Factors associated with bone mineral density loss in patients with spondyloarthropathies: A 4-year follow-up study
Abstract
Methods: A cohort of 41 SpA patients were followed up for 4 years. Disease activity indices, spinal mobility and laboratory tests, BMD using were monitored at the baseline and 4-year follow-up. The 4% BMD loss at either of the proximal femurs was defined as significant.
Results: Over the 4-year study period, 27% of SpA patients experienced femoral BMD loss. Baseline BMD > 0.85 g/cm2 (p = 0.011) was the baseline factor associated with BMD loss at 4- year follow-up. Several clinical and functional tests were helpful in identifying the BMD loss at follow-up: CRP > 15.6 mg/L (sens. 91%, spec. 70%), ESR > 29 mm/h (sens. 82%, spec. 73%), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) > 4.75 (sens. 91%, spec. 62%). At follow-up anti-TNFa treatment history, stable or improved lateral flexion and intermalleolar distance (NPV, accordingly, 95%, 88% and 87%), made BMD loss unlikely. Deterioration of the physician assessment of global disease activity (PAGDA) score from baseline to follow-up was a remarkable predictor of BMD loss (PPV = 0.83), while stable or improved score excluded the BMD loss (NPV = 0.83). According to multiple logistic regression analysis, baseline BMD value and follow-up CRP levels, when considered together, identify BMD status correctly in 85% of SpA patients (Nagelkerke R2 = 0.676).
Conclusion: Baseline BMD, anti-TNFa treatment, PAGDA score, spinal mobility tests and disease activity markers are useful factors in predicting the BMD loss in SpA patients and can provide surrogate information on BMD status.
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Vencevičienė, L.; Butrimienė, I.; Vencevičius, R.; Sadauskienė, E.; Kasiulevičius, V.; Šapoka, V. Factors associated with bone mineral density loss in patients with spondyloarthropathies: A 4-year follow-up study. Medicina 2015, 51, 272-279. https://doi.org/10.1016/j.medici.2015.08.001
Vencevičienė L, Butrimienė I, Vencevičius R, Sadauskienė E, Kasiulevičius V, Šapoka V. Factors associated with bone mineral density loss in patients with spondyloarthropathies: A 4-year follow-up study. Medicina. 2015; 51(5):272-279. https://doi.org/10.1016/j.medici.2015.08.001
Chicago/Turabian StyleVencevičienė, Lina, Irena Butrimienė, Rimantas Vencevičius, Eglė Sadauskienė, Vytautas Kasiulevičius, and Virginijus Šapoka. 2015. "Factors associated with bone mineral density loss in patients with spondyloarthropathies: A 4-year follow-up study" Medicina 51, no. 5: 272-279. https://doi.org/10.1016/j.medici.2015.08.001