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Review

Long Sleep Duration and Stroke—Highly Linked, Poorly Understood

by
Chumeng Cai
1 and
Strahil Atanasov
2,*
1
Department of Neuroscience, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712-0805, USA
2
Division of Pulmonary Critical Care & Sleep Medicine, University of Texas Medical Branch, Galveston, TX 77555-0561, USA
*
Author to whom correspondence should be addressed.
Neurol. Int. 2023, 15(3), 764-777; https://doi.org/10.3390/neurolint15030048
Submission received: 3 June 2023 / Revised: 20 June 2023 / Accepted: 21 June 2023 / Published: 25 June 2023
Browse Figure
Review Reports Versions Notes

Abstract

:
Stroke is one of the leading causes of disability and mortality. Both short and long sleep durations are associated with adverse health outcomes. Cross-sectional studies have shown an increased prevalence of stroke in long sleepers. Long sleep duration increases stroke incidence and mortality in prospective epidemiological studies. Accumulating evidence suggests that the magnitude of the association between sleep and stroke appears to be stronger for longer sleep than shorter sleep, yielding a J-shaped curve. Potential links between long sleep duration and stroke include increased incidence of diabetes and atrial fibrillation, elevated levels of inflammation, arterial stiffness, and blood pressure variability. Long sleep duration is a strong marker and a plausible risk factor for stroke and should be considered in future scoring for risk stratification and stroke prevention.

1. Introduction

Stroke is one of the leading causes of disability and mortality in the United States and worldwide [1,2]. Each year, about 795,000 Americans experience a new or recurrent stroke. By 2030, nearly 4% of the United States population will have had a stroke [3]. Stroke accounts for 1 of every 21 deaths in the United States, ranking fifth among all causes of death [1]. Stroke is also a major contributor to global disability-adjusted life-years, moving from the fifth place in 1990 to the third in 2005 and the second in 2015 [4]. Given the severe burden and consequences, it is important to identify modifiable risk factors to prevent stroke.
Sleep is an indispensable part of human life and is involved in the regulation of essential body functions such as immune defense, neurohormonal processes, metabolic pathways, and coagulation/fibrinolysis cascade [5]. Maintaining a proper amount of sleeping, usually 7–9 h per night, is necessary for normal physiological and psychological functioning [5,6]. Growing evidence indicates that both short and long sleep durations are associated with adverse health outcomes such as diabetes, atherosclerosis, cardiovascular diseases, and all-cause mortality [7,8,9,10,11,12].
There is strong evidence that short or long sleep duration increases the risk of stroke [13,14,15,16]. Due to the trend of insufficient sleep in our current era, much of the research effort in this field has focused on the impact of sleep deprivation on stroke and its mechanisms. However, accumulating evidence suggests that the magnitude of the association appears to be stronger for longer sleep than for shorter sleep, yielding a J-shaped relationship in stroke prevalence, incidence, and mortality [17,18].

2. Long Sleep Duration and Stroke Prevalence

Seixas et al. reported the largest-to-date cross-sectional study on sleep duration and stroke prevalence based on the 2004–2013 United States National Health Interview Survey with 288,888 participants, using machine learning modeling techniques [13]. Stroke was reported in 3.31% of short sleepers (≤6 h), 2.57% of average sleepers (7–8 h), and 4.63% of long sleepers (≥9 h). The odds ratios (OR) for short and long sleepers were 1.29 and 1.80, respectively, compared to average sleepers. This study observed a greater association between long sleep duration with stroke compared to short and average sleep durations (p < 0.001), illustrating a J-shaped relationship between self-reported sleep duration and stroke prevalence.
The National Health and Nutrition Examination Survey included 32,152 participants in the United States from 2005 to 2016 [14]. The prevalence of stroke was 4.4% in short sleepers (<7 h) and 8.6% in long sleepers (>9 h) (p < 0.0001). After multivariable adjustment, in comparison to optimal sleep duration (7–9 h), short sleep duration was associated with an increased prevalence of stroke (OR 1.45; 95% confidence interval [CI] 1.23 to 1.70), whereas long sleep duration was associated with a much higher prevalence of stroke (OR 1.81; 95% CI 1.37 to 2.34).
Ge et al. performed a meta-analysis of six cross-sectional studies evaluating the relationship between sleep duration and stroke prevalence [15]. Compared to normal sleep duration, the pooled OR was 1.71 for short sleep duration (95% CI 1.39–2.02) and 2.12 for long sleep duration (95% CI 1.51–2.73), demonstrating a J-shaped relationship. We summarized 24 such cross-sectional studies in Table 1.

3. Long Sleep Duration and Stroke Incidence

Chen et al. investigated the risk of ischemic stroke in relation to self-reported sleep duration in the Women’s Health Initiative Observational Study, including 93,175 postmenopausal women [40]. This prospective study followed the participants for an average of 7.5 years, during which 1166 cases of ischemic stroke occurred. Multivariable-adjusted relative risks (RR) for ischemic stroke were 1.14 (95% CI 0.97–1.33) and 1.70 (95% CI 1.32–2.21) for women reporting ≤6 and ≥9 h of sleep respectively, using 7 h as the reference. This study suggested that long sleep duration significantly increased the incidence of stroke, while short sleep duration did not.
Another prospective study comprised 82,795 people without prior stroke from the Canadian Community Health Survey between 2000 to 2016. During a median follow-up of 9.1 years, 1705 stroke events occurred [16]. Self-reported sleep duration ≥10 h was associated with increased risk of stroke in participants younger than 70 years (hazard ratio [HR] 2.29; 95% CI 1.04–5.06). However, such association was not found in those 70 years or older and did not persist when the long sleep duration was defined as ≥9 h. Short sleep duration, even when defined as <4 h, did not increase stroke incidence in any age group. We summarized 20 such prospective cohort studies in Table 2.
In Table 3, we summarized seven meta-analyses addressing the relationship between sleep duration and stroke incidence [49,61,62,63,64,65,66]. All seven analyses reported a significantly increased stroke incidence in long sleepers. Two meta-analyses reported no impact of short sleep duration on stroke incidence [61,62]. Furthermore, sleep duration demonstrates a dose response in increasing stroke risk. For every hour increment above optimal sleep hours, stroke risk increases by 13–18%. For every hour decrement below optimal sleep hours, stroke risk increases by 5–7% [61,62,63]. The increased incidence of stroke in long sleepers is more pronounced than in people who sleep short hours, indicating a J-shaped curve (Figure 1a).

4. Long Sleep Duration and Stroke Mortality

The Multiethnic Cohort Study conducted in Los Angeles and Hawaii included 135,685 adults aged 45 to 75 years with no history of stroke [17]. During an average of 12.9 years of follow-up, 1259 patients died from stroke. Self-reported sleep duration ≥9 h as compared to 7 h was associated with an approximately one-third increased risk of stroke mortality for both men (HR 1.35; 95% CI 1.03–1.75) and women (HR 1.39; 95% CI 1.06–1.83). Short sleep duration (≤5 h) did not increase stroke mortality. Of note, long sleep duration was not associated with cancer mortality, indicating a relatively specific impact of long sleep on stroke.
The association between long sleep duration and stroke mortality was reported in the Chinese population in the Shanghai Women’s and Men’s Health Studies [18]. A total of 113,138 participants aged 40–79 were included with a median follow-up of 7 years. Although both short and long sleep durations were associated with increased all-cause mortality, only long sleep duration was associated with increased stroke mortality. Hazard ratios (95% CI) were 0.91 (0.70–1.18) and 2.35 (1.78–3.09) for participants who slept 4–5 and ≥10 h per day respectively, compared with 7 h. The sleep duration–mortality association was similar among both women and men.
In Table 4, we summarized seven prospective studies addressing sleep duration and stroke mortality [17,18,67,68,69,70,71]. All seven analyses reported a significantly increased stroke mortality in people sleeping long hours. Only two studies showed increased stroke mortality in short sleepers, indicating a J-shaped curve between sleep hours and stroke mortality (Figure 1b). Every hour increase in sleep duration led to a 12–17% increased risk of fatal stroke, while every hour decrease was only associated with a 5% increased risk of stroke mortality.

5. Long Sleep Duration and Stroke—Links

5.1. Diabetes

Diabetes is a major risk factor for stroke [72]. Several prospective studies have shown an increased risk of developing type 2 diabetes in long sleepers [73,74,75,76,77]. Cappuccio et al. performed a meta-analysis including 13 independent cohorts with 107,756 participants [78]. In the pooled analysis, long duration of sleep (>8–9 h) was associated with a 48% increased risk of developing diabetes during follow-up (RR 1.48; 95% CI 1.13–1.96). Short sleep duration (≤5–6 h) also increased the incidence of diabetes, albeit to a lesser degree (RR 1.28, 95% CI 1.03–1.60). Another meta-analysis of prospective studies evaluated the dose–response relationship between sleep duration and the risk of diabetes [79]. This analysis included 11 prospective cohorts, 482,502 participants, with follow-up periods ranging from 2.5 to 16 years. Compared with 7 h, each hour increment of sleep duration was associated with a 14% increased risk of diabetes, while each hour decrement was associated with a 9% increase. The pooled RR for diabetes was 1.40 (1.08–1.80) for the longest (≥9 h) sleep duration. Long sleep duration was associated with a greater risk of diabetes than short sleep duration.

