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Volume 41
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10.21775/cimb.041.469
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Alphaherpesvirus Vaccines

by
Clare Burn Aschner
1 and
Betsy C. Herold
1,2,*
1
Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
2
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2021, 41(1), 469-508; https://doi.org/10.21775/cimb.041.469
Submission received: 13 June 2020 / Revised: 11 July 2020 / Accepted: 9 August 2020 / Published: 23 September 2020
Versions Notes

Abstract

Prophylactic and therapeutic vaccines for the alphaherpesviruses including varicella zoster virus (VZV) and herpes simplex virus types 1 and 2 have been the focus of enormous preclinical and clinical research. A live viral vaccine for prevention of chickenpox and a subunit therapeutic vaccine to prevent zoster are highly successful. In contrast, progress towards the development of effective prophylactic or therapeutic vaccines against HSV-1 and HSV-2 has met with limited success. This review provides an overview of the successes and failures, the different types of immune responses elicited by various vaccine modalities, and the need to reconsider the preclinical models and immune correlates of protection against HSV.

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MDPI and ACS Style

Aschner, C.B.; Herold, B.C. Alphaherpesvirus Vaccines. Curr. Issues Mol. Biol. 2021, 41, 469-508. https://doi.org/10.21775/cimb.041.469

AMA Style

Aschner CB, Herold BC. Alphaherpesvirus Vaccines. Current Issues in Molecular Biology. 2021; 41(1):469-508. https://doi.org/10.21775/cimb.041.469

Chicago/Turabian Style

Aschner, Clare Burn, and Betsy C. Herold. 2021. "Alphaherpesvirus Vaccines" Current Issues in Molecular Biology 41, no. 1: 469-508. https://doi.org/10.21775/cimb.041.469

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