Autophagy Regulators in Cancer
Abstract
:1. Introduction
2. Autophagy and Its Formation Process
2.1. Initiation of Autophagy
2.2. Elongation and Autophagosome Formation
2.3. Fusion with the Lysosome and Degradation of the Autophagic Body
3. Autophagy in Cancer Development
3.1. The Role of Autophagy in Apoptosis
3.1.1. Autophagy Inducers Regulate Cancer Cell Apoptosis
Drugs | Cancer Development | Mechanisms | Cancer Type | Refs |
---|---|---|---|---|
Natural Products | ||||
Luteolin | Cell apoptosis | Increased Beclin 1 | Liver cancer | [56] |
Resveratrol (RSV) | Cell apoptosis | LKB1-AMPK and PI3K/AKT-regulated mTOR signaling pathways | HL-60cell | [62] |
Apigenin | Cell apoptosis | Inhibition of PI3K/Akt/mTOR pathway | HCC | [63] |
Erastin | Cell ferroptosis | Increased of TfR1expression and lipid ROS accumulation | Hela, lung | [64] |
Erianin | Cell ferroptosis | Accumulation of Fe2+ and ROS, lipid peroxidation | Colorectal cancer (CRC) | [65] |
Ginsenoside Rh4 | Cell ferroptosis | Activating ROS/P53 pathway | CRC | [66] |
Anomanolide C | Cell ferroptosis | Reduced GPX4 expression, accumulation of Fe2+ | TNBC | [67] |
6-Gingerol | Cell ferroptosis | Increased ROS level and LC3B-II and Beclin-1 expression | Prostate cancer | [68] |
Curcumin | Cell ferroptosis | Increased level of Beclin1 and LC3, decreased P62 | NSCLC | [69] |
Chrysin | Cell ferroptosis | Increased ROS, inhibition of carbonyl reductase1 (CBR1) | PCa | [70] |
Urolithin A | Cell metastasis | Decreased the MMP-9 expression | CRC | [71] |
Gallotannin (GT) | Cell metastasis | Inhibition of PI3K/Akt/mTOR pathway | CRC | [72] |
Halofuginone (HF) | Cell metastasis | Suppression of STMN1 and p53 expression | Breast cancer | [73] |
Salidroside | Cell apoptosis | Activation of the AMPK pathway and downregulation of mTOR pathway | HUVECs | [74] |
Itraconazole | Cell proliferation | Repression of AKT1-MTOR signaling | Glioblastoma | [75] |
Isorhapontigenin (ISO) | Cell growth | MAPK8-JUN-dependent transcriptional induction of SESN2 | Bladder cancer | [76] |
Others | ||||
SGK1 | Cell metastasis | Inhibition EMT process | PCa | [77] |
Valproic acid (VPA) | Tumor growth | Activation of AMPK and inhibition of downstream MTOR signaling | Lymphoma | [78] |
3.1.2. Autophagy Inhibitors Regulate Cancer Cell Apoptosis
Drugs | Cancer Development | Mechanisms | Cancer Type | Refs |
---|---|---|---|---|
Natural Products | ||||
Oridonin | Cell apoptosis | Inhibition of Beclin 1 | Breast cancer | [82] |
Salinomycin | Cell apoptosis | ROS production led to mitochondrial dysfunction | Breast cancer | [84] |
AdoMet | Cell apoptosis | Enhanced beclin-1 and LC3B-II | Breast cancer | [85] |
Metformin | Cell ferroptosis | Inhibiting lncRNA H19, increasing lipid ROS | Breast cancer | [86] |
Melatonin + erastin | Cell ferroptosis | Increased lipid ROS and P62 | Squamous cell carcinoma | [87] |
Deoxypodophyllotoxin (DPT) | Tumor growth | Triggered mitochondrial ROS | PCa | [88] |
miRNAs | ||||
MIR152 | Cell apoptosis | Downregulation of ATG14 | Ovarian cancer | [89] |
MiR-221 | Cell apoptosis | Downregulation of TP53INP1 | CRC | [90] |
MiRNA-30a | Cell metastasis | Increased beclin-1 and Atg5 | HCC | [91] |
Others | ||||
PCBP1 | Cell apoptosis | Downregulation of LC3B | CRC | [92] |