5.2. Atrial Fibrillation

Atrial fibrillation is a common etiology for embolic stroke [72]. The association between sleep duration and incident atrial fibrillation was prospectively evaluated in a cohort of 18,755 United States male physicians [80]. During a mean follow-up of 6.9 years, 1468 cases of atrial fibrillation occurred. Using 7 h of sleep as the reference, the multivariable-adjusted hazard ratios (95% CI) for atrial fibrillation were 1.06 (0.92–1.22) and 1.13 (1.00–1.27) for sleep duration ≤6 and ≥8 h, respectively, indicating a modestly elevated risk of atrial fibrillation with long sleep duration [80]. In a Chinese population including 87,693 participants, sleep duration ≥8 h was associated with a 50% increased risk of incident atrial fibrillation (RR 1.50; 95% CI 1.07–2.10) during a median follow-up of 8 years, compared to 7 h [81]. Short sleep duration ≤6 h showed no correlation with atrial fibrillation incidence (RR 1.07; 95% CI 0.75–1.53). In a meta-analysis including three studies, long sleep duration was associated with a significantly increased incidence of atrial fibrillation with a pooled HR of 1.18 (95% CI 1.03–1.35) [82]. It should be noted that all three studies used ≥8 h as a cutoff for long sleep duration, which may underestimate the impact of longer sleep hours such as ≥9 or 10 h on atrial fibrillation. In addition, atrial fibrillation diagnosis was ascertained through electrocardiogram and self-reported history instead of wearable devices in those cohort studies. Atrial fibrillation is often asymptomatic and frequently undetected clinically. Therefore, the risk of atrial fibrillation attributed to long sleep duration is likely substantially underestimated.

5.3. Arterial Stiffness

Brachial-ankle pulse wave velocity (baPWV) is a noninvasive indicator of arterial stiffness, and it is associated with an increased risk of stroke and all-cause mortality [83]. Yoshioka et al. were the first to report an association between long sleep duration and arterial stiffness measured by baPWV [84]. In 4268 middle-aged Japanese, compared with 7 h of sleep, ≥9 h was associated with significantly higher baPWV after adjustment for biological, socioeconomic, and occupational confounders. Liu et al. reported that in 17,018 Chinese participants, long sleep duration was associated with increased arterial stiffness defined as baPWV ≥ 1400 cm/s. Using 7 h of sleep as the reference, the multivariable-adjusted OR (95% CI) for arterial stiffness was 1.48 (1.05–2.08) for sleep duration ≥9 h [85]. Such association was independent of cardiovascular risk factors, socioeconomic characteristics, inflammation, and subjective sleep quality. Logan et al. found significantly higher aortic stiffness measured by magnetic resonance imaging-based aortic pulse wave velocity in participants with actigraphy-confirmed long sleep duration in a total of 908 participants (9.91 ± 4.86 m/s vs. 8.68 ± 4.22 m/s, p = 0.006) [86]. Similar findings were reported by Tsai et al. from Taiwan and Niijima et al. from Japan [87,88]. In the above five cross-sectional cohort studies, short sleep duration was not associated with elevated arterial stiffness. Overall, cross-sectional studies have shown a J-shaped relationship between sleep duration and markers of arterial stiffness [89]. Arterial remodeling might mediate the impact of long sleep duration on the risk of stroke.

5.4. Inflammation

Inflammation plays a key role in atherogenesis and atherosclerotic cardiovascular diseases such as stroke [90]. Long sleep duration was found to be associated with elevated inflammation marker C-reactive protein (CRP) in the Nurses’ Health Study, which enrolled 935 women with type 2 diabetes [91]. Multivariate-adjusted CRP concentrations were 3.9 mg/L for women sleeping ≤5 h and 5.6 mg/L for those sleeping ≥9 h (p = 0.05). In 1020 Taiwanese, long sleepers (>8 h) had significantly (p < 0.05) higher levels of CRP, interleukin 6 (IL-6), fibrinogen, white blood cells, and lower levels of albumin, compared to those sleeping 6–8 h [92]. These associations remained significant after adjustment for waist circumference, self-reported health decline, diabetes, arthritis/rheumatism, heart disease, and depressive symptoms. For short sleepers (<6 h), a significant relationship was found only with higher levels of soluble intercellular adhesion molecule-1 (sICAM-1). In another analysis adjusted for multiple confounders, for every additional hour of sleep duration, CRP levels increased by 8% (p = 0.004) and IL-6 levels increased by 7% (p = 0.0003) [93]. In American adults, Grandner et al. observed a notable influence of gender and ethnicity on the association between elevated CRP and extreme sleep durations [94].
There are plausible biological mechanisms linking inflammation and long sleep duration bidirectionally in causal relationships. Elevated proinflammatory cytokines predispose to increased sleep duration through somnogenic effects [95]. Dowd et al. found that higher baseline levels of IL-6 and e-selectin predicted long sleep duration 6 years later [92]. Furthermore, increases in IL-6 and sICAM-1 and decreases in albumin during a 6-year follow-up were associated with a higher risk for long but not short sleep duration at the end of follow-up. Long sleep has been associated with increased sleep fragmentation, more frequent awakenings, and incident diabetes, which can influence cytokine expression [96,97]. Another possibility is that the underlying condition predisposes to both increased sleep duration and elevated cytokine levels simultaneously.

5.5. Blood Pressure Variability

Blood pressure variability is a significant indicator of carotid artery atherosclerosis and stiffness, and a strong predictor of subsequent stroke [98,99]. Johansson et al. studied 1908 Finnish adults aged 41–74 years and obtained blood pressure measurements at home on seven consecutive days. Blood pressure variability was defined as the standard deviation of blood pressure measurements. In the fully adjusted model, systolic morning-evening, day-by-day, and morning-day-by-day blood pressure variability were significantly higher in participants who were sleeping ≥9 h than in those sleeping 7 h [100]. Another study included 201 elderly Japanese with one or more cardiovascular risks. Visit-to-visit blood pressure variability was calculated based on 12 visits. After multivariable adjustment, long sleep duration (≥9 h) had significant positive associations with systolic blood pressure variance (p < 0.05) expressed as the difference between maximal and minimal systolic blood pressure. Additionally, significant synergetic interactions were found between carotid artery stiffness and blood pressure variance, whereby long sleep duration is associated with increased artery stiffness for individuals with higher visit-to-visit blood pressure variability [101]. Longer sleep duration might lead to changes in circadian rhythm, which further influences the activity of the autonomic nervous system, leading to abrupt changes in blood pressure, thereby increasing the risk of stroke through hemodynamic swings such as blood pressure variation.

6. Long Sleep Duration and Stroke—Genetic Studies

The associations between sleep duration and stroke from observational studies are prone to confounding and reverse causation biases. Studies have suggested that 9–45% of the variability in self-reported sleep duration is influenced by genetic factors [102]. Genome-wide association studies in 446,118 participants from the United Kingdom Biobank identified eight independent gene loci associated with subjective and objectively measured long sleep duration [103]. Several studies have investigated if genetically determined long sleep traits are associated with increased stroke using a genetic epidemiology approach based on Mendelian randomization analysis. This methodology has the advantage of overcoming the limitations of observational studies such as confounding environmental factors and sleep duration measurement variability. There have been five prospective studies including a total of 3,827,338 participants of European ancestry using Mendelian randomization analysis, and none of them demonstrated a statistically significant association between long sleep-related genetic variants and stroke incidence [44,102,104,105,106]. Two of the five studies showed a significant correlation between genetically determined short sleep duration and stroke [104,105]. These studies suggest that the association between long sleep hours and stroke is not genetically determined, but rather multifactorial in nature. However, an important limitation of such analyses is that fewer genetic variants are associated with long sleep. The variance of self-reported sleep duration explained by the genetic loci was small, thus reducing the statistical power to detect the association.

7. Long Sleep Duration and Stroke—Mediating Factors

The association between long sleep duration and stroke may be modified or mediated by other factors. Hu et al. found a significant interaction between hypertension and sleep duration on stroke prevalence in the China Hypertension Survey study [29]. In this cross-sectional study including 10,516 participants, every 1 h increase in sleep duration was associated with a 37% increased prevalence of stroke among participants without hypertension (OR 1.37; 95% CI 1.09–1.71) and only 8% increased stroke among hypertensive participants (OR 1.08; 95% CI 0.95–1.21). Ye et al. reported that sleeping >9 h increased stroke risk in participants with metabolic syndrome (OR 2.014; 95% CI 1.184–3.426) but not in those without [53]. In a Chinese population of 5312 suburban residents, physical activity intensity, duration, and frequency all partially mediated the association between long sleep duration and stroke risk [107]. The China Health and Retirement Longitudinal Study found that long sleep duration was significantly associated with increased risk of stroke (OR 1.86; 95% CI 1.08–3.21) in individuals who reported poor health status but not in those who reported good health status [32]. The association between long sleep duration and stroke mortality was also significant among subjects with limited physical function and poorer health status [68]. The vulnerability for stroke in long sleepers may differ by ethnicity and gender, highlighting the need for ethnicity-specific targeted education and management [52,108,109].

