707 | <0.001 |
WHtR | 0.491 | 0.645 | 0.637–0.653 | <0.001 |
WC/BMI ratio | 0.0362 | 0.627 | 0.619–0.636 | <0.001 |
Combination of Indices | Rs | 95% CI | p Value |
---|---|---|---|
BMI vs. WC | 0.870 | 0.868–0.872 | <0.001 |
BMI vs. ABSI | 0.063 | 0.054–0.071 | <0.001 |
BMI vs. Conicity index | 0.440 | 0.433–0.446 | <0.001 |
BMI vs. WC/BMI ratio | −0.551 | −0.557–−0.545 | <0.001 |
BMI vs. WHtR | 0.812 | 0.809–0.814 | <0.001 |
WC vs. ABSI | 0.465 | 0.458–0.471 | <0.001 |
WC vs. Conicity index | 0.766 | 0.763–0.769 | <0.001 |
WC vs. WC/BMI | −0.107 | −0.115–−0.099 | <0.001 |
WC vs. WHtR | 0.893 | 0.892–0.895 | <0.001 |
ABSI vs. Conicity index | 0.909 | 0.907–0.910 | <0.001 |
ABSI vs. WC/BMI ratio | 0.674 | 0.669–0.678 | <0.001 |
ABSI vs. WHtR | 0.553 | 0.547–0.558 | <0.001 |
Conicity index vs. WC/BMI ratio | 0.372 | 0.365–0.379 | <0.001 |
Conicity index vs. WHtR | 0.827 | 0.824–0.829 | <0.001 |
WC/BMI ratio vs. WHtR | −0.166 | −0.174–−0.158 | <0.001 |
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Nagayama, D.; Fujishiro, K.; Watanabe, Y.; Yamaguchi, T.; Suzuki, K.; Saiki, A.; Shirai, K. A Body Shape Index (ABSI) as a Variant of Conicity Index Not Affected by the Obesity Paradox: A Cross-Sectional Study Using Arterial Stiffness Parameter. J. Pers. Med. 2022, 12, 2014. https://doi.org/10.3390/jpm12122014
Nagayama D, Fujishiro K, Watanabe Y, Yamaguchi T, Suzuki K, Saiki A, Shirai K. A Body Shape Index (ABSI) as a Variant of Conicity Index Not Affected by the Obesity Paradox: A Cross-Sectional Study Using Arterial Stiffness Parameter. Journal of Personalized Medicine. 2022; 12(12):2014. https://doi.org/10.3390/jpm12122014
Chicago/Turabian StyleNagayama, Daiji, Kentaro Fujishiro, Yasuhiro Watanabe, Takashi Yamaguchi, Kenji Suzuki, Atsuhito Saiki, and Kohji Shirai. 2022. "A Body Shape Index (ABSI) as a Variant of Conicity Index Not Affected by the Obesity Paradox: A Cross-Sectional Study Using Arterial Stiffness Parameter" Journal of Personalized Medicine 12, no. 12: 2014. https://doi.org/10.3390/jpm12122014