The Biological Function and Roles in Phytohormone Signaling of the F-Box Protein in Plants

Round 1

Reviewer 1 Report

The paper presents a literature revision on F-box E3 ligases that include a description of number of F-box, major subfamilies and some biological roles associated to. While the subject is suitable for Agronomy, the revision should be needing an increasing link between sub-subjects through the paper. I think, the manuscript does not display a connection between subfamilies described in the first section, structure, and role of F-box ligases. The paper needs to improve the following comments:

1.- Line 95, The E2 enzymes are also important on SCF-type E3 ligase and is missing in the passage and in the Fig 2a.

2.-Lines 103, The variety of Ub-linkage is one of the big challenges in UPP and should be useful to add a brief discussion.

3.- Line 124, The reference has a misspelling error.

4.- Double check the manuscript for typo errors. For instance, involve (line 312), include (Line 420), etc.

5.- Line 402, The Fig 3e is missing in the manuscript.

6.- It should be useful to show more connection between subfamilies and the plant role through the manuscript or add a brief discussion.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript entitled 'The biological function and roles in phytohormone signaling of the F-box protein in plants' describes the classification, function, and involvement in the hormone signaling pathways. Though the writing is well described, there is a lack of description about SA signaling and the adaptor proteins involved in SA -induced immunity which is similar to F-Box proteins. For instance, the authors did not mention the effects of SA on SlFBX genes. Similarly, CPR1, which negatively regulates both SA-dependent and SA_independent signaling. The authors should also mention about CAF box involved in abiotic stress. 

The figures need to be improved. The writings are not visible. I suggest the authors increase the font of each figure as well as the resolution.

Line 452. We should be able to find...

Author Response

Please see the attachment.

Author Response File: Author Response.docx