8. Sleep Duration and Sleep Quality

Sleep duration may not reflect the quality of sleep. Indices of sleep quality such as sleep fragmentation, periodic limb movement, and sleep apnea have been found to be significant predictors of stroke, independent of sleep length [110]. Sleep quality could be an important factor linking long sleep and stroke. In a prospective study including 37,341 participants, long daytime napping and long night sleep duration were all independent predictors of incident stroke. Long naps and prolonged nocturnal sleep duration also had a joint effect on stroke incidence in the fully adjusted model [37]. It was postulated that napping and long sleep may be markers of subclinical chronic debilitating ill health. Another prospective cohort reported a similar joint effect of daytime napping and long nighttime sleeping. The hazard ratio for stroke incidence for ≥1 h of naps combined with ≥9 h of nighttime sleeping was 3.37, much higher than 1.94 for daytime napping ≥1 h alone or 2.24 for nighttime sleeping ≥9 h alone [48]. In a prospective cohort including 41,786 adults, 35% of stroke events were attributed to the strong additive interaction between poor sleep quality and long sleep duration [50]. Furthermore, Zhou et al. observed significant joint effects between sleeping ≥9 h/night and midday napping >90 min, and between sleeping ≥9 h/night and poor sleep quality in the same cohort [42]. The benefit of sleep can only be achieved if both the duration and quality of sleep are maintained.

9. Evidence Supporting Long Sleep Duration as a Risk Factor for Stroke

First, many prospective cohort studies have demonstrated a temporal relationship between long sleep duration and stroke incidence and mortality. Long sleep duration retained its predictive value even after maximal adjustment of confounders and mediators, favoring a pathogenic contribution to stroke. Second, multiple prospective cohort studies have demonstrated a temporal relationship between long sleep duration and stroke risk factors such as diabetes and atrial fibrillation. Third, longitudinal pattern changes in sleep duration from short to long or from normal to long are associated with increased stroke incidence [42,111]. Fourth, long sleep duration has been associated with stroke precursors. Two imaging studies have shown a J-shaped curve between sleep duration and carotid artery intima media thickness (IMT), with long sleep duration associated with much higher IMT compared to normal and short sleep duration [8,9]. Long sleep, but not short sleep, was associated with greater brain white matter hyperintensity volume, a marker of cerebral small vessel disease, in fully adjusted models [112]. Finally, there seems to be a specific pathophysiological pathway between long sleep duration and stroke [68]. For example, Ikehara et al. found that long sleep duration increased stroke mortality but not cancer or coronary artery disease-related death in the Japan Collaborative Cohort Study [70].

10. Evidence Supporting Long Sleep Duration as a Marker for Stroke

There has been a lack of experimental evidence to clarify the biological mechanisms through which long sleep duration leads to stroke. Long sleepers are more likely to have a history of myocardial infarction, hypertension, or diabetes mellitus. Those diseases are linked to an increased stroke risk themselves. Long sleep duration has been often reported in conjunction with poor lifestyle choices, socioeconomic status, mental health, and behavioral factors such as older age, low physical activity, unemployment, lower levels of education, and depression, all of which portend increased risks for stroke [60]. Smagula et al. followed up 10,335 participants in the Singapore Chinese Health Study for a mean of 12.7 years. Among people with normal sleep duration at baseline, 36% became long (>8 h) sleepers during follow-up. A history of stroke, diabetes, cancer, hip fracture, and older age all independently increased the odds of becoming a long sleeper, while people with higher levels of education and regular physical activity were less likely to become a long sleeper [113]. It has been argued that excessive sleep duration may be simply an epiphenomenon or a marker of poor health, undiagnosed illnesses, or subclinical conditions that predispose to stroke, rather than directly causing stroke. Long sleep duration is commonly associated with poor sleep quality, increased sleep fragmentation/disturbance, and obstructive sleep apnea. Sleep apnea is a known cause of an increased need for sleep and may lead to stroke by decreasing cerebral blood flow and raising intracranial pressure during apneic events [114].

11. Clinical Implications

Healthcare providers should be aware of the increased stroke risk associated with long sleep. For habitual long sleepers who can control their amount of sleep, education should be provided to curtail unnecessary bedtime. For pathological long sleepers, attention should be paid to identifying and managing potential medical, social, and psychological causes of long sleep such as diabetes, depression, and inactivity. Long sleep hours can be used as a marker to identify people at higher risk for stroke. Based on clinical profiles, further testing for diabetes, inflammation markers, atrial fibrillation, sleep apnea, and carotid artery disease may help develop individualized strategies to prevent stroke. Adopting long sleep duration as a new risk factor in daily practice may improve stroke risk assessment [115]. A prospective analysis among 67,250 women in Nurses’ Health Study and 29,114 men in Health Professionals Follow-up Study suggested that adding sleep duration as a prevention target to traditional lifestyle scores could further reduce the risk of stroke by 50% in United States adults [116].

12. Future Directions

Most epidemiologic studies collect self-reported sleep information by questionnaire or interview. Self-reported sleep duration tends to overestimate sleep duration, is prone to recall bias, and only correlates moderately well with objective measures such as actigraphy or polysomnography [117,118]. It would be preferable to rely on repeated objective assessments of sleep quantity to increase the validity of the results. The widespread availability of electronic wearable devices, such as activity monitors, may allow accurate, reliable, and scalable objective sleep duration assessment in large epidemiological studies. Time in bed versus total sleep time is a problematic issue with most of the self-reported epidemiologic studies. Increased time in bed (but not actual sleep duration) may be due to disrupted sleep patterns and poor sleep quality. Disrupted sleep patterns and poor sleep quality are often secondary to sleep apnea, which is a very common and well-established stroke risk factor. Thus, in-laboratory polysomnography and home sleep tests would be better tools for establishing the long sleep–stroke link. In addition, different definitions of long sleep duration could be one of the reasons for the observed heterogeneity across studies. There is a need to unify the cutoffs for long sleep duration based on sleep duration for different age groups as recommended by the National Sleep Foundation. The impact of gender on the association between long sleep duration and stroke needs to be further explored given conflicting data from retrospective and prospective studies [18,28,29,41,49,69]. Given the strong and complex interplay among sleep duration, sleep quality, and stroke, sleep characteristics such as napping, sleep disturbance, and sleep apnea should be collected in future studies as important confounding factors. Further experimental studies are warranted to explore the potential biological pathways by which long sleep leads to stroke. Large-scale longitudinal studies with long duration of follow-up are needed to investigate the efficacy of sleep interventions or changes in sleep habits for the prevention of stroke.

Author Contributions

Conceptualization, C.C. and S.A.; writing—original draft preparation, C.C. and S.A.; writing—review and editing, C.C. and S.A. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

