Direct-Acting Antivirals and the Risk of Hepatitis B Reactivation in Hepatitis B and C Co-Infected Patients: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Search Strategy
2.2. Study Selection
2.3. Data Extraction and Quality Assessment
2.4. Statistical Analysis
3. Results
3.1. Baseline Characteristics of Included Studies
3.2. DAA-Associated HBV Reactivation in HBsAg (+) Patients
3.3. Subgroup Analysis
3.4. DAA-Associated HBV Reactivation in Resolved HBV Patients
3.5. Risk of Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Author, Year | Country | Study Design | Population | HBsAg(+) Population | HBsAg(−), Anti-HBc(+) Population | Genotype | DAA |
---|---|---|---|---|---|---|---|
Wahle 2015 [14] | Brazil | Retrospective | 10 | 10 | 0 | NA | DAA |
Gane 2016 [15] | USA | Prospective | 8 | 8 | NA | 1 | LDV/SOF |
Wang 2016 [16] | China | Prospective | 355 | 10 | 1,2,3,6 | SOF + DCV/LDV + SOF/OMB + PTR + DAS | |
Sulkowski 2016 [17] | Taiwan/Korea | Prospective | 178 | 0 | 103 | NA | LDV + SOF |
Kim 2017 [18] | Korea | Prospective | 821 | 13 | NA | NA | DAA |
Londono 2017 [19] | Spain | Prospective | 352 | 10 | 64 | 1,2,3,4 | OBV/PTV ± DSV ± RBV LDV/SOF ± RBV DCV/SOF ± RBV SOF + RBV DCV/SMV |
Kawagishi 2017 [20] | Japan | Retrospective | 85 | 1 | 82 | 1,2 | LDV/SOF DCV/ASV SOF + RBV |
Wang 2017 [21] | China | Prospective | 327 | 10 | 124 | 1,2 | LDV/SOF, DCV/SOF, OBV/PTV + DSV |
Tamori 2017 [22] | Japan | Prospective | 160 | 25 | 765 | 1,2 | LDV/SOF DCV/ASV OMB/PTR SOF + RBV |
Coppola 2017 [23] | Italy | Prospective | 16 | 16 | 0 | NA | DAA |
Ancha 2017 [24] | USA | Retrospective | 941 | 0 | 188 | NA | DAA |
Hayashi 2017 [25] | Japan | Retrospective | 256 | 17 | 80 | NA | DAA |
Yeh 2017 [26] | Taiwan | Prospective | 64 | 7 | 57 | NA | LDV/SOF ± RBV, SOF + RBV, OMB/PrOD |
Liu 2017 [27] | Taiwan | Prospective | 93 | 12 | 81 | 1,2 | LDV/SOF, LDV/SOF + RBV, SOF + RBV, PrOD, PrOD+RBV |
Doi 2017 [28] | Japan | Prospective | 461 | 4 | 75 | 1,2 | DAA |
Ogawa 2017 [29] | Japan | Retrospective | 183 | 2 | 63 | 1,2 | LDV, SOF |
Mucke 2017 [30] | Germany | Prospective | 848 | 9 | 272 | 1,2,3,4 | LDV, SOF RBV, OBV/PTV + DSV RBV, DCV, SOF + RBV |
Loggi 2017 [31] | Italy | Prospective | 137 | 2 | 42 | 1,2,3,4 | SOF ± RBV, SOF + LDV ± RBV, SOF + SMV ± RBV, PrOD ± RBV |
Macera 2017 [32] | Italy | Prospective | 29 | 29 | 0 | NA | DAA |
Belperio 2017 [33] | USA | Retrospective | 62290 | 377 | 7295 | NA | DAA |
Tang 2017 [34] | Unknown | Unknown | 192 | 0 | NA | LDV/SOF, PrOD, SOF/VEL, GZR/EBR | |
Calvaruso 2018 [35] | Italy | Retrospective | 104 | 8 | 37 | 1,2,3,4 | LDV/SOF ± RBV DCV/SOF + RBV SMV/SOF + RBV OBV/PTV/DSV + RBV SOF + RBV |
