Next Article in Journal
Longitudinal Trajectories of Dietary Fibre Intake and Its Determinants in Early Childhood: Results from the Melbourne InFANT Program
Next Article in Special Issue
Limosilactobacillus fermentum MG4294 and Lactiplantibacillus plantarum MG5289 Ameliorates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Mice
Previous Article in Journal
Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration
Previous Article in Special Issue
Short-Term Intake of Theobroma grandiflorum Juice Fermented with Lacticaseibacillus rhamnosus ATCC 9595 Amended the Outcome of Endotoxemia Induced by Lipopolysaccharide
 
 
Article
Peer-Review Record

Oral intake of Lactiplantibacillus pentosus LPG1 Produces a Beneficial Regulation of Gut Microbiota in Healthy Persons: A Randomised, Placebo-Controlled, Single-Blind Trial

Nutrients 2023, 15(8), 1931; https://doi.org/10.3390/nu15081931
by Elio López-García 1, Antonio Benítez-Cabello 1, Antonio Pablo Arenas-de Larriva 2, Francisco Miguel Gutierrez-Mariscal 2,3, Pablo Pérez-Martínez 2,3, Elena María Yubero-Serrano 2,3,*, Antonio Garrido-Fernández 1 and Francisco Noé Arroyo-López 1
Reviewer 1:
Reviewer 2: Anonymous
Reviewer 3:
Nutrients 2023, 15(8), 1931; https://doi.org/10.3390/nu15081931
Submission received: 15 March 2023 / Revised: 3 April 2023 / Accepted: 12 April 2023 / Published: 17 April 2023
(This article belongs to the Special Issue Role of Lactobacillus and Probiotics in Human Health and Diseases)

Round 1

Reviewer 1 Report

The work presented shows the results of supplementation with lactobacilli in healthy people, which is quite interesting, since most of the studies are carried out with sick individuals.The model is well described, the study group well defined and the microbiota analyzes very well performed.I would like a graphical abstract of the experimental model and key results to be included.Captions for figures and tables could be improved to be more self-explanatory

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Manuscript submited by Elio," Oral intake of Lactiplantibacillus pentosus LPG1 produces a 2 beneficial regulation of gut microbiota in healthy persons: a 3 randomised, placebo-controlled, single-blind trial". 

Authors investigated the probiotic from plant source to check the its effect on the gut microbiota. The present study is poor decribed in terms of results and quality of English wirting. Authors have to resubmit this study by improving its quality of English and separating the  Resutls and discussion section. Methods should be concise and comprehensive. Further most of the results have same trend between placebo and treatment like for Figure 2A individuals diversity decreased both in BF and AF same for dominance, placebo resutls have minimum effects on BF. Figure A Bateroides is the most found genera but BF also shows same increasing trend as AF low value is due to BI low value. There are other concerns like mentioned above. Authors have to adress the concerns and can submit improved manuscript 

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 3 Report

Research well planned and properly executed. However, several aspects would need to be better described to demonstrate the beneficial effects on the intestinal microflora:

1. what metabolites does Lactiplantibacillus pentosus LPG1 produce?

2. does this strain have the ability to adhere to the intestinal epithelium?

3. are the small changes in the composition of the intestinal microflora presented not coincidental? E.g. change in diet.

4. what carbon sources does Lactiplantibacillus pentosus LPG1 use?

5. why did the number of Bifidobacterium cells decrease in this study?

Author Response

Please see the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

Author's response is statisfactory. So it can be published 

 

Back to TopTop