No data were collected in this manuscript, but all were cited as appropriate and can be found in the reference section.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Tsao, C.W.; Aday, A.W.; Almarzooq, Z.I.; Anderson, C.A.M.; Arora, P.; Avery, C.L.; Baker-Smith, C.M.; Beaton, A.Z.; Boehme, A.K.; Buxton, A.E.; et al. Heart Disease and Stroke Statistics-2023 Update: A Report from the American Heart Association. Circulation 2023, 147, e93–e621. [Google Scholar] [CrossRef]
  2. Centers for Disease Control and Prevention (CDC). Prevalence and most common causes of disability among adults—United States, 2005. MMWR Morb. Mortal. Wkly. Rep. 2009, 58, 421–426. [Google Scholar]
  3. Ovbiagele, B.; Goldstein, L.B.; Higashida, R.T.; Howard, V.J.; Johnston, S.C.; Khavjou, O.A.; Lackland, D.T.; Lichtman, J.H.; Mohl, S.; Sacco, R.L.; et al. Forecasting the future of stroke in the United States: A policy statement from the American Heart Association and American Stroke Association. Stroke 2013, 44, 2361–2375. [Google Scholar] [CrossRef] [Green Version]
  4. GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016, 388, 1603–1658. [Google Scholar] [CrossRef] [Green Version]
  5. St-Onge, M.P.; Grandner, M.A.; Brown, D.; Conroy, M.B.; Jean-Louis, G.; Coons, M.; Bhatt, D.L.; American Heart Association Obesity, Behavior Change, Diabetes, and Nutrition Committees of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; et al. Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association. Circulation 2016, 134, e367–e386. [Google Scholar] [CrossRef] [Green Version]
  6. Watson, N.F.; Badr, M.S.; Belenky, G.; Bliwise, D.L.; Buxton, O.M.; Buysse, D.; Dinges, D.F.; Gangwisch, J.; Grandner, M.A.; Kushida, C.; et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. Sleep 2015, 38, 843–844. [Google Scholar] [CrossRef]
  7. Altman, N.G.; Izci-Balserak, B.; Schopfer, E.; Jackson, N.; Rattanaumpawan, P.; Gehrman, P.R.; Patel, N.P.; Grandner, M.A. Sleep duration versus sleep insufficiency as predictors of cardiometabolic health outcomes. Sleep Med. 2012, 13, 1261–1270. [Google Scholar] [CrossRef] [Green Version]
  8. Abe, T.; Aoki, T.; Yata, S.; Okada, M. Sleep duration is significantly associated with carotid artery atherosclerosis incidence in a Japanese population. Atherosclerosis 2011, 217, 509–513. [Google Scholar] [CrossRef]
  9. Wolff, B.; Völzke, H.; Schwahn, C.; Robinson, D.; Kessler, C.; John, U. Relation of self-reported sleep duration with carotid intima-media thickness in a general population sample. Atherosclerosis 2008, 196, 727–732. [Google Scholar] [CrossRef]
  10. Cao, Z.; Dintica, C.; Shang, Y.; Cheng, Y.; Li, S.; Yang, H.; Sun, L.; Xu, W.; Wang, Y. The Role of Cognitive Impairment, Physical Disability, and Chronic Conditions in the Association of Sleep Duration with All-Cause Mortality Among Very Old Adults. J. Am. Med. Dir. Assoc. 2020, 21, 1458–1463.e2. [Google Scholar] [CrossRef]
  11. Jike, M.; Itani, O.; Watanabe, N.; Buysse, D.J.; Kaneita, Y. Long sleep duration and health outcomes: A systematic review, meta-analysis and meta-regression. Sleep Med. Rev. 2018, 39, 25–36. [Google Scholar] [CrossRef]
  12. Yang, L.; Xu, Z.; He, M.; Yang, H.; Li, X.; Min, X.; Zhang, C.; Xu, C.; Angileri, F.; Légaré, S.; et al. Sleep Duration and Midday Napping with 5-Year Incidence and Reversion of Metabolic Syndrome in Middle-Aged and Older Chinese. Sleep 2016, 39, 1911–1918. [Google Scholar] [CrossRef] [Green Version]
  13. Seixas, A.A.; Henclewood, D.A.; Williams, S.K.; Jagannathan, R.; Ramos, A.; Zizi, F.; Jean-Louis, G. Sleep Duration and Physical Activity Profiles Associated With Self-Reported Stroke in the United States: Application of Bayesian Belief Network Modeling Techniques. Front. Neurol. 2018, 9, 534. [Google Scholar] [CrossRef]
  14. Krittanawong, C.; Kumar, A.; Wang, Z.; Jneid, H.; Baber, U.; Mehran, R.; Tang, W.H.W.; Bhatt, D.L. Sleep Duration and Cardiovascular Health in a Representative Community Population (from NHANES, 2005 to 2016). Am. J. Cardiol. 2020, 127, 149–155. [Google Scholar] [CrossRef]
  15. Ge, B.; Guo, X. Short and long sleep durations are both associated with increased risk of stroke: A meta-analysis of observational studies. Int. J. Stroke 2015, 10, 177–184. [Google Scholar] [CrossRef]
  16. Joundi, R.A.; Patten, S.B.; Williams, J.V.A.; Smith, E.E. Association Between Excess Sleep Duration and Risk of Stroke: A Population-Based Study. Can. J. Neurol. Sci. 2021, 50, 17–22. [Google Scholar] [CrossRef]
  17. Kim, Y.; Wilkens, L.R.; Schembre, S.M.; Henderson, B.E.; Kolonel, L.N.; Goodman, M.T. Insufficient and excessive amounts of sleep increase the risk of premature death from cardiovascular and other diseases: The Multiethnic Cohort Study. Prev. Med. 2013, 57, 377–385. [Google Scholar] [CrossRef] [Green Version]
  18. Cai, H.; Shu, X.O.; Xiang, Y.B.; Yang, G.; Li, H.; Ji, B.T.; Gao, J.; Gao, Y.T.; Zheng, W. Sleep duration and mortality: A prospective study of 113 138 middle-aged and elderly Chinese men and women. Sleep 2015, 38, 529–536. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  19. Guo, Q.; Xie, W.; Peng, R.; Ma, Y.; Chong, F.; Wang, Y.; Song, M.; Ye, H.; Wang, P.; Wang, K.; et al. A Dose-Response Relationship Between Sleep Duration and Stroke According to Nonhealth Status in Central China: A Population-based Epidemiology Survey. J. Stroke Cerebrovasc. Dis. 2019, 28, 1841–1852. [Google Scholar] [CrossRef]
  20. Liu, Y.; Wheaton, A.G.; Chapman, D.P.; Croft, J.B. Sleep duration and chronic diseases among U.S. adults age 45 years and older: Evidence from the 2010 Behavioral Risk Factor Surveillance System. Sleep 2013, 36, 1421–1427. [Google Scholar] [CrossRef] [Green Version]
  21. Ke, J.; Zhou, X.; Qiu, H.; Yu, S.; Wu, K.; Rui, X.; Wang, X.; Liu, X.; Lin, T.; Ruan, X. Sex-specific associations between extreme sleep duration and prevalence of cardio-cerebral vascular disease: A community-based cross-sectional study. Sleep Med. 2018, 42, 61–67. [Google Scholar] [CrossRef]
  22. Wang, C.; Hao, G.; Bo, J.; Li, W. Correlations between sleep patterns and cardiovascular diseases in a Chinese middle-aged population. Chronobiol. Int. 2017, 34, 601–608. [Google Scholar] [CrossRef]
  23. Fang, J.; Wheaton, A.G.; Ayala, C. Sleep duration and history of stroke among adults from the USA. J. Sleep Res. 2014, 23, 531–537. [Google Scholar] [CrossRef] [Green Version]
  24. Hu, L.; Zhang, B.; Zhou, W.; Huang, X.; You, C.; Li, J.; Hong, K.; Li, P.; Wu, Y.; Wu, Q.; et al. Sleep duration on workdays or nonworkdays and cardiac-cerebral vascular diseases in Southern China. Sleep Med. 2018, 47, 36–43. [Google Scholar] [CrossRef] [PubMed]
  25. Magee, C.A.; Kritharides, L.; Attia, J.; McElduff, P.; Banks, E. Short and long sleep duration are associated with prevalent cardiovascular disease in Australian adults. J. Sleep Res. 2012, 21, 441–447. [Google Scholar] [CrossRef] [Green Version]
  26. Nuyujukian, D.S.; Anton-Culver, H.; Manson, S.M.; Jiang, L. Associations of sleep duration with cardiometabolic outcomes in American Indians and Alaska Natives and other race/ethnicities: Results from the BRFSS. Sleep Health 2019, 5, 344–351. [Google Scholar] [CrossRef] [PubMed]
  27. Liu, L.; Yang, J.; Wang, J.; Nie, M.; Wang, Z.; Guan, H.; Hu, J.; Hong, F. Relationship Between Sleep Duration and Stroke History in Middle-Aged and Elderly in Guiyang: A Cross-Sectional Survey. Neuropsychiatr. Dis. Treat. 2022, 18, 243–252. [Google Scholar] [CrossRef]
