Marine Drugs

Open AccessArticle

Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand

by Rawiwan Wattanadilok, Pichan Sawangwong, Cátia Rodrigues, Honorina Cidade, Madalena Pinto, Eugenia Pinto, Artur Silva and

Anake Kijjoa

Mar. Drugs 2007, 5(2), 40-51; https://doi.org/10.3390/md502040 - 25 Jun 2007

Cited by 42 | Viewed by 11051

Abstract

A new compound maleimide-5-oxime was isolated, together with 3,4- dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi. Full article

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Open AccessArticle

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

Baoquan Bao

, Ping Zhang, Yoonmi Lee, Jongki Hong, Chong-O. Lee and

Jee H. Jung

Mar. Drugs 2007, 5(2), 31-39; https://doi.org/10.3390/md502031 - 25 Jun 2007

Cited by 50 | Viewed by 10333

Abstract

Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity. Full article

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Open AccessArticle

Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

Gerhard Bringmann

, Tobias A. M. Gulder, Gerhard Lang, Stefanie Schmitt, Rüdiger Stöhr, Jutta Wiese, Kerstin Nagel and

Johannes F. Imhoff

Mar. Drugs 2007, 5(2), 23-30; https://doi.org/10.3390/md502023 - 25 Jun 2007

Cited by 48 | Viewed by 11208

Abstract

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. Full article

(This article belongs to the Special Issue Marine Natural Products as Anti-Cancer Agents)

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Open AccessArticle

Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand

Anake Kijjoa

, Rawiwan Wattanadilok, Werner Herz, Nair Campos, Maria São José Nascimento and Madalena Pinto

Mar. Drugs 2007, 5(2), 6-22; https://doi.org/10.3390/md502006 - 17 Apr 2007

Cited by 41 | Viewed by 11818

Abstract

The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells. Full article

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Mar. Drugs, Volume 5, Issue 2 (June 2007) – 4 articles , Pages 6-51

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