Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET
, Cristina de Oliveira Massoco Salles Gomes 2, Carlos Eduardo Fonseca-Alves 3,4,*, Felipe Noleto de Paiva 1, LaÃs Calazans Menescal Linhares 1, Gabriel João Unger Carra 1, Rodrigo dos Santos Horta 5, Felipe Augusto Ruiz Sueiro 6, Paulo Cesar Jark 7, Adriana Tomoko Nishiya 8, Carmen Helena de Carvalho Vasconcellos 9, Rodrigo Ubukata 10, Karen Batschinski 10, Renata Afonso Sobral 11, Simone Crestoni Fernandes 12, Luiz Roberto Biondi 13, Ricardo De Francisco Strefezzi 14, Julia Maria Matera 15, Marcelo Monte Mor Rangel 16, Denner Santos dos Anjos 17, Heidge Fukumasu 14, Marcus Antônio Rossi Feliciano 14, Maria Lucia Zaidan Dagli 2add
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Round 1
Reviewer 1 Report
Accepted in present form for publication
Author Response
Dear reviewer, thank you so much for your time reviewing our manuscript. Thank you so much for considering our manuscript suitable for publication in the current form.
Reviewer 2 Report
no special comments
Author Response
Dear reviewer, thank you so much for your time reviewing our manuscript. Thank you so much for considering our manuscript suitable for publication in the current form.
Reviewer 3 Report
This paper (cancers-2255161) is a valuable article that summarizes the various views of veterinarians in Brazil on angiosarcoma, a refractory disease in dogs. This paper integrates information from empirical data and a huge of literature data to present extensive knowledge on the pathogenesis, epidemiology, diagnosis, and treatment of canine angiosarcoma.
Minor revisions are requested below to further brush up on this paper.
Lines 169-175: It is not appropriate to mention tp53 mutations as a cause in canine tumors, since they occur frequently in all cancer types; other genetic mutations such as PIK3CA should also be mentioned.
Headings in Tables 4 and 5 must be in English
Correct the character sequence in Table 6 because it is out of alignment.
Author Response
Dear reviewer, thank you so much for your time reviewing our manuscript and we really appreciated you positive and constructive criticism for our manuscript improvement. Thank you for considering our paper for publication after minor revisions. Please, see the specific answer to the comments below:
Lines 169-175: It is not appropriate to mention tp53 mutations as a cause in canine tumors, since they occur frequently in all cancer types; other genetic mutations such as PIK3CA should also be mentioned.
Answer: Dear reviewer, we have included some additional information regarding TP53 and PI3K pathways as suggested.
Headings in Tables 4 and 5 must be in English
Answer: Dear reviewer, we are so sorry for this mistake. We have adjusted as suggested. All modification are highlighted in red.
Correct the character sequence in Table 6 because it is out of alignment.
Answer: Dear reviewer, we are so sorry for this mistake. We have adjusted as suggested. All modification are highlighted in red
