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Pediatric Reports
Volume 10
Issue 1
10.4081/pr.2018.7424
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Case Report

Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Streptococcus sanguinis Sepsis

by
Hitoshi Awaguni
,
Jun Shinozuka
,
Shin-ichiro Tanaka
,
Sayaka Kadowaki
,
Shigeru Makino
,
Rikken Maruyama
,
Yosuke Shigematsu
,
Kenji Hamaoka
and
Shinsaku Imashuku
*
Division of Pediatrics, Uji-Tokushukai Medical Center, Uji, Kyoto, Japan
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2018, 10(1), 7424; https://doi.org/10.4081/pr.2018.7424
Submission received: 27 September 2017 / Revised: 20 January 2018 / Accepted: 12 February 2018 / Published: 29 March 2018

Abstract

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops in association with systemic as well as central nervous system (CNS) viral or bacterial infections. AESD is most often noted with influenza or human herpesvirus 6 infection in previously healthy infants. However, AESD has also been reported in an infant with developmental retardation and in a mentally and motor-disabled adolescent. Here, we report the case of a 4-year-old female with significant development delay due to spinal muscular atrophy, who developed AESD during Streptococcus sanguinis sepsis with no apparent CNS infection. Although the patient had extremely high serum procalcitonin (45.84 ng/mL, reference; <0.4) on admission indicating a poor prognosis, she was successfully managed for sepsis and AESD.
Keywords: Acute encephalopathy with biphasic seizures and reduced diffusion; AESD; spinal muscular atrophy; Streptococcus sanguinis; sepsis Acute encephalopathy with biphasic seizures and reduced diffusion; AESD; spinal muscular atrophy; Streptococcus sanguinis; sepsis

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MDPI and ACS Style

Awaguni, H.; Shinozuka, J.; Tanaka, S.-i.; Kadowaki, S.; Makino, S.; Maruyama, R.; Shigematsu, Y.; Hamaoka, K.; Imashuku, S. Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Streptococcus sanguinis Sepsis. Pediatr. Rep. 2018, 10, 7424. https://doi.org/10.4081/pr.2018.7424

AMA Style

Awaguni H, Shinozuka J, Tanaka S-i, Kadowaki S, Makino S, Maruyama R, Shigematsu Y, Hamaoka K, Imashuku S. Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Streptococcus sanguinis Sepsis. Pediatric Reports. 2018; 10(1):7424. https://doi.org/10.4081/pr.2018.7424

Chicago/Turabian Style

Awaguni, Hitoshi, Jun Shinozuka, Shin-ichiro Tanaka, Sayaka Kadowaki, Shigeru Makino, Rikken Maruyama, Yosuke Shigematsu, Kenji Hamaoka, and Shinsaku Imashuku. 2018. "Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Streptococcus sanguinis Sepsis" Pediatric Reports 10, no. 1: 7424. https://doi.org/10.4081/pr.2018.7424

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