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Molbank
Volume 2023
Issue 2
10.3390/M1656
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Peer-Review Record

(E)-6-Hydroxy-2-oxo-2H-chromen-7-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Molbank 2023, 2023(2), M1656; https://doi.org/10.3390/M1656
by Yang-Heon Song
Reviewer 1: Anonymous
Molbank 2023, 2023(2), M1656; https://doi.org/10.3390/M1656
Submission received: 29 April 2023 / Revised: 26 May 2023 / Accepted: 31 May 2023 / Published: 2 June 2023
(This article belongs to the Section Organic Synthesis)

Round 1

Reviewer 1 Report

Dear Author,

The experimental data have been correctly performed and analyzed. It is recommended to change the following phrase: “A conjugate compound 5, (E)-6-hydroxy-2-oxo-2H-chromen-7-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate, of 6,7-hydroxycoumarin (esculetin) 3 and (E)-3-(4-hydroxy-3-methoxyphenyl)-acrylic acid (ferulic acid) 1 <…>” into: “A hybrid compound 5: (E)-6-hydroxy-2-oxo-2H-chromen-7-yl-3-(4-hydroxy-3-methoxyphenyl)acrylate composed of (E)-3-(4-hydroxy-3-methoxyphenyl)-acrylic acid (ferulic acid) 1 and 6,7-hydroxycoumarin (esculetin) 3 <…>”.

It should be considered to add the Figure in the Introduction presenting the structures of ferulic acid (compound 1) and esculetin (compound 3).

The introduction section should be revised, e.g. line 23: Please rewrite the following sentence starting with “And, …”

It would be worth adding more details regarding the 1H-NMR and 13C-NMR spectra of the title compound 5, instead of giving the details of compound 4 which is the 4-acetoxy-precursor.

In conclusion, it would be helpful if the Author could provide any potential applications for the synthesized hybrid compound 5 in this work.

Summing up, the paper deserves to be published in Molbank after these few issues are addressed.

Author Response

May 26, 2023

Dear Editor:

Thank you very much for reviewing our manuscript “(E)-6-hydroxy-2-oxo-2H-chromen-7-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate”.

We have corrected and revised the original manuscript according to reviewer’s suggestion.

 Reviewer 2:

  • “A conjugate compound 5, (E)-6-hydroxy-2-oxo-2H-chromen-7-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate, of 6,7-hydroxycoumarin (esculetin) 3and (E)-3-(4-hydroxy-3-methoxyphenyl)-acrylic acid (ferulic acid) 1 -----> changed into “A hybrid compound 5: (E)-6-hydroxy-2-oxo-2H-chromen-7-yl-3-(4-hydroxy-3-methoxyphenyl)acrylate composed of (E)-3-(4-hydroxy-3-methoxyphenyl) -acrylic acid (ferulic acid) 1 and 6,7-hydroxycoumarin (esculetin) 3 .
  • Figure in the Introduction presenting the structures of ferulic acid (compound 1) and esculetin (compound 3) ------> Figure 1 was added.
  • line 23: Please rewrite the following sentence starting with “And, …”----> From line 23, the paragraph was changed and added.
  • adding more details regarding the 1H-NMR and 13C-NMR spectra of the title compound 5 ----> more details were added.
  • provide any potential applications for the synthesized hybrid compound 5 in this work. ----> “This compound could be useful as a potential material having various biological activities” was added.

Could you review again and consider this revised manuscript for publication in Molbank.

Thank you very much for your time and consideration.

Best regards,

Yang-Heon Song

_________________________

Yang-Heon Song, Ph. D., Prof.

Department of Chemistry

Mokwon University

Daejeon 35349

South Korea

e-mail: yhsong@mokwon.ac.kr

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