Chinese Herbal Medicine Significantly Impacts the Haematological Variables of the Athlete Biological Passport
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Chinese Herbal Medicine
2.3. Study Design
2.4. Blood Sampling and Analysis
2.5. ABP and Statistical Analyses
3. Results
4. Discussion
4.1. CHMs on ABP Variables and Haematopoiesis
4.2. ABP and Confounding Factors
4.3. Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Phase | Baseline | Intervention | Recovery | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Day | 1 | 8 | 15 | 22 | 29 | 36 | ||||||
Data | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD |
Angelicae Sinensis Radix (ASR) | ||||||||||||
RBC (106/μL) | 5.25 | 0.55 | 5.04 | 0.51 | 5.08 | 0.62 | 5.07 | 0.53 | 5.03 | 0.50 | 4.98 | 0.49 |
MCV (fL) | 86.4 | 7.3 | 86.1 | 7.4 | 85.6 | 7.0 | 85.5 | 7.1 | 85.5 | 7.1 | 85.5 | 7.0 |
HCT (%) | 45.1 | 2.7 | 43.1 | 2.3 | 43.2 | 3.8 | 43.1 | 3.0 | 42.8 | 2.9 | 42.3 | 2.6 |
MCH (pg) | 27.8 | 3.1 | 27.9 | 3.2 | 27.8 | 3.2 | 27.6 | 3.1 | 27.8 | 3.2 | 27.7 | 3.2 |
MCHC (g/dL) | 32.1 | 1.1 | 32.3 | 1.3 | 32.4 | 1.3 | 32.2 | 1.3 | 32.4 | 1.3 | 32.4 | 1.4 |
WBC (/μL) | 6055 | 1036 | 5931 | 1193 | 6041 | 1558 | 6181 | 1513 | 6608 | 1157 | 6283 | 883 |
PLT (103/μL) | 275.6 | 76.3 | 263.1 | 75.0 | 261.3 | 94.5 | 267.6 | 80.7 | 262.0 | 70.2 | 269.8 | 72.0 |
Astragali Radix (AR) | ||||||||||||
RBC (106/μL) | 5.06 | 0.78 | 5.00 | 0.71 | 5.04 | 0.72 | 5.00 | 0.83 | 5.00 | 0.74 | 4.92 | 0.77 |
MCV (fL) | 87.5 | 7.4 | 87.5 | 7.1 | 86.7 | 6.9 | 87.2 | 7.1 | 87.5 | 7.3 | 87.7 | 7.5 |
HCT (%) | 43.9 | 4.1 | 43.4 | 3.6 | 43.4 | 3.5 | 43.1 | 4.4 | 43.3 | 3.9 | 42.8 | 4.3 |
MCH (pg) | 28.6 | 3.1 | 28.6 | 3.1 | 28.4 | 3.2 | 28.5 | 3.2 | 28.6 | 3.1 | 28.7 | 3.1 |
MCHC (g/dL) | 32.6 | 1.3 | 32.7 | 1.4 | 32.7 | 1.6 | 32.7 | 1.5 | 32.7 | 1.3 | 32.6 | 1.3 |
WBC (/μL) | 5896 | 1392 | 6361 | 2120 | 5929 | 1440 | 5881 | 1445 | 5783 | 1365 | 6216 | 1314 |
PLT (103/μL) | 282.5 | 43.7 | 273.1 | 26.4 | 280.5 | 44.3 | 279.8 | 49.2 | 271.9 | 64.0 | 287.3 | 47.4 |
Salviae Miltiorrhizae Radix et Rhizoma (SMR) | ||||||||||||
RBC (106/μL) | 5.11 | 1.03 | 5.15 | 0.92 | 5.14 | 0.96 | 4.97 | 0.96 | 4.98 | 0.91 | 4.98 | 0.91 |
MCV (fL) | 89.0 | 11.0 | 88.6 | 11.4 | 88.3 | 10.2 | 88.4 | 10.9 | 88.3 | 11.3 | 88.9 | 10.8 |
HCT (%) | 44.5 | 3.3 | 44.8 | 2.5 | 44.6 | 3.7 | 43.1 | 3.7 | 43.1 | 2.5 | 43.4 | 2.9 |
MCH (pg) | 28.6 | 4.1 | 28.7 | 3.9 | 28.6 | 4.0 | 28.6 | 4.1 | 28.8 | 4.0 | 28.8 | 3.9 |
MCHC (g/dL) | 32.1 | 1.1 | 32.3 | 1.1 | 32.2 | 1.3 | 32.3 | 1.2 | 32.6 | 1.0 | 32.3 | 1.0 |
WBC (/μL) | 6286 | 1264 | 6105 | 1934 | 6353 | 1788 | 6456 | 1960 | 7104 | 2367 | 6130 | 1998 |
PLT (103/μL) | 255.9 | 57.0 | 256.0 | 49.7 | 261.1 | 54.6 | 254.4 | 50.5 | 269.9 | 64.3 | 280.5 | 57.5 |
Asini Corii Colla (ACC) | ||||||||||||
RBC (106/μL) | 4.90 | 0.61 | 4.87 | 0.56 | 4.91 | 0.63 | 4.91 | 0.51 | 4.99 | 0.58 | 4.82 | 0.51 |
