Brain Functional Connectivity in Low- and High-Grade Gliomas: Differences in Network Dynamics Associated with Tumor Grade and Location
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients
2.2. MRI Acquisition
2.3. Functional Connectivity Analysis
2.4. Statistical Analyses
3. Results
3.1. Patients
3.2. Graph Theory Analysis: Whole-Brain and Hemispheric Network Analysis
3.3. Graph Theory Analysis: Lobar Networks Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Frontal Tumors | HGG/Controls | p-Value | LGG/Controls | p-Value | HGG/LGG | p-Value |
---|---|---|---|---|---|---|
Global Efficiency | SFG r | 0.006 | ||||
Local Efficiency | SFG r | 0.045 | SFG r | 0.045 | ||
Betweenness Centrality | IFG tri l | 0.006 | SFG r | 0.025 | IFG tri l | 0.001 |
SFG l | 0.012 | |||||
Cost | SFG r | 0.028 | ||||
Average Path Length | SFG r | 0.003 | SFG r | 0.045 | ||
SFG l | 0.043 | |||||
Clustering Coefficient | SFG r | 0.017 | MidFG l | 0.042 | ||
IFG tri l | 0.016 | |||||
Degree | SFG r | 0.028 |
Temporal Tumors | HGG/Controls | p-Value | LGG/Controls | p-Value | HGG/LGG | p-Value |
---|---|---|---|---|---|---|
Global Efficiency | pSTG l | 0.010 | aSTG l | 0.027 | ||
Local Efficiency | pMTG r | 0.044 | pSTG l | 0.003 | ||
Betweenness Centrality | pSTG r | 0.040 | aMTG l | 0.030 | ||
Cost | pMTG r | 0.022 | aSTG l | 0.018 | pMTG r | 0.031 |
toMTG r | 0.032 | pSTG l | 0.008 | |||
pSTG l | 0.032 | aMTG l | 0.017 | |||
aITG l | 0.038 | |||||
Clustering Coefficient | aITG r | 0.017 | ||||
pSTG l | 0.018 | |||||
Degree | pMTG r | 0.022 | aSTG l | 0.018 | pMTG r | 0.031 |
toMTG r | 0.032 | pSTG l | 0.008 | |||
pSTG l | 0.032 | aMTG l | 0.017 | |||
aITG l | 0.038 |
Parietal Tumors | HGG/Controls | p-Value | LGG/Controls | p-Value |
Global Efficiency | AG l | 0.0434 | ||
Local Efficiency | PostCG l | 0.0145 | ||
Betweenness Centrality | PostCG l | 0.0051 | PostCG l | 0.0236 |
Average Path Length | AG l | 0.0394 | ||
Insular Tumors | HGG/Controls | p-Value | LGG/Controls | p-Value |
Cost | IC l | 0.0161 | ||
Degree | IC l | 0.0161 |
SFG r | HGG/HC | LGG/HC | pSTG r | HGG/HC | |
---|---|---|---|---|---|
Local Efficiency | Global Efficiency | Betweenness | |||
Clustering Coefficient | Betweenness | pSTG l | HGG/HC | LGG/HC | |
Cost | Global Efficiency | Local Efficiency | |||
Average Path Length | Cost | Cost | |||
Degree | Degree | Clustering Coefficient | |||
SFG l | LGG/HC | Degree | |||
Average Path Length | aSTG l | LGG/HC | |||
MidFG l | LGG/HC | Global Efficiency | |||
Clustering Coefficient | Cost | ||||
IFG tri l | HGG/HC | Degree | |||
Betweenness | aITG l | LGG/HC | |||
Clustering Coefficient | Cost | ||||
pMTG r | HGG/HC | Degree | |||
Local Efficiency | aITG r | LGG/HC | |||
Cost | Clustering Coefficient | ||||
Degree | AG l | HGG/HC | |||
aMTG l | LGG/HC | Global Efficiency | |||
Betweenness | Average Path Length | ||||
Cost | PostCG l | HGG/HC | LGG/HC | ||
Degree | Local Efficiency | Betweenness | |||
Betweenness | |||||
toMTG r | HGG/HC | IC l | LGG/HC | ||
Cost | Cost | ||||
Degree | Degree |
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Pasquini, L.; Jenabi, M.; Yildirim, O.; Silveira, P.; Peck, K.K.; Holodny, A.I. Brain Functional Connectivity in Low- and High-Grade Gliomas: Differences in Network Dynamics Associated with Tumor Grade and Location. Cancers 2022, 14, 3327. https://doi.org/10.3390/cancers14143327
Pasquini L, Jenabi M, Yildirim O, Silveira P, Peck KK, Holodny AI. Brain Functional Connectivity in Low- and High-Grade Gliomas: Differences in Network Dynamics Associated with Tumor Grade and Location. Cancers. 2022; 14(14):3327. https://doi.org/10.3390/cancers14143327
Chicago/Turabian StylePasquini, Luca, Mehrnaz Jenabi, Onur Yildirim, Patrick Silveira, Kyung K. Peck, and Andrei I. Holodny. 2022. "Brain Functional Connectivity in Low- and High-Grade Gliomas: Differences in Network Dynamics Associated with Tumor Grade and Location" Cancers 14, no. 14: 3327. https://doi.org/10.3390/cancers14143327