  28. Akinseye, O.A.; Ojike, N.I.; Akinseye, L.I.; Dhandapany, P.S.; Pandi-Perumal, S.R. Association of Sleep Duration with Stroke in Diabetic Patients: Analysis of the National Health Interview Survey. J. Stroke Cerebrovasc. Dis. 2016, 25, 650–655. [Google Scholar] [CrossRef]
  29. Hu, L.; Huang, X.; Zhou, W.; You, C.; Li, J.; Li, P.; Wu, Y.; Wu, Q.; Wang, Z.; Gao, R.; et al. Effect of hypertension status on the association between sleep duration and stroke among middle-aged and elderly population. J. Clin. Hypertens. 2020, 22, 65–73. [Google Scholar] [CrossRef] [Green Version]
  30. Sabanayagam, C.; Shankar, A. Sleep duration and cardiovascular disease: Results from the National Health Interview Survey. Sleep 2010, 33, 1037–1042. [Google Scholar] [CrossRef]
  31. Pergola, B.L.; Moonie, S.; Pharr, J.; Bungum, T.; Anderson, J.L. Sleep duration associated with cardiovascular conditions among adult Nevadans. Sleep Med. 2017, 34, 209–216. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  32. Li, W.; Kondracki, A.; Gautam, P.; Rahman, A.; Kiplagat, S.; Liu, H.; Sun, W. The association between sleep duration, napping, and stroke stratified by self-health status among Chinese people over 65 years old from the China health and retirement longitudinal study. Sleep Breath. 2021, 25, 1239–1246. [Google Scholar] [CrossRef] [PubMed]
  33. Wen, Y.; Pi, F.H.; Guo, P.; Dong, W.Y.; Xie, Y.Q.; Wang, X.Y.; Xia, F.F.; Pang, S.J.; Wu, Y.C.; Wang, Y.Y.; et al. Sleep duration, daytime napping, markers of obstructive sleep apnea and stroke in a population of southern China. Sci. Rep. 2016, 6, 34689. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  34. Wang, J.; Ren, X. Association Between Sleep Duration and Sleep Disorder Data from the National Health and Nutrition Examination Survey and Stroke Among Adults in the United States. Med. Sci. Monit. 2022, 28, e936384. [Google Scholar] [CrossRef] [PubMed]
  35. Merikanto, I.; Lahti, T.; Puolijoki, H.; Vanhala, M.; Peltonen, M.; Laatikainen, T.; Vartiainen, E.; Salomaa, V.; Kronholm, E.; Partonen, T. Associations of chronotype and sleep with cardiovascular diseases and type 2 diabetes. Chronobiol. Int. 2013, 30, 470–477. [Google Scholar] [CrossRef] [PubMed]
  36. Li, W.; Taskin, T.; Gautam, P.; Gamber, M.; Sun, W. Is there an association among sleep duration, nap, and stroke? Findings from the China Health and Retirement Longitudinal Study. Sleep Breath. 2021, 25, 315–323. [Google Scholar] [CrossRef]
  37. Yang, J.; Liu, X.; Zhai, Z.; Liao, W.; He, Y.; Wu, X.; Wang, C.; Sun, C.; Li, Y. The independent and combined association of napping and night sleep duration with stroke in Chinese rural adults. Sleep Breath. 2022, 27, 265–274. [Google Scholar] [CrossRef]
  38. Kim, M.Y.; Lee, S.; Myong, Y.H.; Lee, Y.J.; Kim, M.R.; Shin, J.S.; Lee, J.; Ha, I.H. Association between sleep duration and stroke prevalence in Korean adults: A cross-sectional study. BMJ Open 2018, 8, e021491. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  39. Kim, T.J.; Kim, C.K.; Kim, Y.; Jung, S.; Jeong, H.G.; An, S.J.; Ko, S.B.; Yoon, B.W. Prolonged sleep increases the risk of intracerebral haemorrhage: A nationwide case-control study. Eur. J. Neurol. 2016, 23, 1036–1043. [Google Scholar] [CrossRef]
  40. Chen, J.C.; Brunner, R.L.; Ren, H.; Wassertheil-Smoller, S.; Larson, J.C.; Levine, D.W.; Allison, M.; Naughton, M.J.; Stefanick, M.L. Sleep duration and risk of ischemic stroke in postmenopausal women. Stroke 2008, 39, 3185–3192. [Google Scholar] [CrossRef]
  41. Kronholm, E.; Laatikainen, T.; Peltonen, M.; Sippola, R.; Partonen, T. Self-reported sleep duration, all-cause mortality, cardiovascular mortality and morbidity in Finland. Sleep Med. 2011, 12, 215–221. [Google Scholar] [CrossRef]
  42. Zhou, L.; Yu, K.; Yang, L.; Wang, H.; Xiao, Y.; Qiu, G.; Liu, X.; Yuan, Y.; Bai, Y.; Li, X.; et al. Sleep duration, midday napping, and sleep quality and incident stroke: The Dongfeng-Tongji cohort. Neurology 2020, 94, e345–e356. [Google Scholar] [CrossRef] [PubMed]
  43. Qureshi, A.I.; Giles, W.H.; Croft, J.B.; Bliwise, D.L. Habitual sleep patterns and risk for stroke and coronary heart disease: A 10-year follow-up from NHANES I. Neurology 1997, 48, 904–911. [Google Scholar] [CrossRef] [PubMed]
  44. Titova, O.E.; Michaëlsson, K.; Larsson, S.C. Sleep Duration and Stroke: Prospective Cohort Study and Mendelian Randomization Analysis. Stroke 2020, 51, 3279–3285. [Google Scholar] [CrossRef]
  45. von Ruesten, A.; Weikert, C.; Fietze, I.; Boeing, H. Association of sleep duration with chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. PLoS ONE 2012, 7, e30972. [Google Scholar] [CrossRef]
  46. Song, Q.; Liu, X.; Zhou, W.; Wang, L.; Zheng, X.; Wang, X.; Wu, S. Long Sleep Duration and Risk of Ischemic Stroke and Hemorrhagic Stroke: The Kailuan Prospective Study. Sci. Rep. 2016, 6, 33664. [Google Scholar] [CrossRef]
  47. Butler, M.J.; Spruill, T.M.; Johnson, D.A.; Redline, S.; Sims, M.; Jenkins, B.C.; Booth, J.N.; Thomas, S.J.; Abdalla, M.; O’Brien, E.C.; et al. Suboptimal sleep and incident cardiovascular disease among African Americans in the Jackson Heart Study (JHS). Sleep Med. 2020, 76, 89–97. [Google Scholar] [CrossRef] [PubMed]
  48. Li, X.; Pang, X.; Liu, Z.; Zhang, Q.; Sun, C.; Yang, J.; Li, Y. Joint effect of less than 1 h of daytime napping and seven to 8 h of night sleep on the risk of stroke. Sleep Med. 2018, 52, 180–187. [Google Scholar] [CrossRef]
  49. Leng, Y.; Cappuccio, F.P.; Wainwright, N.W.; Surtees, P.G.; Luben, R.; Brayne, C.; Khaw, K.T. Sleep duration and risk of fatal and nonfatal stroke: A prospective study and meta-analysis. Neurology 2015, 84, 1072–1079. [Google Scholar] [CrossRef]
  50. Ji, A.; Lou, H.; Lou, P.; Xu, C.; Zhang, P.; Qiao, C.; Yang, Q. Interactive effect of sleep duration and sleep quality on risk of stroke: An 8-year follow-up study in China. Sci. Rep. 2020, 10, 8690. [Google Scholar] [CrossRef]
  51. Li, J.; Zheng, D.; Loffler, K.A.; Wang, X.; McEvoy, R.D.; Woodman, R.J.; Luo, Y.; Lorenzi-Filho, G.; Barbe, F.; Tripathi, M.; et al. Sleep duration and risk of cardiovascular events: The SAVE study. Int. J. Stroke 2020, 15, 858–865. [Google Scholar] [CrossRef] [PubMed]
  52. Petrov, M.E.; Howard, G.; Grandner, M.A.; Kleindorfer, D.; Molano, J.R.; Howard, V.J. Sleep duration and risk of incident stroke by age, sex, and race: The REGARDS study. Neurology 2018, 91, e1702–e1709. [Google Scholar] [CrossRef]
  53. Ye, Y.; Zhang, L.; Wang, A.; Wang, Y.; Wang, S.; Ning, G.; Mu, Y. Association of sleep duration with stroke, myocardial infarction, and tumors in a Chinese population with metabolic syndrome: A retrospective study. Lipids Health Dis. 2020, 19, 155. [Google Scholar] [CrossRef] [PubMed]
  54. Helbig, A.K.; Stöckl, D.; Heier, M.; Ladwig, K.H.; Meisinger, C. Symptoms of Insomnia and Sleep Duration and Their Association with Incident Strokes: Findings from the Population-Based MONICA/KORA Augsburg Cohort Study. PLoS ONE 2015, 10, e0134480. [Google Scholar] [CrossRef]
  55. Hamazaki, Y.; Morikawa, Y.; Nakamura, K.; Sakurai, M.; Miura, K.; Ishizaki, M.; Kido, T.; Naruse, Y.; Suwazono, Y.; Nakagawa, H. The effects of sleep duration on the incidence of cardiovascular events among middle-aged male workers in Japan. Scand. J. Work. Environ. Health 2011, 37, 411–417. [Google Scholar] [CrossRef] [PubMed]
  56. Westerlund, A.; Bellocco, R.; Sundström, J.; Adami, H.O.; Åkerstedt, T.; Trolle Lagerros, Y. Sleep characteristics and cardiovascular events in a large Swedish cohort. Eur. J. Epidemiol. 2013, 28, 463–473. [Google Scholar] [CrossRef]
