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Review

PGC-1: The Energetic Regulator in Cardiac Metabolism

by
Wencheng Di
1,†,
Jianjun Lv
2,3,†,
Shuai Jiang
4,†,
Chenxi Lu
2,
Zhi Yang
3,
Zhiqiang Ma
5,
Wei Hu
3,
Yang Yang
2,3,* and
Biao Xu
1,*
1
Department of Cardiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China
2
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China
3
Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
4
Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
5
Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi'an 710038, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2018, 28(1), 29-46; https://doi.org/10.21775/cimb.028.029
Submission received: 8 November 2017 / Revised: 6 December 2017 / Accepted: 8 January 2018 / Published: 1 February 2018

Abstract

The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1s (PGC-1s) can induce the expression of several downstream genes that play pivotal roles in the regulation of mitochondrial biogenesis and metabolism in the heart. Moreover, PGC-1 signaling pathways have also been reported to play a critical role in cardioprotection. Given the significance of PGC-1 coactivators, we summarize the current literature on the molecular mechanisms and roles of PGC-1s in cardiac metabolism. Thus, in this review, we first introduce the basic knowledge regarding PGC-1 signaling pathways. We then discuss their roles in heart metabolism. Moreover, we describe several significant treatments that target the PGC-1 signaling pathway. This review presents the significant roles of PGC-1s in cardiac metabolism and may contribute to the promotion of PGC-1 signaling pathway as a novel therapeutic target.
Keywords: PGC-1; energetic; regulator; cardiac; metabolism PGC-1; energetic; regulator; cardiac; metabolism

Share and Cite

MDPI and ACS Style

Di, W.; Lv, J.; Jiang, S.; Lu, C.; Yang, Z.; Ma, Z.; Hu, W.; Yang, Y.; Xu, B. PGC-1: The Energetic Regulator in Cardiac Metabolism. Curr. Issues Mol. Biol. 2018, 28, 29-46. https://doi.org/10.21775/cimb.028.029

AMA Style

Di W, Lv J, Jiang S, Lu C, Yang Z, Ma Z, Hu W, Yang Y, Xu B. PGC-1: The Energetic Regulator in Cardiac Metabolism. Current Issues in Molecular Biology. 2018; 28(1):29-46. https://doi.org/10.21775/cimb.028.029

Chicago/Turabian Style

Di, Wencheng, Jianjun Lv, Shuai Jiang, Chenxi Lu, Zhi Yang, Zhiqiang Ma, Wei Hu, Yang Yang, and Biao Xu. 2018. "PGC-1: The Energetic Regulator in Cardiac Metabolism" Current Issues in Molecular Biology 28, no. 1: 29-46. https://doi.org/10.21775/cimb.028.029

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