Effects of Global Warming on Grapevine Berries Phenolic Compounds—A Review

Round 1

Reviewer 1 Report

First, I congratulate the authors for the rather complicated topic they tackled!

The work is also valuable because it concentrates correct information about flavonoids and non-flavonoids, regarding structure, synthesis, cellular localization, and properties. It also follows the oscillations induced in the quality and quantity of the phenolic compounds discussed by climatic factors and describes technological links to protect plants against damage caused by certain unfavorable environmental conditions.

I have the following suggestions for the authors:

- Line 80: The authors do not have as a subject the influence of the soil on the phenolic compounds (but only the soil moisture) nor other environmental factors (precipitation, wind, etc.). Therefore, I suggest changing the text (`environmental factors`) accordingly

- Line 117: `defer`? Is it correct? It could be `different`?

- I believe that the approach of other techniques to reduce the impact of environmental factors on plants, such as netting or arbuscular mycorrhizae, would also be useful.

- References: consider replacing `.....&` by the authors name (4, 6, 9, .....)

-Line 608: abbreviation of Environmental Progress and Sustainable Energy is Environ. Prog. Sustain.

- Line 613: Climate Dynamics should be cited as Clim. Dyn.

- Line 618: Globe. Planet Change

- Line 641: Clim. Res. 

- Line 712: Food Chem.

- Line 833: Plant Mol. Biol.

- Line 941: Front. Plant Sci. (already written above)

- There are many others, so I suggest searching using `Journal abbreviated name Climate Research`, for example

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

The general roles of phenolic compounds (antioxidants, UV filters, etc.) are missing from the manuscript. Why are these compounds important to plants? It is then easier to understand why their role is important in climate change and the response to it.

The title is a bit misleading. The berry (raspberries, blackberries, strawberries, blueberries...) in the title can refer to many berry fruits, while the manuscript only mentions the grapevine berry.

The abstract is very general, it could be written a little about the more important effects of phenolic compounds so that the reader can see what will be discussed in the article. How phenolic compounds can be related to climate change.

The temperature increasing is unfortunately real, I consider it slightly fictitious that the temperature can increase to such an extent until 2049. I hope that won't happen...

In the temperature chapter, there is little mention of flavonoids or other phenolic compounds found in grapes. Anthocyanins are highlighted, although I believe that several flavonoid groups can play an important role in preventing the rise in temperature. For example, flavonols, which are not only in large quantities in the leaf, but also in the berry.

Flavonoids protect against UV radiation, drought, temperature, and various stresses, then a flavonoid or phenolic acid pretreatment (phenolic irrigation, for example) would be obvious, which can increase their amount. Have you found any literature on this?

A conclusion is a bit short, one could write more about the possible roles of phenolic compounds in climate change if this is the title.

In some places the term "anthropic" can be read, in my opinion anthropogenic would be more correct.

In some places the term "grape berry" is readable, in my opinion grapevine berry would be more correct.

In some places it can be read veraison or véraison, please unify this term.

You can read the term "each family" in several places, which is more like compound group or flavonoud group, but my opinion that the each family is not correct.

Figure 1 is a very nice, but have you thought about presenting it as a table instead? Maybe it would be more to the point.

In the case of Figure 1, several groups of compounds are listed, such as flavanones. Based on the literature, these compounds are found in large quantities in what kind of grapes? Grapes primarily contain flavonols and anthocyanins, as well as phenolic acids, but other groups of compounds may also occur in small amounts. Please provide examples and references for each group of compounds in grapevine or grapevine berry (only because then it is irrelevant to list all the groups).

75 row - what effects do flavonoids have, which flavonoids are they, and possibly in which group they are found

91 row - what kind of phenolics, please write examples and then refer

94 row - please write example for the localization and then refer

126 row - "reported in vine plant" The review is about climate change and berry flavonoids, in which part of the grape are they, which were reported earlier.

133 row - Glycolization is a really important point in the case of flavonoids, I like the examples you listed, however, as soon as there are more figures in the manuscript, I would feel it obvious to have a figure of the sugar forms listed, what kind of sugars they are, how and where they can be connected, etc.

137 row - "flavonols synthesized only in skin" I guess this is not true, because flavonols are also present in large quantities in the leaves, too. Please use a reference.

202 row (paragraph) - Caftaric acid is in very large quantities in grapes, leaves, therefore I guess that you need to mention this molecule also. Please use reference.

220 row - Resveratrol is the most famous non-flavonoid (nose, taste, aroma,coloiur etc) in grape berry, I guess that could be more written about this, not just simply stilbene.

237 row - Flavonoids are formed not only from phenylalanine but also from tyrosine. Please look it up and use reference.

409 row - "sunlit chamber" what does it mean? It is mean growing chamber?Please write in parenthesis the type of the chamber).

Author Response

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Author Response File: Author Response.docx

Reviewer 3 Report

The paper is well written and provide useful information to the readers.

Author Response

Dear Reviewer, thank you very much for appreciating our manuscript! We thank you for your kindness.

Best regards,

Authors