Ultra-High Frequency Ultrasound Imaging of Bowel Wall in Hirschsprung’s Disease—Correlation and Agreement Analyses of Histoanatomy
, Magnus Cinthio 2 and Pernilla Stenström 1,*
Round 1
Reviewer 1 Report
Dear Authors
This is an interesting paper.
I would like the Authors to highlight the learning curve needed to be confident in diagnosing HD with US. It would be also interesting to see if a multicentre study is potentially needed. This is an important point as could help many colleagues that don't have pathologists on site.
It is important to have long terms outcomes in a follow-up paper.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript addresses the relevant issue of bowel wall evaluation in Hirschsprung’s disease. There are few minor issues requiring authors' attention:
- UHFUS imaging section should report the acquisition protocol employed, including technical parameters (gain, TGC, etc..)
- Please report how calibration between the two paediatric surgeons was performed (prior to study beginning on samples not included in the study?), and the Cohen kappa value.
- Please specify how the ROI was selected on UHFUS images.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
