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Article

Nonsteroidal Anti-Inflammatory Drug-Induced Severe Hyponatremia

by
Mehmet Emin Demir
1,*,
Mehmet Horoz
1,
Turgay Ulas
2,
Mehmet Ali Eren
3 and
Zafer Ercan
4
1
Department of Nephrology, School of Medicine, Harran University, Sanliurfa
2
Department of Internal Medicine, School of Medicine, Harran University, Sanliurfa
3
Department of Endocrinology, School of Medicine, Harran University Sanliurfa
4
Department of Nephrology, Diskapi Yıldırım Beyazit Education and Training Hospital, Ankara, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2012, 48(12), 90; https://doi.org/10.3390/medicina48120090
Submission received: 21 February 2012 / Accepted: 5 June 2012 / Published: 10 June 2012

Abstract

Hyponatremia (serum sodium level, <135 mmol/L) occasionally may develop in the course of treatment with nonsteroidal anti-inflammatory drugs, which are usually used in daily clinical practice. Nonsteroidal anti-inflammatory drugs diminish the normal inhibitory effect of prostaglandins on the activity of antidiuretic hormone and can therefore reduce free water excretion, leading to water retention and induction or exacerbation of hyponatremia. In this report, we present a case of hyponatremia in a 78-year-old man who had received meloxicam, a nonsteroidal anti-inflammatory drug.
Keywords: drug-induced hyponatremia; meloxicam; nonsteroidal anti-inflammatory drugs drug-induced hyponatremia; meloxicam; nonsteroidal anti-inflammatory drugs

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MDPI and ACS Style

Demir, M.E.; Horoz, M.; Ulas, T.; Eren, M.A.; Ercan, Z. Nonsteroidal Anti-Inflammatory Drug-Induced Severe Hyponatremia. Medicina 2012, 48, 90. https://doi.org/10.3390/medicina48120090

AMA Style

Demir ME, Horoz M, Ulas T, Eren MA, Ercan Z. Nonsteroidal Anti-Inflammatory Drug-Induced Severe Hyponatremia. Medicina. 2012; 48(12):90. https://doi.org/10.3390/medicina48120090

Chicago/Turabian Style

Demir, Mehmet Emin, Mehmet Horoz, Turgay Ulas, Mehmet Ali Eren, and Zafer Ercan. 2012. "Nonsteroidal Anti-Inflammatory Drug-Induced Severe Hyponatremia" Medicina 48, no. 12: 90. https://doi.org/10.3390/medicina48120090

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