  57. Ruiter Petrov, M.E.; Letter, A.J.; Howard, V.J.; Kleindorfer, D. Self-reported sleep duration in relation to incident stroke symptoms: Nuances by body mass and race from the REGARDS study. J. Stroke Cerebrovasc. Dis. 2014, 23, e123–e132. [Google Scholar] [CrossRef] [Green Version]
  58. Amagai, Y.; Ishikawa, S.; Gotoh, T.; Kayaba, K.; Nakamura, Y.; Kajii, E. Sleep duration and incidence of cardiovascular events in a Japanese population: The Jichi Medical School cohort study. J. Epidemiol. 2010, 20, 106–110. [Google Scholar] [CrossRef] [Green Version]
  59. Han, H.; Wang, Y.; Li, T.; Feng, C.; Kaliszewski, C.; Su, Y.; Wu, Y.; Zhou, J.; Wang, L.; Zong, G. Sleep Duration and Risks of Incident Cardiovascular Disease and Mortality Among People With Type 2 Diabetes. Diabetes Care 2023, 46, 101–110. [Google Scholar] [CrossRef]
  60. Cheng, X.; Ouyang, F.; Ma, T.; He, L.; Gong, L.; Yin, J.; Zhang, G.; Bai, Y. The individual and joint associations of depression and sleep duration with cardiometabolic diseases and mortality: A prospective cohort study. Atherosclerosis 2022, 361, 10–17. [Google Scholar] [CrossRef]
  61. Yin, J.; Jin, X.; Shan, Z.; Li, S.; Huang, H.; Li, P.; Peng, X.; Peng, Z.; Yu, K.; Bao, W.; et al. Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. J. Am. Heart Assoc. 2017, 6, e005947. [Google Scholar] [CrossRef] [Green Version]
  62. He, Q.; Sun, H.; Wu, X.; Zhang, P.; Dai, H.; Ai, C.; Shi, J. Sleep duration and risk of stroke: A dose-response meta-analysis of prospective cohort studies. Sleep Med. 2017, 32, 66–74. [Google Scholar] [CrossRef] [PubMed]
  63. Li, W.; Wang, D.; Cao, S.; Yin, X.; Gong, Y.; Gan, Y.; Zhou, Y.; Lu, Z. Sleep duration and risk of stroke events and stroke mortality: A systematic review and meta-analysis of prospective cohort studies. Int. J. Cardiol. 2016, 223, 870–876. [Google Scholar] [CrossRef]
  64. Cappuccio, F.P.; Cooper, D.; D’Elia, L.; Strazzullo, P.; Miller, M.A. Sleep duration predicts cardiovascular outcomes: A systematic review and meta-analysis of prospective studies. Eur. Heart J. 2011, 32, 1484–1492. [Google Scholar] [CrossRef] [Green Version]
  65. Krittanawong, C.; Tunhasiriwet, A.; Wang, Z.; Zhang, H.; Farrell, A.M.; Chirapongsathorn, S.; Sun, T.; Kitai, T.; Argulian, E. Association between short and long sleep durations and cardiovascular outcomes: A systematic review and meta-analysis. Eur. Heart J. Acute Cardiovasc. Care 2019, 8, 762–770. [Google Scholar] [CrossRef]
  66. Wang, H.; Sun, J.; Sun, M.; Liu, N.; Wang, M. Relationship of sleep duration with the risk of stroke incidence and stroke mortality: An updated systematic review and dose-response meta-analysis of prospective cohort studies. Sleep Med. 2022, 90, 267–278. [Google Scholar] [CrossRef] [PubMed]
  67. Pan, A.; De Silva, D.A.; Yuan, J.M.; Koh, W.P. Sleep duration and risk of stroke mortality among Chinese adults: Singapore Chinese health study. Stroke 2014, 45, 1620–1625. [Google Scholar] [CrossRef]
  68. Kakizaki, M.; Kuriyama, S.; Nakaya, N.; Sone, T.; Nagai, M.; Sugawara, Y.; Hozawa, A.; Fukudo, S.; Tsuji, I. Long sleep duration and cause-specific mortality according to physical function and self-rated health: The Ohsaki Cohort Study. J. Sleep Res. 2013, 22, 209–216. [Google Scholar] [CrossRef] [PubMed]
  69. Kawachi, T.; Wada, K.; Nakamura, K.; Tsuji, M.; Tamura, T.; Konishi, K.; Nagata, C. Sleep Duration and the Risk of Mortality From Stroke in Japan: The Takayama Cohort Study. J. Epidemiol. 2016, 26, 123–130. [Google Scholar] [CrossRef] [Green Version]
  70. Ikehara, S.; Iso, H.; Date, C.; Kikuchi, S.; Watanabe, Y.; Wada, Y.; Inaba, Y.; Tamakoshi, A.; JACC Study Group. Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: The JACC study. Sleep 2009, 32, 295–301. [Google Scholar] [CrossRef] [Green Version]
  71. Zhou, B.; Jiang, C.; Zhang, W.; Jin, Y.; Zhu, T.; Zhu, F.; Xu, L. Association of sleep duration and napping with stroke mortality in older Chinese: A 14-year prospective cohort study of the Guangzhou Biobank Cohort study. Sleep Med. 2023, 101, 384–391. [Google Scholar] [CrossRef]
  72. Kleindorfer, D.O.; Towfighi, A.; Chaturvedi, S.; Cockroft, K.M.; Gutierrez, J.; Lombardi-Hill, D.; Kamel, H.; Kernan, W.N.; Kittner, S.J.; Leira, E.C.; et al. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke 2021, 52, e364–e467. [Google Scholar] [CrossRef]
  73. Tuomilehto, H.; Peltonen, M.; Partinen, M.; Lavigne, G.; Eriksson, J.G.; Herder, C.; Aunola, S.; Keinänen-Kiukaanniemi, S.; Ilanne-Parikka, P.; Uusitupa, M.; et al. Sleep duration, lifestyle intervention, and incidence of type 2 diabetes in impaired glucose tolerance: The Finnish Diabetes Prevention Study. Diabetes Care 2009, 32, 1965–1971. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  74. Gangwisch, J.E.; Heymsfield, S.B.; Boden-Albala, B.; Buijs, R.M.; Kreier, F.; Pickering, T.G.; Rundle, A.G.; Zammit, G.K.; Malaspina, D. Sleep duration as a risk factor for diabetes incidence in a large U.S. sample. Sleep 2007, 30, 1667–1673. [Google Scholar] [CrossRef] [PubMed]
  75. Yaggi, H.K.; Araujo, A.B.; McKinlay, J.B. Sleep duration as a risk factor for the development of type 2 diabetes. Diabetes Care 2006, 29, 657–661. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  76. Kowall, B.; Lehnich, A.T.; Strucksberg, K.H.; Führer, D.; Erbel, R.; Jankovic, N.; Moebus, S.; Jöckel, K.H.; Stang, A. Associations among sleep disturbances, nocturnal sleep duration, daytime napping, and incident prediabetes and type 2 diabetes: The Heinz Nixdorf Recall Study. Sleep Med. 2016, 21, 35–41. [Google Scholar] [CrossRef]
  77. Ayas, N.T.; White, D.P.; Al-Delaimy, W.K.; Manson, J.E.; Stampfer, M.J.; Speizer, F.E.; Patel, S.; Hu, F.B. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care 2003, 26, 380–384. [Google Scholar] [CrossRef] [Green Version]
  78. Cappuccio, F.P.; D’Elia, L.; Strazzullo, P.; Miller, M.A. Quantity and quality of sleep and incidence of type 2 diabetes: A systematic review and meta-analysis. Diabetes Care 2010, 33, 414–420. [Google Scholar] [CrossRef] [Green Version]
  79. Shan, Z.; Ma, H.; Xie, M.; Yan, P.; Guo, Y.; Bao, W.; Rong, Y.; Jackson, C.L.; Hu, F.B.; Liu, L. Sleep duration and risk of type 2 diabetes: A meta-analysis of prospective studies. Diabetes Care 2015, 38, 529–537. [Google Scholar] [CrossRef] [Green Version]
  80. Khawaja, O.; Sarwar, A.; Albert, C.M.; Gaziano, J.M.; Djoussé, L. Sleep duration and risk of atrial fibrillation (from the Physicians’ Health Study). Am. J. Cardiol. 2013, 111, 547–551. [Google Scholar] [CrossRef] [Green Version]
  81. Song, Q.; Liu, X.; Hu, W.; Zhou, W.; Liu, A.; Wang, X.; Wu, S. Long Sleep Duration Is an Independent Risk Factor for Incident Atrial Fibrillation in a Chinese Population: A Prospective Cohort Study. Sci. Rep. 2017, 7, 3679. [Google Scholar] [CrossRef] [Green Version]
  82. Arafa, A.; Kokubo, Y.; Shimamoto, K.; Kashima, R.; Watanabe, E.; Sakai, Y.; Li, J.; Teramoto, M.; Sheerah, H.A.; Kusano, K. Sleep duration and atrial fibrillation risk in the context of predictive, preventive, and personalized medicine: The Suita Study and meta-analysis of prospective cohort studies. EPMA J. 2022, 13, 77–86. [Google Scholar] [CrossRef] [PubMed]
  83. Maeda, Y.; Inoguchi, T.; Etoh, E.; Kodama, Y.; Sasaki, S.; Sonoda, N.; Nawata, H.; Shimabukuro, M.; Takayanagi, R. Brachial-ankle pulse wave velocity predicts all-cause mortality and cardiovascular events in patients with diabetes: The Kyushu Prevention Study of Atherosclerosis. Diabetes Care 2014, 37, 2383–2390. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  84. Yoshioka, E.; Saijo, Y.; Kita, T.; Okada, E.; Satoh, H.; Kawaharada, M.; Kishi, R. Relation between self-reported sleep duration and arterial stiffness: A cross-sectional study of middle-aged Japanese civil servants. Sleep 2011, 34, 1681–1686. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  85. Liu, X.; Song, Q.; Wu, S.; Wang, X. Long sleep duration and risk of increased arterial stiffness in a Chinese population. Medicine 2020, 99, e22073. [Google Scholar] [CrossRef]
