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Review

Cancer Gene Suppression Strategies: Issues and Potential

1
School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, Sydney, Australia
2
Children’s Cancer Institute Australia, Kensington, Sydney, Australia
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2004, 6(2), 89-102; https://doi.org/10.21775/cimb.006.089
Submission received: 4 November 2003 / Revised: 9 January 2004 / Accepted: 7 March 2004 / Published: 4 May 2004

Abstract

Oncogenes are ideal targets for therapies which down-regulate gene expression. However, effective modalities for altering gene expression in vivo have thus far proven to be elusive. Whilst there has been recent success with small molecule inhibitors of oncoprotein function, evolution of resistance to these agents has been observed in the clinical setting, indicating the need for combinations of therapies for cancer treatment. Strategies for in vivo gene down-regulation still hold promise for the treatment of cancer. The technologies relevant to such therapeutic strategies are discussed in terms of molecular action, delivery and choice of target gene. Consideration is given to the pre-clinical and clinical efficacy these agents have demonstrated to date.

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MDPI and ACS Style

Passioura, T.; Symonds, G. Cancer Gene Suppression Strategies: Issues and Potential. Curr. Issues Mol. Biol. 2004, 6, 89-102. https://doi.org/10.21775/cimb.006.089

AMA Style

Passioura T, Symonds G. Cancer Gene Suppression Strategies: Issues and Potential. Current Issues in Molecular Biology. 2004; 6(2):89-102. https://doi.org/10.21775/cimb.006.089

Chicago/Turabian Style

Passioura, T., and G. Symonds. 2004. "Cancer Gene Suppression Strategies: Issues and Potential" Current Issues in Molecular Biology 6, no. 2: 89-102. https://doi.org/10.21775/cimb.006.089

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