Yanny 2018 [36] | USA | Retrospective | 283 | 156 | 127 | 1,4 | LDV + SOF |
Preda 2018 [37] | Romania | Prospective | 2070 | 15 | NA | 1 | OBV/PTV/DSV + RBV |
Butt 2018 [38] | USA | Retrospective | DAA:34632, PEG:23475 | DAA group:3322, PEG:1751 | DAA:9343, PEG:5005 | NA | SOF/SMV, SOF/LDV, PrOD, SOF/RBV |
Lee 2018 [39] | Taiwan | Retrospective | 153 | 11 | 53 | 1,2 | SOF + LDV, PrOD, DCV + ASV |
Park 2018 [40] | Korea | Retrospective | 62 | 62 | NA | NA | IFN: 34, DAA:24 |
D’Ambrosio 2018 [41] | Italy | Prospective | 692 | 10 | 301 | 1 | DAA |
Figueiredo 2018 [42] | Portugal | Prospective | 329 | 2 | 123 | NA | DAA |
Wang 2018 [16] | China | Prospective | 111 | 111 | 0 | 1,2 | LDV/SOF |
Liu 2018 [43] | Taiwan | Prospective | 111 | 110 | 0 | 1,2 | LDV + SOF |
Ahmed 2019 [44] | Egypt | Prospective | 20 | 16 | 20 | NA | SOF + DAC + RBV: SOF + DAC:7, SOF + SIM:5 |
Mucke 2019 [45] | Germany | Prospective | 822 | 9 | 263 | 1,2,3,4 | LDV, SOF ± RBV, OBV/PTV + RBV, OBV/PTV+DSV ± RBV, SMV, SOF ± RBV, DCV, SOF ± RBV,SOF + RBV |
Osman 2019 [46] | Egypt | Prospective | 140 | 140 | NA | SOF + DCV | |
GutierrezGarcia 2019 [47] | Spain | Prospective | 1337 | 7 | 356 | NA | DAA |
Tahir 2019 [48] | Pakistan | Retrospective | 260 | 0 | 51 | NA | DAA |
Nagaty 2020 [49] | Egypt | Prospective | 287 | 3 | 38 | NA | SOF + DCV, SOF + DCV + RBV |
Jaroszewicz 2020 [50] | Poland | Retrospective | 10152 | 111 | 1239 | 1,3,4 | OBV/PTV/RBV ± DSV ± RBV, SOF, GZR/EBR ± RBV |
Xu 2020 [51] | China | Prospective | 113 | 12 | 0 | 1,2,3 | SOF/VEL |
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Oh, J.H.; Park, D.A.; Ko, M.J.; Yoo, J.-J.; Yim, S.Y.; Ahn, J.-H.; Jun, D.W.; Ahn, S.B. Direct-Acting Antivirals and the Risk of Hepatitis B Reactivation in Hepatitis B and C Co-Infected Patients: A Systematic Review and Meta-Analysis. J. Pers. Med. 2022, 12, 1957. https://doi.org/10.3390/jpm12121957
Oh JH, Park DA, Ko MJ, Yoo J-J, Yim SY, Ahn J-H, Jun DW, Ahn SB. Direct-Acting Antivirals and the Risk of Hepatitis B Reactivation in Hepatitis B and C Co-Infected Patients: A Systematic Review and Meta-Analysis. Journal of Personalized Medicine. 2022; 12(12):1957. https://doi.org/10.3390/jpm12121957
Chicago/Turabian StyleOh, Joo Hyun, Dong Ah Park, Min Jung Ko, Jeong-Ju Yoo, Sun Young Yim, Ji-Hyun Ahn, Dae Won Jun, and Sang Bong Ahn. 2022. "Direct-Acting Antivirals and the Risk of Hepatitis B Reactivation in Hepatitis B and C Co-Infected Patients: A Systematic Review and Meta-Analysis" Journal of Personalized Medicine 12, no. 12: 1957. https://doi.org/10.3390/jpm12121957