Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Colon Cancer from Primary Tumor and Liver Metastasis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Collection and Preparation of Samples
2.2. Spatial Transcriptomic Analysis
2.3. IHC Staining of TSPAN8 Protein in Primary and Metastatic Liver Tissues of Stage 4 CC
3. Results
3.1. Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Primary CC Tissues
3.2. Spatially Resolved Differential Gene Expression Levels of Tetraspanins in Primary and Metastatic Liver Tissues of Stage 4 CC
3.3. IHC Staining of TSPAN8 Protein in Primary and Metastatic Liver Tissues of Stage 4 CC
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Suwatthanarak, T.; Thanormjit, K.; Suwatthanarak, T.; Acharayothin, O.; Methasate, A.; Chinswangwatanakul, V.; Tanjak, P. Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Colon Cancer from Primary Tumor and Liver Metastasis. Life 2024, 14, 126. https://doi.org/10.3390/life14010126
Suwatthanarak T, Thanormjit K, Suwatthanarak T, Acharayothin O, Methasate A, Chinswangwatanakul V, Tanjak P. Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Colon Cancer from Primary Tumor and Liver Metastasis. Life. 2024; 14(1):126. https://doi.org/10.3390/life14010126
Chicago/Turabian StyleSuwatthanarak, Thanawat, Kullanist Thanormjit, Tharathorn Suwatthanarak, Onchira Acharayothin, Asada Methasate, Vitoon Chinswangwatanakul, and Pariyada Tanjak. 2024. "Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Colon Cancer from Primary Tumor and Liver Metastasis" Life 14, no. 1: 126. https://doi.org/10.3390/life14010126