MCV (fL) | 87.6 | 2.7 | 87.3 | 2.6 | 87.0 | 2.6 | 87.4 | 3.3 | 87.0 | 3.0 | 87.1 | 3.0 |
HCT (%) | 43.1 | 6.2 | 42.5 | 5.3 | 42.8 | 6.0 | 43.0 | 5.5 | 43.4 | 5.8 | 42.0 | 5.4 |
MCH (pg) | 28.4 | 1.6 | 28.5 | 1.7 | 28.5 | 1.7 | 28.5 | 1.7 | 28.3 | 1.7 | 28.4 | 1.7 |
MCHC (g/dL) | 32.4 | 1.0 | 32.6 | 1.1 | 32.6 | 1.1 | 32.6 | 0.9 | 32.5 | 1.1 | 32.6 | 1.0 |
WBC (/μL) | 7198 | 2376 | 6924 | 2196 | 6381 | 2049 | 6931 | 2111 | 7324 | 2622 | 6943 | 2231 |
PLT (103/μL) | 283.6 | 67.3 | 282.5 | 56.8 | 291.9 | 63.4 | 304.9 | 62.1 | 291.8 | 61.7 | 288.3 | 59.1 |
Spatholobi Caulis (SC) | ||||||||||||
RBC (106/μL) | 4.80 | 0.59 | 4.78 | 0.50 | 4.78 | 0.55 | 4.78 | 0.54 | 4.69 | 0.61 | 4.69 | 0.62 |
MCV (fL) | 88.7 | 3.6 | 89.0 | 3.6 | 87.9 | 3.0 | 88.8 | 3.4 | 88.2 | 3.6 | 88.8 | 3.8 |
HCT (%) | 42.4 | 4.4 | 42.4 | 4.0 | 42.0 | 4.4 | 42.3 | 4.0 | 41.3 | 4.9 | 41.5 | 4.9 |
MCH (pg) | 29.0 | 1.5 | 29.0 | 1.3 | 29.0 | 1.5 | 28.9 | 1.5 | 29.2 | 1.4 | 29.2 | 1.5 |
MCHC (g/dL) | 32.7 | 1.1 | 32.6 | 1.0 | 33.0 | 1.2 | 32.5 | 1.0 | 33.1 | 0.9 | 32.9 | 1.0 |
WBC (/μL) | 6823 | 1643 | 6974 | 2264 | 7128 | 1931 | 6423 | 1213 | 6718 | 1971 | 6291 | 1669 |
PLT (103/μL) | 282.9 | 83.6 | 283.1 | 80.5 | 275.3 | 66.6 | 283.9 | 79.6 | 283.1 | 74.6 | 286.6 | 78.7 |
Gui-Pi-Tang (GPT) | ||||||||||||
RBC (106/μL) | 5.28 | 1.08 | 5.30 | 1.09 | 5.25 | 1.13 | 5.30 | 1.14 | 5.28 | 1.08 | 5.21 | 1.10 |
MCV (fL) | 86.4 | 8.9 | 86.4 | 9.2 | 86.0 | 8.5 | 86.3 | 9.2 | 85.9 | 8.9 | 86.1 | 8.9 |
HCT (%) | 44.9 | 4.7 | 45.0 | 4.7 | 44.4 | 5.2 | 44.9 | 4.7 | 44.6 | 4.7 | 44.2 | 5.2 |
MCH (pg) | 28.1 | 3.4 | 28.2 | 3.5 | 28.1 | 3.3 | 28.1 | 3.4 | 28.1 | 3.3 | 28.1 | 3.4 |
MCHC (g/dL) | 32.5 | 1.0 | 32.6 | 1.3 | 32.6 | 1.1 | 32.5 | 1.0 | 32.6 | 0.9 | 32.6 | 1.0 |
WBC (/μL) | 7506 | 1577 | 7231 | 1688 | 7895 | 1690 | 7899 | 2130 | 7623 | 1819 | 7823 | 2127 |
PLT (103/μL) | 317.9 | 76.4 | 318.3 | 71.6 | 315.1 | 75.8 | 326.1 | 62.6 | 320.4 | 64.3 | 329.5 | 61.3 |
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Chang, W.C.-W.; Wang, C.-Y.; Liu, W.-Y.; Tsai, C.-C.; Wu, Y.-T.; Hsu, M.-C. Chinese Herbal Medicine Significantly Impacts the Haematological Variables of the Athlete Biological Passport. Int. J. Environ. Res. Public Health 2021, 18, 9533. https://doi.org/10.3390/ijerph18189533
Chang WC-W, Wang C-Y, Liu W-Y, Tsai C-C, Wu Y-T, Hsu M-C. Chinese Herbal Medicine Significantly Impacts the Haematological Variables of the Athlete Biological Passport. International Journal of Environmental Research and Public Health. 2021; 18(18):9533. https://doi.org/10.3390/ijerph18189533
Chicago/Turabian StyleChang, William Chih-Wei, Chih-Yuan Wang, Wan-Yi Liu, Chin-Chuan Tsai, Yu-Tse Wu, and Mei-Chich Hsu. 2021. "Chinese Herbal Medicine Significantly Impacts the Haematological Variables of the Athlete Biological Passport" International Journal of Environmental Research and Public Health 18, no. 18: 9533. https://doi.org/10.3390/ijerph18189533