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Article
Peer-Review Record

Integrated DNA Copy Number and Expression Profiling Identifies IGF1R as a Prognostic Biomarker in Pediatric Osteosarcoma

Int. J. Mol. Sci. 2022, 23(14), 8036; https://doi.org/10.3390/ijms23148036
by Aaron M. Taylor 1,2,3, Jiayi M. Sun 2,3, Alexander Yu 2, Horatiu Voicu 4, Jianhe Shen 2, Donald A. Barkauskas 5, Timothy J. Triche 6, Julie M. Gastier-Foster 7, Tsz-Kwong Man 2,4 and Ching C. Lau 1,2,3,4,7,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2022, 23(14), 8036; https://doi.org/10.3390/ijms23148036
Submission received: 20 June 2022 / Revised: 17 July 2022 / Accepted: 18 July 2022 / Published: 21 July 2022
(This article belongs to the Special Issue Molecular Biology in Bone Tumors)

Round 1

Reviewer 1 Report

This study is highly relevant for using a large number of samples to investigate molecular biology of osteosarcoma. The amplification of IGFR1 found in this study may in part explain  why this cancer occurs so often during periors of rapid bone growth. IGFR1 overexpression can also now be targeted using an antibody (FPI-1434) with an alpha emitter, Ac-225, (NCT03746431). Instead of just saying overexpression is associated with worse prognosis, Suggest also mentioning this clincal trial in the discussion.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

see attached file

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The authors have adequately responded to the reveiwers' comments and I believe the manuscript has improved sufficiently to warrant publication in its present form.

 

 

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