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Article
Peer-Review Record

Anemia Is a Strong Predictor of Wasting, Disease Severity, and Progression, in Clinical Tuberculosis (TB)

Nutrients 2022, 14(16), 3318; https://doi.org/10.3390/nu14163318
by Senait Ashenafi 1,2, Amsalu Bekele 3, Getachew Aseffa 4, Wondwossen Amogne 3, Endale Kassa 3, Getachew Aderaye 3, Alemayehu Worku 5, Peter Bergman 6,7 and Susanna Brighenti 2,*
Reviewer 1:
Reviewer 2:
Nutrients 2022, 14(16), 3318; https://doi.org/10.3390/nu14163318
Submission received: 18 July 2022 / Revised: 4 August 2022 / Accepted: 10 August 2022 / Published: 12 August 2022
(This article belongs to the Special Issue Nutrition and Metabolic Risk Factors in Patients)

Round 1

Reviewer 1 Report

I read the manuscript, "Anemia is a strong predictor of wasting, disease severity and progression of clinical tuberculosis (TB)," with great interest. I believe this is a scientifically and well-written manuscript on the relation between anemia and TB disease manifestations and outcomes. I have a few minor comments:

1. Introduction, lines 79-81: there is no need to present the main result in the introduction

2. I am having my doubts about the methodology, I think it is better if the authors make it clear that there is no effect of vitamin D deficiency or interventions regarding vitamin D have a cofounding effect on the results of this study. I know it is unlikely, and I can see the clear results from the analysis, but I still find it useful to be clearly mentioned in the results/discussion.

 

3.  I believe SD would be a better fit than SEM for the presentation of the results

Author Response

Please, see the attachment below.

Author Response File: Author Response.docx

Reviewer 2 Report

From my point of view, the article is exciting. It respects the scientific rigor of presenting the results of well-conducted research. It also has a clinical impact by identifying risk factors for a severe form of tuberculosis. The importance of low Hb and a low BMI as unfavorable prognostic factors for the disease is emphasized. Prevention of risk factors can lead to a decrease in TB morbidity and mortality.

Author Response

Please, see the attachment below.

Author Response File: Author Response.docx

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