  86. Logan, J.G.; Kang, H.; Lobo, J.M.; Sohn, M.W.; Lin, G.M.; Lima, J.A.C.; Punjabi, N.M.; Redline, S.; Kwon, Y. Actigraphy-based sleep characteristics and aortic stiffness: The Multi-Ethnic Study of Atherosclerosis. J. Am. Soc. Hypertens. 2018, 12, 841–849. [Google Scholar] [CrossRef] [PubMed]
  87. Tsai, T.C.; Wu, J.S.; Yang, Y.C.; Huang, Y.H.; Lu, F.H.; Chang, C.J. Long sleep duration associated with a higher risk of increased arterial stiffness in males. Sleep 2014, 37, 1315–1320. [Google Scholar] [CrossRef]
  88. Niijima, S.; Nagai, M.; Hoshide, S.; Takahashi, M.; Shimpo, M.; Kario, K.; Japan Morning Surge-Home Blood Pressure Study Investigators Group. Long sleep duration: A nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: The J-HOP study. J. Am. Soc. Hypertens. 2016, 10, 429–437. [Google Scholar] [CrossRef]
  89. Kim, C.W.; Chang, Y.; Zhao, D.; Cainzos-Achirica, M.; Ryu, S.; Jung, H.S.; Yun, K.E.; Choi, Y.; Ahn, J.; Zhang, Y.; et al. Sleep Duration, Sleep Quality, and Markers of Subclinical Arterial Disease in Healthy Men and Women. Arterioscler. Thromb. Vasc. Biol. 2015, 35, 2238–2245. [Google Scholar] [CrossRef] [Green Version]
  90. Kelly, P.J.; Lemmens, R.; Tsivgoulis, G. Inflammation and Stroke Risk: A New Target for Prevention. Stroke 2021, 52, 2697–2706. [Google Scholar] [CrossRef]
  91. Williams, C.J.; Hu, F.B.; Patel, S.R.; Mantzoros, C.S. Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetes. Diabetes Care 2007, 30, 1233–1240. [Google Scholar] [CrossRef] [Green Version]
  92. Dowd, J.B.; Goldman, N.; Weinstein, M. Sleep duration, sleep quality, and biomarkers of inflammation in a Taiwanese population. Ann. Epidemiol. 2011, 21, 799–806. [Google Scholar] [CrossRef] [Green Version]
  93. Patel, S.R.; Zhu, X.; Storfer-Isser, A.; Mehra, R.; Jenny, N.S.; Tracy, R.; Redline, S. Sleep duration and biomarkers of inflammation. Sleep 2009, 32, 200–204. [Google Scholar] [CrossRef] [Green Version]
  94. Grandner, M.A.; Buxton, O.M.; Jackson, N.; Sands-Lincoln, M.; Pandey, A.; Jean-Louis, G. Extreme sleep durations and increased C-reactive protein: Effects of sex and ethnoracial group. Sleep 2013, 36, 769–779. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  95. Opp, M.R.; Kapás, L.; Toth, L.A. Cytokine involvement in the regulation of sleep. Proc. Soc. Exp. Biol. Med. 1992, 201, 16–27. [Google Scholar] [CrossRef] [PubMed]
  96. Grandner, M.A.; Drummond, S.P. Who are the long sleepers? Towards an understanding of the mortality relationship. Sleep Med. Rev. 2007, 11, 341–360. [Google Scholar] [CrossRef] [Green Version]
  97. Rohm, T.V.; Meier, D.T.; Olefsky, J.M.; Donath, M.Y. Inflammation in obesity, diabetes, and related disorders. Immunity 2022, 55, 31–55. [Google Scholar] [CrossRef]
  98. Rothwell, P.M.; Howard, S.C.; Dolan, E.; O’Brien, E.; Dobson, J.E.; Dahlöf, B.; Sever, P.S.; Poulter, N.R. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010, 375, 895–905. [Google Scholar] [CrossRef] [PubMed]
  99. Nagai, M.; Hoshide, S.; Ishikawa, J.; Shimada, K.; Kario, K. Visit-to-visit blood pressure variations: New independent determinants for carotid artery measures in the elderly at high risk of cardiovascular disease. J. Am. Soc. Hypertens. 2011, 5, 184–192. [Google Scholar] [CrossRef]
  100. Johansson, J.K.; Kronholm, E.; Jula, A.M. Variability in home-measured blood pressure and heart rate: Associations with self-reported insomnia and sleep duration. J. Hypertens. 2011, 29, 1897–1905. [Google Scholar] [CrossRef]
  101. Nagai, M.; Hoshide, S.; Nishikawa, M.; Shimada, K.; Kario, K. Sleep duration and insomnia in the elderly: Associations with blood pressure variability and carotid artery remodeling. Am. J. Hypertens. 2013, 26, 981–989. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  102. Lu, H.; Wu, P.F.; Li, R.Z.; Zhang, W.; Huang, G.X. Sleep Duration and Stroke: A Mendelian Randomization Study. Front. Neurol. 2020, 11, 976. [Google Scholar] [CrossRef]
  103. Dashti, H.S.; Jones, S.E.; Wood, A.R.; Lane, J.M.; van Hees, V.T.; Wang, H.; Rhodes, J.A.; Song, Y.; Patel, K.; Anderson, S.G.; et al. Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat. Commun. 2019, 10, 1100. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  104. Ai, S.; Zhang, J.; Zhao, G.; Wang, N.; Li, G.; So, H.C.; Liu, Y.; Chau, S.W.; Chen, J.; Tan, X.; et al. Causal associations of short and long sleep durations with 12 cardiovascular diseases: Linear and nonlinear Mendelian randomization analyses in UK Biobank. Eur. Heart J. 2021, 42, 3349–3357. [Google Scholar] [CrossRef]
  105. Jia, Y.; Guo, D.; Sun, L.; Shi, M.; Zhang, K.; Yang, P.; Zang, Y.; Wang, Y.; Liu, F.; Zhang, Y.; et al. Self-reported daytime napping, daytime sleepiness, and other sleep phenotypes in the development of cardiometabolic diseases: A Mendelian randomization study. Eur. J. Prev. Cardiol. 2022, 29, 1982–1991. [Google Scholar] [CrossRef]
  106. Zhuang, Z.; Gao, M.; Yang, R.; Li, N.; Liu, Z.; Cao, W.; Huang, T. Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: A Mendelian randomization analysis. Lipids Health Dis. 2020, 19, 86. [Google Scholar] [CrossRef]
  107. Liu, X.; Zhang, J.; Wang, Y.; Lu, C.; Gu, X.; Wan, G.; Zhang, P. The Relationship between Sleep Duration and Stroke Risk: The Mediating Role of Physical Activity. Brain Sci. 2022, 12, 601. [Google Scholar] [CrossRef] [PubMed]
  108. Singh, M.; Hall, K.A.; Reynolds, A.; Palmer, L.J.; Mukherjee, S. The Relationship of Sleep Duration with Ethnicity and Chronic Disease in a Canadian General Population Cohort. Nat. Sci. Sleep 2020, 12, 239–251. [Google Scholar] [CrossRef] [Green Version]
  109. Rainer, M.A.; Palmer, P.H.; Xie, B. Sleep Duration and Chronic Disease Among Older Native Hawaiians or Other Pacific Islanders and Asians: Analysis of the Behavioral Risk Factor Surveillance System. J. Racial Ethn. Health Disparities 2022, 1–10. [Google Scholar] [CrossRef] [PubMed]
  110. Huang, T.C.; Tseng, P.T.; Wu, M.N.; Stubbs, B.; Carvalho, A.F.; Lin, P.Y.; Chen, Y.W.; Chen, T.Y.; Hsu, C.Y. Periodic limb movements during sleep are associated with cardiovascular diseases: A systematic review and meta-analysis. J. Sleep Res. 2019, 28, e12720. [Google Scholar] [CrossRef]
  111. Wang, Y.H.; Wang, J.; Chen, S.H.; Li, J.Q.; Lu, Q.D.; Vitiello, M.V.; Wang, F.; Tang, X.D.; Shi, J.; Lu, L.; et al. Association of Longitudinal Patterns of Habitual Sleep Duration With Risk of Cardiovascular Events and All-Cause Mortality. JAMA Netw. Open. 2020, 3, e205246. [Google Scholar] [CrossRef]
  112. Ramos, A.R.; Dong, C.; Rundek, T.; Elkind, M.S.; Boden-Albala, B.; Sacco, R.L.; Wright, C.B. Sleep duration is associated with white matter hyperintensity volume in older adults: The Northern Manhattan Study. J. Sleep Res. 2014, 23, 524–530. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  113. Smagula, S.F.; Koh, W.P.; Wang, R.; Yuan, J.M. Chronic disease and lifestyle factors associated with change in sleep duration among older adults in the Singapore Chinese Health Study. J. Sleep Res. 2016, 25, 57–61. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  114. Gao, C.; Guo, J.; Gong, T.T.; Lv, J.L.; Li, X.Y.; Liu, F.H.; Zhang, M.; Shan, Y.T.; Zhao, Y.H.; Wu, Q.J. Sleep Duration/Quality With Health Outcomes: An Umbrella Review of Meta-Analyses of Prospective Studies. Front. Med. 2021, 8, 813943. [Google Scholar] [CrossRef]
