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Article
Peer-Review Record

SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE

Viruses 2022, 14(5), 983; https://doi.org/10.3390/v14050983
by Charles N. S. Allen 1, Maryline Santerre 1, Sterling P. Arjona 1, Lea J. Ghaleb 1, Muna Herzi 1, Megan D. Llewellyn 1, Natalia Shcherbik 2 and Bassel E. Sawaya 1,3,4,5,*
Reviewer 1:
Reviewer 2: Anonymous
Viruses 2022, 14(5), 983; https://doi.org/10.3390/v14050983
Submission received: 15 April 2022 / Revised: 29 April 2022 / Accepted: 3 May 2022 / Published: 6 May 2022
(This article belongs to the Section Human Virology and Viral Diseases)

Round 1

Reviewer 1 Report

The manuscript is an original work merits publication.

Minor comment:

AGEs concentrations were determined using AGEs ELISA kit. As known, there are many AGEs products, can the authors add some informations on what kind of products were measured?

Author Response

We thank the reviewers for their constructive comments.

We did the requested info in the revised version.

Author Response File: Author Response.docx

Reviewer 2 Report

The article written by Allen CNS et al, is well designed and well written. It prove using some molecular technics that infection by the virus SARS-CoV-2 induce a cascade of metabolic programmation witch finally lead to inflammation and the post COVID-19 symptoms. 

Minor remark:

  • Authors should add more informations in the molecular methods description in MM section...The design of the work is original and more precisions to add in methods section is important for readers.

Author Response

We thank the reviewers for their constructive comments.

We did the requested info in the revised version.

More details about the Methods are now added.

We replaced Fig 6 with a better model.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Manuscript with this version merits publication

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