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Diagnostics
Volume 13
Issue 3
10.3390/diagnostics13030444
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Interesting Images
Peer-Review Record

COVID-19-Associated Erythema Nodosum Detected on FDG PET/CT

Diagnostics 2023, 13(3), 444; https://doi.org/10.3390/diagnostics13030444
by Nora Eberfalvi Lipositsne * and Kirsten Bouchelouche
Reviewer 1:
Marie France Bellin
Reviewer 2:
Lorenzo Faggioni
Reviewer 3:
Marco Fogante
Reviewer 4: Anonymous
Diagnostics 2023, 13(3), 444; https://doi.org/10.3390/diagnostics13030444
Submission received: 16 December 2022 / Revised: 19 January 2023 / Accepted: 23 January 2023 / Published: 26 January 2023
(This article belongs to the Topic F-18 FDG PET/CT Imaging)

Round 1

Reviewer 1 Report

The paper entitled “COVID-19 associated…. FDG PET/CT” is a short and well written case report. It is original because it is the first description of the FDG PET/CT aspect of a case of erythema nodosum related to COVID 19.  The length of the paper is correct, it is easy to follow. The Discussion section is logically constructed. The English is correct, there is no spelling error. The references are OK.  The images are of good quality.

In conclusion, the scope of this short case report is limited but the paper is original and well written.  

Author Response

Please see the attached document.

Thank you.

Author Response File: Author Response.pdf

Reviewer 2 Report

I have a few minor comments regarding this interesting case report:

-It would be worthwhile adding, if available, a patient's picture showing the erythematous nodules related to EN.

-A follow-up lung CT image at the same level of the PET/CT image shown in Figure 1 would be needed to show remission of lung alterations.

Author Response

Please see the attached document.

Thank you.

Author Response File: Author Response.pdf

Reviewer 3 Report

The author reported a case of a 69-year-old woman with erythema nodosum diagnosed by 18F-FDG PET/CT probably

secondary to COVID-19 infection.

The case presented is interesting.

However, I suggest improving it by developing the main topic better. A broader discussion of cases of cutaneous and non-cutaneous pathologies developed after COVID-19 infection and studied by nuclear medicine examination could be useful. Moreover, I also suggest being less definitive about whether erythema nodosum is due to COVID-19.

Author Response

Please see the attached document.

Thank you.

Author Response File: Author Response.pdf

Reviewer 4 Report

"The lung infiltrates were caused by COVID-19 infection with typical presentation on 18F-FDG PET/CT " The most common lung involvement by COVID-19 is instead GGO [doi: 10.1007/s11604-020-01010-7.], this aspect should be better explained

Proposed an explanatory hypothesis for EN related to a previous COVID-19 infection: an immune-mediated reaction, for example?

 

Author Response

Please see the attached document.

Thank you.

Author Response File: Author Response.pdf

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