  115. Ford, E.S. Habitual sleep duration and predicted 10-year cardiovascular risk using the pooled cohort risk equations among US adults. J. Am. Heart Assoc. 2014, 3, e001454. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  116. Guasch-Ferré, M.; Li, Y.; Bhupathiraju, S.N.; Huang, T.; Drouin-Chartier, J.P.; Manson, J.E.; Sun, Q.; Rimm, E.B.; Rexrode, K.M.; Willett, W.C.; et al. Healthy Lifestyle Score Including Sleep Duration and Cardiovascular Disease Risk. Am. J. Prev. Med. 2022, 63, 33–42. [Google Scholar] [CrossRef]
  117. Jackson, C.L.; Patel, S.R.; Jackson, W.B.; Lutsey, P.L.; Redline, S. Agreement between self-reported and objectively measured sleep duration among white, black, Hispanic, and Chinese adults in the United States: Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41, zsy057. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  118. Cespedes, E.M.; Hu, F.B.; Redline, S.; Rosner, B.; Alcantara, C.; Cai, J.; Hall, M.H.; Loredo, J.S.; Mossavar-Rahmani, Y.; Ramos, A.R.; et al. Comparison of Self-Reported Sleep Duration With Actigraphy: Results From the Hispanic Community Health Study/Study of Latinos Sueño Ancillary Study. Am. J. Epidemiol. 2016, 183, 561–573. [Google Scholar] [CrossRef] [Green Version]
Neurolint 15 00048 g001 550
Figure 1. J-shaped curves—sleep duration and relative risks for stroke incidence from meta-analyses (a) and stroke mortality from prospective studies (b).
Figure 1. J-shaped curves—sleep duration and relative risks for stroke incidence from meta-analyses (a) and stroke mortality from prospective studies (b).
Neurolint 15 00048 g001
Table
Table 1. Sleep duration and stroke prevalence—cross-sectional studies.
Table 1. Sleep duration and stroke prevalence—cross-sectional studies.
StudySample SizeSleep Duration (Hours/Day)Long Sleeper %Odds Ratio (95% CI)Country
LongShortLongShort
2019, Guo [19]18,670≥10 <69.5%1.63 (1.30–2.04)1.19 (0.86–1.66)China
2013, Liu [20]54,269≥10 ≤64.1%2.23 (1.71–2.92)1.22 (1.03–1.45)USA
2018, Ke [21]10,657>9 <54.7%2.13 (1.34–3.39)1.22 (0.68–2.19)China
2018, Seixas [13]288,888≥9 <78.7%1.801.29USA
2020, Krittanawong [14]32,152>9 <73.3%1.81 (1.37–2.34)1.45 (1.23–1.70)USA
2017, Wang [22]39,515≥9 <646.8%1.35 (1.05–1.73)1.24 (0.53–2.93)China
2014, Fang [23]154,599≥9 ≤69.0%1.80 (1.63–1.99)1.20 (1.11–1.29)USA
2012, Altman [7]30,934≥10 <53.8%1.86 (1.21–2.52)2.51 (0.97–4.06)USA
2018, Hu [24]15,269>8 <613.8%1.86 (1.29–2.69)1.41 (0.92–2.15)China
2012, Magee [25]218,155≥9 <619.7%1.50 (1.38–1.62)1.54 (1.36–1.75)Australia
2019, Nuyujukian [26]14,536≥8 ≤639.3%1.361.43USA
2022, Liu [27]5065>9 <719.6%2.11 (1.39–3.19)1.67 (0.91–3.07)China
2016, Akinseye [28]26,364≥9 ≤614%1.46 (1.16–1.84)1.15 (0.95–1.40)USA
2020, Hu [29]10,516>8 <618.8%1.59 (1.07–2.38)1.21 (0.73–2.01)China
2010, Sabanayagam [30]30,397≥9 ≤58.8%2.22 (1.69–2.91)2.01 (1.50–2.70)USA
2017, Pergola [31]5101≥10 <52.8%7.17 (3.28–15.65)2.41 (1.14–5.11)USA
2021, Li [32]4785>8 <724%1.86 (1.08–3.21)2.11 (1.30–3.44)China
2016, Wen [33]880≥9 <76.6%2.00 (1.16–3.46)0.94 (0.59–1.49)China
2022, Wang [34]10,442≥8 <633.0%1.31 (0.86–1.99)1.95 (1.19–3.19)USA
2013, Merikanto [35]6258≥9 ≤68.0%1.7 (0.9–3.2)1.9 (1.2–2.9)Finland
2021, Li [36]4334>8 <79.1%1.58 (0.92–2.70)1.81 (1.10–2.97)China
2022, Yang [37]37,341≥9 <610.8%1.11 (0.97–1.27)1.26 (1.09–1.46)China
2018, Kim [38]17,601≥9 ≤67%1.52 (0.93–2.48)1.05 (0.79–1.39)Republic of Korea
2016, Kim [39]1470≥9 ≤55.6%5.00 (2.18–11.47)0.67 (0.36–1.24)Republic of Korea
Table
Table 2. Sleep duration and stroke incidence—prospective studies.
Table 2. Sleep duration and stroke incidence—prospective studies.
StudySample SizeSleep Duration (Hours/Day)Long Sleeper %Follow-Up Duration (Years)Hazard Ratio (95% CI)Country
LongShortLongShort
2011, Kronholm [41]24,025≥10 ≤52.6%29–341.41.15Finland
2020, Zhou [42]31,750≥9 <623.9%6.21.23 (1.07–1.41)1.10 (0.69–1.75)China
2008, Chen [40]93,175≥9 ≤54.6%7.51.70 (1.32–2.21)1.14 (0.97–1.33)USA
1997, Qureshi [43]7844>8 <68.5%101.5 (1.1–2.0)1.0 (0.7–1.5)USA
2021, Joundi [16]82,795≥10 <41.2%9.12.26 (1.02–5.00)1.38 (0.63–3.02)Canada
2020, Titova [44]79,881≥9 <76.1%14.61.12 (1.03–1.22)1.04 (0.99–1.09)Sweden
2012, von Ruesten [45]23,620≥9 <67.5%7.81.65 (1.00–2.73)2.06 (1.18–3.59)Europe
2016, Song [46]95,023>8 <61.7%7.91.29 (1.01–1.64)0.92 (0.81–1.05)China
2020, Butler [47]4522≥9 <64.9%121.32 (1.02–1.70)1.56 (1.06–2.30)USA
2018, Li [48]1928≥9 <710.2%4.942.24 (1.05–4.79)1.27 (0.75–2.16)China
2015, Leng [49]9692>8 <610%9.51.46 (1.08–1.98)1.18 (0.91–1.53)UK
2020, Ji [50]27,712>8 <618.9%71.40 (1.08–1.75)1.63 (1.23–2.11)China
2020, Li [51]2687>8 <630.3%3.71.79 (1.22–2.63)1.20 (0.72–2.00)China
2018, Petrov [52]16,733≥9 <66.8%6.11.71 (1.06–2.76)1.58 (0.90–2.79)USA
2020, Ye [53]8968>9 <69.4%32.01 (1.18–3.43)2.25 (0.97–5.20)China
2015, Helbig [54]15,746≥10 ≤54%141.38 (0.98–1.94)1.36 (0.95–1.94)Germany
2011, Hamazaki [55]2282≥8 <622.3%142.25 (0.91–5.57)1.84 (0.23–4.90)Japan
2013, Westerlund [56]41,192≥8 ≤524.2%13.20.87 (0.72–1.04)1.05 (0.80–1.37)Sweden
2014, Ruiter Petrov [57]5666≥9 <65.9%30.96 (0.45–2.05)1.55 (0.82–2.91)USA
2010, Amagai [58]11,367≥9 <615.1%10.71.39 (0.92–2.10)2.00 (0.93–4.31)Japan
2023, Han [59]18,876≥10 ≤53.6%11.52.08 (1.44–3.01)1.70 (1.23–2.35)UK
2022, Cheng [60]261,297>9<72.4%10.91.22 (1.07–1.38)1.18 (1.11–1.25)UK
Table
Table 3. Sleep duration and stroke incidence—meta-analysis of prospective studies.
Table 3. Sleep duration and stroke incidence—meta-analysis of prospective studies.
StudyParticipantsFollow-Up
(Years)		Hazard Ratio (95% CI)Cohorts
LongShort
2011, Cappuccio [64]474,6846.9–251.65 (1.45–1.87)1.15 (1.00–1.31)24
2015, Leng [49]559,2527.5–351.45 (1.30–1.62)1.15 (1.07–1.24)11
2016, Li [63]136,1103–181.53 (1.40–1.66)1.19 (1.05–1.36)16
2017, Yin [61]301,9922.3–341.45 (1.30–1.62)1.09 (0.99–1.19)20
2017, He [62]528,6537.8–14.71.37 (1.23–1.54)1.10 (0.97–1.24)16
2019, Krittanawong [65]621,8604–221.48 (1.31–1.68)1.32 (1.18–1.47)18
2022, Wang [66]248,8687–181.71 (1.50–1.95)1.33 (1.19–1.49)27
Table
Table 4. Sleep duration and stroke mortality—prospective studies.
Table 4. Sleep duration and stroke mortality—prospective studies.
StudySample SizeSleep Duration (Hours/Day)Long Sleeper %Follow-Up Duration (Years)Hazard Ratio (95% CI)Country
LongShortLongShort
2013, Kakizaki [68]49,256≥10 ≤67.9%10.81.51 (1.24–1.85)1.05 (0.84–1.30)Japan
2013, Kim [17]135,685≥9 ≤58.3%12.91.35 (1.03–1.75)1.02 (0.74–1.40)US
2015, Cai [18]113,138≥10 ≤53.8%7.12.35 (1.78–3.09)0.91 (0.70–1.18)China
2016, Kawachi [69]27,896≥9 ≤69%161.51 (1.16–1.97)0.77 (0.59–1.01)Japan
2014, Pan [67]63,257≥9 ≤57%14.71.54 (1.28–1.85)1.25 (1.05–1.50)Singapore
2009, Ikehara [70]110,792≥10 ≤44%14.31.66 (1.31–2.08)1.56 (0.82–2.94)Japan
2023, Zhou [71]27,254≥9≤510.2%14.31.37 (1.07–1.75)1.27 (1.01–1.59)China
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Cai, C.; Atanasov, S. Long Sleep Duration and Stroke—Highly Linked, Poorly Understood. Neurol. Int. 2023, 15, 764-777. https://doi.org/10.3390/neurolint15030048

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Cai C, Atanasov S. Long Sleep Duration and Stroke—Highly Linked, Poorly Understood. Neurology International. 2023; 15(3):764-777. https://doi.org/10.3390/neurolint15030048

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Cai, Chumeng, and Strahil Atanasov. 2023. "Long Sleep Duration and Stroke—Highly Linked, Poorly Understood" Neurology International 15, no. 3: 764-777. https://doi.org/10.3390/neurolint15030048

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