Preoperative Transient Elastography in Patients with Esophageal Cancer
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Design and Patient Inclusion
2.2. Surgical Procedures
2.3. Transient Elastography
2.4. Perioperative Outcomes
2.5. Statistical Analysis
3. Results
3.1. Patient Characteristics and Surgical Parameters
3.2. Perioperative Outcomes
3.3. The Validity to Predict the Rate of Postoperative Complications and 180-Day Mortality
3.4. The Fluctuation of Liver Enzymes during the Perioperative Period
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Mild (n = 92) | Sever (n = 15) | p-Value |
---|---|---|---|
Age, mean ± std | 57.0 ± 8.9 | 54.3 ± 5.5 | 0.12 b |
Sex, male, n (%) | 87 (94.6%) | 15 (100%) | 1.00 c |
Tumor histology, n (%) | 1.00 c | ||
SCC | 83 (90.2%) | 14 (93.3%) | |
Adenocarcinoma | 9 (9.7%) | 1 (6.7%) | |
Tumor location, n (%) | 0.42 c | ||
Upper third | 9 (9.8%) | 2 (13.3%) | |
Middle third | 43 (46.7%) | 4 (26.7%) | |
Lower third | 38 (40.3%) | 9 (60.0%) | |
ECJ | 2 (2.2%) | 0 (0.0%) | |
Clinical stage a, n (%) | 0.60 c | ||
I | 7 (7.6%) | 2 (13.3%) | |
II | 10 (10.9%) | 1 (6.7%) | |
III | 59 (63.1%) | 8 (53.3%) | |
IV | 16 (17.4%) | 4 (26.7%) | |
Preoperative CCRT, n (%) | 0.13 c | ||
Yes | 79 (85.9%) | 10 (66.7%) | |
No | 13 (14.1%) | 5 (33.3%) | |
Postoperative laboratory test, median (q1, q3) | |||
AST (U/L) | 36.5 (27.0, 48.0) | 28.0 (22.0, 41.0) | 0.12 d |
ALT (U/L) | 27.0 (18.0, 42.0) | 19.0 (13.0, 27.0) | 0.02 d |
Total bilirubin (mg/dL) | 0.4 (0.3, 0.6) | 0.5 (0.3, 0.6) | 0.55 d |
Albumin (g/dL) | 4.2 (3.9, 4.5) | 4.2 (4.0, 4.5) | 0.93 d |
INR | 1.0 (1.0, 1.1) | 1.1 (1.0, 1.1) | 1.00 d |
Variables | Mild (n = 92) | Sever (n = 15) | p-Value |
---|---|---|---|
Operation time (minutes), median (q1, q3) | |||
448.5 (409.5, 511.0) | 474.0 (426.0, 510.0) | 0.25 d | |
Blood loss (mL), median (q1, q3) | |||
67.5 (50.0, 150.0) | 100.0 (70.0, 105.0) | 0.32 d | |
Surgical type of thoracic part, n (%) | 1.00 c | ||
VATS | 45 (48.9%) | 7 (46.7%) | |
RATS | 47 (51.1%) | 8 (53.3%) | |
Conversion of abdominal part, yes, n (%) | 1 (1.1%) | 1 (6.7%) | 0.26 c |
Thoracic duct ligation, n (%) | 71 (77.2%) | 11 (73.3%) | 0.75 c |
Reconstruction route, n (%) | 1.00 c | ||
Retrosternal | 80 (87.0%) | 13 (86.7%) | |
Posterior mediastinum | 12 (13.0%) | 2 (13.3%) | |
Pathology stage a, n (%) | 0.11 c | ||
I | 50 (54.4%) | 6 (40.0%) | |
II | 21 (22.8%) | 3 (20.0%) | |
III | 20 (21.7%) | 4 (26.7%) | |
IV | 1 (1.1%) | 2 (13.3%) |
Variables | Mild (n = 92) | Sever (n = 15) | p-Value |
---|---|---|---|
Reintubation, yes, n (%) | 2 (2.2%) | 1 (6.7%) | 0.36 c |
Readmission to ICU, yes, n (%) | 6 (6.5%) | 2 (13.3%) | 0.31 c |
Pneumonia, yes, n (%) | 9 (9.8%) | 2 (13.3%) | 0.65 c |
Leakage from anastomosis, yes, n (%) | 14 (15.2%) | 2 (13.3%) | 1.00 c |
Pleural effusion, yes, n (%) | 14 (15.2%) | 6 (40.0%) | 0.03 c |
Major complication a, yes, n (%) | 33 (35.9%) | 7 (46.7%) | 0.57 c |
LOS (days), median (q1, q3) | 13 (11, 17) | 14 (12, 22) | 0.42 d |
In-hospital mortality, yes, n (%) | 1 (1.1%) | 0 (0.0%) | 1.00 c |
Variables | <10% (n = 57) | ≥10% (n = 17) | p-Value c |
---|---|---|---|
Reintubation, yes, n (%) | 2 (3.5%) | 0 (0.0%) | 1.00 |
Readmission to ICU, yes, n (%) | 4 (7.0%) | 0 (0.0%) | 0.57 |
Pneumonia, yes, n (%) | 7 (12.3%) | 0 (0.0%) | 0.19 |
Leakage from anastomosis, yes, n (%) | 8 (14.0%) | 2 (11.8%) | 1.00 |
Pleural effusion, yes, n (%) | 12 (21.1%) | 1 (5.8%) | 0.28 |
Major complication a, yes, n (%) | 21 (35.1%) | 5 (29.4%) | 0.78 |
In-hospital mortality, yes, n (%) | 1 (1.8%) | 0 (0.0%) | 1.00 |
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Yang, T.-Y.; Shih, C.-P.; Huang, P.-C.; Tsai, C.-Y.; Chao, Y.-K. Preoperative Transient Elastography in Patients with Esophageal Cancer. Diagnostics 2022, 12, 3194. https://doi.org/10.3390/diagnostics12123194
Yang T-Y, Shih C-P, Huang P-C, Tsai C-Y, Chao Y-K. Preoperative Transient Elastography in Patients with Esophageal Cancer. Diagnostics. 2022; 12(12):3194. https://doi.org/10.3390/diagnostics12123194
Chicago/Turabian StyleYang, Tzu-Yi, Chia-Pang Shih, Pei-Ching Huang, Chun-Yi Tsai, and Yin-Kai Chao. 2022. "Preoperative Transient Elastography in Patients with Esophageal Cancer" Diagnostics 12, no. 12: 3194. https://doi.org/10.3390/diagnostics12123194