Determination of Hyaluronic Acid Dermal Filler Impurities Using SEM/EDS Analysis
Round 1
Reviewer 1 Report
Please see the attached file for comments and queries.
Comments for author File: 
Comments.pdf
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Reviewer 2 Report
The study entitled “Determination of hyaluronic acid dermal filler impurities using SEM/EDS analysis” is very innovative and interesting. The authors presented a new approach for characterising the impurities in hyaluronan. I did not found a similar study on this topic in the literature. From a methodological point of view, I have no objections to the research presented in the manuscript. I also agree with the discussion of the results. It is logical and well supported by reliable results. However there two minor issues, which should be corrected:
(I) I suggest to improve the quality of graphics in case of Figure 8-12, which is very low.
(II) In my opinion the conclusions part should be extended. I suggest to write about some potential applications of the studied approach in terms of quality control.
Author Response
(I) I suggest to improve the quality of graphics in case of Figure 8-12, which is very low.
Response: Thank you for your kind comments. The size of the numbers in the picture has been edited appropriately We increase the resolution of Figures 8-12 and enlarge them for better readability.
(II) In my opinion the conclusions part should be extended. I suggest to write about some potential applications of the studied approach in terms of quality control.
Response : Thank you for your insightful comments. The authors also agree with the reviewer's comment. We have expanded our conclusions to include potential applications. The test can be found in the revised PDF file.
