The Duality of Adiponectin: The Role of Sex in Atherosclerosis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Model
2.2. Aortic Plaque Measurement
2.3. Cytokine, Chemokines, and Lipids Measurements
2.4. Statistics
3. Results
3.1. Plaque Is Reduced in Adiponectin-Deficient Males and Increased in Females
3.2. Adiponectin Has Sex-Dependent Effects on Inflammation
3.3. Plaque Area in the Aortic Tree Correlates with MCP1 Expression
3.4. Adiponectin Deficiency Promotes Atherosclerosis in Both Sexes during Aging
4. Discussion
Limitations
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | n | Mean | SD | % Plaque Area (arch) | % Plaque Area (desc) |
---|---|---|---|---|---|
CHOL | 33 | 131.36 | 52.26 | −0.291 | 0.192 |
ALT | 33 | 22.30 | 17.91 | −0.238 | −0.206 |
AST | 33 | 37.67 | 28.23 | 0.203 | 0.159 |
Glu | 29 | 27.41 | 11.31 | −0.166 | 0.115 |
G-CSF | 29 | 968.37 | 839.28 | 0.331 | 0.074 |
Eotaxin | 32 | 2212.93 | 626.40 | −0.126 | 0.033 |
estradiol | 26 | 0.22 | 0.20 | 0.349 | −0.152 |
IL1α | 29 | 507.76 | 516.39 | −0.452 * | −0.27 |
IL2 | 24 | 3.34 | 1.54 | 0.091 | 0.073 |
IL4 | 29 | 0.78 | 0.33 | 0.362 | 0.498 ** |
IL5 | 28 | 15.14 | 11.65 | 0.391 * | 0.108 |
IL6 | 27 | 28.63 | 23.94 | 0.159 | 0.225 |
IL9 | 24 | 99.94 | 30.17 | −0.348 | 0.156 |
IL13 | 29 | 91.65 | 27.85 | −0.075 | 0.133 |
IL17 | 30 | 5.46 | 4.31 | −0.497 ** | −0.121 |
IP-10/CXCL10 | 29 | 361.60 | 39.98 | 0.326 | 0.265 |
KC/CXCL1 | 30 | 199.51 | 94.44 | 0.237 | 0.049 |
LIX/CXCL5 | 32 | 14,464.27 | 8165.76 | −0.303 | −0.349 |
MCP1 | 27 | 188.14 | 107.77 | 0.615 ** | 0.426 * |
MIP1α/CCL3 | 30 | 102.33 | 50.15 | 0.287 | 0.218 |
MIP2/CXCL2 | 29 | 158.25 | 36.42 | −0.035 | −0.064 |
MIG/CXCL9 | 32 | 656.68 | 166.38 | −0.134 | 0.048 |
MMP2 | 31 | 344,472.71 | 119,686.43 | 0.678 ** | 0.224 |
MMP3 | 32 | 29,474.39 | 14,747.21 | 0.134 | −0.054 |
MMP8 | 30 | 97,594.46 | 41,997.43 | 0.207 | −0.086 |
Rantes/CCL5 | 31 | 23.13 | 14.82 | 0.004 | −0.005 |
TNFα | 29 | 11.80 | 4.42 | −0.291 | 0.192 |
VEGFα | 28 | 0.75 | 0.51 | −0.276 | −0.205 |
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Cullen, A.E.; Centner, A.M.; Deitado, R.; Ukhanov, V.; Muller-Delp, J.; Salazar, G. The Duality of Adiponectin: The Role of Sex in Atherosclerosis. Cells 2024, 13, 1. https://doi.org/10.3390/cells13010001
Cullen AE, Centner AM, Deitado R, Ukhanov V, Muller-Delp J, Salazar G. The Duality of Adiponectin: The Role of Sex in Atherosclerosis. Cells. 2024; 13(1):1. https://doi.org/10.3390/cells13010001
Chicago/Turabian StyleCullen, Abigail E., Ann M. Centner, Riley Deitado, Vladimir Ukhanov, Judy Muller-Delp, and Gloria Salazar. 2024. "The Duality of Adiponectin: The Role of Sex in Atherosclerosis" Cells 13, no. 1: 1. https://doi.org/10.3390/cells13010001