Spatiotemporal Patterns of Adverse Pregnancy Outcomes in Rural Areas of Henan, China
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Area and Data
2.2. APO Outcomes
2.3. Variables
2.4. Geolocation
2.5. Methods of APO Analysis
3. Results
3.1. Participants
3.2. Baseline Characteristics by APOs
3.3. Temporal Distribution of APOs over Time
3.4. Spatial Patterns of APOs
3.5. Spatio-Temporal Clustering of APOs
3.6. Spatio-Temporal Correlation across Eight Types of APOs
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | Adverse Pregnancy Outcomes | p | |
---|---|---|---|
Yes (n = 160,383) | No (n = 1,154,944) | ||
Maternal age | <0.001 * | ||
(20, 25) | 45,306 (11.80%) | 338,611 (88.20%) | |
(25, 30) | 83,920 (12.23%) | 602,031 (87.77%) | |
(30, 35) | 21,650 (12.42%) | 152,673 (87.58%) | |
(35, 40) | 7276 (13.12%) | 48,170 (86.88%) | |
(40, 45) | 1888 (13.81%) | 11,784 (86.19%) | |
(45, 50) | 343 (17.00%) | 1675 (83.00%) | |
Education level completed | <0.001 * | ||
Missing | 4989 (15.25%) | 27,734 (84.75%) | |
College or higher | 17,770 (14.50%) | 104,798 (85.50%) | |
Senior high school | 1520 (12.68%) | 10,471 (87.32%) | |
Junior high school | 26,395 (12.81%) | 179,693 (87.19%) | |
Primary school or below | 109,709 (11.65%) | 832,248 (88.35%) | |
Maternal occupation | <0.001 | ||
Farmer | 138,965 (11.89%) | 1,029,831 (88.11%) | |
Other | 21,418 (14.62%) | 125,113 (85.38%) | |
Maternal ethnicity | <0.001 | ||
Han | 156,389 (12.15%) | 1,130,794 (87.85%) | |
Other | 3994 (14.19%) | 24,150 (85.81%) | |
Maternal BMI | <0.001 * | ||
<18.5 | 15,221 (12.70%) | 104,627 (87.30%) | |
18.5–23.9 | 116,835 (12.01%) | 856,197 (87.99%) | |
24.0–27.9 | 22,540 (12.67%) | 155,357 (87.33%) | |
≥28.0 | 5564 (13.01%) | 37,194 (86.99%) | |
Missing | 223 (12.44%) | 1569 (87.56%) | |
Season of conception | <0.001 | ||
Spring | 49,473 (12.66%) | 341,325 (87.34%) | |
Summer | 40,332 (12.34%) | 286,477 (87.66%) | |
Autumn | 32,561 (11.16%) | 259,263 (88.84%) | |
Winter | 38,017 (12.43%) | 267,879 (87.57%) | |
Maternal pre-gestational smoking | <0.001 | ||
Missing | 616 (0.38%) | 4093 (0.35%) | |
None | 158,573 (98.87%) | 1,142,311 (98.91%) | |
Yes | 1184 (0.74%) | 8492 (0.74%) | |
Maternal pre-gestational drinking | <0.001 | ||
Missing | 616 (13.08%) | 4093 (86.92%) | |
No | 158,573 (12.19%) | 1,142,311 (87.81%) | |
Occasionally | 1184 (12.24%) | 8492 (87.76%) | |
Often | 10 (17.24%) | 48 (82.76%) | |
Paternal pre-gestational drinking | <0.001 | ||
Missing | 1,838 (14.30%) | 11,016 (85.70%) | |
No | 119,913 (11.93%) | 884,923 (88.07%) | |
Occasionally | 37,929 (12.94%) | 255,161 (87.06%) | |
Often | 703 (15.46%) | 3844 (84.54%) | |
Paternal pre-gestational smoking | <0.001 | ||
Missing | 1710 (14.10%) | 10,416 (85.90%) | |
None | 123,761 (11.99%) | 908,074 (88.01%) | |
Yes | 34,912 (12.87%) | 236,454 (87.13%) | |
Region 1 | <0.001 | ||
East | 49,228 (13.15%) | 325,085 (86.85%) | |
West | 12,038 (9.46%) | 115,203 (90.54%) | |
Middle | 23,827 (12.69%) | 163,970 (87.31%) | |
South | 46,429 (11.36%) | 362,457 (88.65%) | |
North | 28,861 (13.30%) | 188,229 (86.71%) |
Pregnancy Outcomes | Autumn | Spring | Summer | Winter | p Values | ||||
---|---|---|---|---|---|---|---|---|---|
n | % | n | % | n | % | n | % | ||
PreD | 7431 | 2.55 * | 12,421 | 3.18 Δ | 9626 | 2.95 | 9292 | 3.04 | <0.001 |
LBWI | 1952 | 0.67 | 2717 | 0.70 | 2123 | 0.65 * | 2173 | 0.71 Δ | 0.015 |
MedA | 780 | 0.27 | 1149 | 0.29 | 933 | 0.29 | 829 | 0.27 | 0.13 |
TIL | 270 | 0.09 | 352 | 0.09 | 320 | 0.1 | 304 | 0.1 | 0.553 |
SponD | 2828 | 0.97 * | 4024 | 1.03 | 3819 | 1.17 Δ | 3568 | 1.17 Δ | <0.001 |
StiB | 195 | 0.07 | 269 | 0.07 | 222 | 0.07 | 231 | 0.08 | 0.568 |
ProD | 3911 | 1.34 | 5276 | 1.35 | 4940 | 1.51 Δ | 4027 | 1.32 * | <0.001 |
MF | 17,117 | 5.87 * | 26,268 | 6.72 Δ | 20,602 | 6.3 | 19,905 | 6.51 | <0.001 |
APOs | 32,563 | 11.16 * | 49,474 | 12.66 Δ | 40,332 | 12.34 | 38,018 | 12.43 | <0.001 |
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Chai, J.; Zhang, J.; Shi, Y.; Sun, P.; Wang, Y.; Zhou, D.; Dong, W.; Jiang, L.; Jia, P. Spatiotemporal Patterns of Adverse Pregnancy Outcomes in Rural Areas of Henan, China. Int. J. Environ. Res. Public Health 2022, 19, 15966. https://doi.org/10.3390/ijerph192315966
Chai J, Zhang J, Shi Y, Sun P, Wang Y, Zhou D, Dong W, Jiang L, Jia P. Spatiotemporal Patterns of Adverse Pregnancy Outcomes in Rural Areas of Henan, China. International Journal of Environmental Research and Public Health. 2022; 19(23):15966. https://doi.org/10.3390/ijerph192315966
Chicago/Turabian StyleChai, Jian, Junxi Zhang, Yuanyuan Shi, Panpan Sun, Yuhong Wang, Dezhuan Zhou, Wei Dong, Lifang Jiang, and Peng Jia. 2022. "Spatiotemporal Patterns of Adverse Pregnancy Outcomes in Rural Areas of Henan, China" International Journal of Environmental Research and Public Health 19, no. 23: 15966. https://doi.org/10.3390/ijerph192315966