Parent-Adolescent Conflict, Depressive Symptoms, and Non-Suicidal Self-Injury among Chinese Adolescents: The Moderating Effect of the COMT Gene rs4680 Polymorphism
Abstract
:1. Introduction
1.1. The Mediating Effect of Depressive Symptoms
1.2. The Moderating Effect of COMT Gene rs4680 Polymorphism
1.3. The Present Study
2. Methods
2.1. Participants
2.2. Measures
2.2.1. Parent-Adolescent Conflict
2.2.2. Depressive Symptoms
2.2.3. NSSI
2.3. The COMT Gene rs4680 Polymorphism
2.4. Control Variables
2.5. Research Procedures and Statistical Analysis
3. Results
3.1. Descriptive Statistics
3.2. The Mediating Effect of Depressive Symptoms
3.3. Testing for the Moderated Mediation Model
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Gender | Age | FFD | PAC | DS | NSSI | rs4680 | |
---|---|---|---|---|---|---|---|
Gender | 1.00 | ||||||
Age | 0.06 | 1.00 | |||||
FFD | 0.03 | 0.03 | 1.00 | ||||
PAC | 0.11 ** | 0.05 | 0.13 ** | 1.00 | |||
DS | −0.05 | 0.04 | 0.21 *** | 0.18 *** | 1.00 | ||
NSSI | −0.06 | −0.01 | 0.13 ** | 0.13 *** | 0.30 *** | 1.00 | |
rs4680 | −0.02 | −0.03 | −0.02 | −0.04 | −0.02 | 0.06 | 1.00 |
Equation 1 (DS) | Equation 2 (NSSI) | |||||||
---|---|---|---|---|---|---|---|---|
β | SE | t | 95% CI | β | SE | t | 95% CI | |
Covariates: | ||||||||
Gender | −0.16 | 0.08 | −2.11 * | [−0.31, −0.01] | −0.10 | 0.07 | −1.38 | [−0.25, 0.04] |
Age | 0.03 | 0.04 | 0.89 | [−0.04, 0.11] | −0.02 | 0.04 | −0.64 | [−0.10, 0.05] |
FFD | 0.19 | 0.04 | 5.16 *** | [0.12, 0.27] | 0.06 | 0.04 | 1.61 | [−0.01, 0.13] |
Study variables: | ||||||||
PAC | 0.17 | 0.04 | 4.38 *** | [0.09, 0.24] | 0.08 | 0.04 | 2.10 * | [0.01, 0.15] |
DS | 0.27 | 0.04 | 7.11 *** | [0.20, 0.35] | ||||
R2 | 0.08 | 0.10 | ||||||
F | 13.88 *** | 15.26 *** |
DS | NSSI | |||||||
---|---|---|---|---|---|---|---|---|
β | SE | t | 95% CI | β | SE | t | 95% CI | |
Covariates: | ||||||||
Gender | −0.16 | 0.08 | −2.11 * | [−0.31, −0.01] | −0.09 | 0.07 | −1.23 | [−0.24, 0.05] |
Age | 0.03 | 0.04 | 0.80 | [−0.04, 0.10] | −0.03 | 0.04 | −0.74 | [−0.10, 0.05] |
FFD | 0.19 | 0.04 | 5.07 *** | [0.12, 0.26] | 0.07 | 0.04 | 1.75 | [−0.01, 0.14] |
Study variables: | ||||||||
PAC | 0.09 | 0.05 | 1.37 | [−0.01, 0.20] | 0.05 | 0.05 | 0.93 | [−0.05, 0.15] |
rs4680 | −0.01 | 0.07 | −0.14 | [−0.16, 0.14] | 0.12 | 0.07 | 1.69 | [−0.02, 0.27] |
PAC × rs4680 | 0.15 | 0.07 | 1.97 * | [0.00, 0.29] | 0.06 | 0.07 | 0.79 | [−0.09, 0.21] |
DS | 0.17 | 0.06 | 3.05 ** | [0.06, 0.28] | ||||
DS × rs4680 | 0.17 | 0.08 | 2.30 * | [0.03, 0.32] | ||||
R2 | 0.08 | 0.12 | ||||||
F | 9.93 *** | 10.85 *** |
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Deng, Y.; Li, M.; Wang, H.; Li, J.; He, X.; Yu, C. Parent-Adolescent Conflict, Depressive Symptoms, and Non-Suicidal Self-Injury among Chinese Adolescents: The Moderating Effect of the COMT Gene rs4680 Polymorphism. Int. J. Environ. Res. Public Health 2022, 19, 10567. https://doi.org/10.3390/ijerph191710567
Deng Y, Li M, Wang H, Li J, He X, Yu C. Parent-Adolescent Conflict, Depressive Symptoms, and Non-Suicidal Self-Injury among Chinese Adolescents: The Moderating Effect of the COMT Gene rs4680 Polymorphism. International Journal of Environmental Research and Public Health. 2022; 19(17):10567. https://doi.org/10.3390/ijerph191710567
Chicago/Turabian StyleDeng, Yuting, Meijin Li, Huahua Wang, Jingjing Li, Xu He, and Chengfu Yu. 2022. "Parent-Adolescent Conflict, Depressive Symptoms, and Non-Suicidal Self-Injury among Chinese Adolescents: The Moderating Effect of the COMT Gene rs4680 Polymorphism" International Journal of Environmental Research and Public Health 19, no. 17: 10567. https://doi.org/10.3390/ijerph191710567