IBP | Cell metastasis | Repression of MTORC2 signaling | Breast cancer | [93] |
KPNA2 | Cell metastasis | Inhibition of p53 | OSCC | [94] |
MCT4 | Cell ferroptosis | Increasing lipid ROS, inhibiting AMPK pathways | Bladder cancer | [95] |
H2S | Cell proliferation and differentiation | Elevated LC-3II, ATG5, and Beclin-1 | HaCaT cells | [96] |
3.2. Interaction between Autophagy and Ferroptosis
3.2.1. Autophagy Inducers Regulate Cancer Cell Ferroptosis
3.2.2. Autophagy Inhibitors Regulate Cancer Cell Ferroptosis
3.3. Autophagy Regulates Cancer Cell Metastasis
3.3.1. Autophagy Inducers Regulate Cancer Cell Metastasis
3.3.2. Autophagy Inhibitors Regulate Cancer Cell Metastasis
3.4. Autophagy and Cancer Cell Cycle
3.5. Autophagy in Cancer Proliferation and Differentiation
3.6. Defective Autophagy in Tumorigenesis
4. Autophagy in Cancer Therapeutics
4.1. Promotion of Autophagy in Cancer Therapeutics
4.2. Inhibition of Autophagy in Cancer Therapeutics
5. Conclusions and Outlooks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AdoMet | S-adenosyl-L-methionine |
AL | autophagolysosome |
ATG | autophagy related |
Atg | autophagy-related genes |
ASICs | acid-sensing ion channels |
CAM | clarithromycin |
CBR1 | carbonyl reductase1 |
CLC | chloroquine |
CMA | chaperone-mediated autophagy |
CRC | colorectal cancer |
CSFV | classical swine fever virus |
CS-NPs | chitosan nanoparticles |
CREB1 | cAMP response element-binding protein 1 |
DPT | deoxypodophyllotoxin |
GEF | gefitinib |
EMT | epithelial–mesenchymal transition |
GQ | 7-O-geranylquercertin |
GT | gallotannin |
HaCaT | human keratinocytes |
HCC | hepatocellular carcinoma |
HCQ | hydroxychloroquine |
HDAC | histone deacetylase |
HF | halofuginone |
H2S | hydrogen sulfide |
HUVECs | human umbilical vein endothelial cells |
IBP | interferon regulatory factor-4 binding protein |
ISO | isorhapontigenin |
KPNA2 | karyopherin α2 |
LC3B | microtubule-associated protein light chain 3B (LC3B) |
MSCs | mesenchymal stem cells |
mTOR | mammalian target of rapamycin |
MβCD | methyl-β-cyclodextrin |
MM9 | matrix metalloproteinas-9 |
NSCLC | non-small cell lung cancer |
OSCC | oral squamous cell carcinoma |
PE | phosphatidylethanolamine |
PCBP1 | poly C binding protein |
PI3K | phosphoinositide 3-kinase |
PCa | prostate cancer |
RSV | resveratrol |
ROS | reactive oxygen species |
SGK1 | serum- and glucocorticoid-induced protein kinase 1 |
TEM | temsirolimus |
TP53INP1 | tumor protein 53-induced nuclear protein 1 |
Ubl | ubiquitin-like |
ULK1 | unc-51 like autophagy activating kinase |
VPA | valproic acid |
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Zhang, J.; Xiang, Q.; Wu, M.; Lao, Y.-Z.; Xian, Y.-F.; Xu, H.-X.; Lin, Z.-X. Autophagy Regulators in Cancer. Int. J. Mol. Sci. 2023, 24, 10944. https://doi.org/10.3390/ijms241310944
Zhang J, Xiang Q, Wu M, Lao Y-Z, Xian Y-F, Xu H-X, Lin Z-X. Autophagy Regulators in Cancer. International Journal of Molecular Sciences. 2023; 24(13):10944. https://doi.org/10.3390/ijms241310944
Chicago/Turabian StyleZhang, Juan, Qian Xiang, Man Wu, Yuan-Zhi Lao, Yan-Fang Xian, Hong-Xi Xu, and Zhi-Xiu Lin. 2023. "Autophagy Regulators in Cancer" International Journal of Molecular Sciences 24, no. 13: 10944. https://doi.org/10.3390/ijms241310944